ライフサイエンスコーパス: phosphonic acid

1 P ((+/-)3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid)].

2 -1,2,3,4-tetrahydroquin oxalin-5-yl)-methyl]-phosphonic acid.

3 (+/-)-3-[2-carboxypiperazine-4-yl]-propyl-1-phosphonic acid.

4 t (RS)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid.

5 ns can be modulated by esterification of the phosphonic acid.

6 f the formed phosphonate ester into the free phosphonic acid.

7 azide linker between a carboxylic acid and a phosphonic acid.

8 achieved by linking a 2-aminothiazole with a phosphonic acid.

9 alogues, phosphonothioic acids compared with phosphonic acids.

10 ntrast to the higher pK(a) values typical of phosphonic acids.

11 cleavage of the products to the parent amino phosphonic acids.

12 and selectively self-assembled monolayers of phosphonic acids.

13 ar dichroism dissymmetry factor of the three phosphonic acids.

14 azapurine derivatives or deprotected to free phosphonic acids.

15 ydrogen in the alpha-methylene groups of the phosphonic acid 1, 3-BPG analogs markedly improves their

16 N(6)-benzyl-adenosine-5'-O-[(phosphonomethyl)phosphonic acid] (10g, PSB-12379, Ki 9.03 nM).

17 ives, i.e., two monoesters (13 and 14), four phosphonic acids (15-18), and one cyclic phosphonate (23

18 nd 2-chloro-adenosine-5'-O-[(phosphonomethyl)phosphonic acid] (15, 16) being the most potent inhibito

19 (153)Sm-ethylenediamine tetramethylene phosphonic acid ((153)Sm-EDTMP) therapy for osteosarcoma

20 )SrCl, (153)Sm-ethylenediaminetetramethylene phosphonic acid ((153)Sm-EDTMP), (179m)SnCl, and (166)Ho

21 The resulting benzimidazole phosphonic acid, 16, inhibited human FBPase (IC50 = 90 n

22 with a novel Mn complex, fac-[MnBr(4,4'-bis(phosphonic acid)-2,2'-bipyridine)(CO)3 ] (MnP), immobili

23 An aromatic phosphonic acid, [2-(9-ethyl-9H-carbazol-3-yl)ethyl]phos

24 Optimization of the diamide prodrugs of phosphonic acid 2a (MB05032) led to the identification o

25 iodide (PMAI) and [2-(9H-carbazol-9-yl)ethyl]phosphonic acid (2PACz) are introduced into the precurso

26 crystallography depicted the binding mode of phosphonic acid 3 to both CAs II and VII.

27 A synthesis of the benzothiazepine phosphonic acid 3, employing both enzymatic and transiti

28 er(OBn)TrpNH2 (3), and alpha-hydroxyfarnesyl phosphonic acid (4).

29 No conversion of monoester 4c to phosphonic acid 4a was observed in rats after intravenou

30 -4-(2-fluorophenyl)but-3- yny l]amino]methyl]phosphonic acid (56), an arylacetylene amino phosphonate

31 of [1, 1-difluoro-1-(2-naphthalenyl)-methyl]phosphonic acid (6) complexed within the catalytic site

32 w [(bpHc)Ru(L)2] (bpH2cH = 2,2'-bipyridine-6-phosphonic acid-6'-carboxylic acid, L = 4-picoline or is

33 ifluoro-1-[2-(4-hydroxynaphthalenyl)] methyl]phosphonic acid (8), could potentially replace a water m

34 1,4,8,11-tetraazacyclotetradecane-1-(methane phosphonic acid)-8-(methane carboxylic acid) (CB-TE1A1P)

35 1,4,8,11-tetraazacyclotetradecane-1-(methane phosphonic acid)-8-(methane carboxylic acid) and a polye

36 Both phosphonic acids ( 9, 12, or 13) and their disodium salt

37 s of CPP (3-(2-carboxypiperazin4-yl)propyl-l-phosphonic acid), a competitive NMDA receptor antagonist

38 surements of the binding affinity of leucine phosphonic acid, a transition state analogue, and leucin

39 ivudine (3TC), and cytarabine as well as the phosphonic acid adefovir were shown to cleave following

40 tions indicate that cluster formation during phosphonic acid adsorption leads to incomplete SAM cover

41 The engineering of phosphonic acid adsorption on textured substrates offers

42 ackbone and a layered morphology with planar phosphonic acid aggregates separated by 29 and 55 A for

43 [(+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid], alone (n = 14) or combined with AMPA r

44 -1,2,3,4-tetrahydro-qu inoxalin-5-yl)-methyl]phosphonic acid), an antagonist with relative NR1/NR2A s

45 The enantiomeric phosphonic acid analogs of Leu and hPhe, which correspon

46 aterials such as (4-(9H-carbazol-9-yl)phenyl)phosphonic acid and (4-(diphenylamino)phenethyl)phosphon

47 ibutable to the deviated orientations of its phosphonic acid and 3-pentyl groups in the NA active sit

48 of 3-((R)-2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid and CNQX or by uncaging IP3.

