ライフサイエンスコーパス: phospholipase A

1 is an acyl hydrolase, rather than a specific phospholipase A.

2 s comprising sequential sn-1 hydrolysis by a phospholipase A(1) (e.g. by patatin-like phospholipase d

3 Trypanosoma brucei phospholipase A(1) (TbPLA(1)) is unique from previously

4 Phospholipase A(1) activities have been detected in most

5 2)delta stands out as having relatively high phospholipase A(1) activity.

6 idosis, which is caused by the inhibition of phospholipase A(1) activity.

7 e also demonstrated that sertraline inhibits phospholipase A(1) and phospholipase D, exhibits mixed e

8 by protect the lipids from being degraded by phospholipase A(1) rather than inhibiting the enzyme.

9 The lysophospholipase, phospholipase A(1), and phospholipase A(2) activities of

10 onoyl-lysophospholipids produced from either phospholipase A(1)-mediated hydrolysis of diacyl arachid

11 of the cobra venom (Naja naja naja) group IA phospholipase A 2 (GIA PLA 2) was carried out in the pre

12 Pig pancreatic IB phospholipase A 2 (PLA2) forms three distinguishable pre

13 At 1 year, an allograft biopsy showed phospholipase A 2 receptor-negative membranous nephropat

14 Among the phospholipases A 2 (PLA 2s) are the group VI Ca (2+)-ind

15 Adipose phospholipase A(2) (AdPLA or Group XVI PLA(2)) plays an

16 are responsible for this response: cytosolic phospholipase A(2) (cPLA(2)) and diacylglycerol lipase;

17 semblies of 5-LO and FLAP included cytosolic phospholipase A(2) (cPLA(2)) and were linked to LTB(4) p

18 Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central molecule in NK

19 e present work, we have identified cytosolic phospholipase A(2) (cPLA(2)) as an effector molecule of

20 hain (ETC) derived H(2)O(2) versus cytosolic phospholipase A(2) (cPLA(2)) derived LOOHs in neurogenic

21 C), catalyzed by the activation of cytosolic phospholipase A(2) (cPLA(2)) in the PPT1-KO mouse brain,

22 lation by Ang II was attenuated by cytosolic phospholipase A(2) (cPLA(2)) inhibitor pyrrolidine-1 and

23 a cAMP-independent mechanism, i.e. cytosolic phospholipase A(2) (cPLA(2)) signalling.

24 5LO interacts with the membranous cytosolic phospholipase A(2) (cPLA(2)) to produce leukotriene B(4)

25 creasing cholesterol, activating cytoplasmic phospholipase A(2) (cPLA(2)), and triggering synapse dam

26 used RT-PCR to identify mRNAs for cytosolic phospholipase A(2) (cPLA(2)), COX-1, COX-2, 5-LOX, and 1

27 eta oligomers activated synaptic cytoplasmic phospholipase A(2) (cPLA(2)).

28 anes and increased activation of cytoplasmic phospholipase A(2) (cPLA(2)).

29 e reported that mice deficient for cytosolic phospholipase A(2) (cPLA(2)-KO) are protected against th

30 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) catalyzes release of a

31 Although group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) has been reported to b

32 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) initiates eicosanoid p

33 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) is regulated by phosph

34 y binds to and activates group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) to stimulate the produ

35 at mediate activation of group IVA cytosolic phospholipase A(2) (cPLA(2)alpha), a regulatory enzyme t

36 The cytosolic (group IV) phospholipase A(2) (cPLA(2)s) family contains six member

37 phage encoding a previously unknown secreted phospholipase A(2) (designated SlaA) has been implicated

38 Highly cationic mammalian group IIA phospholipase A(2) (gIIA PLA(2)) kills S. aureus at nano

39 ed the inhibition mode of group IIA secreted phospholipase A(2) (GIIA sPLA(2)) selective inhibitors a

40 ncreased activity of the group IV isoform of phospholipase A(2) (GIVA-PLA(2)).

