ライフサイエンスコーパス: phosphonate

1 oxymethyl) (E)-4-hydroxy-3-methyl-but-2-enyl phosphonate.

2 oxymethyl) (E)-4-hydroxy-3-methyl-but-2-enyl phosphonate.

3 and benzyl bromide to produce diethylbenzyl phosphonate.

4 s, pseudodisaccharide, and phytoceramide-1-H-phosphonate.

5 chieved in high yield from the corresponding phosphonates.

6 ford tetrasubstituted alpha-amino-beta-nitro-phosphonates.

7 are more potent inhibitors than monoanionic phosphonates.

8 of alpha,beta-unsaturated aldehydes and acyl phosphonates.

9 ich is required for the biosynthesis of most phosphonates.

10 n of phosphazenes and fluorinated acetylenic phosphonates.

11 me complex evolved to extract phosphate from phosphonates.

12 its by ring-opening polymerization of cyclic phosphonates.

13 linear polymerization of simple difunctional phosphonates.

14 nediphosphonate gave gamma,delta-epoxy vinyl phosphonates.

15 ines to produce aromatic phosphonium ions or phosphonates.

16 hesis of other types of 3'-fluoro nucleoside phosphonates.

17 ed in the clinic, representative spirocyclic phosphonate 18a(-) features improved selectivity for the

18 nomethyl phosphonate [AMP](2-), 1-aminoethyl phosphonate [1AEP](2-), 2-aminoethyl phosphonate [2AEP](

19 noethyl phosphonate [1AEP](2-), 2-aminoethyl phosphonate [2AEP](2-), aminopropyl phosphonate [APP](2-

20 hydrogenation of (S)-alpha-amino-beta-nitro-phosphonate 2d gives enantiopure (S)-alpha,beta-diaminop

21 openta[b]-pyrrole-2-phosphine oxides 4a and -phosphonates 4b,c are generated by the addition of cycli

22 ented C-P bond cleavage reaction of ribose-1-phosphonate-5-phosphate to methane and ribose-1,2-cyclic

23 h as the fluoro(5), chloro(6,7), bromo(7,8), phosphonate(9), enediyne(10,11), cyano(12), diazo(13), a

24 is to characterize the effects of FTY720 (S)-phosphonate, a novel analog of FTY720-phosphate, on vari

25 while directed concentration of cyanomethyl phosphonate, a smaller non-aromatic organophosphate, is

26 propyl phosphonate [APP](2-), and aminobutyl phosphonate [ABP](2-).

27 osphonate scaffold, alpha-carboxy nucleoside phosphonate (alpha-CNP), was designed that is recognized

28 Alpha-carboxynucleoside phosphonates (alpha-CNPs) are novel viral DNA polymerase

29 se (RT) inhibitors, alpha-carboxy nucleoside phosphonates (alpha-CNPs).

30 Site-specific incorporation of alkyl phosphonates altered the RNaseH1 cleavage patterns but o

31 report for the first time the development of phosphonate amidines and sulfonate amidines as isosteres

32 This includes aminomethyl phosphonate [AMP](2-), 1-aminoethyl phosphonate [1AEP](2

33 bited by alternative substrates (aminomethyl phosphonate [AMPA] and N-methyl glyphosate [NMG]), which

34 taAla(P) would be generated from Ser(P), the phosphonate analog of Ser, by phosphorylation and subseq

35 he first series of a new class of nucleoside phosphonate analogues is described.

36 the alpha position of carbocyclic nucleoside phosphonate analogues leads to a novel class of potent H

37 fferent DHTKD1 expression to the synthesized phosphonate analogues of homologous 2-oxodicarboxylates.

38 own sugar nucleotide substrates and selected phosphonate analogues.

39 inated polymers were readily immobilized via phosphonate anchoring groups.