49 sitivity of the rho1 GABACR to 3-aminopropyl-phosphonic acid and its analog 3-aminopropyl-(methyl)pho

50 digit nanomolar affinities were exhibited by phosphonic acid and malonyl-containing diacidic phosphor

51 The phosphonic acid and sulfuric acid analogs of OVS are als

52 he chiral axis) and the distance between the phosphonic acid and the binaphthyl chiral units signific

53 A direct approach to important alpha-amino phosphonic acids and its derivatives has been developed

54 ,7aS)- and (1R,3aR,7aR)-octahydroisoindole-1-phosphonic acids and their enantiomers were obtained wit

55 r pesticides (fosetyl-Al and its metabolite, phosphonic acid, and ethephon) and environmental contami

56 idation of antigen, conjugation to polymers, phosphonic acids, and other linkers to achieve surface a

57 enerate trialkylphosphine oxide and oleic or phosphonic acid anhydride products.

58 hints for understanding the translocation of phosphonic acid antibiotics through other outer membrane

59 ve found that lipophilic diester prodrugs of phosphonic acid antibiotics, such as fosmidomycin (Fsm),

60 -, monoanhydride with (dichloromethylene)bis[phosphonic acid] (AR-C69931MX) as a neutral antagonist.

61 activity relationships of a small library of phosphonic acid arginine mimetics that probe the S1 pock

62 er of (4-(7H-dibenzo[c,g]carbazol-7-yl)butyl)phosphonic acid as a hole-selective layer for wide-bandg

63 Using (4-(diphenylamino)phenyl)phosphonic acid as a model molecule, Compared to traditi

64 We have synthesized arylazopyrazole (AAP) phosphonic acids as a new class of photoswitchable molec

65 e report the discovery of a series of purine phosphonic acids as AMP mimics targeting the AMP site of

66 ty of microorganisms have the ability to use phosphonic acids as sole sources of phosphorus.

67 ally diverse compounds (benzoic, diketo, and phosphonic acids, as well as a bisamidine and a bisamine

68 h began by replacing the 5'-phosphate with a phosphonic acid attached to C8 of the adenine base via a

69 (4-(diphenylamino)phenyl)phosphonic acid-based device achieve power conversion ef

70 These new precise phosphonic acid-based materials illustrate the importanc

71 e crystallographic phase of the film through phosphonic acid-based surface modification.

72 bled monolayer of [2-(9H-carbazol-9-yl)ethyl]phosphonic acid between the NiO(x) and poly(9-vinylcarba

73 ric films enabled by polarizable pi-electron phosphonic acid building blocks and ultrathin ZrO(2) lay

74 e diamides that convert to the corresponding phosphonic acid by sequential action of an esterase and

75 rrent conversions of several phosphonates to phosphonic acids by reduction (R-P -> H-P) and to pentav

76 (+/-)-3-(2-carboxypiperazin-4-yl)-propyl -1-phosphonic acid caused a dose-dependent attenuation of S

77 enylethyl)amino-2-(S) hydroxypropyl-p-benzyl-phosphonic acid (CGP 55845A), but not by the A(1)R antag

78 based on soy, rice, cow, and goat milk, and phosphonic acid, chlorate, perchlorate, fosetyl-Al, and

79 the alternative cadmium precursors, cadmium-phosphonic acid complexes.

80 ct with metal ions, we designed three chiral phosphonic acids (CPAs) to impose chirality in otherwise

81 receptor 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) high-affinity binding site is modi

82 t d(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP) on the extinction of conditioned f

83 agonist 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) or the AMPA receptor antagonist 1,

84 tagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) prevents modification of the recep

85 tor antagonist 3-(2-carboxypiperazin-4-yl)-1-phosphonic acid (CPP) reduces NMDA-mediated neurotoxicit

86 l-3[(+/-)-2-carboxypiperazine-4-yl]-propyl-1-phosphonic acid (CPP) to determine whether the alteratio

87 ist ((+)-3-2-(carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP)) treatment also increased the R1 a

88 st (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), administered in a dose that block

89 ist [(+/-)-2-carboxypiperazin-4-yl] propyl-1-phosphonic acid (CPP), were performed on sections from C

90 st (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP).

