ライフサイエンスコーパス: phosphorylase

1 degraded in the cytosol by purine nucleoside phosphorylase.

2 RhlB and the exoribonuclease polynucleotide phosphorylase.

3 nversion to hexose phosphate via a cytosolic phosphorylase.

4 lated metabolites by human purine nucleoside phosphorylase.

5 lymerase and a Mn(2+)*PO(4)-dependent DNA 3'-phosphorylase.

6 einhardtii VTC2 as an active GDP-L-galactose phosphorylase.

7 gene encoding thymidine phosphorylasethymine phosphorylase.

8 was dependent on the DeoD purine nucleoside phosphorylase.

9 as widely inferred to be a purine nucleoside phosphorylase.

10 e in [AMP] is necessary to activate glycogen phosphorylase.

11 igh level in a strain lacking polynucleotide phosphorylase.

12 ucts of an unlinked but essential nucleoside phosphorylase.

13 e, and our data reveal that MbcT is a NAD(+) phosphorylase.

14 lacking the processing enzyme polynucleotide phosphorylase.

15 P, the chloroplast isozyme of polynucleotide phosphorylase.

16 K), cytidylate kinase, and purine nucleotide phosphorylase.

17 hese enzymes act preferentially as glycoside phosphorylases.

18 ctive than naturally occurring glucosaminide phosphorylases.

19 turn upregulated mRNA expression of uridine phosphorylase 1 (UPP1).

20 A second gene, uridine phosphorylase 2, with a joint P-value of 2.3E-9, has bee

21 h vehicle infused ZDF (ZDF-V), high glycogen phosphorylase a activity was decreased and low synthase

22 Thymidine phosphorylase, a cellular enzyme markedly induced by ORF

23 MTAP encodes the enzyme methylthioadenosine phosphorylase, a key enzyme in the methionine salvage pa

24 The plant VTC2 gene encodes GDP-L-galactose phosphorylase, a rate-limiting enzyme in plant vitamin C

25 lly, BMI1 coprecipitated with polynucleotide phosphorylase, a ribonuclease that is responsible for de

26 zyme having both cellodextrin and cellobiose phosphorylases activities.

27 ycemia was associated with elevated glycogen phosphorylase activity and decreased glycogen synthase a

28 atures of these patients including thymidine phosphorylase activity deficiency, elevated thymidine an

29 ain deletions enhance the DNA polymerase and phosphorylase activity of mycobacterial PNPase.

30 Thymidine phosphorylase activity rose from undetectable to normal

31 vity was approximately 50% greater, glycogen phosphorylase activity was approximately 50% lower, and

32 phosphorylase, and S-methyl-5'-thioadenosine phosphorylase activity, hence, combine activities of the

33 he purified proteins also display GDP-hexose phosphorylase activity.

34 in life, and may reflect residual thymidine phosphorylase activity.

35 glycogen synthase and a decrease in glycogen phosphorylase activity.

36 tations cause severe reductions of thymidine phosphorylase activity; marked elevations of the pyrimid

37 rain was found to totally lack GDP-D-glucose phosphorylase activity; this activity was also found to

38 r the treatment of type II diabetes has made phosphorylase an active target of research for the past

39 l proangiogenic factors, including thymidine phosphorylase and angiopoietin-1 both in vitro and in vi

40 the isoform-specific regulation of glycogen phosphorylase and glycogen metabolism.

41 ic enzyme with Mg(2+)*PO(4)-dependent RNA 3'-phosphorylase and Mg(2+)*ADP-dependent RNA polymerase ac

42 etabolism was attributed to loss of glycogen phosphorylase and phosphoglucomutase at the protein leve

43 Subtracting the S1 domain diminishes RNA phosphorylase and polymerase activity; simultaneous dele

44 chloroplast gene expression (polynucleotide phosphorylase and PTAC12), and prosthetic group attachme

45 nced ribonuclease activity of polynucleotide phosphorylase and reduced mtRNA stability.