40 5'-Phosphonate and 5'-phosphate analogues of AMP containing

41 By introducing POC groups on both the phosphonate and alpha-carboxylate, we synthesized Tris-P

42 hesis of a 3'-fluoro-3'-deoxytetrose adenine phosphonate and can be expanded toward the synthesis of

43 e, which results in surface stabilization of phosphonate and carboxylate derivatives of Ru(II)-polypy

44 Finally, the iminosugar phosphonate and its elongated phosphate analogue were ac

45 ligand (E)-(7-hydroxy-6-methylhept-5-en-1-yl)phosphonate and mutated proposed binding site residues.

46 For example, we observed higher coverage of phosphonate and siderophore metabolic pathways in the st

47 the biosynthesis of MPn from 2-hydroxyethyl phosphonate and the bacterial C-P lyase complex is known

48 esents the most porous crystalline zirconium phosphonate and the only porous MOF material reported to

49 However, 1 is highly polar containing a phosphonate and two carboxylates, severely limiting its

50 heteroatom (N or O) in alpha-position to the phosphonate and using the resultant OH and NH(2) groups

51 Both H-phosphonates and diaryl phosphine oxides are suitable co

52 We report the synthesis of a series of phosphonates and ketosephosphonates possessing an L-rham

53 coupling and iodocyclization to give cyclic phosphonates and other cyclization reactions to give pi-

54 sphorus-containing functional groups such as phosphonates and phosphinates are established structural

55 el methodology proceeds with a wide range of phosphonates and phosphoramidates under mild conditions

56 ng alkenyl halides, sulfides, triflates, and phosphonates and provides a mild and practical alternati

57 The hydroxyl groups of the phosphonates and pyrrole -NH protons are further engaged

58 he largest void volume recorded in zirconium phosphonates and SZ-3 represents the most porous crystal

59 e structure-activity relationships for these phosphonates and validate enolase as a promising target

60 o form surface bound n-alkylammonium oleate, phosphonate, and carbamate ion pairs that bind with grea

61 Molecules bearing phosphonamidate, phosphonate, and phosphinate moieties were synthesized.

62 s of alcohols, carboxylic acids, sulfonates, phosphonates, and amines.

63 re particularly useful in the preparation of phosphonate- and phosphinoxide-functionalized molecules.

64 f a series of beta-modified acyclonucleoside phosphonate (ANP) derivatives, using commercially availa

65 Here, newly synthesized acyclic nucleoside phosphonates (ANPs) have been shown to be competitive in

66 Acyclic nucleoside phosphonates (ANPs) that contain a 6-oxopurine base are

67 inoethyl phosphonate [2AEP](2-), aminopropyl phosphonate [APP](2-), and aminobutyl phosphonate [ABP](

68 These BZN-phosphonates are highly adsorbed onto alum, which signif

69 Phosphonates are organophosphorus compounds characterize

70 Phosphonates are rare and unusually bioactive natural pr

71 The beta-borylated phosphonates are readily converted to chiral beta- and g

72 sts, this method provides steady access to o-phosphonate arylboronic esters bearing pendant functiona

73 sed nucleosides, nucleotides, and nucleoside phosphonates as potential antiviral or anticancer agents

74 In light of the importance of amides and phosphonates as synthetic intermediates, we envision tha

75 e end of follow-up, 17.5%) followed by alkyl phosphonate-associated pol-gene (7.4%), immune-associate

76 olefins (vinyl amides, vinyl boranes, vinyl phosphonates) at room temperature in a highly regio- and

77 The aza-acyclic nucleoside phosphonates (aza-ANPs) are good inhibitors of Plasmodiu

78 with dialkyl phosphites [P(O)-H] to access 2-phosphonated azoles using Cu(I)/Cu(II) as catalyst and K

79 rthogonal polymer embracing a chiral acyclic-phosphonate backbone [(S)-ZNA] is presented that uniquel

80 The pendant phosphonate base mediates O-O bond formation via intramo

81 e mechanism of proton diffusion within a new phosphonate-based metal-organic framework (MOF) material

82 e chains were introduced via stereoselective phosphonate-based olefinations.

83 oxyphosphonates and aminophosphonates and to phosphonates bearing a quaternary carbon stereocenter.

