ライフサイエンスコーパス: phospholipase D

1 odulation of N-acyl phosphatidylethanolamine phospholipase D).

2 ost typically with Streptomyces chromofuscus phospholipase D.

3 ctivation of phosphoinositide hydrolysis and phospholipase D.

4 elial cells requires activation of host-cell phospholipase D.

5 ector of Ras is the lipid hydrolyzing enzyme phospholipase D.

6 n requires an intact copy of SPO14, encoding phospholipase D.

7 biosynthetic enzymes, N-acyltransferase and phospholipase D.

8 ving the interaction between aquaporin 3 and phospholipase D.

9 y accessible to its periplasmic, PC-specific phospholipase D.

10 tudy, we set out to test the hypotheses that phospholipase D 1 (PLD1) is an upstream regulator of mTO

11 M-interacting proteins in B cells, including phospholipase D 1 (PLD1), and kinase adaptor proteins AK

12 Phospholipase D 1, a PA-generating enzyme that is an est

13 Inhibitors of phospholipase D (1-butanol and a dominant negative const

14 abolism of phosphatidic acid, the product of phospholipase D(2), and gangliosides, and point to a cen

15 Finally, genetic ablation of phospholipase D(2), which rescues the synaptic and behav

16 The kinetics of bombesin-induced phospholipase D activation and LPA production were simil

17 ontrast, neither transactivation of RhoA nor phospholipase D activation was detected in cells express

18 of the small G-protein RhoA is required for phospholipase D activation.

19 from G(13) heterotrimers are responsible for phospholipase D activation.

20 ), calcium-dependent phospholipase A(2), and phospholipase D activities, but inhibition of these enzy

21 ease in AEA levels and N-acyltransferase and phospholipase D activities.

22 nd coat proteins as well as in regulation of phospholipase D activity and cytoskeleton modifications.

23 The effects of phospholipase D activity and its product phosphatidic ac

24 Both phospholipase D activity and vesicular trafficking were

25 nt phosphatidylcholine reveal a low level of phospholipase D activity associated with cortical vesicl

26 Recent studies have revealed that elevated phospholipase D activity generates survival signals in b

27 Increasing the phospholipase D activity in MCF7 cells also suppressed p

28 We report here that the elevated phospholipase D activity in the human breast cancer cell

29 monstrate that Gbetagamma directly regulates phospholipase D activity in vitro and suggest a novel me

30 Phospholipase D activity increased by 62% (p < 0.01).

31 In mammalian cells, phospholipase D activity is tightly regulated by diverse

32 However, blocking phospholipase D activity resulted in release of MV incap

33 Elevated phospholipase D activity suppressed association of prote

34 We demonstrate that ARF6 stimulates a sperm phospholipase D activity to produce phosphatidic acid an

35 inant Gbeta1gamma2 was also found to inhibit phospholipase D activity under basal and stimulated cond

36 otease, a hypothetical protein with putative phospholipase D activity, and a riboflavin specific deam

37 Phosphatidylcholine-phospholipase D activity, cell membrane cholesterol, and

38 ins, we have identified a novel inhibitor of phospholipase D activity, Gbetagamma subunits of heterot

39 prowazekii pld gene, encoding a protein with phospholipase D activity, has been associated with phago

40 the individual activities of arcanolysin and phospholipase D affect A. haemolyticum host-pathogen int

41 modulators of development such as CDC48A and phospholipase D alpha 1.

42 However, a lipolytic enzyme Phospholipase D alpha1 (OsPLDalpha1) causes rancidity an

43 ll-molecule inhibitors, we demonstrated that phospholipase D and diacylglycerol lipase were required

44 Immunostaining studies revealed that NAPE-phospholipase D and fatty acid amide hydrolase are expre

45 rpretations concerning the possible roles of phospholipase D and its biologically active product phos

46 ovide mechanistic insights into the roles of phospholipase D and PIP kinases in the late stages of re

47 ha, N-acyl-phosphatidylethanolamine-specific phospholipase D, and 12-lipoxygenase, as well as type I

48 of ABA signaling: 1-butanol, an inhibitor of phospholipase D, and abi1-1, a dominant negative mutant

49 protein kinase B and p38MAPK, activation of phospholipase D, and calcium fluxes were equivalent in w

50 pression of the OEA-synthesizing enzyme NAPE-phospholipase D, and decreased activity and expression o

