ライフサイエンスコーパス: phospho-

1 -phosphocholine/1,2-dimyristoyl-sn-glycero-3-phospho- (1'-rac-glycerol)/cholesterol lipid bilayers us

2 -hexadecyl-2-(11Z-octadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol), in which the sn-1 position co

3 serine (POPS), and 1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DOPG) under mild shear flow.

4 nic lipid 1-myristoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) (LPG).

5 hannel in 1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) (LPPG) micelles.

6 olipin and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG) mediated by singlet oxy

7 ly charged 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG), or a POPC/POPG mixture

8 ta segment in LPPG (1-palmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)) micelles show e

9 ids, POPG (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)), POPS (1-palmit

10 phocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) membranes compared to OG micel

11 holine and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) were used to determine which o

12 12:0PC:diC12:0PG [1,2-dilauroyl-sn-glycero-3-phospho-(1'-rac-glycerol)] liposomes were investigated u

13 phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol)] units.

14 rol) and Phos (1,2-dipalmitoyl-sn-glycerol-3-phospho-(1'rac-glycerol)) via disulfide bond formation.

15 er sulfate from adenosine 3'-phosphophate 5'-phospho-[35S]sulfate ([35S]PAPS) to the 3-OH position of

16 pho-AKT staining was associated with that of phospho (active)-mTOR in 27 of 31 (87%) ovarian tumors,

17 factor-alpha (6.4+/-1.3-fold) and increased phospho-(active) EGFR (5.9+/-1.1-fold), phospho-(active)

18 ased phospho-(active) EGFR (5.9+/-1.1-fold), phospho-(active) ErbB2 (2.3+/-0.2-fold), and phospho-(ac

19 phospho-(active) ErbB2 (2.3+/-0.2-fold), and phospho-(active) extracellular signal-regulated kinase (

20 in a stable complex with the abortive RNA-2'-phospho-(ADP-2"OMe-ribose) intermediate.

21 he 2'-PO4 attacks NAD+ C1" to form an RNA-2'-phospho-(ADP-ribose) intermediate and nicotinamide; and

22 t generates the normally undetectable RNA-2'-phospho-(ADP-ribose) intermediate in amounts stoichiomet

23 he 2'-PO(4) attacks NAD(+) to form an RNA-2'-phospho-(ADP-ribose) intermediate, and transesterificati

24 (Fe-Met80); it did not bind to several cyt c phospho- and acetyl-mimetics.

25 Using an integrated chemical, phospho- and ADP-ribosylation proteomics approach, we so

26 differences in the RNA-binding properties of phospho- and dephosphoPKR.

27 izing enzymes it is able to increase overall phospho- and glycolipid synthesis.

28 by visualizing the distribution of numerous phospho- and glycolipids in mouse cerebellum and kidney

29 numerous classes of biomolecules, including phospho- and glycolipids in tissue sections at high late

30 to hundreds of different biomolecules (e.g., phospho- and glycolipids) in tissue sections and in cell

31 nitric oxide production, as well as various phospho- and glycosphingolipids.

32 ence of modified octadecanoid acyl chains in phospho- and neutral lipids, is drastically shifted towa

33 resolving acidic phosphopeptides from other phospho- and non-phosphopeptides.

34 By comparing the levels of phospho- and nonphosphopeptides, the in vivo phosphoryla

35 These fractions, rich in phospho- and sphingolipids, were strongly antiproliferat

36 al liquid-crystalline bilayer arrangement of phospho- and sphingolipids, which in turn embeds several

37 characterized have four chemically distinct phospho- and sulfoesterase activities, with rate acceler

38 libraries using these scaffolds yielded >50 phospho- and target-specific mAbs against 70% of target

39 Integration with our ERK-regulated phospho- and total proteome highlights ERK deregulation

40 Both phospho- and total SGK1 increased 2 to 7 days after band

41 d the overlap in chemical properties between phospho- and unmodified peptides, it is likely that the

42 n cell proliferation (PCNA, Ki-67, cyclin A, phospho- cdc2, p21Waf, p27Kip) was transient ( approxima

43 The developed strategy enriches phospho- content from biological samples like phosvitin

44 ded tissue archival samples were stained for phospho- extracellular signal-regulated kinase (p-ERK) w

45 sphorylation with formation of GalNAcbeta1-4(phospho-)GlcNAc.

46 A decrease of phosphorylated (phospho-) GR and phospho-GR/tot-GR protein expression oc

47 creatine and accumulation of the precursor (phospho-)guanidinoacetate (P-GA).

