ライフサイエンスコーパス: phospho

1 hannel in 1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) (LPPG) micelles.

2 olipin and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG) mediated by singlet oxy

3 phocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) membranes compared to OG micel

4 High EDE levels of Abeta40, Abeta42, and phospho-181T-tau in patients with WMH suggesting SCeVD a

5 (PrPc), a receptor for amyloid peptides, and phospho-181T-tau were higher in both CN and pAD/MCI with

6 Moreover, proximity ligation assays for phospho-4E-BP1 and eIF4E revealed different in situ inte

7 phospho-ataxia-telangiectasia mutated (ATM), phospho-53BP1, gammaH2AX and neuronal apoptosis.

8 cardiomyocytes from mouse models expressing phospho-ablated (AAA) and phosphomimetic (DDD) cMyBP-C a

9 a phosphomimetic mutant of GAPVD1, but not a phospho-ablating mutant, were able to rescue defects in

10 rates, the mechanism by which the disordered phospho-acceptor on the substrate transiently interacts

11 by interactions with a few residues near the phospho-acceptor residue, forming the so-called kinase-s

12 ntrinsically disordered linker with multiple phospho-acceptor threonines.

13 Enforced TCL1A enhanced phospho-activation of TCR kinases, second-messenger gene

14 he 2'-PO(4) attacks NAD(+) to form an RNA-2'-phospho-ADP-ribosyl intermediate that undergoes transest

15 RNA splice junction and the mechanism of RNA phospho-ADP-ribosylation.

16 ming growth factor beta (TGF-beta)-regulated phospho-Akt (p-Akt) and peroxisome proliferator-activate

17 Phospho-AKT (Ser473) expression (as a readout of PI3K) w

18 ession of regulatory molecules, TGF-beta1/2, phospho-Akt (Ser473), PPARalpha, sterol regulatory eleme

19 tinib significantly reduced tumor growth and phospho-Akt and cyclin D1 expression, as compared with u

20 IRL-1620-treated rats showed an increase in phospho-Akt and decrease in Bad level 7 h post-occlusion

21 decreased AXL-mediated signaling, including phospho-AKT and phospho-ERK signaling; and decreased the

22 l transition, expression of Slug, TGF-beta3, phospho-AKT and phospho-PRAS40, but increased expression

23 53, total p53, cleaved caspase 3, ERK1/2 and phospho-AKT in white individuals compared to AAs.

24 , mitochondrial deformation, upregulation of Phospho-AKT level, aberrant intramuscular lipid infiltra

25 e by suppressing intramuscular fat deposits, Phospho-AKT level, mitochondrial aberrations, and marker

26 hydrated AKT, the interaction between AKT or phospho-AKT with GSK3beta was restored, and GSK3beta bec

27 Phospho-AlgB represses biofilm and virulence genes, whil

28 utes at reperfusion recovered poorly with no phospho-AMP-activated protein kinase alpha activation, d

29 ctional recovery and significantly increased phospho-AMPKalphaThr172 and phospho-ULK-1Ser757.

30 There are two species of GRTH the 56 kDa non-phospho and 61 kDa phospho forms.

31 by visualizing the distribution of numerous phospho- and glycolipids in mouse cerebellum and kidney

32 numerous classes of biomolecules, including phospho- and glycolipids in tissue sections at high late

33 nitric oxide production, as well as various phospho- and glycosphingolipids.

34 al liquid-crystalline bilayer arrangement of phospho- and sphingolipids, which in turn embeds several

35 characterized have four chemically distinct phospho- and sulfoesterase activities, with rate acceler

36 ite directed mutagenesis and a site-specific phospho-antibody, we have identified T239, structurally

37 ctivation of the DNA damage response factors phospho-ataxia-telangiectasia mutated (ATM), phospho-53B

38 determine the relative expression levels of phospho-BAD isoforms in tumour samples.

39 tumours were enriched for the expression of phospho-BAD isoforms.

40 The phospho-Bad level was lower in vehicle- but not in IRL-1

41 ffer in their ability to perform the initial phospho-base methylation of PEA.