51 cylethanolamine acid amidase, NAPE-selective phospholipase D, and protein tyrosine phosphatase non-re

52 Exogenous ATP activates phospholipase D, and we show here that ATP activates the

53 ], GPLD1 [phosphate inositol-glycan specific phospholipase D], APOE [apolipoprotein E], IHH [Indian h

54 by extracellular signal-regulated kinase or phospholipase D, as exemplified by the lack of effect of

55 nd LEP localization in cells lacking Sma1, a phospholipase D-associated protein dispensable for initi

56 KY-18 DNA-binding protein (AtWRKY-18), and a phospholipase D (AtPLD-1) from Arabidopsis.

57 raction occurs through the amino terminus of phospholipase D, because Gbeta1gamma1 is unable to inhib

58 Infection of phospholipase D beta1 (PLDbeta1)-deficient plants by Pse

59 ospholipase D or after addition of bacterial phospholipase D, binding of PA to RdgBbeta was greater a

60 e PAs by activating diacylglycerol kinase or phospholipase D, both of which were elevated in the live

61 ble to inhibit an amino-terminally truncated phospholipase D construct, PLD1.d311, which like full-le

62 n consisting of the amino-terminal region of phospholipase D containing the phox/pleckstrin homology

63 least in part, by glutamate acting through a phospholipase D-coupled metabotropic glutamate receptor.

64 sponses elicited by Chlamydophila pneumoniae phospholipase D (CpPLD) in the pathogenesis of atheroscl

65 The internalized BCR signals through a phospholipase-D-dependent pathway to recruit TLR9-contai

66 and molecular aspects of the involvement of phospholipase D-derived phosphatidic acid in regulated e

67 We propose that Phospholipase D-derived phosphatidic acid promotes ectop

68 (14)C]Glc or UDP-[(14)C]GlcUA, we found that phospholipase D digestion of the Glc-labeled lipid yield

69 (GPI) anchor signal sequence followed by GPI-phospholipase D digestion, appending a trimeric coiled-c

70 t synthesized in vitro was also sensitive to phospholipase D digestion, suggesting that the same lipi

71 ization of a P. aeruginosa H3-T6SS-dependent phospholipase D effector, PldB, and its three tightly li

72 Here, we characterized LpdA, a phospholipase D effector, which was previously proposed

73 ver, treating activated human platelets with phospholipase D enhanced the rates of factor X activatio

74 Venoms of the sicariid spiders contain phospholipase D enzyme toxins that can cause severe derm

75 rown spiders in the genus Loxosceles contain phospholipase D enzyme toxins that can cause severe derm

76 line to choline was found to be catalysed by phospholipase D enzymes from diverse members of the gut

77 Phospholipase D enzymes have long been proposed to play

78 ecreasing levels of diacylglycerol kinase or phospholipase D-enzymes that produce phosphatidic acid-r

79 t sertraline inhibits phospholipase A(1) and phospholipase D, exhibits mixed effects on phospholipase

80 ndicates greater architectural similarity to phospholipase-D family nucleases than to phospholipases.

81 la melanogaster Zucchini, is a member of the phospholipase-D family of phosphodiesterases, which incl

82 duction (e.g. PTK2/Focal Adhesion Kinase and Phospholipase D- following chronic RE), TGF-beta signall

83 Phospholipase D from Streptomyces chromofuscus (sc-PLD)

84 oteins with basic-aromatic clusters, such as phospholipase D, GAP43, SCAMP2, and the N-methyl-d-aspar

85 he GPI-anchorage site by the activity of GPI-phospholipase D (GPI-PLD), because CR-1 shedding was sup

86 resence of phosphatidic acid, the product of phospholipase D, growth in soft agar and tumor formation

87 s in chlamydial cytotoxins, guaBA-add, and a phospholipase D homolog developed normally in cell cultu

88 Phospholipase D, however, could not complement a vaccini

89 Additionally, a phospholipase D implicated in soluble N-ethyl-maleimide

90 of extracellular signal-regulated kinase and phospholipase D in CaP cells.