84 ctivation as a predominant chemical logic in phosphonate biosynthesis and set the stage for probing d

85 Collectively, our analyses show that phosphonate biosynthesis is both diverse and relatively

86 Based on the presence of this gene, phosphonate biosynthesis is common in microbes, with ~5%

87 However, most bacterial phosphonate biosynthetic capacity is dedicated to tailor

88 ucleotidyltransferases in over two-thirds of phosphonate biosynthetic gene clusters, including direct

89 arby genes, suggesting that the diversity of phosphonate biosynthetic pathways can be predicted by ex

90 , PCMOF10 is water stable owing to strong Mg phosphonate bonding.

91 structural basis for understanding microbial phosphonate breakdown.

92 ifluoroacetate, diethyl (bromodifluoromethyl)phosphonate, [(bromodifluoromethyl)sulfonyl]benzene, and

93 e, through dienamine formation, and the acyl phosphonate by hydrogen-bonding.

94 ly modified lipophilic prodrugs at the gamma-phosphonate by the attachment of an acyloxybenzyl (ester

95 e rhodium-catalyzed hydroboration of allylic phosphonates by pinacolborane affords chiral tertiary bo

96 n the P horizontal lineO groups in the tetra-phosphonate calix[4]pyrrole cavitands are conformational

97 y constants than the previously reported bis-phosphonate calix[4]pyrrole counterparts in the complexa

98 The tetra-phosphonate calix[4]pyrroles exhibited larger affinity c

99 of the different classes of solids based on phosphonates, carboxylates and other linkers.

100 nalysis supports previous studies that infer phosphonate catabolism via C-P lyase is an important ada

101 e, combining the features of single-site bis-phosphonate catalysts and fast bimolecular bis-carboxyla

102 ndings are relevant for the potential use of phosphonate cavitands as synthetic receptors for the det

103 Calix[4]pyrrole phosphonate-cavitands were used as receptors for the des

104 uced oxidation state P compounds include the phosphonates, characterized by C-P bonds, which bear up

105 Furthermore, a zero-dimensional zirconium phosphonate cluster acting as secondary building unit ha

106 ilt by previously unknown isolated zirconium phosphonate clusters and exhibit combined high porosity

107 stabilized by adsorbed metal carboxylate or phosphonate complexes or by ion pairs.

108 ationic calcium surface sites to form Ca(2+)-phosphonate complexes.

109 potential active sites that probably couple phosphonate compounds to ATP and subsequently hydrolyse

110 Among these phosphonate compounds, the dehydration derivative 7a tha

111 imited supply, some bacteria are able to use phosphonate compounds, which require specialized enzymat

112 s (H1N1, H3N2, H5N1, and H7N9), although the phosphonate congener 6a is unexpectedly less active than

113 ion bridging group, which can bind a second phosphonate containing species from solution to establis

114 of new somatostatin analogues modified with phosphonate-containing cross-bridged chelators for evalu

115 h strains were subsequently shown to produce phosphonate-containing exopolysaccharides (EPS), also kn

116 were compared to those obtained for the bis-phosphonate counterparts.

117 y benign agent diethyl (bromodifluoromethyl) phosphonate (DBDFP) as a difluorocarbene-generating spec

118 Addition of the surface-bound phosphonate derivatives with L = 4-pyridyl phosphonic ac

119 9-deazapurines, leading to new deazapurine-8-phosphonate derivatives, which can be further modified a

120 n measurements, the MLCT excited state(s) of phosphonate derivatized [Ru(bpy)2((4,4'-(OH)2PO)2bpy)](2

121 In this procedure, solution deposited, phosphonate derivatized metal complexes on metal oxide s

122 Phosphonate-derivatized catalysts and molecular assembli

123 n this Communication, covalently anchoring a phosphonate-derivatized complex, Fe(tebppmcn)Cl2 (1), to

124 hesis has been applied to the preparation of phosphonate-derivatized oligoproline assemblies containi

125 Wittig-Horner reaction of a chiral phosphonate derived from (S)-lactic acid and ring-closin

126 Previous studies on ligands equipped with phosphonate diester and ether H-bond acceptors were inco

127 ries but similar H-bond strengths (amide and phosphonate diester), there is little correlation betwee