42 One pathway plants use for synthesis is the phospho-base methylation pathway, which forms the head-g

43 mutant of Arabidopsis (Arabidopsis thaliana) PHOSPHO-BASE N-METHYLTRANSFERASE 1 (PMT1) and PMT3 was r

44 se-PTS system together with a bifunctional 6-phospho-beta-gal/glucosidase, Gan1D.

45 was shown to be in an operon with a putative phospho-beta-glucosidase (bglB) downstream and a predict

46 pathogen Enterococcus faecalis, encodes a 6-phospho-beta-glucosidase (GenA) and a phosphotransferase

47 se and characterized the corresponding GH1 6-phospho-beta-glucosidase, Cel1A.

48 ation of multiple conformational states of a phospho-beta2 adrenergic receptor/beta-arrestin-1(beta-a

49 Mapping the phospho-catalytic profile of kinases in cells or tissues

50 Furthermore, mapping the phospho-catalytic signatures of melanoma specimens ident

51 utyric acid (GABA) and glutamate release and phospho-cFos expression in the NAc and observed a robust

52 cant increase in extracellular glutamate and phospho-cFos expression.

53 of ATP, citrate and CoA substrates reveals a phospho-citryl-CoA intermediate in the ASH domain.

54 ded within S6K1 is a target-selective kinase phospho-code that integrates signals from mTORC1 and Cdk

55 B phosphorylation, leading to recruitment of phospho-CREB (pCREB) to the promoter of the CREB-respons

56 cAMP signaling is CREB; decreased levels of phospho-CREB seem to mediate the observed effects of met

57 derived atrial cells demonstrated increased phospho-Cx43, which was further accentuated by retinoic

58 oduction of miR-181c significantly inhibited phospho-cyclin-dependent kinase 2 (CDK2) and cyclin-A ex

59 e PfPGP enzyme has been inferred to act on 2-phospho-D-lactate and not on the L isomer.

60 Phospho-DbfR represses biofilm dispersal.

61 3T cells, both phosphomimetic Drp1-S637D and phospho-deficient Drp1-S637A variants, like wild-type Dr

62 Phospho-deficient Env7 mutants were defective in negativ

63 ho-Y876 in synaptic plasticity, we generated phospho-deficient GluA2 Y876F knock-in mice.

64 Notably, functional studies of a phospho-deficient mutant in the C-terminal hotspot regio

65 ORC1 activity; however, co-expression of the phospho-deficient mutant of PRAS40 inhibited the effect

66 Here we report that microglia containing phospho-deficient mutant PS1 display a slower kinetic re

67 An Alzheimer's mouse model containing phospho-deficient PS1 show severe Abeta accumulation in

68 This phospho-dependent binding interaction is conserved in Dr

69 Thus, phospho-dependent Expanded turnover ensures a tight coup

70 (3MC)-induced murine tumor exhibit distinct phospho-dependent localization of NMIIA and NMIIB at the

71 is phosphorylated by LsrK, and the resulting phospho-DPD activates QS.

72 Loss of PINK1, phospho-Drp1, and total Drp1 was prominent after MN-indu

73 itions occurs through concomitant binding of phospho-Drp1S600 with mitochondrial fission factor (Mff)

74 d protein kinase alpha activation, decreased phospho-eNOSSer633, and decreased mitochondrial cytochro

75 Here, we manually curated 112 datasets of phospho-enriched proteins, generated from 104 different

76 -associated modifications, including the AT8 phospho-epitope and the P301L tau mutation linked to an

77 with a panel of tau antibodies specific for phospho-epitopes (PHF1, CP13, AT100, pS262), microtubule

78 eins and their interactions with acetyl- and phospho-eraser proteins.

79 pha promoter also eliminated cocaine-induced phospho-ERK activation and Egr-1/Zif268 induction, but w

80 al adaptations, mediated through NCS-Rapgef2/phospho-ERK activation, independently of PKA/CREB signal

81 ere completely free of tumors and had normal phospho-ERK activity compared with Nf1(flox/flox) ;Postn

82 ere completely free of tumors and had normal phospho-ERK activity compared with Nf1(flox/flox);PostnC

83 scence; and fibrosis, angiogenesis, and cAMP/phospho-ERK expression.

84 2V) and study its downstream effects through phospho-ERK levels and cellular proliferation.