91 t evidence has emerged indicating a role for phospholipase D in cell proliferation, membrane traffick

92 e C in COS-7 cells (EC(50) = 0.18 microM) or phospholipase D in chick primary cardiomyocytes, both me

93 us TRPC3 channel and identify a key role for phospholipase D in the generation of the slow excitatory

94 asma membrane, thus demonstrating a role for phospholipase D in the juxtanuclear translocation of PKC

95 To study the potential importance of phospholipase D in the oncogenic ability of Ras, we used

96 Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and

97 While using phospholipase D inhibitors (which block the conversion o

98 in regulated exocytosis, we used an array of phospholipase D inhibitors for ex vivo and in vitro trea

99 evidence that the plasma membrane localized phospholipase D, involved in the biosynthesis of PA, is

100 e investigated whether the signaling protein phospholipase D is implicated in leukocyte cell motility

101 of Pseudomonas aeruginosa, a eukaryotic-like phospholipase D, is a member of the type VI lipase effec

102 construct, PLD1.d311, which like full-length phospholipase D isoforms, requires phosphatidylinositol-

103 -type Arabidopsis (Arabidopsis thaliana) and phospholipase D knockout mutants pld zeta1, pld zeta2, a

104 hat increased phosphatidic acid derived from Phospholipase D leads to defects in binary cell-fate dec

105 t the N terminus and a unique, unanticipated phospholipase D-like (PLD) domain at the C terminus that

106 F) domain protein (CT153) and members of the phospholipase D-like (PLD) family, are related to protei

107 east in part, through the recently described phospholipase D-linked metabotropic Glu receptor to main

108 Phospholipase D-mediated hydrolysis of phosphatidylcholi

109 We suggest that a phospholipase D might cleave N-acyl-PS to generate N-acy

110 The mammalian Phospholipase D MitoPLD facilitates mitochondrial fusion

111 ns 1 and 2, Miros 1 and 2, and mitochondrial phospholipase D (mitoPLD) all localize to discrete, regu

112 identifies a critical target of an emerging phospholipase D/mTOR survival pathway in the transformat

113 N-Acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD) (EC 3.1.4.4) catalyzes the fi

114 by N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and its degradation by fatty

115 by N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and its degradation by fatty

116 N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) catalyzes the cleavage of mem

117 N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the main enzym

118 Recently, an N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) was identified as a candidate

119 N-Arachidonoyl phosphatidylethanolamine-phospholipase D (NAPE-PLD), glycerophosphodiesterase (GD

120 n of N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD), which catalyzes the producti

121 dylethanolamine (NAPE) through cleavage by a phospholipase D (NAPE-PLD).

122 s) in a single enzymatic step catalyzed by a phospholipase D (NAPE-PLD).

123 annabinoids (N-acyl phosphatidylethanolamine phospholipase D [NAPE-PLD] and diacylglycerol lipase alp

124 he PhoD protein of Bacillus subtilis and the phospholipase D of Streptomyces chromofuscus.

125 PA levels following activation of endogenous phospholipase D or after addition of bacterial phospholi

126 al signals lost by the suppression of either phospholipase D or mTOR.

127 acological inhibitors of phosphatidylcholine-phospholipase D (PC-PLD), butan-1-ol and C2 ceramide, pr

128 ression of catalytically inactive mutants of phospholipase D (PLD) 1 or 2 attenuated LPA-induced IL-1

129 at the membrane-associated signaling protein phospholipase D (PLD) accumulates abnormally in cilia of

130 Here we demonstrate that phospholipase D (PLD) activation is required to support

131 Moreover inhibition of phospholipase D (PLD) activity and inhibition of PLD1 an

132 that infection by influenza virus stimulates phospholipase D (PLD) activity and that PLD co-localizes

133 n of phagocytosis by the FcgammaR stimulates phospholipase D (PLD) activity and triggers the producti

134 nvasive metastatic cell line that depends on phospholipase D (PLD) activity for survival when deprive

135 Phospholipase D (PLD) activity is elevated in response t

136 Phospholipase D (PLD) activity was required for high PA

137 re that elevated FAM83B expression increases Phospholipase D (PLD) activity, and that suppression of

138 ation of lymphocytes induces upregulation of phospholipase D (PLD) activity, but the biological signi

139 ted but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-buta

140 h levels of a mutant p53, has high levels of phospholipase D (PLD) activity, which provides a surviva

141 KC) plays an important role in regulation of phospholipase D (PLD) activity.

142 hat photoreceptors contain a light-dependent phospholipase D (PLD) activity.

143 ol 4,5-bisphosphate (PIP(2)) and in inducing phospholipase D (PLD) activity.

144 on of HUVECs with StxB transiently increased phospholipase D (PLD) activity.

