ライフサイエンスコーパス: phosphohydrolase

1 gylcerol acyltranferase or phosphatidic acid phosphohydrolase).

2 encoding CNPase (2',3' cyclic nucleotide 3'-phosphohydrolase).

3 an ADP-ribosyltransferase and a nucleotidase/phosphohydrolase.

4 te for human diphosphoinositol polyphosphate phosphohydrolase.

5 rter suggests a unique role for this unusual phosphohydrolase.

6 res prior generation of DAG by phosphatidate phosphohydrolase.

7 ontains both annexin III and cyclic inositol phosphohydrolase.

8 rminal "HD domain," found in metal-dependent phosphohydrolases.

9 he members of HAD and DDDD super families of phosphohydrolases.

10 - and/or Mg(2+)-activated ecto-5'-nucleotide phosphohydrolases.

11 ies: GDP/GTP exchange factors and nucleotide phosphohydrolases.

12 tion 89 (DUF89) proteins are metal-dependent phosphohydrolases.

13 enzyme superfamily is the largest family of phosphohydrolases.

14 r may contribute to the catalytic effects of phosphohydrolases.

15 s not a substrate for type 2 lipid phosphate phosphohydrolases.

16 rce as compared with other P-loop nucleotide phosphohydrolases.

17 rs from previously described lipid phosphate phosphohydrolases.

18 ikingly dependent on an active phosphatidate phosphohydrolase 1 (PAP-1).

19 ty of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1).

20 homologue of Lcb3p, sphingosine-1-phosphate phosphohydrolase 1 (SPP-1), an endoplasmic reticulum res

21 onstrated that sphingosine-1-phosphate (S1P) phosphohydrolase 1 (SPP-1), which is located mainly in t

22 COX-2 expression and implicate phosphatidate phosphohydrolase 1 as a key regulatory component of eico

23 The enzyme ectonucleotide tri(di)phosphohydrolase-1 (ENTPD1, also known as CD39) on the s

24 Depletion of S1P phosphohydrolase-1 (SPP1), which degrades intracellular

25 bstrate, but BEL also inhibits phosphatidate phosphohydrolase-1 and a group VIB phospholipase A(2).

26 nt of protein kinase C and phosphatidic acid phosphohydrolase-1 hydrolase signaling.

27 The intracellular localization of S1P phosphohydrolase-1 necessitates the import of extracellu

28 specific actions of BEL on phosphatidic acid phosphohydrolase-1, p47(phox) phosphorylation, and apopt

29 e kinase 1 and its functional antagonist S1P phosphohydrolase-1.

30 gral membrane protein, human lipid phosphate phosphohydrolase-3 (hLPP-3) enzyme, which hydrolyzes pho

31 Mutation of the AdnB phosphohydrolase abolished duplex unwinding, consistent

32 Crippling the AdnA phosphohydrolase active site did not affect the rate of

33 of GMP to RNA kinetically differentiates the phosphohydrolase active site from the guanylyltransferas

34 Mutations of the phosphohydrolase active site of the AdnB subunit ablate

35 by members of two classes (types 1 and 2) of phosphohydrolase activities (PAPs).

36 effective inhibitor of type 1 phosphatidate phosphohydrolase activities and is only modestly effecti

37 presence of two cation-dependent nucleotide phosphohydrolase activities in membranes of Caenorhabdit

38 hat the GTP cyclohydrolase and pyrophosphate phosphohydrolase activities occur at independent sites,

39 inhibited protein kinase C and phosphatidate phosphohydrolase activities paving the way for further d

40 te general acid catalyst was dispensable for phosphohydrolase activity and phosphoenzyme formation by

41 Furthermore, phosphatidic acid phosphohydrolase activity assays showed that the bromoen

42 279A-D280A and F272A-L273A proteins retained phosphohydrolase activity but sedimented as monomers.