85 e PNs, also exhibited increased RAC1-GTP and phospho-ERK levels compared with Nf1(flox/flox);PostnCre

86 e PNs, also exhibited increased RAC1-GTP and phospho-ERK levels compared with Nf1(flox/flox);PostnCre

87 ediated signaling, including phospho-AKT and phospho-ERK signaling; and decreased the invasion capabi

88 th human and murine MEP have lower levels of phospho-ERK1/2 in iron-deficient conditions compared wit

89 ch is inhibited by expression of the nuclear phospho-ERK1/2-specific dual-specificity phosphatase, DU

90 eling, and point-like adhesions that contain phospho-FAK and phosphopaxillin, located in small protru

91 in alone or in complex with conventional and Phospho-FFAT peptides revealed new mechanisms of interac

92 the repertoire of candidate proteins with a Phospho-FFAT that are able to create membrane contact si

93 ical for non-conventional FFAT motifs (named Phospho-FFAT) to be recognized by the MSP domain.

94 d IL-12 by cell culture, flow cytometry, and phospho-flow assays.

95 n that when expressed in COS1-cells lack the phospho-form of GRTH.

96 caused marked reduction or abolition of the phospho-form.

97 es of GRTH the 56 kDa non-phospho and 61 kDa phospho forms.

98 n as the respective anionic sila-, thia- and phospho-Fries rearrangements.

99 f axonal G3BP1 granules as well as increased phospho-G3BP1 and axon growth, although depletion of Csn

100 decrease of phosphorylated (phospho-) GR and phospho-GR/tot-GR protein expression occurred in the hip

101 A decrease of phosphorylated (phospho-) GR and phospho-GR/tot-GR protein expression oc

102 their unmodified counterparts, facilitating phospho-group site localization.

103 These findings demonstrate the relevance of phospho-GRTH in the structure of the chromatoid body, sp

104 To investigate the role of the phospho-GRTH species in spermatogenesis, we generated a

105 spermatid stage and loss of the cytoplasmic phospho-GRTH species.

106 t esophagi, as observed by reduced levels of phospho-H2A histone family member X.

107 ression levels of two proliferative markers, phospho-histone H3 and Ki-67, were substantially suppres

108 ells in tubules express proliferation marker phospho-histone H3(S10) (pH3(S10) ).

109 y influenced markers of proliferation (Ki67, phospho-histone H3).

110 s grown in vivo also recapitulated a similar phospho-immunopeptidome, with common sequences being tho

111 K3) in innate immune cells, and subsequently phospho-inactivates Nedd4-2, an ubiquitin E3 ligase.

112 a signaling microdomain that sequesters and phospho-inactivates the tumor suppressor NF2/Merlin, dri

113 spho-specific antibodies and transfection of phospho-inactive DEPDC5 mutants.

114 an NSCLC patient tissues displayed increased phospho-IQGAP1, which correlated with poor survival.

115 teract with eIF4E, whereas a distinct 4E-BP1 phospho-isoform, EB-gamma, phosphorylated at Thr-70, Ser

116 Endogenous JAK2 and phospho-JAK2 were rapidly K63-ubiquitinated upon TPO sti

117 XR1's downstream signaling was delineated by phospho-kinase array and knockdown of candidate mediator

118 tly higher mean expression levels of nuclear phospho-KIT and NFKBIB as compared with those of interme

119 Critically, we demonstrate that 2-phospho-L-ascorbic reduces mycobacterial survival in mac

120 wo inhibitors of SapM, L-ascorbic acid and 2-phospho-L-ascorbic, which define two different mechanism

121 e identification of 2-phosphoglycolate and 2-phospho-L-lactate as the relevant physiological substrat

122 nerated during repair of damaged DNA ends, 2-phospho-L-lactate is a product of pyruvate kinase side r

123 to be a free l-serine kinase that produces O-phospho-l-serine (OPS), a substrate for SB biosynthesis.

124 eudovirions (PsVs) were confirmed using anti-phospho-L2-specific antibodies.

125 n the presence of the LHCI and PSI subunit L phospho-LHCII binding sites on PSI.

126 The ubiquity of phospho-ligands suggests that phosphate binding emerged

127 shorter and simpler polypeptides that bound phospho-ligands via N-helix sites.