46 nucleases of E. coli, such as polynucleotide phosphorylase and RNase II, cannot complement the cold s

47 a coli phosphorolytic RNases, polynucleotide phosphorylase and RNase PH, leads to marked growth and r

48 Thymidine phosphorylase and uridine phosphorylase double knockout

49 nucleotidase cytosolic-II, purine nucleoside phosphorylase and xanthine oxidase) was performed using

50 both human and Plasmodium purine nucleoside phosphorylases and adenosine deaminases are inhibited.

51 annose are conserved in both GH130 mannoside phosphorylases and beta-1,2-mannosidases.

52 s such as in permeabilized cells that harbor phosphorylases and kinases, ion pumps exhibiting substan

53 rylase phosphatase, inactivation of glycogen phosphorylase, and activation of glycogen synthase.

54 ndoglucanase, cellobiohydrolyase, cellobiose phosphorylase, and alpha-glucan phosphorylase originatin

55 have adenosine deaminase, purine nucleoside phosphorylase, and S-methyl-5'-thioadenosine phosphoryla

56 o the multiple binding sites of the glycogen phosphorylase, and then we have investigated the use of

57 eported examples of retaining beta-glycoside phosphorylases, and the first instance of free beta-GlcN

58 s, including glycoside hydrolases, glycoside phosphorylases, and transglycosylases.

59 Because the synthase and phosphorylase are critical to homeostasis, their roles i

60 Many crystallographic structures of phosphorylase are currently available to aid in this res

61 Nucleoside phosphorylases are essential for the salvage and catabol

62 Moreover, uridine phosphorylases are not found in obligate oomycete pathog

63 oomycete genomes revealed that both uridine phosphorylases are present in Phytophthora and Pythium g

64 Glycoside hydrolases and phosphorylases are two major classes of enzymes responsi

65 bonucleotides (synthesized by polynucleotide phosphorylase) as messenger RNA in a cell-free protein-s

66 o enzyme-catalyzed reaction using the enzyme phosphorylase b from rabbit muscle and Deinococcus geoth

67 16 subunits of the (alphabetagammadelta)(4) phosphorylase b kinase (PhK) complex can only be achieve

68 the glycogen branching enzyme (GBE) and the phosphorylase b kinase alpha subunit (PhKalpha) protein,

69 The original report on phosphorylase b' examined the allosteric characteristics

70 It has been reported that phosphorylase b' shows no allostery, neither homotropic

71 of phosphorylase that lacked the N-terminus (phosphorylase b').

72 time the full thermodynamic effect of AMP on phosphorylase b.

73 ing the allosteric effect of AMP on glycogen phosphorylase b.

74 determine whether plasma levels of glycogen phosphorylase BB (GPBB) isoform increased in patients wi

75 ion enzymes glycogen synthase I and glycogen phosphorylase BB, dispersed throughout the type I cell c

76 ldithiocarbamate suggest that brain glycogen phosphorylase (bGP) and glycogen metabolism could be alt

77 reactive cysteine residues in brain glycogen phosphorylase (bGP).

78 In these phosphorylases, bond cleavage was mediated by a single d

79 ere we show that mammalian purine nucleoside phosphorylase but not methylthioadenosine phosphorylase

80 NAcase enzymes can be converted to efficient phosphorylases by a single point mutation.

81 time course studies demonstrate that uridine phosphorylase can catalyze the hydrolysis of the fluorin

82 Uridine phosphorylase catalyzes the reversible phosphorolysis of

83 ne (THA_1941) encoding a putative cellobiose phosphorylase (CBP) from Thermosipho africanus TCF52B ha

84 ection, it was categorized as a cellodextrin phosphorylase (CDP).

85 sphoribosyltransferase (TrpD) and nucleoside phosphorylase class II enzymes but bind with high affini

86 s paralogue VTC5 function as GDP-L-galactose phosphorylases converting GDP-L-galactose to L-galactose

87 using the pyrophosphatase-purine nucleoside phosphorylase coupling system with the chromogenic subst

88 Ribonuclease R (RNR1) and polynucleotide phosphorylase (cpPNPase) are the two known 3'-->5' exori

89 l encephalomyopathy and had severe thymidine phosphorylase deficiency in the buffy coat (<10% of norm

90 e to TYMP mutations that result in thymidine phosphorylase deficiency.

