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1 SI IRMPD FTICR mass spectrometry of a 20-mer phosphorothioate oligonucleotide.
2  stability of the TFO, we have used modified phosphorothioate oligonucleotides.
3 reated with CD44 sequence-specific antisense phosphorothioate oligonucleotides.
4 eversal potential between phosphodiester and phosphorothioate oligonucleotides.
5 plicable to the analysis and quantitation of phosphorothioate oligonucleotides.
6 s, and what was the effect of IL-6 antisense phosphorothioated oligonucleotides.
7 to analyze the stereochemical composition of phosphorothioated oligonucleotides.
8 d by transfection with antisense PKC-epsilon phosphorothioate oligonucleotides (1,000 nM for 6 h).
9     The enzyme is inhibited by single-strand phosphorothioate oligonucleotides and displays no eviden
10     Down-regulation of PKCalpha by antisense phosphorothioate oligonucleotides and expression vectors
11  are relevant to both the therapeutic use of phosphorothioate oligonucleotides and the potential desi
12 d by 5' and 3' HNA sequences to conventional phosphorothioate oligonucleotides and to a 2'-O-methoxye
13 on the immunomodulatory effects of synthetic phosphorothioated oligonucleotides and raise questions a
14 letion of DNA methyltransferase 1 (DNMT1) by phosphorothioate oligonucleotide antisense (DNMT1 AS) we
15                                     A 20-mer phosphorothioate oligonucleotide (AS1) was designed to h
16 ined whether the administration of antisense phosphorothioate oligonucleotides (ASOs) can mimic the l
17                                     A 20-mer phosphorothioate oligonucleotide capped with two phospho
18 mice with locked nucleic acid (LNA)-modified phosphorothioate oligonucleotide complementary to miR 14
19 myelogenous leukemia with OL(1)p53, a 20-mer phosphorothioate oligonucleotide complementary to p53 mR
20  suppression by G3139 (oblimersen sodium), a phosphorothioate oligonucleotide complementary to the bc
21 Retinal toxicity of ISIS 2922 and ISIS 4015, phosphorothioate oligonucleotides complementary to human
22 s well as cartilage slices were treated with phosphorothioate oligonucleotides comprised of sequence
23 t pulmonary endothelial cells given a 20-mer phosphorothioate oligonucleotide comprising an antisense
24 second strategy used isosequential "gap-mer" phosphorothioate oligonucleotides containing 2'-O-methyl
25 to increase stability, we have used modified phosphorothioate oligonucleotides for cell culture exper
26  Methods are presented for the extraction of phosphorothioate oligonucleotides from human plasma to p
27                            Extraction of the phosphorothioate oligonucleotides from plasma was accomp
28                                          The phosphorothioate oligonucleotide 'gapmers', with 2'-O-DM
29                                              Phosphorothioate oligonucleotides have been demonstrated
30 d for their gene, mRNA, siRNA and 2'O-methyl phosphorothioate oligonucleotide in vitro transfection a
31                               A MT antisense phosphorothioate oligonucleotide inhibited growth induct
32 we report that transfection of 2'-F-modified phosphorothioate oligonucleotides into cells can reduce
33 uptake of 15 different fluorescently labeled phosphorothioate oligonucleotides into human keratinocyt
34 ed HCV core protein levels as effectively as phosphorothioate oligonucleotide ISIS 6095 but without r
35 ve investigated the antiviral mechanism of a phosphorothioate oligonucleotide, ISIS 5652, which has a
36 wnregulation of IGF I receptors by antisense phosphorothioate oligonucleotides likewise markedly inhi
37  Triplex formation by the cyclin D1 targeted phosphorothioate oligonucleotide occurs with a binding a
38            Triplex formation with a modified phosphorothioate oligonucleotide occurs with approximate
39  gapmer was substantially more potent than a phosphorothioate oligonucleotide of the same sequence in
40                                            A phosphorothioate oligonucleotide, OL(1)p53, can be admin
41 antisense chimeric 2'-O-(2-methoxy)ethyl/DNA phosphorothioate oligonucleotides (ONs) to affect cell g
42 poteichoic acid (LTA), thymidine homopolymer phosphorothioate oligonucleotide [Poly(dT)], and polyino
43 on of RLIP76 using either siRNA or antisense phosphorothioate oligonucleotides preferentially caused
44                                              Phosphorothioate oligonucleotides (PS ODNs) prolong the
45 re systems were used to study the effects of phosphorothioate oligonucleotides (PS-ONs), as amphipath
46                             Determination of phosphorothioate oligonucleotide purity and impurity pro
47       Isis 3521 and G3139 are 20- and 18-mer phosphorothioate oligonucleotides, respectively, targete
48 vage as compared with the 7-mer C-5 propynyl phosphorothioate oligonucleotide (S-ON).
49                                              Phosphorothioate oligonucleotides (S-ODNs) or phosphorod
50                                The antisense phosphorothioate oligonucleotides specific for IL-2, IL-
51                                 Proapoptotic phosphorothioate oligonucleotides such as G3139 (an 18-m
52                   Here we have used specific phosphorothioate oligonucleotides targeted against the t
53                                 An antisense phosphorothioated oligonucleotide targeted to a unique s
54 inistration of ISIS 2302, a 20-mer antisense phosphorothioate oligonucleotide targeting human interce
55 imized C-5 propyne pyrimidine modified 7-mer phosphorothioate oligonucleotide targeting SV40 large T
56                                     A 20-mer phosphorothioate oligonucleotide targeting the 3'-untran
57           Fully modified 2'-O:-methoxy ethyl/phosphorothioate oligonucleotides that hybridize to the
58 this, we have synthesized a series of G-rich phosphorothioate oligonucleotides that inhibited activat
59 o test this hypothesis, we used an antisense phosphorothioate oligonucleotide to effect a 50% reducti
60 e demonstrate the ability of G3139 and other phosphorothioate oligonucleotides to bind directly to mi
61 or within the cell, the ability of antisense phosphorothioate oligonucleotides to inhibit the growth
62  parallel studies using hydrolysis-resistant phosphorothioate oligonucleotides to monitor DNA transfe
63  important degradation pathway for antisense phosphorothioate oligonucleotides under conditions of th
64 s, and subsequently protein levels, by these phosphorothioate oligonucleotides was consistent with RN
65                     Both phosphoramidate and phosphorothioate oligonucleotides were efficiently taken
66 , the combination of Ad.mda-7 with antisense phosphorothioate oligonucleotides, which target the K-ra
67 dy was to determine the abilities of various phosphorothioate oligonucleotides with cytosine-guanosin
68                    Synthetic double-stranded phosphorothioate oligonucleotides with high affinity for