128 otection was associated with suppression of (phospho)lipid peroxidation.

129 ction on account of the strong retention of (phospho)lipids by the copolymeric sorbent.

130 xes [4-6] via a direct Bub3 interaction with phospho-MELT motifs [7, 8].

131 hoprotein reporter, we also demonstrate that phospho-mimetic and nonphosphorylatable point mutations

132 ouse models with alanine- (DNA-PKcs(PQR)) or phospho-mimetic aspartate (DNA-PKcs(SD)) substitutions a

133 ct is active and highly polarized, while the phospho-mimetic form is not.

134 102 proteins mutated either to the potential phospho-mimetic glutamic acid (Y102E) or to the nonphosp

135 In cells, phosphorylation of Y155, or its phospho-mimetic mutation (Glu), prevents the interaction

136 Also, a phospho-mimetic mutation of A303 in NEMO, corresponding

137 horylated S473 in OPTN and its corresponding phospho-mimetic residue in ABIN-1 (E484) are essential f

138 Furthermore, overexpression of a phospho-mimetic S175E AMOT mutant, which has been establ

139 However, the phospho-mimic mutant, S224E, is detrimental to mouse emb

140 Here, we show that transgenic expression of phospho-mimicking EZH2 mutant EZH2(T416D) in mammary gla

141 Cx43 serine-triplet was replaced with either phospho-mimicking glutamic acids (mdxS3E) or nonphosphor

142 inases phosphorylated LC3B Thr-50 in vitro A phospho-mimicking substitution of Thr-50 impaired bindin

143 ly, reconstitution of LC3B-KO cells with the phospho-mimicking T50E variant inhibited autophagic p62

144 Analyses of the crystal structure of a phospho-mimicking, condensation-proficient CPB mutant re

145 ith microinvasion expressed higher levels of phospho-MNK1 and NODAL versus low-grade (invasion-free)

146 owever, the flg22-induced nuclear export and phospho-mobility shift can still be observed for the CAM

147 The phospho-modification of L2 and its presence in HPV pseud

148 rgent need for affinity reagents that target phospho-modified sites on individual proteins; however,

149 r Plk1, suggesting that Nek6/7/9 function as phospho-motif amplifiers of Plk1 signaling.

150 One such target is phospho-MurNAc-pentapeptide translocase (MraY), an essen

151 Viral overexpression of YAP phospho-mutants dampened the proliferative competence of

152 Confocal images of phospho-myosin light chain (pMLC) immunofluorescence, mo

153 we found that active RhoA and ROCK effector phospho-myosin light chain (pMLC) were downregulated in

154 s significantly correlated with the level of phospho-NCOA3 (S1062/T1067) in human GC specimens.

155 QC also suppressed phospho-NF-kappaB p65 more profoundly than HCQ.

156 ased levels of p-TAK1, TRAF6, NF-kappaB p50, phospho-NF-kappaB- p65, pCREB, HMGB1, and inflammatory m

157 avior and toxicity of NPM was assessed using phospho-NPM mutant proteins that either mimic stress-ind

158 n turn, induces the nuclear translocation of phospho-Nrf2 protein to regulate the expression of antio

159 In this study, we show that an S209A phospho-null Foxo1 exhibited Akt-dependent nuclear traff

160 AvrPtoB phospho-null mutants exhibited compromised virulence fun

161 ontrast, plants expressing Rca-beta with the phospho-null T78A mutation had faster photosynthetic ind

162 y shift can still be observed for the CAMTA3 phospho-null variant of the MAPK-modified sites, suggest

163 The phospho-obviation mutant, S224A, appeared normal.

164 flow also allows for the characterization of phospho- or glycopeptides only and enables additional an

165 reover, spinal microglia activation (IBA-1), phospho-P38 MAPK, and nuclear factor NF-kappaB inflammat

166 t the expression of sequestosome 1 (p62) and phospho-p38 mitogen-activated protein kinases (p-p38) sh

167 However, EV cargo showed increased levels of phospho-p53, total p53, cleaved caspase 3, ERK1/2 and ph

168 D-methadone increased phospho-p70S6 kinase, a downstream target of mTORC1 in t

169 cimens revealed an accumulation of PINK1 and phospho-Parkin (Ser65) along with loss of total Parkin a

170 osette formation with menadione (MN), led to phospho-Parkin accumulation in fragmented mitochondria r

171 enzyme:substrate complex, while the product phospho-peptide allows for accessing modes of enzyme:pro

172 strate networks, including kinases and their phospho-peptide targets; (iii) mapping and visualization

173 In addition, we find that phospho-PLK4 (pPLK4) is cleaved and distributed to kinet

174 pression of Slug, TGF-beta3, phospho-AKT and phospho-PRAS40, but increased expression of E-cadherin.