41 ated whether deficiency of group V secretory phospholipase A(2) (GV sPLA(2)) protects from experiment

42 Ca(2+)-independent phospholipase A(2) (GVIA iPLA(2)) has gained increasing

43 The Group VIA-2 Ca(2+)-independent phospholipase A(2) (GVIA-2 iPLA(2)) is composed of seven

44 In particular, the Group VIA phospholipase A(2) (GVIA-iPLA(2)) subfamily of enzymes f

45 with targeted deletion of group X secretory phospholipase A(2) (GX KO).

46 ies in vitro indicate that group X secretory phospholipase A(2) (GX sPLA(2)) potently releases arachi

47 he X-ray structure of human group X secreted phospholipase A(2) (hGX), we carried out structure-based

48 f inhibition of group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)) by fluoroketone (FK) ligand

49 Group VI Ca(2)(+)-independent phospholipase A(2) (iPLA(2)) is a water-soluble enzyme t

50 d others have shown that calcium-independent phospholipase A(2) (iPLA(2)) is involved in epithelial o

51 Calcium-independent phospholipase A(2) (iPLA(2)) plays a pivotal role in pho

52 sults in activation of a calcium-independent phospholipase A(2) (iPLA(2)), and this leads to arachido

53 molecular biologic manipulation of Group VIA phospholipase A(2) (iPLA(2)beta) activity in pancreatic

54 Group VIA phospholipase A(2) (iPLA(2)beta) hydrolyzes beta-cell me

55 The Group VIA phospholipase A(2) (iPLA(2)beta) hydrolyzes glycerophosp

56 Group VIA phospholipase A(2) (iPLA(2)beta) in pancreatic islet bet

57 Group VIA phospholipase A(2) (iPLA(2)beta) is expressed in phagocy

58 Whether group VIA phospholipase A(2) (iPLA(2)beta) is involved in vascular

59 We reported that Group VIA phospholipase A(2) (iPLA(2)beta) is required for this re

60 is by a pathway involving Ca(2+)-independent phospholipase A(2) (iPLA(2)beta)-mediated ceramide gener

61 INS-1 cell apoptosis by a Ca(2+)-independent phospholipase A(2) (iPLA(2)beta)-mediated mechanism that

62 Increased lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity is associated wi

63 e prognostic value of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associated with high-dens

64 Lipoprotein associated phospholipase A(2) (Lp-PLA(2)) has been characterized fo

65 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been shown to be asso

66 AF-AH), also known as lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inactivates potent lipid

67 rapladib, a selective lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inhibitor, on biomarkers

68 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phosph

69 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a proinflammatory enzy

70 Elevated lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) may be positively associa

71 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) plays important roles in

72 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an inflammatory enzyme e

73 ted risk for elevated lipoprotein-associated phospholipase A(2) (Lp-PLA(2)).

74 o examine the role of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)/PLA2G7) in human inflammat

75 mouse alveolar macrophages release lysosomal phospholipase A(2) (LPLA(2)) into the medium of cultured

76 uller glia and Xenopus oocytes, but required phospholipase A(2) (PLA(2)) activity exclusively in Mull

77 ndosomal compartments requires a cytoplasmic phospholipase A(2) (PLA(2)) activity.

78 soPC in vitro indicating that the enzyme has phospholipase A(2) (PLA(2)) activity.

79 R inhibited GABAergic IPSCs through both the phospholipase A(2) (PLA(2)) and cAMP/protein kinase A (P

80 The GIVA phospholipase A(2) (PLA(2)) contains two domains: a calc

81 ntain motifs that are highly homologous to a phospholipase A(2) (PLA(2)) domain and nuclear localizat

82 erminal half of ExoU contains a patatin-like phospholipase A(2) (PLA(2)) domain that requires the hos

83 Recently, a phospholipase A(2) (PLA(2)) encoded by a majority of A.

84 Phospholipase A(2) (PLA(2)) enzyme could be acted as a u

85 Phospholipase A(2) (PLA(2)) enzymes become activated by

86 or their function, the membrane insertion of phospholipase A(2) (PLA(2)) enzymes has not been studied

87 Phospholipase A(2) (PLA(2)) has long been proposed to be

88 Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 position

89 iously reported a role for group V secretory phospholipase A(2) (PLA(2)) in regulating phagocytosis o