43 butes to diabetes, and mutations that impair phosphohydrolase activity form the clinical basis of gly

44 um and centrifugation, while cyclic inositol phosphohydrolase activity in both of these tissues remai

45 Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal my

46 tribution of annexin III and cyclic inositol phosphohydrolase activity in rat kidney and spleen indic

47 positions had no significant effect on Cet1 phosphohydrolase activity in vitro and had no effect on

48 e triphosphate tunnel that are essential for phosphohydrolase activity in vitro and in vivo: Arg393,

49 h enzymes exhibited divalent metal dependent phosphohydrolase activity in vitro toward phosphoserine-

50 The R321A and D425A proteins had full phosphohydrolase activity in vitro, but were profoundly

51 Thirteen residues required for the phosphohydrolase activity of CaCet1p (Glu287, Glu289, As

52 a substrate of this enzyme, suggesting that phosphohydrolase activity of SAMHD1 is regulated by dGTP

53 possesses a general nucleoside triphosphate phosphohydrolase activity that lacks a preference for th

54 ofar as their replacement by alanine reduced phosphohydrolase activity to <5% of the wild-type value.

55 Activation of SAMHD1 phosphohydrolase activity was tested under physiological

56 ne of the richest sources of cyclic inositol phosphohydrolase activity, possesses very little (immuno

57 serine abrogates phosphoenzyme formation and phosphohydrolase activity.

58 xin III, but has very little cyclic inositol phosphohydrolase activity.

59 III can be dissociated from cyclic inositol phosphohydrolase activity.

60 PGA mutase that also exhibited low levels of phosphohydrolase activity.

61 uf89 and Duf8901 are cobalt/nickel-dependent phosphohydrolases adept at hydrolyzing p-nitrophenylphos

62 homology (NUDT9-H) domain homologous to ADPR phosphohydrolases (ADPRases).

63 ur studies clearly show that cyclic inositol phosphohydrolase and annexin III are two different prote

64 While gp2 contains the phosphohydrolase and endonuclease activities of terminas

65 We conclude that the phosphohydrolase and helicase activities of NPH-II are e

66 m of action, propranolol, an inhibitor of PA phosphohydrolase and phosphatidylcholine biosynthesis, w

67 luenzae belongs to the "DDDD" superfamily of phosphohydrolases and is the prototype of class C nonspe

68 The majority of HAD members are phosphohydrolases and may be divided into three subclass

69 is protein requires functional HD (predicted phosphohydrolase) and DEXD/H (predicted helicase) domain

70 as well as acid phosphatase, naphthol-AS-BI-phosphohydrolase, and beta-glucosidase activities in som

71 A 5'-triphosphatase, nucleoside triphosphate phosphohydrolase, and guanylyltransferase activities of

72 , glycine N-methyltransferase, pyrophosphate phosphohydrolase, and protein phosphatase 1D were down-r

73 rotein coupled receptor, two lipid phosphate phosphohydrolases, and isoprenylation.

74 ty characteristic of the apyrase category of phosphohydrolases, and its sequence contains four motifs

75 ers of the HD-domain protein superfamily are phosphohydrolases, and newly discovered members are gene

76 only to diphosphorylated inositol phosphate phosphohydrolase as a candidate for regulating signaling

77 roposed molecular mechanism for an HD-domain phosphohydrolase based directly on substrate-bound cryst

78 suppressed the cold sensitivity of the Cet1 phosphohydrolase, but did not suppress the cs growth def

79 sphate (S1P) or inhibiting phosphatidic acid phosphohydrolase by propranolol (Ppl).

80 iana, two Mg(2+)-dependent phosphatidic acid phosphohydrolases called PAH1 and PAH2 act redundantly t

81 ansports Glu-6-P into the lumen of the ER, a phosphohydrolase catalytic subunit residing in the lumen

82 1), Glu(181), and Glu(183) are essential for phosphohydrolase chemistry and likely comprise the metal

83 lex unwinding, including those implicated in phosphohydrolase chemistry via transition state stabiliz

84 c protein (GFAP), 2;,3;-cyclic nucleotide 3;-phosphohydrolase (CNPase), and vimentin, suggesting that

85 ized protein that contains a lipid phosphate phosphohydrolase consensus motif.

