ライフサイエンスコーパス: phosphodiester backbone

1 is possibly important for DNA binding at the phosphodiester backbone.

2 ve charge that oligonucleotides carry on the phosphodiester backbone.

3 d is not influenced by the continuity of the phosphodiester backbone.

4 ino acids at these positions may contact the phosphodiester backbone.

5 t with tDNA bases, while Arg362 contacts the phosphodiester backbone.

6 e-specific endonucleolytic breaks in the RNA phosphodiester backbone.

7 tRNAs by catalyzing the cleavage of the tRNA phosphodiester backbone.

8 l difference is the result of changes in the phosphodiester backbone.

9 is allow the enzyme to translocate along the phosphodiester backbone.

10 d to make 12 symmetrical contacts to the DNA phosphodiester backbone.

11 he RNA bases and has little influence on the phosphodiester backbone.

12 to the nonbridging phosphate oxygens in the phosphodiester backbone.

13 RNA body primarily through contacts with the phosphodiester backbone.

14 m was sufficient for optimal cleavage of the phosphodiester backbone.

15 s necessary to perform hydrolysis of the DNA phosphodiester backbone.

16 rostatically stabilized interaction with the phosphodiester backbone.

17 polycation, neutralizing the highly negative phosphodiester backbone.

18 recognize damaged DNA as well as cleave the phosphodiester backbone.

19 governs the conformational properties of the phosphodiester backbone.

20 lting break, and the rejoining of the broken phosphodiester backbone.

21 ccelerate site-specific cleavage/ligation of phosphodiester backbones.

22 ules that catalyze the cleavage of their own phosphodiester backbones.

23 feature of DNA helicases that move along DNA phosphodiester backbones.

24 mes catalyze site-specific cleavage of their phosphodiester backbones.

25 c DNA lesions in prokaryotes by cleaving the phosphodiester backbone 5' of either uracil or hypoxanth

26 d platinum G-G diadducts and cleaves the DNA phosphodiester backbone 5' to a lesion.

27 izing intermediary abasic sites cleaving the phosphodiester backbone 5' to the abasic site.

28 ir of this common DNA lesion by incising the phosphodiester backbone 5' to the damage site.

29 pair enzyme for abasic sites and incises the phosphodiester backbone 5' to the lesion to initiate a c

30 they both recognize AP sites and incise the phosphodiester backbone 5' to the lesion, yet they lack

31 An adjustment in the position of the phosphodiester backbone 5'-phosphate enables 8-oxoG to a

32 out from the minor groove and loops over the phosphodiester backbone, adds a substantial negative ent

33 ted in the duplex by a slight opening in the phosphodiester backbone; all sugars retain a C2'-endo pu

34 , an initial enzyme binding primarily to the phosphodiester backbone and a base dependent isomerizati

35 ation reduces the amplitude of motion in the phosphodiester backbone and furanose ring of the same DN

36 lane reflecting interactions between the DNA phosphodiester backbone and positively charged arginine

37 wobble pair distorts the conformation of the phosphodiester backbone and presents the functional grou

38 etween them, involving torsion angles of the phosphodiester backbone and the arrangements of stacked

39 asymmetric contacts between the A-duplex RNA phosphodiester backbone and the EF-loop in one coat prot

40 tion that engages a continuous region of the phosphodiester backbone and the hydrophobic faces of exp

41 IHF contacts the DNA exclusively via the phosphodiester backbone and the minor groove and relies

42 used defined dsDNA fragments with a natural (phosphodiester) backbone and show that unmethylated CpG

43 rporated into model oligomers with a natural phosphodiester backbone, and enzymatic degradation was m

44 olyamide molecules alter the geometry of the phosphodiester backbone, and the water molecules mediati

45 of two invariant interfacial contacts to the phosphodiester backbone, and two semi-conserved base-spe

46 on, but some changes in the positions of the phosphodiester backbone are present compared to a C+ x G

47 rly show that portions of the anticodon loop phosphodiester backbone are protected from cleavage only

48 ive contacts between the protein and the DNA phosphodiester backbone, as well as a number of direct h

49 ning complementary sequences and cleaves the phosphodiester backbone at a specific site measured from

50 g that integrase requires flexibility of the phosphodiester backbone at the 3'-P site.

