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1 utations resulting in lower abundance of the phosphorylated protein.
2 e previous lower-resolution structure of the phosphorylated protein.
3 as Delta Np63 alpha, and it was present as a phosphorylated protein.
4 tent with a chaperoning role for this highly phosphorylated protein.
5 er reaction and decrease in stability of the phosphorylated protein.
6 also observed in the presence of the 97-kDa phosphorylated protein.
7 RasGAP, and an unidentified 145-kDa tyrosine-phosphorylated protein.
8 ipitate with an unidentified 87 kDa tyrosine-phosphorylated protein.
9 ed an additional 2 mol of phosphate into the phosphorylated protein.
10 be easily modified to evaluate any tyrosine-phosphorylated protein.
11 serines are replaced with glutamate to mimic phosphorylated protein.
12 nd IRAK4 mRNA as well as increased total and phosphorylated protein.
13 me-mediated degradation of the mature, fully phosphorylated protein.
14 plex between c-Src and at least one tyrosine-phosphorylated protein.
15 This study revealed a plethora of newly phosphorylated proteins.
16 c kinase activity and PP2-sensitive tyrosine-phosphorylated proteins.
17 reflecting the experimental data, including phosphorylated proteins.
18 ern blotting with antibodies specific to the phosphorylated proteins.
19 Western blotting with antibodies specific to phosphorylated proteins.
20 motility, and alters the pattern of tyrosine phosphorylated proteins.
21 tacts containing enriched levels of tyrosine-phosphorylated proteins.
22 ellular location, and/or turnover of certain phosphorylated proteins.
23 trometric analysis of proteolytic digests of phosphorylated proteins.
24 rafts colocalized with the BCR and tyrosine-phosphorylated proteins.
25 when the SH2 domains of p85 bind to tyrosyl-phosphorylated proteins.
26 tion and proteasome-dependent degradation of phosphorylated proteins.
27 ate the conformation and function of certain phosphorylated proteins.
28 o catalyze the dephosphorylation of tyrosine-phosphorylated proteins.
29 greatly enhanced by enriching the sample of phosphorylated proteins.
30 -induced functional changes in other heavily phosphorylated proteins.
31 phosphate groups, such as phospholipids and phosphorylated proteins.
32 components paxillin, vinculin, and tyrosine-phosphorylated proteins.
33 as associated with 100- and 180-kDa tyrosine phosphorylated proteins.
34 ellular activity by binding and sequestering phosphorylated proteins.
35 regulation of the turnover of sumoylated and phosphorylated proteins.
36 tography (IMAC), which specifically binds to phosphorylated proteins.
37 oxal 5'-phosphate (PLP) and serine/threonine-phosphorylated proteins.
38 nes by lowering the levels of both total and phosphorylated proteins.
39 hich are known to interact with and regulate phosphorylated proteins.
41 cumulation of tyrosine- and serine/threonine-phosphorylated proteins, a marked increase in cellular T
42 ppressor protein with various functions) and phosphorylated proteins (Abraxas/BACH1/CtIP), implicated
45 tified 11,552 distinct nonmodified and 2,852 phosphorylated proteins across the four root tissues.
49 AT5B mutations are associated with increased phosphorylated protein and a growth advantage to transdu
50 on the simultaneous measurement of multiple phosphorylated protein and phospholipid components in th
51 t, in dark-grown seedlings, NPH3 exists as a phosphorylated protein and that BL stimulates its dephos
52 n this study, we demonstrate that Atg29 is a phosphorylated protein and that this modification is cri
54 nd vinculin, have a central core of tyrosine phosphorylated proteins and are depleted of integrins at
55 in proteomics studies to effectively detect phosphorylated proteins and avoid time-consuming and exp
56 e results in decreased affinity for tyrosine-phosphorylated proteins and decreased PI3K membrane loca
57 ieval of rich biological information for the phosphorylated proteins and facilitates database annotat
58 mass spectrometry identification of tyrosine phosphorylated proteins and growth inhibition in the pre
59 ytes, M-CSF increased the levels of tyrosine-phosphorylated proteins and induced Akt activation in a
61 orylation, decreased the numbers of tyrosine-phosphorylated proteins and levels of type I collagen, a
62 ation of PI3-kinase associated with tyrosine-phosphorylated proteins and of p85/PI3-kinase associated
63 ing network describing the interaction of 11 phosphorylated proteins and phospholipids in human immun
64 tes the conformation and function of certain phosphorylated proteins and plays an important role in c
67 to both substrates and appropriate tyrosine-phosphorylated proteins and therefore can compete with t
68 Among the information were three partially phosphorylated proteins and three proteins heterozygous
69 ome mobility shift assays with both in vitro-phosphorylated proteins and with point mutants bearing n
72 s demonstrate that both Vac8p and Apg13p are phosphorylated proteins, and Apg13p phosphorylation is r
73 plicable to serine-, threonine- and tyrosine-phosphorylated proteins, and is capable of selectively i
75 th ligand stimulation, a broader spectrum of phosphorylated proteins appears compared with EGF-treate
78 the past, identifying spectral variations in phosphorylated proteins arising from either the phosphat
80 immunoprecipitates for the existence of such phosphorylated proteins as targets for barrier regulatio
82 rometric identification of a 155-kD tyrosine phosphorylated protein associated with src homologous an
83 pectrometry was used to identify three major phosphorylated proteins associated with this PSI-Cyt b(6
85 chromatin-associated proteins, with the most phosphorylated protein band being near the same molecula
86 light chain 2 were identified in the highly phosphorylated protein bands with the highest scores.