128 uated several alkoxyalkyl acyclic nucleoside phosphonate diesters and identified octadecyloxyethyl be

129 interactions with the enzyme and why neutral phosphonate diesters are more potent inhibitors than mon

130 Phosphonate-directed ortho C-H borylation of aromatic ph

131 itrogen, protonated forms of dimethyl methyl phosphonate (DMMP) and methyl phosphonic acid (MPA) exhi

132 ly detected three compounds, dimethyl methyl phosphonate (DMMP), cyclotrimethylene trinitramine (RDX)

133 FTY720 (S)-phosphonate does not induce beta-arrestin recruitment, s

134 mpared 177Lu-ethylene diamine tetramethylene phosphonate (EDTMP) with 153Sm-EDTMP for painful skeleta

135 enables rapid polymerization of difunctional phosphonates employing different aliphatic linkers (C(6)

136 e rare 2:2 stoichiometry between the anionic phosphonate end groups and a pair of pai-stacked cyanost

137 double hydroxides, metal(iv) phosphates and phosphonates, especially zirconium, and zeolites.

138 Chemical warfare agents containing phosphonate ester bonds are among the most toxic chemica

139 type associative displacement of the polymer phosphonate ester by a monomer as the rate-determining s

140 tic resolution of a 1:1 mixture of activated phosphonate ester diastereoisomers.

141 Intraperitoneal administration of FTY720 (S)-phosphonate every other day for 1 week in normal or bleo

142 organic frameworks (MOFs) based on zirconium phosphonates exhibit superior chemical stability suitabl

143 analysis demonstrated that these nucleoside phosphonates exist in solution as conformers predominant

144 Using the known affinity of phosphonates for bone minerals in a model system, two fa

145 effect to synthesize high surface area metal phosphonates for catalytic and other applications.

146 tly shown to be superior to standard (99m)Tc-phosphonates for diagnosis and (153)Sm-ethylenediaminete

147 thesis of pentopyranoside nucleosides with a phosphonate functionality at the 1'-anomeric oxygen.

148 Fluorescent molecular probes based on phosphonate-functionalized porphyrin derivatives have be

149 The novel green magnetic phosphonated-functionalized sporopollenin nanocomposite

150 e-1,4-diols and naphtha-1,4-diones bearing a phosphonate group at the 2-position and various (het)ary

151 These novel compounds contain a second phosphonate group attached to the ANP scaffold.

152 phate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimic

153 the glyphosate binds to gamma-alumina via a phosphonate group, bridging the mineral surface and Zn.

154 ng the carboxylate group in peramivir with a phosphonate group, phosphono-peramivir (6a), the dehydra

155 esis of an indenopyrazole scaffold bearing a phosphonate group.

156 an included water molecule and the linker's phosphonate group.

157 ter-filled channels lined with free hydrogen phosphonate groups and gives a very low activation energ

158 tors resulting from the installation of four phosphonate groups at the upper rim of a calix[4]pyrrole

159 A is a bipyridine ligand functionalized with phosphonate groups for surface attachment to TiO2.

160 d coordination sphere effects exerted by the phosphonate groups in lowering the activation energy at

161 to a TiO(2) surface through carboxylate and phosphonate groups is demonstrated to be an effective me

162 In these complexes, the phosphonate groups provide redox-potential leveling thro

163 r anchors a robust backbone and has hydrogen phosphonate groups that interact with the lattice water

164 cting the N(9) atom of guanine to one of the phosphonate groups.

165 tetraethyl (2,3-dihydroxy-1,4-phenylene)bis(phosphonate) (H2 -DPC), has been used to prepare a serie

166 route to a 3'-fluoro-3'-deoxytetrose adenine phosphonate has been developed.

167 egard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substitu

168 large number of biologically important amino phosphonates have been synthesized, isolated (37 example

169 Phosphonates have emerged as an alternative for function

170 IDA approach is demonstrated on sensing of a phosphonate herbicide glyphosate and other biologically

171 Oxidation of 30 to sulfone 31 and phosphonate hydrolysis completed the synthesis of 3 in 1

172 he (R)-BINOL Fc phosphate gave Fc-rearranged phosphonate in 91% de.