51 removal of the damaged base, incision of the phosphodiester backbone at the abasic sugar residue, inc

52 metrical, characterized by a reversal of the phosphodiester backbone at the UC step (hydrogen bond C1

53 displays a weak preference for cleaving the phosphodiester backbone between 5'-GC dinucleotides.

54 a P-site-bound tRNA(Met) with a break in the phosphodiester backbone between positions 56 and 57 in t

55 tack of a tyrosine hydroxyl group on the DNA phosphodiester backbone bond during the step of DNA clea

56 ame or overlapping site on 2C, driven by the phosphodiester backbone, but only RNA stimulates ATP hyd

57 d to substitution of the negatively-charged, phosphodiester backbone by a nonionic, internucleoside l

58 hat asymmetric neutralization of the anionic phosphodiester backbone by basic histone proteins could

59 and to reveal unexpected control of the DNA phosphodiester backbone by electrostatic interactions.

60 Substitution of the 2',5'-phosphodiester backbone by phosphorothioate linkages giv

61 acids are dominated by their highly charged phosphodiester backbone chemistry.

62 cative of small changes in base stacking and phosphodiester backbone conformation.

63 e changes in base vibrational ring modes and phosphodiester backbone conformation.

64 crossed a turn rather than running along the phosphodiester backbone contour.

65 ity imparted by these sugar modifications in phosphodiester backbones correlated with the size of the

66 modified oligonucleotides that possessed the phosphodiester backbone demonstrated excellent resistanc

67 Conserved patterns of phosphodiester backbone dihedral distortions during flip

68 hosphoramidate DNA backbone differs from the phosphodiester backbone due to the N3'-H moiety having o

69 results in the protection of regions of the phosphodiester backbone expected for tertiary folding of

70 ntly alters the intrinsic flexibility of the phosphodiester backbone, favoring the A-form in duplex R

71 ntact the AMP adenine (Lys(290)), engage the phosphodiester backbone flanking the nick (Arg(218), Arg

72 groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); pe

73 he P4-P6 RNA induces formation of a specific phosphodiester-backbone geometry that is required for CY

74 DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the dama

75 backbone and by >1,000-fold over the natural phosphodiester backbone, improving tissue exposure, tiss

76 tion, by introducing symmetrical cuts in the phosphodiester backbone in a Mg2+ dependent reaction.

77 f APE1, which is responsible for nicking the phosphodiester backbone in DNA on the 5' side of an apur

78 The dynamics of the phosphodiester backbone in the [5'-GCGC-3'] 2 moiety of

79 semi-synthetic tRNA contained a break in the phosphodiester backbone in the D loop and was an efficie

80 structures reveal a subtle distortion to the phosphodiester backbone in the dimer-containing sequence

81 talyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a beta-elimination

82 onomer in solution and that DNA ligands with phosphodiester backbones induce TLR9 dimerization in a s

83 on-template single strand bases, leaving the phosphodiester backbone intact, did not interfere with b

84 Phosphodiester backbone interactions between the protosp

85 e base interactions together with additional phosphodiester-backbone interactions along one face of t

86 25 mM KCl, indicating a strong dependence on phosphodiester-backbone interactions.

87 ch or hole in the protein, thus bringing the phosphodiester backbone into close proximity with the ac

88 Electrostatic interactions with the RNA phosphodiester backbone involve protein side chains that

89 The joining of breaks in the DNA phosphodiester backbone is essential for genome integrit

90 We show here that cleavage of the phosphodiester backbone is not an end point for RNA repl

91 d through noncanonical pairings and that the phosphodiester backbone is not contacted by the RNA.

92 demonstrates that the anomeric effect in the phosphodiester backbone is significantly more complex th

93 By analyzing the conformation of the phosphodiester backbones, it is possible to understand f

94 at divalent metal ion coordination along the phosphodiester backbone may play a role in the inhibitor

95 between cisplatin and the negatively charged phosphodiester backbone may play an important role in fa

96 nces that originate from displacement of the phosphodiester backbone near the effector binding pocket

97 Thus, a continuous phosphodiester backbone negative charge is not essential

98 e site are stacked in an A-form pattern, the phosphodiester backbone next to the cleavage site on the

99 n of structural transitions of the sugar and phosphodiester backbone observed during computational st

100 ly active homodimeric enzyme each cleave the phosphodiester backbone of a cruciform within the lifeti

101 on of a nonbridging oxygen for sulfur on the phosphodiester backbone of an oligonucleotide enhances i

102 ed dipole-enhanced hydrogen bond between the phosphodiester backbone of bound DNA and the N terminus

103 Here we report the effects of modifying the phosphodiester backbone of d(ATGACT) with phosphorothioa

104 BD binds d9 by a mechanism that perturbs the phosphodiester backbone of d9.

105 yme uracil DNA glycosylase (UDG) pinches the phosphodiester backbone of damaged DNA using the hydroxy

106 DNA ligases join breaks in the phosphodiester backbone of DNA molecules and are used in

107 te unwinding from discontinuities within the phosphodiester backbone of DNA.