91 agonist 3-[2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP; 5 microM) elevated the threshold f

92 er) and 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP; NMDA receptor blocker) greatly dim

93 (3-((+/-)-2- carboxypiperazin-4-yl)propyl-1-phosphonic acid, CPP) systemically either before examini

94 M, ((2,7-dimethoxy-9H-carbazol-9-yl) methyl) phosphonic acid (DC-PA).

95 Fosfomycin is a phosphonic acid derivative active against a wide spectru

96 tarting from the neurotransmitter NAAG and a phosphonic acid derivative to simplified Glu-urea scaffo

97 iethoxyphosphoryl)phenyl substituent (or the phosphonic acid derivative).

98 iazofurin (24) with the difluoromethylenebis(phosphonic acid) derivative gave the phosphonate 25 whic

99 an effective sequence for the preparation of phosphonic acid derivatives of the diamondoids diamantan

100 es, providing beta-stereogenic alpha-hydroxy phosphonic acid derivatives.

101 e formation of P-stereogenic cyclohexadienyl-phosphonic acid derivatives.

102 inhibitors were the 5'- O-[(phosphonomethyl)phosphonic acid] derivatives of 5-fluorouridine (4l), N(

103 We synthesized 5'- O-[(phosphonomethyl)phosphonic acid] derivatives of purine and pyrimidine nu

104 The compound with a phosphonic acid directly bound to one of the naphthalene

105 etraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid (DOTMP) and were a subset of patients en

106 s (EC50 = 19-89 nM) than their corresponding phosphonic acids (EC50 = 50-343 nM) in protection of cel

107 oride, (153)Sm-ethylenediaminetetramethylene phosphonic acid (EDTMP), and (223)Ra-dichloride.

108 ), and 153Sm-ethylene diamine tetramethylene phosphonic acid (EDTMP), have been used to treat bone pa

109 ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acid) (EDTMP).

110 Phosphonic acids encompass a common yet chemically diver

111 nic acid, [2-(9-ethyl-9H-carbazol-3-yl)ethyl]phosphonic acid (EtCz3EPA), enhanced bonding at the pero

112 metric behavior indicates that the porphyrin-phosphonic acids form robust, electrically well-behaved

113 es have been synthesized with bipyridine and phosphonic acid functional groups.

114 mechanical properties is investigated, with phosphonic acid functionalities being installed in the p

115 The derivatization of the phosphonic acid functionality of FPMPs with a diamyl asp

116 studies have revealed that SF2312, a natural phosphonic acid, functions as a potent inhibitor of huma

117 ding at the perovskite/HTM/TCO region with a phosphonic acid group bonded to TCOs and a nitrogen grou

118 Replacement of the phosphonic acid group by either a carboxylic acid or a t

119 synthetic approaches for introduction of the phosphonic acid group include derivatization of a bromoa

120 ficant antiureolytic effect achieved, with a phosphonic acid group intended to block the function of

121 nt of the carboxylic acid functionality by a phosphonic acid group which delivered the most potent mo

122 Synthetic molecules bearing phosphonic acid groups can be readily attached to oxide

123 Polymers bearing phosphonic acid groups have been proposed as anhydrous p

124 he routes enable (1) incorporation of masked phosphonic acid groups in precursors for use in the rati

125 15 type and macroporous) containing sulfonic/phosphonic acid groups obtained by co-condensation sol-g

126 ent lead-absorbing molecular film containing phosphonic acid groups that bind strongly to lead.

127 nodisperse polyethylenes with the ability of phosphonic acid groups to form strong hydrogen-bonding n

128 s contain varying numbers of sulfonic and/or phosphonic acid groups, serving as hydrophilizing units

129 The MOF contains free phosphonic acid groups, shows high humidity stability, a

130 (2) derivatization of porphyrins with masked phosphonic acid groups.

131 h of the hydrogen bond network formed by the phosphonic acid groups.

132 emistry associated with deprotonation of the phosphonic acid groups.

133 h contains an outer coordination sphere with phosphonic acid groups.