91 A mycoplasma-encoded purine nucleoside phosphorylase (designated PNPHyor) has been cloned and c

92 Chemical inhibition of purine nucleoside phosphorylase did not improve deoxyguanosine recycling b

93 Thymidine phosphorylase and uridine phosphorylase double knockout mice recapitulated several

94 he rNDPs to RNA by the enzyme polynucleotide phosphorylase (EC 2.7.7.8) and detection of the RNA by t

95 rmore, our analyses show that two cellobiose phosphorylases encoded by R. albus 8 can function synerg

96 m cell transplantation can restore thymidine phosphorylase enzyme function in patients with mitochond

97 uction of known inhibitors from the glycogen phosphorylase enzyme, a therapeutic target against type

98 Starch synthases and phosphorylases exhibit highest nucleotide diversities, w

99 Based on high thymidine phosphorylase expression in the liver, a 25-year-old sev

100 It also showed increased glycogen phosphorylase flux in L-G6pc(-/-) mice, which is coupled

101 r selective effective inhibitors of glycogen phosphorylase for the treatment of type II diabetes has

102 lin-dependent kinase 5) from Cdk2, thymidine phosphorylase from a bacterial homologue, and dihydrofol

103 e phosphorolysis, using enzymes cellodextrin phosphorylase from Clostridium stercorarium or Clostridi

104 stingly, deletion of the methylthioadenosine phosphorylase gene (MTAP) results in accumulation of the

105 Deletion of the putative nucleoside phosphorylase gene deoD resulted in an inability of H. p

106 a primer complementary to the polynucleotide phosphorylase gene revealed two major extension products

107 ranscriptional repression of GDP-l-galactose phosphorylase (GGP), a major control enzyme in the ascor

108 cations between orthologs of GDP-L-galactose phosphorylase (GGP), dehydroascorbate reductase (DHAR),

109 es, although recently, a family of glycoside phosphorylases, GH130, have also been shown to target be

110 ity in P-HFF versus P and increased glycogen phosphorylase (GP) activity in both P (1.7-fold greater

111 Glycogen phosphorylase (GP), a key enzyme in glycogen metabolism,

112 GMPMT was compared with glycogen phosphorylase (GP).

113 tivity against glycogen synthase (GS) and/or phosphorylase (GP).

114 gainst muscle and liver isoforms of glycogen phosphorylase (GP).

115 We show that phosphorylated glycogen phosphorylase (GPa), glycogen synthase (GSa) - respectiv

116 isiae, neutral trehalase (Nth1) and glycogen phosphorylase (Gph1), and show that their activities are

117 that glycogen synthase (gsn) mRNA, glycogen phosphorylase (gpn) mRNA, and glycogen levels, accumulat

118 Glycoside phosphorylases (GPs) catalyze the phosphorolysis of glyc

119 eoxyribose-1-phosphate by the host thymidine phosphorylase greatly increases the sensitivity of phage

120 Recently, one subfamily, the uridine phosphorylases, has been subdivided into two types which

121 Human MTA phosphorylase (hMTAP) has a transition state structure c

122 omolar inhibitors of human purine nucleoside phosphorylase (hPNP).

123 Human polynucleotide phosphorylase (hPNPase(old-35)) is an evolutionary conse

124 Human polynucleotide phosphorylase (hPNPase(old-35)), a type I IFN-inducible

125 Overexpressed human thymidine phosphorylase (hTP) has been associated with cancer aggr

126 Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) ho

127 Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) ho

128 Selective inhibitors of human uridine phosphorylase (hUP) have been proposed as a strategy to

129 thin the greater radiation of the nucleoside phosphorylase/hydrolase-peptide/amidohydrolase fold prio

130 ng likely organellar enzymes: polynucleotide phosphorylase, hydrolytic exoribonuclease, poly(A) polym

131 erase; (ii) LipP, a 5'-amino-5'-deoxyuridine phosphorylase; (iii) LipM, a UTP:5-amino-5-deoxy-alpha-D

132 arly, PI3K/AKT pathway was also activated by phosphorylase in LMP1-induced CD44(+/High) cells.

133 te the activity of the enzyme polynucleotide phosphorylase in Streptomyces species.

134 sequence annotated as a putative nucleoside phosphorylase in the Trypanosoma cruzi genome was overex

135 xplains the occurrence of unexpected uridine phosphorylases in some genomes.

