ライフサイエンスコーパス: phosphofructokinase

1 d in glycolysis (muscle-specific enolase and phosphofructokinase).

2 lytic enzymes, triosephosphate isomerase and phosphofructokinase.

3 ycolysis was activated through activation of phosphofructokinase.

4 ort chain component; and a muscle isozyme of phosphofructokinase.

5 ng two-photon FCS is also demonstrated using phosphofructokinase.

6 m pH 8 to pH 5.0 is detectable for the enyme phosphofructokinase.

7 nding to V(1) subunits and the C terminus to phosphofructokinase.

8 y steps in primary carbon metabolism such as phosphofructokinase.

9 ck regulation of the parasite hexokinase and phosphofructokinase.

10 ose-6-phosphate dehydrogenase (85%), but not phosphofructokinase.

11 and down-regulation of the glycolytic enzyme phosphofructokinase.

12 Escherichia coli phosphofructokinase 1 (EcPFK) is a homotetramer with fou

13 reduced glucose utilization and activity of phosphofructokinase 1 (PFK-1), which could be reversed b

14 O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia.

15 on of PFKP in human glioblastoma development.Phosphofructokinase 1 (PFK1) plays a critical role in gl

16 Phosphofructokinase 1 (PFK1) plays a critical role in gl

17 Human liver-type phosphofructokinase 1 (PFKL) has been shown to regulate

18 de compelling evidence that human liver-type phosphofructokinase 1 (PFKL), which catalyzes a bottlene

19 mmitment, those for Glut1, hexokinase 2, and phosphofructokinase 1, was found to rapidly decline to n

20 The enzyme phosphofructokinase-1 (PFK-1) catalyzes the first commit

21 equired for glycolysis through activation of phosphofructokinase-1 (PFK-1), one of the key enzymes th

22 llosteric activator of the glycolytic enzyme phosphofructokinase-1 (PFK-1).

23 Functionally, we found miR-135 targets phosphofructokinase-1 (PFK1) and inhibits aerobic glycol

24 s best explained by allosteric regulation at phosphofructokinase-1 (PFK1) and/or fructose 1,6-bisphos

25 Phosphofructokinase-1 (PFK1) catalyzes the rate-limiting

26 e feedback mediated by the glycolytic enzyme phosphofructokinase-1 (PFK1) enables beta-cells to gener

27 A key player in energy metabolism is phosphofructokinase-1 (PFK1) whose activity and behavior

28 Phosphofructokinase-1 (PFK1), the 'gatekeeper' of glycol

29 and substrate-dependent filament assembly by phosphofructokinase-1 (PFK1), which is considered the "g

30 s known to suppress glycolysis by inhibiting phosphofructokinase-1 and activate gluconeogenesis by st

31 m through changes in allosteric effectors of phosphofructokinase-1 and fructose bisphosphatase-1, inc

32 s best explained by allosteric regulation of phosphofructokinase-1 and/or fructose bisphosphatase-1,

33 al. show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro and local

34 l for selective activation of PFKL, the main phosphofructokinase-1 isoform expressed in immune cells.

35 trophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL) and dampening fl

36 and activity of the glycolytic enzyme PFKL (phosphofructokinase-1 liver type) and promoted glycolysi

37 te and explained why NA-11 failed to agonize phosphofructokinase-1 platelet type (PFKP) or muscle typ

38 ume more glucose, did not maintain prolonged phosphofructokinase-1 protein levels and activity, and d

39 Both phosphofructokinase-1 subunits co-immunoprecipitated wit

40 We investigated the roles of the yeast phosphofructokinase-1 subunits Pfk1p and Pfk2p for V-ATP

41 bcellular localization of glycolytic protein phosphofructokinase-1/PFK-1.1 in Caenorhabditis elegans.