134 anine ammonia lyase inhibitor 2-aminoindan-2-phosphonic acid, guaiacol and veratrole levels were redu

135 st, 3-((R)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, had no effect on the depolarizations at

136 ly used anchors such as carboxylic acids and phosphonic acids have limited stability in aqueous envir

137 acid, boronic acid, 2-oxoaldehyde, and ethyl phosphonic acid hydrogen bond-acceptor analogues were in

138 ioselective sensing of 35 amino acids, amino phosphonic acids, hydroxy acids, amino alcohols, and dia

139 ddition of a small amount of stearic acid or phosphonic acid, immediate partial dissolution of ZnO na

140 ating (4-(7H-dibenzo[c,g]carbazol-7-yl)butyl)phosphonic acid in devices, we demonstrate a high open-c

141 dible oils and nuts were analysed, detecting phosphonic acid in nuts at concentrations up to 4.6 mg k

142 ons with 4,4'-biphenyl and 4,4'-terphenylbis(phosphonic acid) in DMSO or DMSO-ethanol mixtures produc

143 l AMPA, N-acetyl glyphosate, perchlorate and phosphonic acid) in fruit and vegetables is described.

144 of UMP-morpholidate with fluoromethylenebis(phosphonic acid)) in D2O at pH 10 are indeed readily dis

145 tly discovered potent and selective thiazole phosphonic acid inhibitors of fructose 1,6-bisphosphatas

146 rst and second generation aryldifluoromethyl-phosphonic acid inhibitors.

147 yl thiophene) containing chain-end thiols or phosphonic acids is crystallized to yield nanowires with

148 Thus the reaction with phosphonic acids is not just surface-limited, but can co

149 l)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid) is a dAMP (2'-deoxyadenosine monophosph

150 nions of phosphonothioic acids compared with phosphonic acids, it was found that, with some exception

151 ied with a self-assembled monolayer (SAM) of phosphonic acid ITO linkers with a dangling carboxylate

152 nic acid or diethyl 3-(pyridin-4-yloxy)decyl-phosphonic acid, leads to well-defined surfaces but, fol

153 We found that carboxylic and phosphonic acids led only to oxides, whereas tri-n-octyl

154 cule [4-(3,6-dimethyl-9H-carbazol-9-yl)butyl]phosphonic acid (Me-4PACz) with the multiple aromatic ca

155 dimethoxy-7H-dibenzo[c,g]carbazol-7-yl)butyl)phosphonic acid (MeO-4PADBC) SAM that can improve and st

156 In this regard, this novel phosphonic acid methodology provides a new high-yielding

157 The phosphonic acid methyl ester monosodium salt 11 did not

158 the glycerol backbone and phosphonoinositol, phosphonic acid, methyl phosphonate, phosphatidic acid,

159 ium methoxide afforded disodium salts of the phosphonic acid moiety.

160 titution of the distal carboxylic acid for a phosphonic acid moiety.

161 a monolayer of t-butyl carbazole-substituted phosphonic acid molecules and subsequent p-doping.

162 By comparison, phosphonic acid molecules are found to adsorb electrosta

163 hat a perfectly ordered layer of monodentate phosphonic acid molecules is chemically grafted at room

164 find that the interactions of loosely bound phosphonic acid molecules with evaporated precursors, fo

165 sters, thus homogenizing the distribution of phosphonic acid molecules, and thereby minimizing interf

166 The phosphonic acid mono alkyl esters are accessible by the

167 Treatment of nonstabilized beta-hydroxy phosphonic acid mono methyl esters with diisopropyl carb

168 analogous lariat ether carboxylic acids and phosphonic acid monoethyl esters.

169 Binding of phosphonic acid monolayers on supported Pt and Pd cataly

170 ndergo ring opening was exploited to prepare phosphonic acid monomethyl esters in high yield by trans

171 The beta-hydroxy phosphonic acid monomethyl esters were dehydrated with d

172 resistance using a covalent attachment of a phosphonic acid motif to a peptidomimetic inhibitor scaf

173 imethyl methyl phosphonate (DMMP) and methyl phosphonic acid (MPA) exhibit the reduced mobility value

174 The complex Tb-3,6,9-tris(methylene phosphonic acid n-butyl ester)-3,6,9,15-tetraazabicyclo[

175 irulence, is required for production of this phosphonic acid natural product, but the metabolic steps

176 trichloroacetimidates for the benzylation of phosphonic acid nerve agent markers under neutral, basic

177 -1,2,3,4-tetrahydroquinoxalin- 5-yl)-methyl]-phosphonic acid (NVP-AAM077) and the NR2B-receptor-antag

178 -1,2,3,4-tetrahydroquino xalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) at rat recombinant N-methyl

179 o-1,2,3,4-tetrahydroquinoxalin-5 -yl)-methyl-phosphonic acid (NVP-AAM077), contains a unique combinat

180 3aR,7aS)- and (2S,3aS,7aR)-octahydroindole-2-phosphonic acid (Oic(P) trans-fused stereoisomers) from

181 ntration of glyphosate and AMPA (aminomethyl phosphonic acid, one of its major degradation products)