173 lyfunctionalized cyclohexenones containing a phosphonate in one pot is described.

174 methyl methylphosphonate, diisopropyl methyl phosphonate in positive polarity and carbon dioxide, sul

175 ates into the corresponding gamma-keto allyl phosphonates in 70-93% yields is described herein.

176 tic strategy for "stable isotope labeling of phosphonates in extract" (SILPE) that facilitates their

177 anes, leading to the corresponding propargyl phosphonates in good to excellent yields.

178 g a palladium or nickel catalyst giving aryl phosphonates in good to excellent yields.

179 c and cyclic amines to the alpha-position of phosphonates in one step.

180 rapid access to cyclic tertiary alpha-amino phosphonates in one-pot procedure under additive-free mi

181 tforward access to valuable mixed alkyl aryl phosphonates in very good yields and near perfect select

182 y decreased by the shorter, OGDH-preferring, phosphonate, in agreement with the known OGDH dependence

183 classes of phosphorus-containing compounds, phosphonates, in particular.

184 ide substrate sequences to develop selective phosphonate inhibitors with the structure Ac-peptidyl(P)

185 FTY720 (S)-phosphonate is a promising barrier-promoting agent that

186 Synthesis of amino phosphonates is more important owing to their significan

187 te-directed ortho C-H borylation of aromatic phosphonates is reported.

188 with H2(17)O to yield a mixture of cyclic H-phosphonates labeled with (17)O and (18)O.

189 ound with N ligand as eta(2) bound motifs or phosphonate ligand as a monodentate, as well as on tetra

190 The N and phosphonate ligand-functionalized MMSNs hold promise as

191 stituted with a C(3)-symmetric tris(hydrogen phosphonate) ligand in a proton conducting metal-organic

192 oxo-[2,2':6',2''-terpyridine]-6,6''-diyl)bis(phosphonate) ligand.

193 benzyl alcohol solutions in the presence of phosphonate ligands.

194 gomers tethered to graphene through covalent phosphonate linkages.

195 FTY720 (S)-phosphonate maintains endothelial sphingosine 1-phosphat

196 o GlgEI-V279S complexed with alpha-maltose-C-phosphonate (MCP), a non-hydrolyzable substrate analogue

197 We used the phosphonate methyltransferase DhpI involved in dehydroph

198 el approach in vaccine adjuvant design using phosphonate modification to afford adsorption of small m

199 Using the phosphonate moiety as an efficient trans-directing group

200 The phosphonate moiety in both phosphonoglycans was shown to

201 Here, we show that the conversion of the phosphonate moiety into acyloxymethyl and alkoxycarbonyl

202 triphosphate analogues comprising a C-alkyl-phosphonate moiety replacing the gamma-phosphate.

203 Additionally, the phosphonate moiety represents a source of inorganic phos

204 Finally, the phytoceramide-1-H-phosphonate moiety was coupled with pseudodisaccharide f

205 rotease inhibitor (PI) with a unique diethyl-phosphonate moiety.

206 Attaching the phosphonated molecular catalyst [Re(I)Br(bpy)(CO)3](0) t

207 e polymer films are similar to those for the phosphonated molecular catalyst on metal oxide electrode

208 ommon in nature, suggesting that the role of phosphonate molecules in the biosphere may be more impor

209 An enigmatic pool of dissolved phosphonate molecules, with phosphorus in the +3 oxidati

210 Phosphonates, molecules containing direct carbon-phospho

211 The phosphonate monoalkyl esters (6b, 6c, 7b, 7c, 8b, and 8c

212 The phosphonate monoalkyl esters are stable in buffer soluti

213 sition zone between arylsulfatases (ASs) and phosphonate monoester hydrolases (PMHs).

