ライフサイエンスコーパス: phosphinic acid

1 f the GABA(B) agonist, 3-aminopropyl-(methyl)phosphinic acid.

2 dary phosphine, and finally oxidation to the phosphinic acid.

3 ficient method for the synthesis of glycosyl phosphinic acids (21) from the corresponding C-phosphona

4 competitive antagonist 3-aminopropyl(methyl)phosphinic acid (3-APMPA) induced fluorescence changes i

5 l)ethyl]amino-2-hydroxypropyl](phenylme thyl)phosphinic acid] (a GABA(B) antagonist)-sensitive respon

6 el and practical approach to monosubstituted phosphinic acid (alkylphosphonous acid) derivatives from

7 When evaluated in vivo, the methyl phosphinic acid analogue (4b) produced a bone anabolic r

8 hylene glutaric acid ester provided the aryl phosphinic acid analogue of p-aminobenzoyl glutamic acid

9 protecting groups, provided the target aryl phosphinic acid analogues of folic acid and related anti

10 r concentrations, both 3-aminopropyl(methyl)-phosphinic acid and GABA directly activated the A, G, S,

11 thesis of suitably protected p-aminophenyl H-phosphinic acids and esters from the corresponding para-

12 pon previous routes for the preparation of H-phosphinic acids and other organophosphorus compounds.

13 Monosubstituted phosphinic acids are usually obtained in better than 90%

14 agonists, such as baclofen or 3-aminopropyl phosphinic acid, are presented.

15 we disclose a desymmetrization that employs phosphinic acids as prochiral nucleophiles in a Pd-catal

16 A novel series of phosphinic acid based inhibitors of the neuropeptidase N

17 III)) cations with bis(2,4,4-trimethylpentyl)phosphinic acid, bis(2,4,4-trimethylpentyl)monothiophosp

18 ophenyl)-methyl]amino]propyl](diethoxymethyl)phosphinic acid blocked ACh-induced reduction in the evo

19 ic approaches, not only to prepare allylic H-phosphinic acids but also their esters via one-pot tande

20 mporal analysis revealed that perfluoroalkyl phosphinic acids (C6/C6, C6/C8) and polyfluoroalkyl sulf

21 Previously inaccessible phosphinic acids can be prepared in a single step from c

22 ne, and tetrahydrothiophene derivatives with phosphinic acid catalysis.

23 ly affected by 3-amino-propyl(diethoxymethyl)phosphinic acid (CGP 35348; 1 mM).

24 yl)ethyl]amino- 2-(S)-hydroxypropyl-P-benzyl-phosphinic acid (CGP 55845A, 1 microM).

25 ich was used in two approaches to the target phosphinic acid containing pseudopeptide.

26 ious PIII species derived from p-aminophenyl phosphinic acid derivatives is significantly reduced com

27 H-phosphinic acids derived from N-Cbz vinyl glycine esters

28 competitive antagonist 3-aminopropyl(methyl)-phosphinic acid did not block the resting conductance, t

29 Racemization experiments show that phosphinic acid does not promote SN1 reactivity.

30 ogenation to yield an alpha,beta-unsaturated phosphinic acid ester, following which conjugate additio

31 on of these suitably protected p-aminophenyl phosphinic acid esters with a 6-(bromomethyl)pteridine o

32 nd the same suitably protected p-aminophenyl phosphinic acid esters, followed by removal of protectin

33 Phenyl phosphinic acid has been the catalyst of choice to study

34 ning carbon-phosphorus bonds (phosphonic and phosphinic acids) have found widespread use in medicine

35 ted vinyl glycine led to the corresponding H-phosphinic acid in excellent yield.

36 lysin was prepared for comparison to a known phosphinic acid inhibitor, providing the first compariso

37 edure to convert alpha,alpha-difluorinated H-phosphinic acids into the corresponding H-phosphinothioa

38 (K(i) = 41 nM) was comparable to that of the phosphinic acid (K(i) = 10 nM) even though the silanedio

39 ic acid and its analog 3-aminopropyl-(methyl)phosphinic acid mainly depended on residues Tyr102, Val1

40 sed drug design, we have discovered that the phosphinic acid moiety (P(O)(OH)R) behaves as an isoster

41 Simultaneously, the oxo group of phosphinic acid operates as a base abstracting the nucle

42 ons corroborate a reaction pathway where the phosphinic acid operates as a bifunctional catalyst in t

43 on, generated in situ from either the free H-phosphinic acid or ester, to a 2-methylene glutaric acid

44 raalkyl orthosilicate, to provide the free H-phosphinic acid or the corresponding ester, respectively

45 Perfluoroalkyl phosphinic acids (PFPIAs) are perfluoroalkyl acids (PFAA

46 In this mechanism, the acidic proton of the phosphinic acid protonates the hydroxyl group, enhancing

47 cyclopent-1-ene, led to a rearranged allylic phosphinic acid rather than the desired homoallylic deri

48 r antagonist (3-aminopropyl)(diethoxymethyl) phosphinic acid shifted PPD to PPF, indicating that pres

49 The non-nucleophilic H-phosphinic acid was converted to a nucleophilic P(III) s