175 Single-cell mutation and phospho-protein analyses reveal the segregation of oncog

176 yscomitrella patens, assessing the thylakoid phospho-protein profile and dynamics in response to chan

177 erapeutics tailored against disease specific phospho-protein targets.

178 Although di-BRCT recognition of phospho-proteins is well known to support the genotoxic

179 haracterization of IAV-triggered patterns of phospho-proteins provides a rich resource to further und

180 ta of IFNgamma-stimulated THP1 cells with 26 phospho-proteins simultaneously measured.

181 As a natural next step, we show that native phospho-proteoforms of proteins display a distinct and e

182 study, we measure transcriptomic, proteomic, phospho-proteomic and fluxomics data in a breast cancer

183 Transcriptomic, proteomic, and phospho-proteomic profiling revealed enrichment of Hippo

184 e inhibition we have performed quantitative (phospho)-proteomics of human melanoma cells treated with

185 Our transcriptomics, proteomics and phospho-proteomics studies implicate the glucocorticoid

186 or multiplex analysis of global, glyco-, and phospho-proteomics using breast cancer patient-derived x

187 te, at therapeutic levels in the RV, reduced phospho-pyruvate dehydrogenase expression, RV fibrosis,

188 mulation not only of phosho-RAB8 but also of phospho-RAB10, and the effects on centrosomal cohesion a

189 osomal accumulation of both phospho-RAB8 and phospho-RAB10.

190 te with the centrosomal accumulation of both phospho-RAB8 and phospho-RAB10.

191 nct cellular readouts of the same underlying phospho-RAB8/RAB10/RILPL1 nexus and highlight the possib

192 0 mol % of 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-glycerol in the outer leaflet only was quant

193 Phospho-RB (Ser807/811) was found to oscillate in a circ

194 oncomitant with inhibition of CDK6-regulated phospho-RB and FOXM1 expression.

195 palbociclib and enhances the suppression of phospho-Rb, providing a mechanistic explanation for thes

196 Thus, MSL10 functions as a phospho-regulated membrane-based sensor that connects th

197 , providing the first direct evidence of the phospho-regulation of MmpL11 transporter activity in M.

198 This phospho-regulation of RNF43 is required for zebrafish de

199 Therefore, harnessing phospho-regulation of RNF43 might be a potential therape

200 ble and function as transplantable units for phospho-regulation of stability.

201 eased expression and nuclear accumulation of phospho-RelA/p65, occurred in both an in vitro model of

202 nds, as well as human plasma exRNA Analyzing phospho-RNA-seq data using a custom, high-stringency bio

203 explored realm of mRNA and lncRNA fragments, phospho-RNA-seq opens up new possibilities for plasma tr

204 ts were revealed using a modified protocol ("phospho-RNA-seq") incorporating RNA treatment with T4-po

205 ng a proteomics approach, we identified that phospho-RON (p-RON) was one of the most remarkably up-re

206 duced levels of endogenous mouse full-length phospho-S13 HTT, supporting the importance of IKKbeta in

207 uced LDs without NSP5, suggesting that vNSP2 phospho-S313 is sufficient for interacting with LDs and

208 These data suggest that NSP2 phospho-S313 is sufficient for interaction with lipid dr

209 dies were conducted in two xenograft models; phospho-S6 (Ser235/236) expression (as a readout of mTOR

210 ited by both drugs but less markedly so than phospho-S6 expression.

211 taining confirmed layer-specific increase of phospho-S6 ribosomal protein in mouse M1.

212 This coincided with elevated Myc and phospho-S6, an indicator of mTOR signalling, followed by

213 Using the neural activity marker phospho-S6, we show increased galanin neuron activation

214 fter treatment cessation was associated with phospho-S6/total S6 expression ratio.