48 Activated (phospho-) JNK colocalizes with FAK in focal adhesions of

49 of coenzyme F 420 involves the coupling of 2-phospho- l-lactate (LP) to 7,8-didemethyl-8-hydroxy-5-de

50 ensation requires an initial activation of 2-phospho- l-lactate through a pyrophosphate linkage to GM

51 -L 5', coding for the nucleocapsid, unknown, phospho-, matrix, fusion, hemagglutinin-neuraminidase, a

52 tion and to maintain a high level of active (phospho-) mitogen-activated protein kinases (MAPKs).

53 The enriched phospho- moieties are analyzed by matrix-assisted laser

54 Neither phospho- nor dephospho-KEPI inhibits protein phosphatase

55 -RCN and inhibited by high concentrations of phospho- or dephospho-RCN.

56 flow also allows for the characterization of phospho- or glycopeptides only and enables additional an

57 sphingosine 1-phosphate, or other sphingo-, phospho-, or glycerolipids tested.

58 The phospho- (P) protein, the co-factor of the RNA polymeras

59 wo viral polypeptides, the large (L) and the phospho- (P) proteins.

60 Morphine-induced phospho- (P-)GSK3beta was reduced 5 min after reperfusio

61 Rabies virus (RabV) phospho (P) protein, which is largely responsible for an

62 Activated phospho (p)-(Tyr416)-SRC was detected in the majority of

63 LX4032-resistant (PPRM) cell lines show dual phospho (p)-ERK and p-AKT upregulation, and their growth

64 ithelial cells showed enhanced expression of phospho (p)-mTOR in HIV-1 transgenic mice (Tgs).

65 IHC was performed for p53, p21, and phospho (p)-p38 mitogen-activated protein kinase (MAPK)

66 PI3K, phospho (p)-PKB, and PAK were co-localized to the site o

67 utable to its abnormal association with more phospho (P)-serine-type 1 insulin receptor substrate (IR

68 signaling in vivo, increasing the levels of phospho (P)-SMAD1 and decreasing P-SMAD3.

69 PA buffer and subjected to Western blot with phospho (p)-specific antibodies against p-JNK and p-c-Ju

70 to these developmental defects, an unbiased phospho-(p)-proteome screen was performed.

71 43 RNA-binding activity, affecting SNMT1 and phospho-(p)CREB levels, thus contributing to neuronal da

72 We describe the synthesis of 3'-phospho-(para-nitrophenyl) oligonucleotides (3'-pNP DNAs

73 use single-cell RNA sequencing to link the (phospho-)protein signaling network to transcriptomic sta

74 learning, we identified an 18-feature G2019S phospho-/protein signature discriminating G2019S L2PD, L

75 lly interpreted the exomes and quantitative (phospho-)proteomes of five ovarian cancer cell lines and

76 Using phospho-/proteomic analyses, we assessed the impact of L

77 Through global- and phospho- proteomics of the mouse cortex, we focused on s

78 sponses in quantitative gene expression and (phospho-)proteomics data sets.

79 enzyme 11 (MRE11)-dependent accumulation of (phospho-)replication protein A (RPA)-coated ssDNA.

80 otidase had no effect on ATP/ADP/UTP-induced phospho- rylation of AMPK, indicating that AMPK activati

81 rnating animals, reduction of immunoreactive phospho (S473)-Akt was noted throughout the brain.

82 IX that accommodates an amphipathic helix in phospho (Ser-133) KID.

83 ecognize full-length CREB.CBP complexes in a phospho-(Ser(133))-dependent manner demonstrates that th

84 recruitment of CBP and RNA polymerase II to phospho-(Ser-133) CREB, attenuates transcriptional induc

85 A polymerase II to be recruited to CREB in a phospho-(Ser-133)-dependent manner.

86 body recognizing the Akt phosphomotif (alpha-phospho-[Ser/Thr] Akt substrate [PAS]), and PAS immunore

87 ver, and this repression was relieved by the phospho (Ser133) KID-dependent recruitment of p300 histo

88 KID stimulates transcription via a phospho (Ser133)-dependent interaction with the coactiva

89 Basal phospho-(Ser40)-TH levels did not differ between groups

90 to D-amphetamine (0.5 and 5.0 mg/kg, i.p.), phospho-(Ser40)-TH was selectively decreased in NAc of F

91 Phosphorylated (phospho-)TRIP13 promotes non-homologous end joining (NHE