108 catalyze the joining of strand breaks in the phosphodiester backbone of duplex DNA and play essential

109 ic ones, such as Lys-Trp-Lys, can incise the phosphodiester backbone of duplex DNA at an AP site via

110 ase isolated from vaccinia virus cleaves the phosphodiester backbone of duplex DNA at the sequence 5'

111 a specific three-dimensional geometry of the phosphodiester backbone of group I introns.

112 Hydroxyl radicals (.OH) can cleave the phosphodiester backbone of nucleic acids and are valuabl

113 The anomeric effect in the phosphodiester backbone of nucleic acids is a stereoelec

114 Amides are remarkably good mimics of the phosphodiester backbone of RNA and can be prepared using

115 onomers was developed for replacement of the phosphodiester backbone of RNA by a sulfonamide-containi

116 zyme accelerates cleavage or ligation of the phosphodiester backbone of RNA has been incompletely und

117 urface provides an extended scaffold for the phosphodiester backbone of the conserved catalytic core

118 Functionalization of the sugar/phosphodiester backbone of the GS, which is in direct co

119 domains of repressor which interact with the phosphodiester backbone of the operator site.

120 cures the duplex by binding the 7-nucleotide phosphodiester backbone of the overhang-containing stran

121 ation reduces the amplitude of motion in the phosphodiester backbone of the same DNA, and our observa

122 he N-terminal helix of NC interacts with the phosphodiester backbone of the SL2 RNA stem mainly via e

123 At one site, Mg(H(2)O)(6)(2+) ligates the phosphodiester backbone of the trinucleotide bulge in th

124 Because EF-Tu is known to contact only the phosphodiester backbone of tRNA, the observed specificit

125 y enriched MPOs) or (ii) alternating R(P) MP/phosphodiester backbone oligonucleotides, depending on t

126 We have examined the effects of the phosphodiester backbone on the reactions of cisplatin wi

127 part due to additional contacts made to the phosphodiester backbone outside the 8 bp target via the

128 described as a three-step process involving phosphodiester backbone pinching, base extrusion through

129 the sugar pucker 5' to the flipped base, and phosphodiester backbone rearrangement.

130 site-specific self-cleavage of the viral RNA phosphodiester backbone requires both divalent cations a

131 Neutralization of the phosphodiester backbone resulted in a DNA-footprinting p

132 toplasmic thioesterases into native, charged phosphodiester-backbone siRNAs, which induce robust RNAi

133 ommodates the 7G with less distortion of the phosphodiester backbone than would be required for an N9

134 The structure has a kink in the phosphodiester backbone that causes a sharp turn in the

135 ed pseudosugar induces a conformation on the phosphodiester backbone that corresponds to that of a di

136 The molecular properties of the phosphodiester backbone that made it the evolutionary ch

137 s fails, Fanconi anaemia proteins incise the phosphodiester backbone that surrounds the interstrand c

138 interactions; and (b) the arrangement of the phosphodiester backbone to focus negative electrostatic

139 of a phosphorothioate (PS) linkage along the phosphodiester backbone to improve the drug performance

140 ir X(6).T(17), accompanied by a shift in the phosphodiester backbone torsion angle beta P5'-O5'-C5'-C

141 The phosphodiester backbone twists at the lesion site, accou

142 A substrate containing a single break in the phosphodiester backbone was joined by DNA ligase.

143 When the phosphodiester backbone was replaced by a phosphorothioa

144 isorder is observed at several places in the phosphodiester backbone, which results from a simple cra

145 c-di-GMP structure and replacing the charged phosphodiester backbone with an isosteric nonhydrolyzabl

146 We report that replacement of the phosphodiester backbone with cationic phosphoramidate li

147 However, substituting oxygen in the phosphodiester backbone with sulfur introduce chirality

148 es and, less frequently, clear breaks in the phosphodiester backbone, with the probability of both ev