90 An analysis of group IVA (GIVA) phospholipase A(2) (PLA(2)) inhibitor binding was conduc

91 CGG (rCGG) repeats, among them several known phospholipase A(2) (PLA(2)) inhibitors.

92 acetylhydrolase (PAFAH) Ib, comprised of two phospholipase A(2) (PLA(2)) subunits, alpha1 and alpha2,

93 The phospholipase A(2) (PLA(2)) superfamily consists of 16 g

94 branes and reduced activation of cytoplasmic phospholipase A(2) (PLA(2)), consistent with the hypothe

95 Using a fluorogenic substrate for phospholipase A(2) (PLA(2)), we observed an increased va

96 Eicosanoids produced after phospholipase A(2) (PLA(2))-catalyzed release of arachid

97 udy, we show that 1,25(OH)(2)D(3) stimulates phospholipase A(2) (PLA(2))-dependent rapid release of p

98 Phospholipase A(2) (PLA(2))-derived arachidonic acid (AA

99 We found that, among the three phospholipase A(2) (PLA(2))-regulated arachidonic acid (

100 an enzymatic product of autotaxin (ATX) and phospholipase A(2) (PLA(2))enzymes.

101 Recently, PEDF-R (TTS-2.2/independent phospholipase A(2) (PLA(2))zeta and mouse desnutrin/ATGL

102 Group IValpha phospholipase A(2) (PLA(2)IValpha) is a lipolytic enzyme

103 ytes, whereas expression of adipose-specific phospholipase A(2) (pla2g16) was unchanged.

104 This study used group 1B phospholipase A(2) (Pla2g1b)-deficient mice, which are r

105 Female mice lacking group IVA phospholipase A(2) (Pla2g4a(-/-)) have a smaller litter

106 ties of 15-lipoxygenase (15-LO) and secreted phospholipase A(2) (sPLA(2)) are needed for the formatio

107 Some isoforms of secretory phospholipase A(2) (sPLA(2)) distinguish between healthy

108 Secreted phospholipase A(2) (sPLA(2)) enzymes release free fatty

109 Secretory phospholipase A(2) (sPLA(2)) enzymes, produced and secre

110 Recently, a secreted phospholipase A(2) (sPLA(2)) motif was identified in the

111 have previously shown that group V secretory phospholipase A(2) (sPLA(2)) regulates phagocytosis of z

112 Secretory phospholipase A(2) (sPLA(2)) represents a family of proa

113 The ability of secretory phospholipase A(2) (sPLA(2)) to hydrolyze cell membranes

114 Conversely, overexpression of GX secretory phospholipase A(2) (sPLA(2)), but not a catalytically in

115 SAA increases simultaneously with secretory phospholipase A(2) (sPLA(2)), compelling us to determine

116 ce by phagocytes and hydrolysis by secretory phospholipase A(2) (sPLA(2)).

117 them susceptible to hydrolysis by secretory phospholipase A(2) (sPLA(2)).

118 associated with elevated levels of secreted phospholipase A(2) (sPLA(2)).

119 he endothelially expressed secretory group V phospholipase A(2) (sPLA(2)-V).

120 We have shown that group VIA phospholipase A(2) [calcium-independent phospholipase A(

121 ture, whereas the addition of surfactants or phospholipase A(2) activation increases the outer monola

122 The results suggest that cytosolic phospholipase A(2) activation triggered by the beta-gluc

123 dose-dependently inhibited platelet Nox2 and phospholipase A(2) activation, along with inhibition of

124 Upstream, MAPK-p38 mediates cytosolic phospholipase A(2) activation, which is required for PPA

125 e lysophospholipase, phospholipase A(1), and phospholipase A(2) activities of the full set of mammali

126 noacylglycerol acyltransferase and increased phospholipase A(2) activities.

127 it both monoacylglycerol acyltransferase and phospholipase A(2) activities.