86 obic enzyme, which contains the type 2 lipid phosphohydrolase conserved sequence motif, shows substra

87 HD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of the intracellul

88 olichos biflorus contain a lectin/nucleotide phosphohydrolase (Db-LNP) that binds to the Nod factor s

89 denosine and diphosphoinositol polyphosphate phosphohydrolase DDP1 is a Nudix enzyme with pyrophospha

90 isoforms of diphosphoinositol synthases and phosphohydrolases determines the rates of phosphorylatio

91 rostacyclin production via the phosphatidate phosphohydrolase/diacylglycerol lipase pathway.

92 Diphosphoinositol polyphosphate phosphohydrolase (DIPP) hydrolyzes diadenosine 5',5"'-P(

93 rat hepatic diphosphoinositol polyphosphate phosphohydrolase (DIPP) that cleaves a beta-phosphate fr

94 R as a novel diphosphoinositol polyphosphate phosphohydrolase (DIPP).

95 o new 19-kDa diphosphoinositol polyphosphate phosphohydrolases (DIPPs), named types 3alpha and 3beta,

96 One particular group of Nudix phosphohydrolases (DIPPs), through their metabolism of d

97 sly characterized relaxases, including an HD phosphohydrolase domain and an N-terminal hydrophobic re

98 tion of the catalytic residues of the SAMHD1 phosphohydrolase domain or by a Thr-592 phosphomimetic m

99 A thermostable phosphosulfolactate phosphohydrolase (EC 3.1.3.-) catalyzing the second step

100 hosphatidate phosphatase (3-sn-phosphatidate phosphohydrolase, EC 3.1.3.4) activity by phospholipids

101 tidate phosphatase (PAP1, 3-sn-phosphatidate phosphohydrolase, EC 3.1.3.4) catalyzes the dephosphoryl

102 atidate (PA) phosphatase (3-sn-phosphatidate phosphohydrolase, EC 3.1.3.4) catalyzes the dephosphoryl

103 phosphatase (PTP; protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48), called PTPepsilon.

104 atidate (PA) phosphatase (3-sn-phosphatidate phosphohydrolase; EC 3.1.3.4) activity.

105 The enzyme ectonucleoside tri(di)phosphohydrolase (ENTPD1, also known as CD39) is a vascu

106 Lumenal ecto-nucleoside tri- and di-phosphohydrolases (ENTPDases) of the secretory pathway o

107 endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme (PAP-1) to catalyze the penultim

108 hibits dual functions as a phosphatidic acid phosphohydrolase enzyme in the triglyceride synthesis pa

109 HD domain phosphohydrolase enzymes are characterized by a conserve

110 However, isotope effects associated with phosphohydrolase enzymes involved in P remineralization

111 The diphosphoinositol phosphate phosphohydrolase enzymes of the Nudix protein family hav

112 t and DNA viruses comprise a novel family of phosphohydrolase enzymes with a common active site.

113 sphatase EcCet1 belongs to a metal-dependent phosphohydrolase family that includes the triphosphatase

114 which suggest that different members of the phosphohydrolase family vary in their reliance on certai

115 B-40 family, Diphosphoinositol polyphosphate phosphohydrolase family, Transcription Elongation Factor

116 ng ATP-Binding Cassettes (ABC) transporters, phosphohydrolase, flagellar biosynthesis, chemotaxis, co

117 DGPP phosphatases (DGPP phosphohydrolase) from Saccharomyces cerevisiae and Esch

118 HD-domain phosphohydrolases have nucleotidase and phosphodiesteras

119 totype human diphosphoinositol-polyphosphate phosphohydrolase (hDIPP1), we now describe new 21-kDa hu

120 type 2 human diphosphoinositolpolyphosphate phosphohydrolases (hDIPP2alpha and 2beta) are distinguis

121 Nucleoside triphosphate phosphohydrolase I (NPH I) is a single-stranded DNA-depe

122 Nucleoside triphosphate phosphohydrolase I (NPH I) is an essential component of

123 Vaccinia virus nucleoside triphosphate phosphohydrolase I (NPH I) serves as the ATPase activity

124 COOH-terminal end of nucleoside triphosphate phosphohydrolase I (NPH I), an ATPase that is employed i

125 termination factor, nucleoside triphosphate phosphohydrolase I (NPH I), and ATP.