136 olism-related gene MTAP (methylthioadenosine phosphorylase) in SSM resulted in reduced cell growth.

137 erglycemia to directly hyperinhibit glycogen phosphorylase, in turn blocking glycogenolysis causing t

138 )) were measured with and without a glycogen phosphorylase inhibitor (GPI) using [2-(3)H]glucose, [3-

139 Forodesine, a purine nucleoside phosphorylase inhibitor, displays in vitro activity in c

140 Uridine phosphorylase is a key enzyme in the pyrimidine salvage

141 Glycogen phosphorylase is a key enzyme in the regulation of glyco

142 de phosphorylase but not methylthioadenosine phosphorylase is responsible for mammalian nicotinamide

143 Glycogen phosphorylase is the key enzyme that breaks down glycoge

144 atural starch metabolism catalyzed by starch phosphorylase, isoamylase is essential to debranch alpha

145 The glycogen phosphorylase isoenzyme BB (GPBB) was detected during ea

146 ists of three isoenzymes, including glycogen phosphorylase isoenzyme BB (GPBB).

147 orter (MEX1), the activity of the plastidial phosphorylase isozyme (PHS1) is increased.

148 hat in normally grown plants, the plastidial phosphorylase isozyme participates in transitory starch

149 In the brain, both muscle and brain glycogen phosphorylase isozymes regulate glycogen mobilization.

150 Phosphorylase kinase (PhK) is a hexadecameric (alphabeta

151 Phosphorylase kinase (PhK), an (alphabetagammadelta)(4)

152 activation loop with a homologous loop from phosphorylase kinase 1 (Ire1(PHK)).

153 Glycogen phosphorylase kinase activates glycogen phosphorylase, t

154 minant manner to completely inhibit glycogen phosphorylase kinase enzyme activity and that this inter

155 oxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron avail

156 n in the catalytic subunit of liver glycogen phosphorylase kinase in a patient with Mauriac syndrome

157 's mother possessed the same mutant glycogen phosphorylase kinase subunit, but did not have diabetes

158 sion of GDP-Man pyrophosphorylase, GDP-l-Gal phosphorylase, l-Gal-1-phosphate phosphatase, GDP-Man-3'

159 by mutations in the gene encoding thymidine phosphorylase, leading to reduced enzymatic activity, to

160 Four selected proteins, uridine phosphorylase-like protein-1, protein 21.1 (GL50803_2792

161 ant worms, suggesting that the GDP-D-glucose phosphorylase may function to remove GDP-D-glucose forme

162 21 mimics into LMP1-transformed cells led to phosphorylase-mediated activation of the PI3K/AKT pathwa

163 5'-Methylthioadenosine phosphorylase (MTAP) and 5'-methylthioadenosine nucleosi

164 Methylthioadenosine phosphorylase (MTAP) and the tumor suppressor genes CDKN

165 ity was identified as 5'-methylthioadenosine phosphorylase (MTAP) based on its biochemical properties

166 that loss of the enzyme methylthioadenosine phosphorylase (MTAP) confers a selective dependence on p

167 doMet) salvage enzyme 5'-methylthioadenosine phosphorylase (MTAP) has been implicated as both a cance

168 e polyamine enzyme methylthioadenosine (MTA) phosphorylase (MTAP) in 36% of lines, transcription fact

169 5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine s

170 Human 5'-methylthioadenosine phosphorylase (MTAP), a reported anticancer target, cata

171 e salvage pathway enzyme methylthioadenosine phosphorylase (MTAP), frequently deleted in cancer, affe

172 e cancer (CaP) relies on methylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme, to relie

173 lacking expression of 5'-methylthioadenosine phosphorylase (MTAP).

174 ons of the gene encoding methylthioadenosine phosphorylase, MTAP.

175 c MSP functions via sequential action of MTA phosphorylase (MtnP), 5-(methylthio)ribose-1-phosphate i

176 gradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al.