88 VCaB45 are modulated by phosphorylation; the phosphorylated protein binds up to 100-fold more calcium
91 ed with the tryptic digests of the naturally phosphorylated proteins bovine alpha- and beta-casein.
92 ide G(M1), a lipid raft marker, and tyrosine-phosphorylated proteins, but not CD45 and transferrin re
93 ells showed a small set of discrete tyrosine-phosphorylated proteins, but these proteins were not rec
95 in a sequential gel staining procedure, the phosphorylated proteins can be visualized in the same ge
96 duced specific differences in the pattern of phosphorylated proteins, caused changes in lipid metabol
98 table differences in the pattern of tyrosine phosphorylated proteins compared with that obtained in c
99 r networks indicated differences in tyrosine phosphorylated proteins compared with the poorly aggress
105 The availability of large pools of tyrosine-phosphorylated proteins derived from normal tissues faci
106 ed by MALDI-MS was then utilized to identify phosphorylated proteins detected by autoradiography.
107 E4 in the Nova-1 pre-mRNA itself, encoding a phosphorylated protein domain, as an additional target o
108 teome analysis identified 310 differentially phosphorylated proteins (DP) from 350 phosphopeptides wi
109 d recombinant PP(240), and the native highly phosphorylated protein (equivalent to the PP(523) isofor
114 les (AuNPs) can then be attached to the thio-phosphorylated proteins, forming a Au-film/AuNP plasmoni
115 hat is suited for nucleocapsid assembly, and phosphorylated protein forms a liquid-like compartment f
116 ion of TGF beta1, Smad2, and Samd3 and their phosphorylated protein forms, and cell cycle inhibitors,
117 e have partially purified a 105-kDa tyrosine-phosphorylated protein from platelets stimulated with ph
118 zation Protein 1 (CMP-1), an abundant mildly phosphorylated protein from the flexible membrane sugges
119 phosphorylated peptides corresponding to 449 phosphorylated proteins from 200 mug of zebrafish embryo
120 1 interacted with a small subset of tyrosine-phosphorylated proteins from lysates of the human breast
121 we performed a global profiling of tyrosine-phosphorylated proteins from mutant Kit-driven murine le
122 included redistribution of epithelial serine-phosphorylated proteins from the cytoplasm to the nucleu
123 the levels of the early apoptosis-associated phosphorylated protein, H2A-X (ser 139), as well as decr
124 have opposing effects on degradation of the phosphorylated protein; Hsp90 is protective, whereas Hsp
129 ote cell migration, as a major hyper-tyrosyl-phosphorylated protein in mouse and zebrafish models of
133 y proteomic approaches were used to identify phosphorylated proteins in a chronic pressure-induced ra
135 -Cbl is one of the most prominently tyrosine-phosphorylated proteins in Bcr-Abl-expressing cells.