215 kinases using biological peptide targets as phospho-sensors to reveal kinase dependencies in tumour

216 lpha and that PP2A-B55alpha dephosphorylates phospho-Ser(315) Spreading, attachment, migration, and i

217 ted state by preventing dephosphorylation of phospho-Ser(495) We also report the crystal structure of

218 inactivating post-translational modification phospho-Ser-127 in YAP1, coinciding with increased YAP1

219 essary for androgen's inactivating effect on phospho-Ser-127 levels and increased YAP1 nuclear entry.

220 n phosphatase 2A, and thereby attenuates the phospho-Ser-127 modification and promotes YAP1 nuclear l

221 nd regulate neuronal signaling by catalyzing phospho-Ser/Thr dephosphorylations in diverse substrates

222 A crystal structure of phospho-Ser429 (pS429)-MDM2 bound to E2-ubiquitin reveal

223 s have more phospho-Ser754 STAT3 relative to phospho-Ser727 and fail to upregulate the STAT3 target S

224 ponse, Trim14 knockout macrophages have more phospho-Ser754 STAT3 relative to phospho-Ser727 and fail

225 We here identified several phospho-serine and phospho-threonine residues in the kno

226 with the BARD1 BRCT domains via a C-terminal phospho-serine motif.

227 a new Raptor (AA) mouse model, in which AMPK phospho-serine sites Ser722 and Ser792 of RAPTOR were mu

228 equencing, multiplex cytokine profiling, and phospho-signaling analyses.

229 ordinated cell division that is regulated by phospho-signaling gives rise to a measurable periodicity

230 tabolism, protein translation processes, and phospho-signaling modules.

231 te the activation status of host erythrocyte phospho-signaling pathways at three blood stages of para

232 We found that a 40 Hz flicker upregulates phospho-signaling within the nuclear factor kappa-light-

233 Two phospho-signalling proteins, the transmembrane histidine

234 ape from the microdomain as well as enhanced phospho-signalling within, leading to a submicron gradie

235 ischemic proteo- and cytotoxicity, whereas a phospho-silenced CHIP-S20A amplifies both.

236 HO gene expression is influenced by the Thr4 phospho-site in the RNA polymerase II CTD and the 3' pro

237 ent to the patient's mutant site as the GRTH phospho-site.

238 PK6, directly phosphorylate CAMTA3, with the phospho-sites contributing to CAMTA3 degradation and sup

239 secondary eIF4E-binding site and three other phospho-sites, whose mechanisms in inhibiting binding ar

240 CVR1, which over-activates signaling through phospho-Smad1/5 (pSmad1/5).

241 pr1a-disrupted osteoclasts displayed reduced phospho-SMAD1/5/9 (pSMAD1/5/9) levels when induced by BM

242 y we find that beside Blimp1, down-regulated phospho-Smad159 levels also distinguishes PGCs from thei

243 ells leads to loss of the 61 kDa cytoplasmic phospho-species.

244 confirmed in cancer cells through the use of phospho-specific antibodies and transfection of phospho-

245 Using a Ser68 phospho-specific antibody (P-Panx3) revealed Panx3 was p

246 izable protein engineering tool for studying phospho-specific binding proteins and customizing their

247 then use the selection to affinity-mature a phospho-specific DARPin without compromising its selecti

248 strategy for routine laboratory isolation of phospho-specific designed ankyrin repeat proteins (DARPi

249 Here we employ high-content multi-parameter phospho-specific flow cytometry, fluorescent cell barcod

250 In this study, we report the first phospho-specific modification of the BPV-1 and HPV-16 L2

251 H2Bub1 and phospho-Spt5 have similar genome-wide distributions; bot

252 s in vitro and in vivo leads to overwhelming phospho-STAT1 activation, turning on its tumor-suppressi

253 PR-positive tumors exhibited lower levels of phospho-STAT1 as compared with their PR-negative counter

254 SFX-01 suppressed phospho-STAT3 and SFN directly bound STAT3 in patient an

255 steosarcoma cell line, and increase cellular phospho-STAT3 levels in J774.2 mouse macrophage cells.

256 that IL-1beta-mediated increases in nuclear phospho-STAT3 were decreased by TEPP46.