145 thway involving the combined activities of a phospholipase D (PLD) and a phosphatidic acid (PA) phosp

146 scade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK).

147 yte (PMN) phagocytosis through inhibition of phospholipase D (PLD) and downstream events, including a

148 Phospholipase D (PLD) and heterotrimeric G-protein both

149 ncreased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1

150 We show here that phospholipase D (PLD) and its enzymatic reaction product

151 Phospholipase D (PLD) and its metabolite phosphatidic ac

152 Phospholipase D (PLD) and its product phosphatidic acid

153 Recent evidence suggested the involvement of phospholipase D (PLD) and its product phosphatidic acid

154 Phospholipase D (PLD) and its product, phosphatidic acid

155 , and so is the overexpression of the enzyme phospholipase D (PLD) and its reaction product, phosphat

156 ) and MMP9, whereas the ED peptide activates phospholipase D (PLD) and MMP2, but not MMP9.

157 r, in situ and in real-time, the activity of phospholipase D (PLD) and phospholipase C (PLC) on plana

158 Activation of phospholipase D (PLD) and protein kinase C (PKC) as well

159 Phospholipase D (PLD) and protein phosphatase 2C (PP2C)

160 Phospholipase D (PLD) and small GTPases are vital to cel

161 The signaling enzyme phospholipase D (PLD) and the lipid second messenger it

162 ory pathway for mTOR signaling that involves phospholipase D (PLD) and the lipid second messenger pho

163 n-coupled receptors can potentially activate phospholipase D (PLD) by a number of routes.

164 Phospholipase D (PLD) catalyzes the conversion of phosph

165 The membrane-active enzyme phospholipase D (PLD) catalyzes the hydrolysis of the ph

166 lts revealed that disruption of A. baumannii phospholipase D (PLD) caused a reduction in the organism

167 ther genes annotated as a helicase domain, a phospholipase D (PLD) domain, a DUF1998 domain and a gen

168 The product of phospholipase D (PLD) enzymatic action in cell membranes

169 gut microorganisms can hydrolyse PC using a phospholipase D (PLD) enzyme and further convert the rel

170 of eukaryotic and prokaryotic members of the phospholipase D (PLD) enzyme family varies among chlamyd

171 or imaging sites of cellular PA synthesis by phospholipase D (PLD) enzymes is reported.

172 Phospholipase D (PLD) enzymes play a double vital role i

173 h for imaging physiological PA production by phospholipase D (PLD) enzymes.

174 BceSIV and Bce14579I belong to the phospholipase D (PLD) family of endonucleases that are w

175 Recombinant phospholipase D (PLD) from Streptomyces chromofuscus (sc

176 phatidic acid generated by the activation of phospholipase D (PLD) functions as a second messenger an

177 Phospholipase D (PLD) generates a metabolite, phosphatid

178 Phospholipase D (PLD) generates lipid signals that coord

179 Phospholipase D (PLD) has also been implicated in signal

180 Phospholipase D (PLD) has been implicated in regulating

181 Phospholipase D (PLD) has been linked to the regulation

182 Phospholipase D (PLD) has been reported to generate surv

183 In animals, the enzyme phospholipase D (PLD) has been shown to generate alcohol

184 sphate metabolism, respectively, the role of phospholipase D (PLD) has so far remained elusive.

185 specifically releases proteins, including a phospholipase D (PLD) homolog, which facilitate membrane

186 Phospholipase D (PLD) hydrolyzes membrane phospholipids

187 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to

188 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to

189 Experiments were performed with phospholipase D (PLD) in a Ca(2+) dependent fashion.

190 Hyperactivation of phospholipase D (PLD) in certain tumor-derived cell line

191 To investigate the role of phospholipase D (PLD) in FcepsilonRI signaling, the wild

192 , we provide evidence for the involvement of phospholipase D (PLD) in LPA-mediated transactivation of

193 In this study, we investigated the role of phospholipase D (PLD) in mediating Arf6 function in cell

194 A recent report has implicated phospholipase D (PLD) in mTOR signaling.

195 Phospholipase D (PLD) is a key facilitator of multiple t

196 Because phospholipase D (PLD) is linked to several signaling pat

197 gh its production of phosphatidic acid (PA), phospholipase D (PLD) is strongly involved in vesicular

198 The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed i

199 eviously that it can also signal through the phospholipase D (PLD) pathway in an ADP-ribosylation fac