42 cerol 3-phosphate an allosteric inhibitor of phosphofructokinase-1; and by marked G6P elevation by se

43 ked G6P elevation by selective inhibition of phosphofructokinase-1; but not by a more reduced cytopla

44 -functional key energy metabolism regulator, phosphofructokinase 2, Vip1 is a kinase and pyrophosphat

45 osphatase-active kinase-deficient variant of phosphofructokinase 2/fructosebisphosphatase 2, which pr

46 Phosphofructokinase-2 (Pfk-2) from Escherichia coli is h

47 Escherichia coli phosphofructokinase-2 (Pfk-2) is an obligate homodimer t

48 A damage by repressing the expression of the phosphofructokinase-2 (PFK2) isoform 6-phosphofructo-2-k

49 hout the protein amide exchange increases as phosphofructokinase-2 cold denatures provides experiment

50 ssion of the rate-limiting glycolytic enzyme phosphofructokinase-2 in activated astrocytes, and by se

51 Phosphofructokinase-2 is a dimeric enzyme that undergoes

52 ice constitutively express an active form of phosphofructokinase-2, resulting in elevated levels of t

53 as increase in Rib-1,5-P2 and activation of phosphofructokinase 30 s after hypoxia.

54 protein phosphatase-1 (PP1) binds to muscle phosphofructokinase (6-phosphofructo-1-kinase, PFK).

55 ,6-biphosphatase 3 (PFKFB3), which activates phosphofructokinase, a rate-determining enzyme of glycol

56 ptation, there was an increase in myocardial phosphofructokinase activity and glycolysis.

57 lexibility caused by invariantly low or high phosphofructokinase activity caused modest mitochondrial

58 ts demonstrate that fatty acyl-CoA modulates phosphofructokinase activity through both covalent and n

59 Modulation of phosphofructokinase activity was sufficient to regulate

60 Because increased pH stimulates phosphofructokinase activity, the ouabain-insensitive po

61 dulating circulating substrates and reducing phosphofructokinase activity; however, in the recovered

62 ises three substrate specificities; specific phosphofructokinases (ADP-PFKs), specific glucokinases (

63 rmine whether FBP and citrate (inhibitors of phosphofructokinase) ameliorate hypoxia-induced injury t

64 n bears closest homology to a subdomain of 6-phosphofructokinase, an important enzyme in the glycolyt

65 ediated by allosteric feedback regulation of phosphofructokinase and ADP-glucose pyrophosphorylase.

66 scade: hexokinase, phosphoglucose isomerase, phosphofructokinase and aldolase.

67 This cluster also included a 6-phosphofructokinase and an ABC transport system, whereas

68 to obtain flux through 'distal' glycolysis (phosphofructokinase and beyond) to lactate; 'proximal' f

69 p-regulates cell-cycle inhibitors, decreases phosphofructokinase and cytochrome C expression, and cau

70 crystal structures of the glycolytic enzymes phosphofructokinase and enolase are presented and discus

71 ctose 2,6-P(2), the most potent activator of phosphofructokinase and glycolysis.

72 two key enzymes in the glycolytic pathway, 6-phosphofructokinase and pyruvate kinase M2.

73 hat shares an evolutionary relationship with phosphofructokinase and suggests links between metabolis

74 or more glycolytic metabolites downstream of phosphofructokinase and upstream of GAPDH mediates the e

75 ynucleotide phosphorylase (PNPase), enolase, phosphofructokinase, and a DEAD box RNA helicase.

76 irectly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose u

77 y steps of glycolysis, including hexokinase, phosphofructokinase, and pyruvate kinase, appeared to be

78 , Phgdh interacts with the glycolytic enzyme phosphofructokinase, and the loss of this interaction ac

79 phosphate (Rib-1,5-P2), potent activators of phosphofructokinase, (b) the enzymes responsible for the

80 RBSK proteins are part of the phosphofructokinase-B (pfkB) family of carbohydrate kina

81 Bacillus stearothermophilus phosphofructokinase (BsPFK) is a homotetramer that is al

82 1 increases glycolysis through activation of phosphofructokinase by a calcium-dependent pathway.