214 uous members of this superfamily, namely the phosphonate monoester hydrolases from Burkholderia caryo

215 The longest, OADH-preferring, phosphonate mostly affects the glutarate level.

216 Recovery efficiencies for methyl phosphonate (MPA), nerve agent degradate, and ethylhydro

217 unreactive carbon-phosphorus bond in methyl phosphonate (MPn), but the biological or terrestrial sou

218 ophos biosynthesis to methylate a variety of phosphonate natural products in crude spent medium with

219 dinal FLARE studies in mice demonstrate that phosphonated near-infrared fluorophores remain stable in

220 inct surface charges, were synthesized using phosphonate (neutral), ammonium (cationic), and carboxyl

221 aturated aldehydes, ketones, esters, amides, phosphonates, nitro, and sulfur compounds was involved i

222 Nucleoside phosphonates (NP) are good inhibitors of EcXGPRT and EcH

223 with an uncharged backbone chemistry: alkyl phosphonate nucleic acids (phNAs) in which the canonical

224 y-2'-fluoro- and 3'-C-ethynyl L-threose 3'-O-phosphonate nucleosides.

225 The development of phosphate and phosphonate nucleotide prodrugs has led to important dru

226 A arms via solution-phase syntheses, using H-phosphonates of protected dinucleoside phosphates.

227 tack of the terminal oxygen from the dialkyl phosphonate on the silicon atom in bromotrimethylsilane.

228 Using succinyl, glutaryl and adipoyl phosphonates on the enzyme preparations from tissues wit

229 the inhibitors consist of a combination of a phosphonate or (2-carboxyethyl)phosphinate functionality

230 is and (153)Sm-ethylenediaminetetramethylene phosphonate or (89)SrCl2 for therapy.

231 tron donor, the dyad linked to Pt-TiO2 via a phosphonate or carboxylate attachment shows excellent li

232 eophilic attack of a conveniently positioned phosphonate or phosphinate group to the transient oxocar

233 e hydrolysis and subsequent cyclization, the phosphonate or phosphinate intermediates can be converte

234 a series of pyrrolo[1,2-a]quinolines bearing phosphonate or phosphine oxide moieties is presented.

235 a = 2,2'-bipyridine-6,6'-dicarboxylate) with phosphonate or pyridyl sites for water oxidation, gives

236 TP binding through a carboxylate oxygen, two phosphonate oxygens, and base-pairing with the template.

237 s in which one TriMP oxygen is replaced by a phosphonate P-C linkage.

238 The developed dual function phosphonated p1TAM-D probe provides a unique tool for in

239 Perfluoroalkyl phosphonates (PFPAs) and perfluoroalkyl phosphinates (PF

240 l phosphate esters (PAPs) and perfluoroalkyl phosphonates (PFPAs).

241 minophosphonates at the CH3O group to induce phosphonate-phosphinate rearrangements.

242 ving access to a wide variety of substituted phosphonates, phosphinates, and phosphine oxides.

243 ituted oximes (beta-oximinoalkyl-substituted phosphonates, phosphine oxides, phosphine-borane complex

244 , boronates, germanes, stannanes, pivalates, phosphonates, phthalimides, and tosylates from the corre

245 Tag domain react with an ethyl p-nitrophenyl phosphonate (pNPP) or a chloro-pyrimidine (CP) group, re

246 FTY720 (S)-phosphonate potently increases human pulmonary endotheli

247 e than 50 y ago, the extent and diversity of phosphonate production in nature remains poorly characte

248 , which ultimately leads to decomposition to phosphonate products.

249 on subsequent coupling with tetramannosyl-H-phosphonate provided the fully protected PLM anchor.

250 ic activation of alkynylphosphine oxides and phosphonates provides a novel approach to the synthesis

251 Reduction of the functionalized phosphonates provides access to novel primary and second

252 ynamic kinetic resolution of alpha-aryl acyl phosphonates, providing beta-stereogenic alpha-hydroxy p

253 This mild lithiated phosphonate reagent allows the synthesis of functionaliz

254 ric hydroxymethylphosphonamidates (phosphate-phosphonate rearrangement).

255 The isolated tetra-phosphonate receptors display either three (iooo) or fou

256 ed asymmetric transfer hydrogenation of acyl phosphonates: reduction proceeded from the opposite face

257 he details of how this machinery catabolizes phosphonates remain unknown.