200 Phospholipase D (PLD) plays a major role in the activati

201 Activation of phospholipase D (PLD) produces phosphatidic acid (PA), a

202 We show here that phospholipase D (PLD) production of the lipid phosphatid

203 Phospholipase D (PLD) proteins are enzymes that catalyze

204 Phospholipase D (PLD) regulates the polymorphonuclear le

205 Most types of plant phospholipase D (PLD) require Ca(2+) for activity, but h

206 Phospholipase D (PLD) signaling plays a critical role in

207 The Phospholipase D (PLD) superfamily is linked to neurologi

208 Tdp1 is a member of the phospholipase D (PLD) superfamily of enzymes and hydroly

209 Here, we identify an ancestral member of the phospholipase D (PLD) superfamily of lipid-modifying enz

210 s measurements suggested that sperm activate phospholipase D (PLD) to elevate phosphatidic acid (PA).

211 The A3 receptor signals via RhoA and phospholipase D (PLD) to induce cardioprotection.

212 hosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylchol

213 hat D-series resolvins (RvD1- RvD5) activate phospholipase D (PLD), a ubiquitously expressed membrane

214 cum virulence factors, arcanolysin (ALN) and phospholipase D (PLD), affect the ability of the bacteri

215 shown that alpha and beta-synucleins inhibit phospholipase D (PLD), an enzyme involved in lipid-media

216 Small molecule inhibitors of phospholipase D (PLD), an enzyme that produces phosphati

217 the role of protein kinase C (PKC) isoforms, phospholipase D (PLD), and Rac in S1P-induced migration

218 bition or depletion of the mTORC1 regulator, phospholipase D (PLD), and recapitulated with the additi

219 itors of casein kinase II, NFkappaB, PLA(2), phospholipase D (PLD), cyclooxygenases, lipoxygenase, or

220 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and

221 PA > 300 nM or the enzyme that produces it, phospholipase D (PLD), downregulate EGFR expression.

222 Phosphatidic acid, as synthesized by phospholipase D (PLD), enhances cancer cell survival.

223 embrane lipid phosphatidic acid, produced by phospholipase D (PLD), has been shown to take part in bo

224 tidic acid and the enzyme that generates it, phospholipase D (Pld), in this process.

225 hatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spor

226 feedback loop between the signaling protein phospholipase D (PLD), phosphatidic acid (PA), and a spe

227 The role of phospholipase D (PLD), phosphatidylinositol-specific pho

228 DNase II exhibits a similar overall fold as phospholipase D (PLD), phosphatidylserine synthase (PSS)

229 Here, a plasmid-encoded phospholipase D (PLD), previously characterized as Yersi

230 Rapid activation of phospholipase D (PLD), which hydrolyzes membrane lipids

231 reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylchol

232 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylchol

233 ipase activity in breast cancers in vitro is phospholipase D (PLD), which is also involved in cell mi

234 Phospholipase D (PLD), which is commonly elevated in ren

235 We exploited a microbial phospholipase D (PLD), which produces PA by phosphatidyl

236 nd on EGFR and the newly identified mediator phospholipase D (PLD), which promotes both mTORC1-depend

237 PA is the metabolic product of phospholipase D (PLD), whose activity is elevated in a l

238 lves the presence of an enzymatically active phospholipase D (PLD), with the PLD2 isoform being more

239 ne lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatid

240 ian target of rapamycin) signaling through a phospholipase D (PLD)-dependent increase in the concentr

241 assical PKCalpha and PKCbetaII induces their phospholipase D (PLD)-dependent internalization and tran

242 y, Han et al., 2011 clearly demonstrate that phospholipase D (PLD)-dependent production of membrane p

243 PAR1-activating peptide (PAR1-AP) requires a phospholipase D (PLD)-mediated phosphatidic acid (PA) si

244 ATC1 and Galpha(i) or Galpha(o)-PKCalpha-PLC-phospholipase D (PLD)-mTOR in a bell-shaped, dose-depend

245 ino acids and growth factors also induce the phospholipase D (PLD)-phosphatidic acid (PA) pathway, re

246 dy showed that cholinergic agonists activate phospholipase D (PLD).

247 ment whose formation is dependent on PKC and phospholipase D (PLD).

248 g the synthesis of phosphatidic acid (PA) by phospholipase D (PLD).

249 ylcholine, suggesting that PTEN may regulate phospholipase D (PLD).

250 hospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD).