137 blot analysis, enables detection of specific phosphorylated proteins in complex mixtures such as cell
138 ever, current methods for analyzing tyrosine-phosphorylated proteins in crude protein extracts provid
139 kinase) substrates indicated the presence of phosphorylated proteins in cytosolic, membrane, and nucl
140 mutant (YF-Brk) and associates with tyrosine-phosphorylated proteins in deregulated signaling complex
141 d by immunoaffinity purification of tyrosine-phosphorylated proteins in GIST cells before and after t
142 Phosphoprotein profiling identified diverse phosphorylated proteins in glutamate-treated SCs in addi
143 SHP-1 is associated with two major tyrosine-phosphorylated proteins in hematopoietic cells treated w
145 n cell culture (SILAC), to identify tyrosine phosphorylated proteins in isogenic human bronchial epit
147 we found there were complex interactions of phosphorylated proteins in modulating cancer stemness in
148 low abundance tissue-annotated proteins and phosphorylated proteins in plasma, as well as quantitate
151 ing set of serine-, threonine-, and tyrosine-phosphorylated proteins in the Archaea that may offer ne
153 s in the rapid accumulation of many tyrosine-phosphorylated proteins in the liver and kidney of treat
156 sphoisoform-specific regulation of histidine-phosphorylated proteins in vivo, and we link these modif
157 , we analyzed the levels of nuclear tyrosine phosphorylated proteins in WT and Itgalpha1-null kidney
159 GP Ib, and associates with several tyrosine-phosphorylated proteins including the Fc receptor gamma-
160 hich, when activated, initiates a cascade of phosphorylated proteins including the SRC family of kina
163 ormed stable complexes with several tyrosine-phosphorylated proteins, including PLCgamma2, only in Bt
164 lls, SLAP-2 associated with several tyrosine phosphorylated proteins, including the ubiquitin ligase
165 were incubated with ATP, the peak levels of phosphorylated proteins increased in the presence of the
166 domains serve an essential role as histidine-phosphorylated protein intermediates during phosphoryl t
167 CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organiza
168 croscopy studies revealed that this tyrosine-phosphorylated protein is localized to the cytoplasmic f
170 RAP-HAP interaction in the N-terminus of the phosphorylated protein is very stable to changing soluti
173 nformation and function of a subset of these phosphorylated proteins is regulated by the prolyl isome
175 respectively, compared with the gel from non-phosphorylated protein isolate at the same ZnSO4 level,
176 at the same ZnSO4 level, suggesting that the phosphorylated protein isolate was more crosslinked by Z
177 lts, we observed >50% reduction in levels of phosphorylated protein kinase B (Akt) and H3K36me3 in bo
178 The contents of GLUT1, GLUT4, total and phosphorylated protein kinase B (Akt), phosphorylated AM
179 n analysed for cell growth and expression of phosphorylated protein kinase B (Akt/PKB) and MMAC1/PTEN
180 tenuated senescence in part by up-regulating phosphorylated protein kinase B (p-AKT) and decreasing p
181 uch as phosphatidylinositol 3-kinase (PI3K), phosphorylated protein kinase B (PKB; also known as Akt)
182 n by more than 50% (of phosphorylated IGF1R, phosphorylated protein kinase B, and phosphorylated MAPK
183 lated extracellular signal-regulated kinase, phosphorylated protein kinase B, phosphorylated mammalia
184 n chromosome 10 protein, whereas the mass of phosphorylated protein kinase B/Akt was increased by C3a
185 ociation with an increase in CaR protein and phosphorylated protein kinase C alpha and beta in caveol
186 on chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-H
187 Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppressio
188 ACSL1 kd adipocytes displayed an increase in phosphorylated protein kinase C and phosphorylated JNK,
191 such as PEP005, reduced alpha-synuclein and phosphorylated protein kinase Calpha levels while increa
192 ation of soluble alpha-synuclein protein and phosphorylated protein kinase Calpha, as well as reduced
193 nfolded protein response (UPR), specifically phosphorylated protein kinase R-like endoplasmic reticul
194 tein were accompanied by increased levels of phosphorylated protein kinase R-like ER kinase (pPERK),
195 s: (a) the survival/rescue molecules such as phosphorylated protein kinase-like ER-resident kinase (p
198 K and its association with specific tyrosine-phosphorylated proteins may be important in insulin and
200 small interfering RNA to deplete a subset of phosphorylated proteins not previously linked to thrombi
201 was no difference in the pattern of tyrosine-phosphorylated proteins observed following stimulation o
202 lioside G(M1) and cholesterol where tyrosine phosphorylated proteins occur at late anaphase at the co
203 main of CMS bound specifically to a tyrosine-phosphorylated protein of 120 kDa, which we identified a
205 imulated by casein kinase 2 (CK2) and that a phosphorylated protein of approximately 85 kDa is presen
209 Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated wi
211 al immunosensor has been developed to detect phosphorylated proteins, phospho-p53(15) and phospho-p53
212 presents extracted phosphorylation objects (phosphorylated proteins, phosphorylation sites and prote
215 SHPS-1 also associates with two tyrosine-phosphorylated proteins (pp55 and pp130) and a protein t
217 crease is the appearance of several tyrosine phosphorylated proteins present only in differentiated c
219 ,4,5)P3] and Src homology 2 domain [tyrosine-phosphorylated proteins, PtdIns(3,4,5)P3] of PLC-gamma;
221 e and the interaction of AuNPs with the thio-phosphorylated proteins quantified by quartz crystal mic
222 However, after purification, the highly phosphorylated protein readily formed oligomers, whereas
223 on the contrary, detected similar amounts of phosphorylated proteins regardless of sex or gonad devel
224 14-3-3 proteins via binding serine/threonine-phosphorylated proteins regulate diverse intracellular p
225 fied protein required for NMD; (ii) SMG-2, a phosphorylated protein required for NMD in worms, yeasts
233 Diatom biomineralization involves highly phosphorylated proteins (silaffins and silacidins), anal
234 or for the selective detection of proximally phosphorylated protein sites, suitable for application i
235 ng in a less active form of PGI, whereas non-phosphorylated protein species retain cytokine activity.