83 tumor cells, we show that the inhibition of phosphofructokinase by excess ATP in the cytoplasm can d

84 raphy on PP1-Sepharose and was identified as phosphofructokinase by partial amino acid sequence analy

85 olase C (AldoC, also known as zebrin II) and phosphofructokinase C and the excitatory amino acid tran

86 of Vmax values for flight muscle hexokinase, phosphofructokinase, citrate synthase, and cytochrome c

87 e, glyceraldehyde-3-phosphate dehydrogenase, phosphofructokinase, deoxyhemoglobin, p72syk protein tyr

88 enzymes (glucose-6-phosphate dehydrogenase, phosphofructokinase), DNA repair molecules (MRE11A, ATM)

89 was found for fructokinase and PPi-dependent phosphofructokinase during cell division and for sucrose

90 uvate (PEP) to the single allosteric site on phosphofructokinase (EC ) from Bacillus stearothermophil

91 The side chains of Escherichia coli phosphofructokinase (EcPFK) that interact with bound sub

92 The canine muscle-type-phosphofructokinase-encoding gene (M-PFK) was sequenced

93 ction during growth on inulin, whereas the 1-phosphofructokinase enzyme and linked sugar phosphotrans

94 ed, purified, and characterized a variety of phosphofructokinase enzymes from mammalian tissues.

95 for glycogen phosphorylase, hexokinase, and phosphofructokinase, enzymes catalyzing nonequilibrium r

96 A third control regime in which phosphofructokinase exerted dominant glycolytic flux con

97 properties of a tryptophan-shifted mutant of phosphofructokinase from Bacillus stearothermophilus (Bs

98 Phosphofructokinase from Bacillus stearothermophilus (Bs

99 interactions that exist in the homotetramer phosphofructokinase from Bacillus stearothermophilus is

100 the pattern determined for PEP inhibition in phosphofructokinase from Bacillus stearothermophilus, su

101 Phosphofructokinase from Escherichia coli (EcPFK) is a h

102 Phosphofructokinase from Escherichia coli (EcPFK) is a h

103 ubstrate, fructose 6-phosphate (Fru-6-P), in phosphofructokinase from Escherichia coli (EcPFK).

104 n reported to be a nonallosteric analogue of phosphofructokinase from Escherichia coli at pH 8.2.

105 Phosphofructokinase from Lactobacillus delbrueckii subsp

106 ve study of the LbPFK structure with that of phosphofructokinases from E. coli (EcPFK) and Bacillus s

107 Two phosphofructokinase genes have been described previously

108 transporter GLUT1, phosphoglucose isomerase, phosphofructokinase, glyceraldehyde-3-phosphate dehydrog

109 tegrin beta2) and PFKL (the liver isoform of phosphofructokinase), has proven refractory to cloning,

110 Consistent with activation of phosphofructokinase in diabetic cells, stable isotope ca

111 stematic addition of fructose 6-phosphate to phosphofructokinase in the absence and presence of sever

112 and inhibitors of wild-type Escherichia coli phosphofructokinase influenced the kinetic rate and equi

113 nine residues (Arg-433 and Arg-429) of mouse phosphofructokinase is used to identify the ATP inhibito

114 is system (e.g. hexokinase, pyruvate kinase, phosphofructokinase, isocitrate dehydrogenase and citric

115 ldehyde-3-phosphate dehydrogenase, aldolase, phosphofructokinase, lactate dehydrogenase, and pyruvate

116 Muscle type phosphofructokinase (M-PFK) deficiency is a rare inherit

117 ory enzyme in the glycolytic pathway, namely phosphofructokinase-M (PFK-M).