177 a class of dual-activity mannosyltransferase/phosphorylases (MTPs) that catalyze both the sugar nucle

178 ation of phosphoglycerate mutase 2, glycogen phosphorylase muscle form, pyruvate kinase muscle isozym

179 e form of Rac 1 GTPase binds to the glycogen phosphorylase muscle isoform (PYGM) and modulates its en

180 emically characterized a putative nucleoside phosphorylase (NP) from the pathogenic protozoan Trypano

181 substrate specificity of UhgbMP, a mannoside phosphorylase of the GH130 protein family discovered by

182 ene expression products as the GDP-D-glucose phosphorylases of these organisms.

183 , cellobiose phosphorylase, and alpha-glucan phosphorylase originating from bacterial, fungal, and pl

184 A level by 20-30%, and KO of GDP-L-galactose phosphorylase (OsGGP) by 80%, while KO of myo-inositol o

185 terized two evolutionarily divergent uridine phosphorylases, PcUP1 and PcUP2 from the oomycete pathog

186 arum purine salvage enzyme purine nucleoside phosphorylase (PfPNP) is a potential drug target.

187 It was mediated by activation of phosphorylase phosphatase, inactivation of glycogen phos

188 sides STARCH SYNTHASE4 (SS4), the PLASTIDIAL PHOSPHORYLASE (PHS1) also seems to be involved, since dp

189 the 3' to 5' exoribonuclease polynucleotide phosphorylase (PNP) and additional nucleases are all inv

190 Purine nucleoside phosphorylase (PNP) and xanthine oxidase (XOD) were co-i

191 Human purine nucleoside phosphorylase (PNP) belongs to the trimeric class of PNP

192 sampling study with heavy purine nucleoside phosphorylase (PNP) characterized the experimentally obs

193 otein, 70 kDa (ZAP70), and purine nucleoside phosphorylase (PNP) deficiencies had low responses, pati

194 Purine nucleoside phosphorylase (PNP) deficiency is a rare form of autosom

195 n the rNDP pools generated by polynucleotide phosphorylase (PNP) degradation of RNA is responsible fo

196 Human purine nucleoside phosphorylase (PNP) forms a ribocation-like transition s

197 bitors of glycosidases and purine nucleoside phosphorylase (PNP) have been synthesized via selective

198 desine is a new and potent purine nucleoside phosphorylase (PNP) inhibitor.

199 Human purine nucleoside phosphorylase (PNP) is a homotrimer binding tightly to t

200 Purine nucleoside phosphorylase (PNP) is an important enzyme in purine met

201 Purine nucleoside phosphorylase (PNP) is part of the human purine salvage

202 as potential inhibitors of purine nucleoside phosphorylase (PNP) isolated from peripheral blood monon

203 Polynucleotide phosphorylase (PNP) plays a central role in RNA degradat

204 Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated T-cells an

205 icine in 1959 for discovering polynucleotide phosphorylase (PNP), the first enzyme found to synthesiz

206 barrier-crossing) in human purine nucleoside phosphorylase (PNP).

207 the chemical step of human purine nucleoside phosphorylase (PNP).

208 he catalytic site of human purine nucleoside phosphorylase (PNP).

209 ditionally, we identified the Polynucleotide Phosphorylase PNPase as a repressor of yeeJ transcriptio

210 letions of the genes encoding polynucleotide phosphorylase (PNPase) and RNase R had little effect on

211 sembly in mutants lacking the polynucleotide phosphorylase (PNPase) binding domain led to a significa

212 Polynucleotide phosphorylase (PNPase) catalyzes RNA polymerization and

213 reported that mutation in the polynucleotide phosphorylase (PNPase) coding gene pnp increases the lev

214 ated that the exoribonuclease polynucleotide phosphorylase (PNPase) facilitates survival of Campyloba

215 t Rsr and the exoribonuclease polynucleotide phosphorylase (PNPase) form an RNA degradation machine t

216 rved 3'-to-5' exoribonuclease polynucleotide phosphorylase (PNPase) has an indispensable role in para

217 Polynucleotide phosphorylase (PNPase) is a processive exoribonuclease t

218 rn blotting demonstrated that polynucleotide phosphorylase (PNPase) levels increased in the rnc mutan

219 exoribonucleases RNase R and polynucleotide phosphorylase (PNPase) play critical roles in degrading

220 Polynucleotide phosphorylase (PNPase) plays synthetic and degradative r

221 Escherichia coli polynucleotide phosphorylase (PNPase) primarily functions in RNA degrad

222 in which the exoribonuclease polynucleotide phosphorylase (PNPase) removes the Rho-independent trans

223 ppressor of Var1 3) dimer and polynucleotide phosphorylase (PNPase) trimer form a 330-kDa heteropenta

224 ltransferase (Ntr) family and polynucleotide phosphorylase (PNPase) was examined.