126 Vaccinia virus nucleoside triphosphate phosphohydrolase I (NPH-I) is a DNA-dependent ATPase tha

127 capping enzyme, and nucleoside triphosphate phosphohydrolase I, and two core proteins required for m

128 y factor X as NPH-I (nucleoside triphosphate phosphohydrolase-I), a virus-encoded DNA-dependent ATPas

129 C2 in human PMN is the first lipid phosphate phosphohydrolase identified for PSDP.

130 a virus RNA helicase nucleoside triphosphate phosphohydrolase II (NPH-II) result in the production of

131 cinia viral helicase nucleoside triphosphate phosphohydrolase-II (NPH-II) exhibits robust RNA helicas

132 that the major ecto-nucleoside triphosphate phosphohydrolase in the chicken liver membranes is an ec

133 NPH-II mutations that inactivated the phosphohydrolase in vitro were lethal in vivo, as judged

134 y studies using propranolol, a phosphatidate phosphohydrolase inhibitor.

135 prevention of PA dephosphorylation by the PA phosphohydrolase inhibitors propranolol and bromoenol la

136 and wunen2 encode Drosophila lipid phosphate phosphohydrolases, integral membrane enzymes that dephos

137 Cyclic inositol phosphohydrolase is a phosphodiesterase that cleaves the

138 n placenta and reported that cyclic inositol phosphohydrolase is identical to annexin III.

139 DGPP phosphatase (DGPP phosphohydrolase) is a membrane-associated 34-kDa enzyme

140 s known about the role of the 2 S1P-specific phosphohydrolase isoforms, SGPP1 and SGPP2, which cataly

141 ) and 2-keto-3-deoxy-9-O-phosphonononic acid phosphohydrolase (KDN9P phosphatase, KDN9PP).

142 eto-3-deoxy-d-manno-octulosonate 8-phosphate phosphohydrolase (KDO8P phosphatase, KDO8PP) and 2-keto-

143 ast, the long-chain sphingoid base phosphate phosphohydrolase Lcb3p is required for efficient ceramid

144 -sensitive, endoplasmic reticulum-associated phosphohydrolase, like G6Pase-alpha.

145 approaches have identified LECTIN NUCLEOTIDE PHOSPHOHYDROLASE (LNP) as a Nod factor-binding protein.

146 This lectin-nucleotide phosphohydrolase (LNP) has a substrate specificity chara

147 e acyltransferases (AGPATs), lipid phosphate phosphohydrolases (LPINs) and diacylglycerol acyltransfe

148 Unlike other known type 2 lipid phosphate phosphohydrolases (LPPs), but similar to the yeast ortho

149 SAMHD1 is a phosphohydrolase maintaining cellular dNTP homeostasis b

150 Collectively, our results suggest that SPP phosphohydrolase may regulate the dynamic balance betwee

151 aspartate (HD)-domain fold characteristic of phosphohydrolase metalloenzymes and its activity mitigat

152 protein as an ecto-5'-nucleoside diphosphate phosphohydrolase (NudP) involved in the degradation of e

153 annexin III co-migrates with cyclic inositol phosphohydrolase on ion exchange chromatography, while g

154 is clearly dissociated from cyclic inositol phosphohydrolase on ion exchange chromatography.