251 s of mTOR, phosphatidylinositol 3-kinase and phospholipase D (PLD).

252 activation of phospholipase C (PLC) but not phospholipase D (PLD).

253 phatidic acid (PA), the metabolic product of phospholipase D (PLD).

254 recursor, N-acylphosphatidylethanolamine, by phospholipase D (PLD).

255 RNAs (miRs) mediated by the signaling enzyme phospholipase D (PLD).

256 for up to 6 h and mediated through RhoA and phospholipase D (PLD).

257 en primarily attributed to the activation of phospholipase D (PLD).

258 The rat mast cell line RBL-2H3 contains both phospholipase D (PLD)1 and PLD2.

259 t deletion and pharmacological inhibition of phospholipase D (PLD)2, which generates the signaling li

260 2 tyrosine phosphorylation via activation of phospholipase D (PLD)2.

261 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of

262 ating the activities and/or levels of either phospholipase D (PLD1 and PLD2) or diacylglycerol kinase

263 ently reported that the inducible isoform of phospholipase D (PLD1) was significantly increased in sy

264 of the gene for a membrane lipid-hydrolyzing phospholipase D (PLDalpha1) in Arabidopsis enhanced seed

265 interact with the plasma membrane-associated phospholipase D (PLDdelta) to transduce the ROS hydrogen

266 Here, we show that the plasma membrane-bound phospholipase D, PLDdelta, is activated in response to H

267 that two Arabidopsis (Arabidopsis thaliana) phospholipase Ds (PLDs), PLDzeta1 and PLDzeta2, were inv

268 ndings suggest that A. haemolyticum utilizes phospholipase D primarily for adherence and utilizes arc

269 e shedding, ARF6-GTP-dependent activation of phospholipase D promotes the recruitment of the extracel

270 Transport defects via PA generated by phospholipase D require the activity of type I phosphati

271 pathways, involving the exocyst complex and phospholipase D, respectively.

272 g cells, but not to the extent found for the phospholipase D signal.

273 ysis revealed enrichment of calcium, Wnt and phospholipase D signaling in patients.

274 est a novel mechanism to negatively regulate phospholipase D signaling in vivo.

275 Blocking phospholipase D signals also led to reduced phosphorylat

276 small GTP-binding protein Rho and subsequent phospholipase D stimulation.

277 The HKD-containing Phospholipase D superfamily catalyzes the cleavage of th

278 n TDP belongs to a distinct class within the phospholipase D superfamily in spite of very low sequenc

279 hosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3'-phospho-D

280 we show that glaikit (gkt), a member of the phospholipase D superfamily, is essential for the format

281 tivated catalysis that applies to the entire phospholipase D superfamily.

282 with ClsA and ClsB, which all belong to the phospholipase D superfamily.

283 critical role for protein phosphatase 2A in phospholipase D survival signals, either SV40 small t-an

284 g N-acylphosphatidylethanolamine-hydrolyzing phospholipase D that generates anandamide.

285 DAG kinases and phospholipase D, the enzymes that produce PA, are identi

286 tioned in an additive manner with gonococcal phospholipase D to augment Akt kinase activity.

287 Multiple signaling pathways converge upon phospholipase D to modulate cellular actions, such as ce

288 The ability of phospholipase D to suppress protein phosphatase 2A ident

289 8690 using a combination of base hydrolysis, phospholipase D treatment, ESI-MS, and MS/MS to show tha

290 glycerol into PG and is catalyzed by ClsB, a phospholipase D-type cardiolipin synthase.

291 madillo-like repeats, and NAPE-PLD encodes a phospholipase D-type phosphodiesterase.

292 human 5-HT2C receptor isoform INI activates phospholipase D via the G13 heterotrimer G-protein.

293 cerol released by phospholipase C but not by phospholipase D was implicated as a substrate for 2-AG p

294 The sphingomyelinase activity of phospholipase D was necessary to increase bacterial adhe

295 Using phospholipase D, we incorporated tritium into each analo

296 d lysophospholipase 1, phospholipase A2, and phospholipase D were significantly underexpressed, in br

297 n addition, increased expression of cellular phospholipase D, which has a similar phospholipase motif

298 expansion, blocked by acute perturbation of phospholipase D, which reflects both properties intrinsi

299 rturbed phospholipid synthesis by activating phospholipase D with sphingosine 1-phosphate (S1P) or in

300 aII, but not PKCbetaI, was found to activate phospholipase D within this time frame.