118 When PEX14 and phosphofructokinase mRNAs were jointly targeted for RNAi

119 on studies have shown that endogenous PFK-M (phosphofructokinase, muscle-specific isoform) associates

120 ak1-interacting target chromatins, including phosphofructokinase-muscle isoform (PFK-M) and nuclear f

121 The negative flux control exerted by phosphofructokinase on the PP and polyol pathways reveal

122 We found decreases in hexokinase (HXK) and phosphofructokinase (PFK) activity in the DLPFC, as well

123 ich acts as a potent allosteric activator of Phosphofructokinase (Pfk) and thus stimulates glycolysis

124 We have previously found that phosphofructokinase (PFK) appeared to colocalize with th

125 study the kinetic mechanism of Ascaris suum phosphofructokinase (PFK) at pH 8.0 for the native enzym

126 nhibits glucose oxidation, and inhibition of phosphofructokinase (PFK) by a rise in citrate so that g

127 Phosphofructokinase (PFK) catalyzes the phosphorylation

128 te enhances the affinity of Escherichia coli phosphofructokinase (PFK) for fructose 6-phosphate (Fru-

129 of inhibitor-bound and uninhibited forms of phosphofructokinase (PFK) from B. stearothermophilus hav

130 A tryptophan-shifted mutant of phosphofructokinase (PFK) from Bacillus stearothermophil

131 e dependence of the allosteric properties of phosphofructokinase (PFK) from Bacillus stearothermophil

132 fructose 6-phosphate (Fru-6-P) and MgATP to phosphofructokinase (PFK) from Escherichia coli.

133 Escherichia coli phosphofructokinase (PFK) has been proposed to have a ra

134 Mammalian phosphofructokinase (PFK) has evolved by a process of ta

135 6-Phosphofructokinase (PFK) is a key enzyme for glycolysis

136 Phosphofructokinase (PFK) is a key rate-limiting enzyme

137 ong these PSTKs, Pkn4 has been shown to be 6-phosphofructokinase (PFK) kinase.

138 Phosphofructokinase (PFK) plays a major role in glycolys

139 olecule allosteric inhibitors of trypanosome phosphofructokinase (PFK) that block the glycolytic path

140 he key event was proposed to be an increased phosphofructokinase (PFK) Vmax secondary to an upregulat

141 phosphate shunt activity, (c) 50% increased phosphofructokinase (PFK) Vmax, (d) a normal ATP/ADP rat

142 have demonstrated a similar distribution of phosphofructokinase (PFK) with caveolin-1 (CAV-1) mainly

143 Kinetic regulation of phosphofructokinase (PFK), a key-control point in glycol

144 ocated previously (such as AMP activation of phosphofructokinase (PFK), ADP inhibition of ATPase and

145 e located 18 bp downstream of the gene for 6-phosphofructokinase (PFK), is a PSTK for M. xanthus PFK

146 d glucose transporter 3 (GLUT-1 and GLUT-3), phosphofructokinase (PFK), lactate dehydrogenase (LDH),

147 xed and stained with Abs to GAPDH, aldolase, phosphofructokinase (PFK), pyruvate kinase (PK), lactate

148 is even more common among cyanobacteria than phosphofructokinase (PFK), the key enzyme of the EMP pat

149 , and MgATP on E187A mutant Escherichia coli phosphofructokinase (PFK).

150 ramer of an isoform of the glycolytic enzyme phosphofructokinase (PFK).

151 dation of the rate-limiting metabolic enzyme phosphofructokinase (PFK).

152 xtracts, we identified the muscle isoform of phosphofructokinase (PFK-M) as a protein that binds to n

153 in beta-cells of the oscillatory isoform of phosphofructokinase (PFK-M).