128 operoxidase mass, and lipoprotein-associated phospholipase A(2) activity and association with CAD eve

129 of 22:6 FA in phospholipids suggests altered phospholipase A(2) activity and changes in membrane dyna

130 oubled) by the highest tertiles of secretory phospholipase A(2) activity and mass but less so for mye

131 associated with the inhibition of cytosolic phospholipase A(2) activity and the PI3K/ERK/NF-kappaB p

132 Kinetic characterization of bee venom phospholipase A(2) activity at bile salt+phospholipid ag

133 antly, PEDF binding stimulates the enzymatic phospholipase A(2) activity of PEDF-R.

134 Phospholipase A(2) activity plays key roles in generatin

135 high binding affinity for PEDF, has a potent phospholipase A(2) activity that liberates fatty acids,

136 oth a monoacylglycerol acyltransferase and a phospholipase A(2) activity.

137 r myeloperoxidase and lipoprotein-associated phospholipase A(2) activity.

138 function through glutathione peroxidase and phospholipase A(2) activity.

139 and seem to be independent of its effect on phospholipase A(2) activity.

140 t is postulated that inhibition of cytosolic phospholipase A(2) alpha (cPLA(2)alpha) can reduce sever

141 arachidonic acid-generating enzyme cytosolic phospholipase A(2) alpha (cPLA(2)alpha) has been implica

142 Cytosolic phospholipase A(2) alpha (cPLA(2)alpha, type IVA phospho

143 associated augmentation of ERK1/2, cytosolic phospholipase A(2) alpha, and cysteinyl-leukotriene synt

144 Phosphorylation of ERK1/2 and cytosolic phospholipase A(2) alpha, known to enhance the release o

145 essary to generate hepoxilin A(3), including phospholipase A(2) and 12-lipoxygenase, potently interfe

146 Arachidonic acid is released by phospholipase A(2) and converted into hundreds of distin

147 Inhibitors of phospholipase A(2) and cytochrome P450 epoxygenase atten

148 at inhibition of the overexpressed secretory phospholipase A(2) and cytosolic phospholipase A(2) duri

149 of phospholipase A(2) isoenzymes, secretory phospholipase A(2) and cytosolic phospholipase A(2), are

150 MAPK-activated c-Src subsequent to cytosolic phospholipase A(2) and generation of AA metabolites via

151 Platelet phospholipase A(2) and thromboxane A(2) significantly de

152 The Group IVA (GIVA) phospholipase A(2) associates with natural membranes in

153 functional inhibition of Ca(2+)-independent phospholipase A(2) beta (iPLA(2)beta or PLA2g6A), or dep

154 A supplementation on membrane incorporation, phospholipase A(2) catalyzed release, and eicosanoid pro

155 n the enzymatic activity of the patatin-like phospholipase A(2) domain localized to the N-terminal ha

156 d secretory phospholipase A(2) and cytosolic phospholipase A(2) during sepsis benefits the disease's

157 (VEGFs), angiopoietins (Angs), and secreted phospholipase A(2) enzymes (sPLA(2) ) were evaluated.

158 nditions in which both sphingomyelinases and phospholipase A(2) enzymes are activated, such as during

159 Phospholipase A(2) enzymes hydrolyze phospholipids to li

160 hospholipase, designated calcium-independent phospholipase A(2) gamma (iPLA(2)gamma), which possesses

161 rload caused overexpression and secretion of phospholipase A(2) group IIA (pla2g2a) from immune cells

162 Secretory phospholipase A(2) group IIA (PLA2G2A) is a phospholipas

163 Secretory phospholipase A(2) group IIA enhances the metabolic rate

164 Secreted phospholipase A(2) group X (sPLA(2)-X) has recently been

165 Phospholipase A(2) has been implicated to play a pivotal

166 te that antisense strategy against secretory phospholipase A(2) IIa and cytosolic phospholipase A(2)

167 s is mediated by the activation of cytosolic phospholipase A(2) in resident peritoneal macrophages, w

168 elles; (iv) removal of bound phospholipid by phospholipase A(2) inactivates the cytochrome complex; a

169 Using the GIVA phospholipase A(2) irreversible inhibitor methyl-arachid

170 The mitochondrial Ca(2+)-independent phospholipase A(2) is activated during energy-dependent

171 of arachidonate release, group IIA secreted phospholipase A(2) is induced (detected at the mRNA and