155 ization of the Bacillus megaterium HD domain phosphohydrolase OxsA, involved in the biosynthesis of t

156 oMet) radical enzyme, OxsB, and an HD-domain phosphohydrolase, OxsA, reveals that OXT-A is derived fr

157 wed that the disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH) activity in Arabidopsis thaliana

158 BEL also inhibits cellular phosphatidic acid phosphohydrolase (PAP) activity in intact P388D1 macroph

159 phospholipase D (PLD) and phosphatidic acid phosphohydrolase (PAP) are two pivotal enzymes in this s

160 Phosphatidic acid phosphohydrolase (PAP) catalyzes the dephosphorylation o

161 homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride-synthe

162 The phosphatidic acid phosphohydrolase (PAP) inhibitor dl-propranolol also inh

163 Lipin-1 is a phosphatidate phosphohydrolase (PAP) required for the generation of di

164 PA is converted to DG by PA phosphohydrolase (PAP).

165 Mg2+-independent form of PA phosphatase (PA phosphohydrolase, PAP2) purified from rat liver catalyze

166 Experiments with phosphatidate phosphohydrolase (PAPH) and phospholipase D (PLD) inhibi

167 also inhibited islet cytosolic phosphatidate phosphohydrolase (PAPH), but the PAPH inhibitor proprano

168 and oligodendrocytes (anti-cyclic nucleotide phosphohydrolase polyclonal antibody).

169 like enzymes comprise a large superfamily of phosphohydrolases present in all organisms.

170 Moreover, inhibitors of phosphatidate phosphohydrolase (propranolol) and diacylglycerol lipase

171 zed as a diphosphorylated inositol phosphate phosphohydrolase represents the first example, in any an

172 biquitin is a substrate for the nucleotidase/phosphohydrolase, resulting in either transfer of ubiqui

173 f CD81 with the deoxynucleoside triphosphate phosphohydrolase SAMHD1.

174 rresponding diacylglycerols by phosphatidate phosphohydrolase, since diacylglycerols were much slower

175 the NTPase domains to form two composite NTP phosphohydrolase sites.

176 racterized mammalian sphingosine-1-phosphate phosphohydrolase (SPP1), an enzyme that specifically dep

177 ogy between SPP1s and the other type 2 lipid phosphohydrolases, SPP1s are significantly different and

178 ancient L-2-halo-acid dehalogenase and DDDD phosphohydrolase superfamilies, but is specific for doub

179 MTH1 is a member of the nudix phosphohydrolase superfamily of enzymes, and it is invol

180 ly similar to enzymes from the all-alpha NTP phosphohydrolase superfamily.

181 a large family of hydrolytic enzymes, the HD-phosphohydrolase superfamily.

182 recently cloned based on homology to a lipid phosphohydrolase that regulates the levels of phosphoryl

183 ased on sequence homology with LBP1, a lipid phosphohydrolase that regulates the levels of phosphoryl

184 diesterases (PDEs) comprise a superfamily of phosphohydrolases that degrade 3',5'-cyclic nucleotides.

185 Apyrases are non-energy-coupled nucleotide phosphohydrolases that hydrolyze nucleoside triphosphate

186 a member of a new family of metal-dependent phosphohydrolases that includes the RNA triphosphatases

187 allest member of a family of metal-dependent phosphohydrolases that includes the RNA triphosphatases

188 ongs to the tunnel family of metal-dependent phosphohydrolases that includes the RNA triphosphatases

189 allest member of a family of metal-dependent phosphohydrolases that includes the RNA triphosphatases

190 xed with natural substrates) of an HD-domain phosphohydrolase, the Escherichia coli 5'-nucleotidase Y

191 fold rate enhancements that are generated by phosphohydrolases, the most powerful biological catalyst

192 f the fungal/viral family of metal-dependent phosphohydrolases, which are structurally and mechanisti

193 atase belongs to a family of metal-dependent phosphohydrolases, which includes the RNA triphosphatase

194 dition to catalyzing hydrolysis, a number of phosphohydrolases will catalyze a phosphate (oxygen)-wat

195 a family of viral and fungal metal-dependent phosphohydrolases with a distinctive capacity to hydroly

196 ng to a single family of metal-dependent NTP phosphohydrolases with a unique tunnel active site compo