257 nd IL-17, and the Th17 polarisation mediator phospho-STAT3 were reduced significantly, while STAT1, E

258 ompetent animal models demonstrate decreased phospho-STAT3, indicating on-target activity.

259 ia/macrophages (i.e., enhanced expression of phospho-STAT6 in Iba1(+) cells).

260 capable of activating Myo2, dependent on its phospho state, and Rgd3 overexpression rescues aberrant

261 in the C-terminal segment interact with the phospho-sugar backbone of the non-target strand.

262 f 0.04 mM and with lower affinity also other phospho-sugars.

263 y imprinted polymers (MIPs) with an external phospho-sulpho switch driven by small molecule modifiers

264 Together, PPM1F controls the T788/T789 phospho-switch in the integrin beta1 cytoplasmic tail an

265 Hence, a phospho-switch in TRF2 coordinates the assembly and disa

266 We thus reveal a "phospho-switch" within delta-catenin, subject to a gluta

267 ere, we report that T788/T789 functions as a phospho-switch, which determines the association with ei

268 w affinity state under fluid shear activated phospho-Syk- and ADAM17-mediated proteolytic cleavage of

269 red in CSF, along with total-tau (T-tau) and phospho-tau (P-tau((181))).

270 Phospho-tau accumulation and adult hippocampal neurogene

271 we conducted in vitro PBB3 fluorescence and phospho-tau antibody immunofluorescence labelling of bra

272 rmal prion protein dendritic receptor and of phospho-tau species with their synaptogyrin-3 synaptic v

273 wever, neuronal accumulation of AT8 positive phospho-tau was sustained in the chronic phase, in paral

274 However, CSF total-tau and phospho-tau were associated with the SNP rs9877502 (p =

275 olase, beta-amyloid protein, tau protein and phospho-tau were determined in CSF.

276 sect the link between cholesterol synthesis, phospho-Tau, and amyloid-beta, revealing new therapeutic

277 loss was attenuated (-27%) at 12 months and phospho-tau-181 was reduced at 6 months and 12 months in

278 myloid beta is highly toxic to synapses in a phospho-Tau-dependent manner.

279 s last case showed positive staining for all phospho-tau-specific antibodies tested, similar to the p

280 Plasma phospho-tau181 (p-tau181) is a promising blood biomarker

281 These sections were stained for phospho-TDP-43 immunohistochemically and evaluated indep

282 complete inhibition of fibrillation for the phospho-Thr-13 hCT analog, whereas phosphorylation in th

283 (iii) Activated phospho-Thr-315 cyclin H is up-regulated during HCMV rep

284 e here identified several phospho-serine and phospho-threonine residues in the known TLR pathway kina

285 recruitment of adaptor proteins to FLT3 in a phospho-tyrosine (Y) residue 969 (Y969) dependent or ind

286 llular interaction with a negatively charged phospho-tyrosine on the receptor tyrosine kinase EphB2.

287 tified through binding to phosphate group of phospho-tyrosine via computational calculation and exper

288 oxidative stress, metabolic dysfunction and phospho-Ub levels are all elevated in PD, we suggest tha

289 s interaction with phosphorylated ubiquitin (phospho-Ub) and is mediated by proteasomal degradation.

290 cantly increased phospho-AMPKalphaThr172 and phospho-ULK-1Ser757.

291 Phospho-USP20 was significantly increased in LVs of wild

292 Phospho-USP20 was undetectable in beta(1)AR KO mice subj

293 tenuated the induction of (protein kinase A) phospho-vasodilator-stimulated phosphoprotein (p-VASP) b

294 ed increased plasma membrane localization of phospho-VEGFR2 compared with normal ECs.

295 The knockdown also increased phospho-VEGFR2 in whole cell lysates and membrane fracti

296 In live cells, phospho-Y155 RLC is prominently featured in protrusions,

297 To address the necessity of GluA2 phospho-Y876 in synaptic plasticity, we generated phosph

298 GluA2 phospho-Y876 is necessary for synaptic accumulation of g

299 We show that, while GluA2 phospho-Y876 is not necessary for Hebbian plasticity, it

300 Bidirectional changes in GluA2 phospho-Y876 were observed during homeostatic scaling, w