172 ent of sepsis by targeting multiple forms of phospholipase A(2) isoenzymes with DNA antisense oligome

173 The two major forms of phospholipase A(2) isoenzymes, secretory phospholipase A

174 cretory phospholipase A(2) IIa and cytosolic phospholipase A(2) IVa can inhibit their target protein

175 ipase A2 IIa and the other against cytosolic phospholipase A(2) IVa) (Group 4) increased the median s

176 oteins, the mitochondrial Ca(2+)-independent phospholipase A(2) may be an important factor governing

177 e membrane, we have shown that the action of phospholipase A(2) on acyl-based phospholipids triggers

178 one and oligomycin, but not by the cytosolic phospholipase A(2) or xanthine oxidase inhibitors.

179 PI3K/Btk pathway does not regulate cytosolic phospholipase A(2) phosphorylation but rather appears to

180 tofluorescence findings suggest that group V phospholipase A(2) plays a role in the phagocytosis of p

181 Autoantibodies to the M-type phospholipase A(2) receptor (PLA(2)R) are sensitive and

182 The phospholipase A(2) receptor (PLA(2)R) is the major targe

183 he reactive protein band detected the M-type phospholipase A(2) receptor (PLA(2)R).

184 ts in remission who tested positive for anti-phospholipase A(2) receptor (PLA2R) antibodies, the decl

185 Antibodies against phospholipase A(2) receptor 1 (PLA(2)R1) are found in 80

186 opathy with fine granular co-localization of Phospholipase A(2) receptor and IgG evident on transplan

187 f idiopathic disease is associated with anti-Phospholipase A(2) receptor autoantibodies.

188 nd elevated circulating levels of serum anti-Phospholipase A(2) receptor autoantibody that declined o

189 membranous nephropathy with circulating anti-Phospholipase A(2) receptor autoantibody, which supports

190 This is a very early case of Phospholipase A(2) receptor-associated recurrent membran

191 holipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing cha

192 erated channels, and the calcium-independent phospholipase A(2) that activates these channels were re

193 poptosis because overexpression of PAFAH2 (a phospholipase A(2) that selectively hydrolyzes truncated

194 asured in bovine RPE was highly sensitive to phospholipase A(2) treatment, but the observed decline i

195 Their relationship to secretory phospholipase A(2) type IIA mass and activity, myelopero

196 acrophages have long been known to secrete a Phospholipase A(2) with an acidic pH optimum in response

197 ed for IL-33 to activate group IVa cytosolic phospholipase A(2) with consequent AA release for synthe

198 t-activating factor (PAF) acetylhydrolase, a phospholipase A(2) with selectivity for acetyl residues

199 e four most abundant proteins (disintegrins, phospholipase A(2)'s, serine proteinases, and snake veno

200 Higher lipoprotein-associated phospholipase A(2)(Lp-PLA2) activity is associated with

201 Phospholipase A(2)(PLA(2)) enzymes are considered the pr

202 e encoding a secreted phospholipase (group V phospholipase A(2)).

203 PLA(2) that we named AdPLA (adipose-specific phospholipase A(2)).

204 d S. flexneri activate different subtypes of phospholipase A(2), a critical enzyme involved in the li

205 Group X (GX) phospholipase A(2), a member of a large group of secrete

206 role of the newly identified major adipocyte phospholipase A(2), AdPLA (encoded by Pla2g16, also call

207 PGLYRPs and antibacterial peptides (phospholipase A(2), alpha- and beta-defensins, and bacte

208 lipid classes suggests increased activity of phospholipase A(2), an enzyme that has been implicated i

209 tes LPA from CHO cells primed with bee venom phospholipase A(2), and ATX-mediated LPA production is e

210 endent phospholipase A(2), calcium-dependent phospholipase A(2), and phospholipase D activities, but

211 , secretory phospholipase A(2) and cytosolic phospholipase A(2), are overexpressed during sepsis.