225 Previously, we localized polynucleotide phosphorylase (PNPASE), a 3' --> 5' exoribonuclease and

226 Polynucleotide phosphorylase (PNPase), a 3'-to-5' phosphorolytic exorib

227 RNase E, the exoribonuclease polynucleotide phosphorylase (PNPase), a DEAD-box RNA helicase and the

228 c-di-GMP target in E. coli is polynucleotide phosphorylase (PNPase), an important enzyme in RNA metab

229 portantly, cells also lacking polynucleotide phosphorylase (PNPase), and dependent for growth on RNas

230 eam products were degraded by polynucleotide phosphorylase (PNPase), and the downstream products were

231 d degradosome-related enzymes polynucleotide phosphorylase (PNPase), ATP-dependent RNA helicase (RhlE

232 RNase J1, RNase J2, RNase Y, polynucleotide phosphorylase (PNPase), enolase, phosphofructokinase, an

233 The RNA import component, polynucleotide phosphorylase (PNPASE), facilitates transfer of this hyb

234 osphorolytic exoribonuclease, polynucleotide phosphorylase (PNPase), has previously been shown to be

235 es, RNases II, R, and PH, and polynucleotide phosphorylase (PNPase), participate in maturation of the

236 s, of which two, RNase PH and polynucleotide phosphorylase (PNPase), use inorganic phosphate as a nuc

237 exonuclease turnover enzyme, polynucleotide phosphorylase (PNPase), was shown previously to cause a

238 ns in a mutant strain lacking polynucleotide phosphorylase (PNPase), which is considered the major 3'

239 bolism is the exoribonuclease polynucleotide phosphorylase (PNPase), whose reversible activity is gov

240 ase D, RNase BN, RNase II and polynucleotide phosphorylase [PNPase]) to generate the mature CCA termi

241 Purine nucleoside phosphorylases (PNPs) and uridine phosphorylases (UPs) a

242 ments, we found evidence that polynucleotide phosphorylase processivity was inhibited by a GCGGCCGC s

243 roperties due to enzyme inhibition (glycogen phosphorylase, protein tyrosine phosphatase 1B) or by in

244 mmunication bridge is essential for glycogen phosphorylase (PYG) activation through the canonical pat

245 nd gluconeogenesis, including liver glycogen phosphorylase (PYGL), phosphoenolpyruvate carboxykinase

246 spectrometry the muscle isoform of glycogen phosphorylase (PYGM) as a novel Rac1 effector molecule i

247 ry pathway of the muscle isoform of glycogen phosphorylase (PYGM) that plays an important role in reg

248 ly, mycoplasma-derived pyrimidine nucleoside phosphorylase (PyNP) activity indirectly potentiated dea

249 tion of protein spots identified as glycogen phosphorylase, pyruvate kinase muscle isozyme, isoforms

250 Thymidine phosphorylase replacement has been achieved by allogenei

251 acid transporter (CAT4) and a polynucleotide phosphorylase resistant to inhibition with fosmidomycin.

252 Deletion of glgB or glgP (glycogen phosphorylase) resulted in defective growth and increase

253 A phosphorylase (Rhodospirillum rubrum) or separate nucleo

254 We identified a phosphorylase sequence from Ochromonas spp. (OcP1) toget

255 Crystal structure of this uridine phosphorylase showed strict conservation of key residues

256 with rabbit muscle and human liver glycogen phosphorylases showed that the (R)-imidazolinones were 1

257 -monophosphate as the source of the sugar, a phosphorylase strategy to generate a sugar-1-phosphate,

258 The nucleotide phosphorylase superfamily 1 encompasses a number of diff

259 The findings imply that the nucleoside phosphorylase superfamily 1 evolved through a series of

260 tive sites of glycogen synthase and glycogen phosphorylase support the idea of a common catalytic mec