154 , glpR was cotranscribed with the downstream phosphofructokinase (PFK; pfkB) gene, and the transcript

155 We also find that the specific activity of phosphofructokinase (PFK; the rate limiting enzyme in gl

156 6-Phosphofructokinases (Pfk) are homo- and heterooligomeri

157 A yeast strain lacking the beta-subunit of phosphofructokinase (pfk2Delta) accumulates a high level

158 ies of pyruvate kinase (PykF, but not PykA), phosphofructokinase (PfkB, but not PfkA), glucosamine-6-

159 asing mitochondrial mass and by inducing the phosphofructokinase PFKFB3 (fructose-2,6-bisphosphatase

160 One of these associations, fasting insulin/phosphofructokinase (PFKM), overlaps with an eQTL.

161 rate-limiting glycolytic enzyme muscle-type phosphofructokinase (PFKm, >2 fold, P<0.05) and accumula

162 The gene for muscle phosphofructokinase, PFKM, is mutated in Tarui disease a

163 reased expression of the platelet isoform of phosphofructokinase (PFKP), a key glycolytic enzyme, in

164 ulates expression of the platelet isoform of phosphofructokinase (PFKP), the rate-limiting enzyme of

165 Pyruvate kinase M2 (PKM2) and platelet phosphofructokinase (PFKP), two key enzymes involved in

166 5957, endothelin-converting enzyme 1 [ECE1], phosphofructokinase [PFKP], and C-type lectin domain con

167 to mitochondrial ATP production in hypoxia: phosphofructokinase, phosphoglucokinase, complex II, com

168 e, glyceraldehyde-3-phosphate dehydrogenase, phosphofructokinase, phosphoglycerate kinase) and DNA-bi

169 ediated post-transcriptional upregulation of phosphofructokinase platelet (PFKP) and lactate dehydrog

170 HP-1 inhibition leads to the upregulation of phosphofructokinase platelet (PFKP) through the AKT-beta

171 yrin repeat domain containing protein 23 and phosphofructokinase, platelet in fructose-mediated CRC r

172 ylates the glycolysis rate-limiting enzyme 6-phosphofructokinase, platelet type (PFKP) and promotes a

173 The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role

174 (SBP) pathway, using pyrophosphate-dependent phosphofructokinase (PP(i)-PFK) instead of transaldolase

175 The pyrophosphate-dependent phosphofructokinase (PP(i)-PFK) of Entamoeba histolytica

176 Inorganic pyrophosphate-dependent phosphofructokinase (PP(i)-PFK) of the amitochondriate e

177 The pyrophosphate-dependent phosphofructokinase (PPi-PFK) of the amitochondriate pro

178 equired for this (for example, hexokinase-2, phosphofructokinase, pyruvate kinase, and lactate dehydr

179 avoids feedback inhibition of glycolysis via phosphofructokinase, supporting viability.

180 glycogen phosphorylase, hexokinase I, muscle phosphofructokinase, the E1alpha subunit of pyruvate deh

181 a potent inhibitor of the glycolytic enzyme phosphofructokinase, the pacemaker of glycolytic oscilla

182 nase, to form fructose 6-phosphate, and (ii) phosphofructokinase, to form fructose 1,6-bisphosphate,

183 We show that the step catalyzed by phosphofructokinase together with ATP demand and glycoge

184 o-Ser226-glucose transporter type 1 and anti-phosphofructokinase type L antibodies.

185 hospho-Ser226-glucose transporter type 1 and phosphofructokinase type L likely participate in cancer

186 Knockdown of phosphofructokinase was benign in the absence of glucose

187 system, whereas a distinct inulin-induced 1-phosphofructokinase was linked to a fructose-specific ph

188 Pathways branching off of glycolysis above phosphofructokinase were activated as indicated by over

189 properties of the wild-type Escherichia coli phosphofructokinase were compared to the E187A mutant by

190 enase, 6-phosphogluconate dehydrogenase, and phosphofructokinase were significantly reduced in Deltah

191 The rate-limiting step was most likely at phosphofructokinase, which has a Km(Mg2+) of 0.025 mM in

192 thanococcus jannaschii is now annotated as a phosphofructokinase, which was regarded previously as a