212 released from the membrane by the action of phospholipase A(2), are potent lipid mediators of the in

213 soforms of bradykinin-potentiating peptides, phospholipase A(2), C-type lectins, serine proteinases a

214 ation is known to induce calcium-independent phospholipase A(2), calcium-dependent phospholipase A(2)

215 ptosis is often accompanied by activation of phospholipase A(2), causing release of free fatty acids

216 ong up-regulation of expression of secretory phospholipase A(2), group IIA (sPLA(2)) was identified.

217 n of the gene encoding a calcium-independent phospholipase A(2), iPLA2-VIA, which also prevents cardi

218 reases the levels of mRNA encoding cytosolic phospholipase A(2), LTA(4) hydrolase, and 5-LO-activatin

219 ration and survival, activation of cytosolic phospholipase A(2), mast cell degranulation, and phagocy

220 l being activated by a downstream product of phospholipase A(2), relegating mechanosensitivity to the

221 the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus liberating arachidonic acid, wh

222 stimulated phosphoprotein, nitric oxide, and phospholipase A(2), were determined at baseline and afte

223 s suppress COX-2 expression while activating phospholipase A(2), which enhances AA levels by hydrolys

224 se effects are recapitulated with pancreatic phospholipase A(2), which hydrolyses the release of memb

225 ed kinase, an upstream effector of cytosolic phospholipase A(2), which was restored by exogenous PGH(

226 anosporum ortholog, is a self-processing pro-phospholipase A(2), whose phospholipase activity increas

227 In contrast, the synapse damage induced by a phospholipase A(2)-activating peptide was independent of

228 protein levels), and the action of cytosolic phospholipase A(2)-alpha is required for this induction.

229 PLOOH peroxidase nor hydrolase and that the phospholipase A(2)-like activity previously attributed t

230 f protein synthesis and priming for enhanced phospholipase A(2)-mediated eicosanoid production work t

231 tion in most mammalian cells is initiated by phospholipase A(2)-mediated release of arachidonic acid,

232 sults with RGM1 cells and group IIA secreted phospholipase A(2)-transfected HEK293 cells show that th

233 lcholine externally or by generating it with phospholipase A(2).

234 ed effects on phospholipase C, and activates phospholipase A(2).

235 ies identify LPLA(2) as a high m.w.-secreted Phospholipase A(2).

236 evealed a gene with homology to patatin-like phospholipase A(2).

237 (AA) from cellular membranes by cytoplasmic phospholipase A(2)alpha (cPLA(2)alpha) and contributes t

238 p44/42(ERK1/2) or inactivation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha) completely inhibi

239 We have previously shown that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contributes to E.

240 he first direct evidence that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contributes to ty

241 In the vascular endothelium, group IV phospholipase A(2)alpha (cPLA(2)alpha) enzyme activity i

242 the release of arachidonic acid by cytosolic phospholipase A(2)alpha (cPLA(2)alpha) followed by its e

243 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the rate-limit

244 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the rate-limit

245 and specific activator of group IV cytosolic phospholipase A(2)alpha (cPLA(2)alpha) via interaction w

246 ion of Smad and phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), a rate-limiting

247 esis proximal to the activation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), the initial rate

248 host signaling molecules including cytosolic phospholipase A(2)alpha (cPLA(2)alpha).

249 Here we report that calcium-independent phospholipase A(2)beta (iPLA(2)beta) is required for hig

250 VIA phospholipase A(2) [calcium-independent phospholipase A(2)beta (iPLA(2)beta)] is important in re

251 trate that mice null for calcium-independent phospholipase A(2)gamma (iPLA(2)gamma(-/-)) are complete

252 Calcium-independent phospholipase A(2)gamma (iPLA(2)gamma) (PNPLA8) is the p

253 ein, we demonstrate that calcium-independent phospholipase A(2)gamma (iPLA(2)gamma) is a critical mec

254 Genetic ablation of calcium-independent phospholipase A(2)gamma (iPLA(2)gamma) results in profou

255 ling pathways, including calcium-independent phospholipase A(2)gamma (iPLA(2)gamma), and mitogen-acti

256 ent eicosanoid biosynthesis is controlled by phospholipase A(2)s (PLA(2)s), most notably cytosolic PL