236 phosphoproteins, and include several highly phosphorylated proteins such as MAP1B (33 sites) and Bas
237 es directed against known 60-70-kDa tyrosine-phosphorylated proteins suggest that pp68 may be a novel
238 he transcriptional activity of the wild-type phosphorylated protein, suggesting that the negative cha
241 trate, was originally identified as a highly phosphorylated protein that is localized to focal adhesi
242 ve identified a high-molecular-mass tyrosine-phosphorylated protein that is rapidly phosphorylated on
244 CKAP4 is a reversibly palmitoylated and phosphorylated protein that links the ER to the cytoskel
245 le minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating n
247 Phosphopeptides derived from aberrantly phosphorylated proteins that are presented on tumors and
251 ensing pathways, resulting in alterations of phosphorylated proteins that play a key role in the regu
252 aded filament proteins filensin and CP49 are phosphorylated proteins that undergo proteolytic degrada
255 n signal transduction pathways by binding to phosphorylated proteins to activate, inactivate, or sequ
256 subsequent, specific recruitment of tyrosine phosphorylated proteins to APP, including Lyn and Syk.
257 ly applicable tool to generate conditionally phosphorylated proteins to identify those whose dephosph
260 complexes, acting as E3 ligases that target phosphorylated proteins to ubiquitylation and degradatio
263 ly small; only 7% of glycosylated and 13% of phosphorylated proteins undergo global changes >2 A.
265 able of predicting the global structure of a phosphorylated protein using only knowledge of the struc
266 st Dma1, relay checkpoint signals by binding phosphorylated proteins via their FHA domains and promot
267 d, nine-plex immunoassay measuring total and phosphorylated protein was constructed to measure tempor
268 n of the fusion protein at Ser(523), and the phosphorylated protein was found chiefly in the cytoplas
271 rse of this purification, a 105-kDa tyrosine-phosphorylated protein was only detected in fractions th
272 ns of a direct interaction with tubulin, the phosphorylated protein was released from microtubules.
273 scernible 2.1-fold increase in the number of phosphorylated proteins was detected when the panA gene
274 pecific phosphate binding tag for separating phosphorylated proteins, we found that Gpa2 undergoes ph
275 hotyrosine antibodies to enrich for tyrosine phosphorylated proteins, we have identified a novel sign
279 omes and detergent-resistant membranes, 1622 phosphorylated proteins were detected, including more th
283 hosphopeptides, corresponding to 1701 unique phosphorylated proteins, were identified and quantified.
287 A mutant trapped primarily a 97-kDa tyrosine-phosphorylated protein, which was determined to be VCP (
288 ciated with an approximately 72-kDa tyrosine-phosphorylated protein, which we identify here as G3BP,
289 B also showed increased binding of tyrosine-phosphorylated proteins, which included the negative reg
290 e EGFR was confirmed by analysis of tyrosine phosphorylated proteins, which revealed a rapid, damage-
291 ing affinity for gefitinib is weaker for the phosphorylated protein while for the oncogenic mutant, L
292 domain of the Nck adaptor can bind tyrosine-phosphorylated proteins, while its SH3 domains can modul
295 or molecule CBL, and association of tyrosine-phosphorylated proteins with phosphatidylinositol 3-kina
297 ed by an increase in association of tyrosine-phosphorylated proteins with the adapter protein Grb2.
298 Synaptogyrins comprise a family of tyrosine-phosphorylated proteins with two neuronal (synaptogyrins
299 ed with an increase in the number of Ser/Thr-phosphorylated proteins within the newly dispersed cells
300 egulated by phosphorylation, a means to cage phosphorylated proteins would be generally applicable.