258 In contrast to analogous tetra-phosphonate resorcin[4]arene cavitands, the 14-membered

259 yl groups, forming the corresponding phenoxo-phosphonate Ru complex [Ru(III)(tPaO-kappa-N(2)O(P)O(C))

260 etics were carried out in combination with a phosphonated Ru(II) tris(bipyridine) dye (RuP) in homoge

261 esent the first well-defined degradable poly(phosphonate)s with adjustable UCST.

262 re we describe the discovery of a heteroaryl phosphonate scaffold that exhibits noncovalent cross-cla

263 acute lung injury in mice, while FTY720 (S)-phosphonate significantly decreases lung leak and inflam

264 This commercially available phosphonate smoothly reacts with a fluoride ion to liber

265 of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H b

266 d approximately 90% loading efficiency using phosphonate surface chemistry.

267 It was attached to the TiO2 shell by phosphonate-surface oxide binding.

268 We illustrate its utility by purifying a phosphonate that led to the identification of the fosfaz

269 nd obtain single crystals of three zirconium phosphonates that are suitable for structural analysis.

270 valuable, densely functionalized fluorinated phosphonates that takes advantage of (i) a Clostridial e

271 sed nucleosides, nucleotides, and nucleoside phosphonates, their stereoisomers, and their close analo

272 ) TLR7 agonists are chemically modified with phosphonates to allow adsorption onto aluminum hydroxide

273 echanism of the addition of nitroalkanes and phosphonates to benzaldehyde catalyzed by a chiral phosp

274 nthesized N-terminally biotinylated peptidyl phosphonates to identify the PR3 in complex biological s

275 d ketones, esters, sulfones, sulfoxides, and phosphonates to yield the corresponding adducts in good

276 The reactivity of phosphanyl phosphonates toward diacetylenic ketones was studied.

277 Gene transcripts encoding phosphonate transport and hydrolysis proteins are upregu

278 ive nucleases, phosphotriesterases, putative phosphonate transporters and outer membrane proteins.

279 In the phosphonates-treated cells with the high and low DHTKD1

280 re it is shown that the recently synthesized phosphonated trityl radical possesses long relaxation ti

281 o hydrogenation, and the resulting saturated phosphonates underwent base-catalyzed cyclization to giv

282 Moreover, the chromatographic retentivity of phosphonate versus sulfonate was shown to be completely

283 ynthesis route to alpha-L-threose nucleoside phosphonates via 2-O and 3-O selectively protected L-thr

284 f serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and

285 A spirocyclic phosphonate was identified as the optimal ring system fo

286 The phytoceramide-1-H-phosphonate was synthesized through an enantioselective

287 The alkene of the vinyl phosphonates was subjected to hydrogenation, and the res

288 ly selective catalytic hydrogenation of acyl phosphonates was utilized in the dynamic kinetic resolut

289 itionally, orthophosphate, pyrophosphate and phosphonates were also detected.

290 ss and the unique reactivity of the obtained phosphonates were demonstrated in different one-step tra

291 e reduced, and 3-azabicyclo[3.1.0]hexan-1-yl phosphonates were obtained.

292 3-Azabicyclo[3.1.0]hex-2-en-1-yl phosphonates were prepared in a five-step reaction route

293 lly hindered aldehydes, (alpha-fluoroallenyl)phosphonates were the solely isolated products.

294 The unsaturated phosphonates were utilized as Hauser acceptors successfu

295 Instead, DeltaAla(P) is hydrolyzed to acetyl phosphonate, which is converted to Ala(P) by a second py

296 Our initial strategy was to cover the phosphonate with hydrophobic moieties such as pivaloylox

297 f the intermediate (3,3-dibromodifluoroallyl)phosphonate with potassium tert-butoxide gave rise to th

298 llows the direct oxygen-arylation of dialkyl phosphonates with diaryliodonium salts.

299 thesis of four l-2'-deoxy-threose nucleoside phosphonates with the natural nucleobases adenine, thymi

300 r-catalyzed electrophilic amination of alpha-phosphonate zincates with O-acyl hydroxylamines.