257 Secretory phospholipase A(2)s (sPLA(2)) hydrolyze glycerophospholi

258 generated by one or more calcium-independent phospholipases A(2) (iPLA(2)s) participate in the regula

259 Phospholipases A(2) (PLA(2)) hydrolyze the sn-2 fatty ac

260 Phospholipases A(2) (PLA(2)s) catalyze hydrolysis of fat

261 The mechanisms by which secretory phospholipases A(2) (PLA(2)s) exert cellular effects are

262 The beta-neurotoxic secreted phospholipases A(2) (sPLA(2)s) block neuro-muscular tran

263 A(2), a member of a large group of secreted phospholipases A(2) (sPLA(2)s), has recently been demons

264 s of the fungal/bacterial group XIV secreted phospholipases A(2) (sPLA(2)s).

265 (2+) flux and activation of Ca(2+)-dependent phospholipases A(2) that cycle polyunsaturated FA into p

266 chromatographic-mass spectrometric assay for phospholipases A(2) to perform inhibition analysis using

267 The other eight secreted phospholipases A(2) were not detected in RGM1 cells at t

268 cytosolic, calcium-independent, and secreted phospholipases A(2) were used to establish and validate

269 characterization lags far behind that of the phospholipases A(2), C and D.

270 eal epithelial (HCE) cells via the cytosolic phospholipase A(2alpha) (cPLA(2alpha)) pathway.

271 We describe mycobacterial phospholipase A activity (MPLA) and, using reverse genet

272 Both cytotoxicity and phospholipase A activity associated with RT0522 were red

273 emonstrate that recombinant RT0522 possesses phospholipase A activity that requires a eukaryotic host

274 tified from Rickettsia typhi with functional phospholipase A activity.

275 s of RT0522 also eliminates cytotoxicity and phospholipase A activity.

276 for phosphatidyl-based substrate binding and phospholipase A activity.

277 es an essential enzyme with thioesterase and phospholipase A activity.

278 The phospholipase A and acyltransferase (PLAAT) family of cy

279 ed with and without ATP, ATP inhibitors, and phospholipase-A and -C inhibitors.

280 protein kinase A, target of rapamycin (TOR), phospholipase A, and ERK1, but does not require the PI3

281 f genes encoding 13-lipoxygenases (LOXs) and phospholipase A-Igamma3 (At1g51440), a plastid lipase wi

282 Castor patatin-like phospholipase A IIIbeta facilitates the exclusion of hyd

283 ure the DeltaG(o)(w,l) of the outer membrane phospholipase A into large unilamellar vesicles (LUVs) o

284 Outer membrane phospholipase A (OMPLA) is a widely conserved transmembr

285 In Gram-negative bacteria, outer membrane phospholipase A (OmpLA) is involved in outer-membrane li

286 smembrane beta-barrel protein outer membrane phospholipase A (OMPLA) revealed an intermolecular hydro

287 tinized the unfolded state of outer-membrane phospholipase A (OmpLA) to provide a detailed view of it

288 cA gene product (PagP), OmpT, outer membrane phospholipase A (OmpLa), the fadl gene product (FadL), t

289 r interface of beta-barrel MP outer membrane phospholipase A (OMPLA).

290 those parameters for E. coli outer membrane phospholipase A (OmpLA).

291 er phosphodiesterases and three patatin-like phospholipases A on the transcriptome level.

292 hrome groups, are usually employed to screen phospholipase A (PLA) activities.

293 chniques, we discover that ACT has intrinsic phospholipase A (PLA) activity, and that such activity d

294 Plant phospholipase A (PLA) catalyzes the hydrolysis of PC to

295 homologue of the Pseudomonas aeruginosa ExoU phospholipase A (PLA) secreted cytotoxin.

296 spholipases, including at least 15 different phospholipases A (PLA).

297 secreted by Legionella pneumophila, such as phospholipases A (PLAs) and glycerophospholipid:choleste

298 The patatin-related phospholipase A (pPLA) hydrolyzes membrane glycerolipids

299 d that the dominant mlaA* mutation activates phospholipase A, resulting in increased levels of lipopo

300 se (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003).