261 T. brucei methylthioadenosine phosphorylase (TbMTAP) was found to be responsible for t

262 tion state for the Trypanosoma cruzi uridine phosphorylase (TcUP) reaction has an expanded S(N)2 char

263 ctivity was biochemically determined to be a phosphorylase that could reversibly catalyze adenosine +

264 ucted with a proteolytically derived form of phosphorylase that lacked the N-terminus (phosphorylase

265 led that A. fumigatus contains two trehalose phosphorylases that may be responsible for trehalose pro

266 t the helical organization of polynucleotide phosphorylase, the cytoskeletal-like organization of eno

267 ogen phosphorylase kinase activates glycogen phosphorylase, the enzyme that catalyzes the first step

268 are structurally related to bacterial mannan phosphorylases, they constitute a distinct family of gly

269 sine, which is readily converted by the DeoD phosphorylase to deoxyribose-1-phosphate, the critical i

270 cose levels physiologically inhibit glycogen phosphorylase to diminish glucose release from the liver

271 In this study, we describe the ability of phosphorylases to participate in the breakdown of human

272 Accordingly, we have generated thymidine phosphorylase (TP) and uridine phosphorylase (UP) double

273 1 (TK1), thymidylate synthase, and thymidine phosphorylase (TP) were analyzed by Western blot and imm

274 ons in TYMP gene, encoding nuclear thymidine phosphorylase (TP).

275 de functional domains of TPS and trehalose-6-phosphorylase (TPP) in tandem as a fused gene product of

276 lycerate mutase 2, beta enolase and glycogen phosphorylase), transport proteins (fatty acid-binding p

277 Crystals of bovine uridine phosphorylase treated with 2'-deoxyuridine and sulfate s

278 idine and sulfate and dimeric bovine uridine phosphorylase treated with 5-fluoro-2'-deoxyuridine or u

279 ucture of hexameric Escherichia coli uridine phosphorylase treated with 5-fluorouridine and sulfate a

280 Platelets contain abundant thymidine phosphorylase (TYMP), which is highly expressed in disea

281 YMS, thymidine kinase 1 (TK-1) and thymidine phosphorylase (TYMP).

282 Here, we now identify thymidine phosphorylase (TYMP; previously known as endothelial cel

283 ifically to one DNA half-site of the uridine phosphorylase (udp) operator.

284 Alpha skeletal actin, glycogen phosphorylase, unnamed protein product (UNP) similar to

285 ted thymidine phosphorylase (TP) and uridine phosphorylase (UP) double knockout (TP(-/-)UP(-/-)) mice

286 ophosphate decarboxylase (OMPDC) and uridine phosphorylase (UP) genes.

287 Uridine phosphorylase (UP) is a key enzyme of pyrimidine salvage

288 the pyrimidine salvage pathway, the uridine phosphorylase (UP) salvage activity was knocked out and

289 nucleoside phosphorylases (PNPs) and uridine phosphorylases (UPs) are closely related enzymes involve

290 ecial polypeptide cap in potato alpha-glucan phosphorylase was essential to push a partially hydrolyz

291 The highest expression of GDP-D-glucose phosphorylase was found in the nervous and male reproduc

292 bsence of the exoribonuclease polynucleotide phosphorylase was markedly diminished when the RNase II

293 debranching enzymes, pullulanase, and starch phosphorylases were largely down-regulated.

294 ll wall invertase, alpha-amylase, and starch phosphorylase) were expressed at higher levels in stem s

295 ssed either MTN or human methylthioadenosine phosphorylase (which metabolizes MTA without producing M

296 affected in theVTC2 gene encoding GDP-l-Gal phosphorylase, which catalyzes the first committed step

297 at of characterized GH149 beta-(1->3)-glucan phosphorylases, which operate on acceptors with DP >= 1.

298 urther show that a complex of polynucleotide phosphorylase with the direct oxygen sensors DosC and Do

299 e evolution of uridine and purine nucleoside phosphorylases with respect to DNA/RNA metabolism and wi

300 neity, and shown to be a homodimeric uridine phosphorylase, with similar specificity for uridine and