182 d phosphonate derivatives with L = 4-pyridyl phosphonic acid or diethyl 3-(pyridin-4-yloxy)decyl-phos

183 sphonic acid and (4-(diphenylamino)phenethyl)phosphonic acid, our material generates a high-quality p

184 Phosphonic acid (PA) thyroid hormone receptor (TR) agoni

185 rature via thermal evaporation by depositing phosphonic acids (PAc) on substrates and subsequently co

186 -1,2,4,5-tetrahydrocyclopenta[de]quinoline-3-phosphonic acid, PAnt, specifically designed to dynamica

187 veys the literature on TCO modification with phosphonic acids (PAs), which has increasingly been used

188 luble protein receptors for pinacolyl methyl phosphonic acid (PMPA), the predominant hydrolytic produ

189 Farnesyl phosphonic acids potentiate the upregulation of these pr

190 mprinting of the mono- or dianions of phenyl phosphonic acid (PPA), phenyl sulfonic acid (PSA), and b

191 s NRRL B-16338, were identified as potential phosphonic acid producers by screening for the gene enco

192 Titrations of G6P itself and the free phosphonic acids provides second pKa values of 6.5 (1, b

193 We found that both the position of the phosphonic acid relative to the bond between the two nap

194 combination with the monomethylation of the phosphonic acid, renders DHP a Trojan horse type antibio

195 evelopment of a recyclable polystyrene-based phosphonic acid resin and its use for the synthesis of i

196 ogue of 2-(3-pyridyl)-1-hydroxyethylidenebis(phosphonic acid) (risedronic acid, 2), an osteoporosis d

197 st 3-((RS)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid ((RS)-CPP), and completely blocked by th

198 ohol could not react with the resulting zinc phosphonic acid salt, it could force the newly formed zi

199 n contrast (comparable to that obtained from phosphonic acid SAMs deposited from solution).

200 ontact printing to pattern pentafluorobenzyl phosphonic acid self-assembled monolayers (SAMs) on indi

201 o-1,2,3,4-tetrahydroquino xalin-5-yl)-methyl-phosphonic acid-sensitive (NVP-AAM077-sensitive) (NR2A-c

202 saccharide sucrose or industrially important phosphonic acid species slow dramatically the hydration

203 zed conditions for the derivatization of the phosphonic acids specifically for their benzylation, inc

204 chalcogenides deoxygenate the oleic acid or phosphonic acid surfactant to generate trialkylphosphine

205 Oseltamivir phosphonic acid (tamiphosphor, 3a), its monoethyl ester

206 , we report the straightforward synthesis of phosphonic acid-terminated, long-chain aliphatic materia

207 aration of the p-methoxybenzyl esters of the phosphonic acids, the acid-catalyzed process appeared to

208 For selected porphyrin-phosphonic acids, the electrochemical characteristics ha

209 Like most phosphonic acids, the recently discovered potent and sel

210 ted precursors, followed by the migration of phosphonic acids through the deposited thin film, dictat

211 h the UiO-66 topology, achieved by attaching phosphonic acid to the 1,4-benzenedicarboxylate ligand a

212 koxide layer, which reacts with solutions of phosphonic acids to attach monolayer films of phosphonat

213 Motivated by the ability of phosphonic acids to interact with metal ions, we designe

214 vity using the hydroxy-2-naphthalenyl methyl phosphonic acid tris acetoxymethyl ester (HNMPA-(AM)(3))

215 dical reactivity took place depending on the phosphonic acid used.

216 The phosphonic acids used in this work included ethyl-, cycl

217 th an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of formalin-i

218 roM 3-((D)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid was applied during the preconditioning i

219 tors of this enzyme, a series of benzoic and phosphonic acids was designed and synthesized.

220 ,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid, was identified as a potent NMDA antagon

221 ADP (AOPCP, adenosine-5'-O-[(phosphonomethyl)phosphonic acid]) was used as a lead structure, and deri

222 The phosphonic acids were backflush-desorbed onto a polymeri

223 The benzyl-derived phosphonic acids were detected and analyzed by Electron

224 s of phosphonothioic acids and corresponding phosphonic acids were synthesized and their inhibitory p

225 us protecting groups, the four alpha-hydroxy phosphonic acids were tested for their ability to serve

226 D-3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid, which binds to NR2A/B with very high af

227 boxylic acids, sulfonic acids, alcohols, and phosphonic acids, which are the most common polar head g

228 ization of the resulting [(alkyloxy)carbonyl]phosphonic acids with 2 equiv of sodium methoxide afford