ライフサイエンスコーパス: phosphorylation

1 53 transcriptional activity through tyrosine phosphorylation.

2 by N-acetyl cysteine partially reversed the phosphorylation.

3 ellae into PSI-LHCII supercomplexes upon its phosphorylation.

4 ntriolar receptor through multiple rounds of phosphorylation.

5 sed as a master regulator of tumor oxidative phosphorylation.

6 hinery needed for local control of oxidative phosphorylation.

7 c stimulation impaired ADP-coupled oxidative phosphorylation.

8 e inhibitor blocked TGF-beta1-mediated Smad2 phosphorylation.

9 g NAD+ for glycolysis and NADH for oxidative phosphorylation.

10 ion at the same site, thereby preventing its phosphorylation.

11 ion mechanisms, including ubiquitination and phosphorylation.

12 egulated glycolysis and suppressed oxidative phosphorylation.

13 egulation of genes associated with oxidative phosphorylation.

14 regulate CAP1 by facilitating its transient phosphorylation.

15 tment or deletion of PTPsigma increases TRKB phosphorylation.

16 kinase (PKA) and subsequent cardiac protein phosphorylation.

17 y hijacking PRK and RSK and directing linker phosphorylation.

18 on and reduced myosin light chain (MLC(20) ) phosphorylation.

19 L-17A and IL-6, and increased STAT3 tyrosine phosphorylation.

20 ction of IL-1A and IL-2, as well as Akt/mTOR phosphorylation.

21 by post-translational modifications such as phosphorylation.

22 rylation and increased level of beta-catenin phosphorylation.

23 witch in specificity towards S29 TopoIIalpha phosphorylation, a response necessary for catenation res

24 yses of the transport cycle show that serine phosphorylation abolishes the K(+)-dependence of ATP hyd

25 volve posttranslational modifications (e.g., phosphorylation and acetylation) and DNA binding coopera

26 PPECs, TM2 inhibited thrombin-induced ERK1/2 phosphorylation and activation of Ras homolog gene famil

27 d that NUB1 also mediated a reduction in tau phosphorylation and aggregation following proteasome inh

28 mal changes of neuronal Tau protein, such as phosphorylation and aggregation, are considered hallmark

29 his pocket to inhibit MAPKAP2-mediated HSP27 phosphorylation and depolymerization, thereby blocking H

30 -deficient cells displayed reduced ATM S1981 phosphorylation and diminished formation of gammaH2AX fo

31 ersistent WEE1 activity, which blocks lamina phosphorylation and disassembly.

32 refractory to MFH290 and restored Pol II CTD phosphorylation and DNA damage repair gene expression.

33 SHIP1/SHIP2 reduced cellular survival and S6 phosphorylation and enhanced basal calcium levels in hum

34 pin 1 (PLIN1), which leads to elevated PLIN1 phosphorylation and enhanced lipolysis.

35 ming of tumor metabolism involving oxidative phosphorylation and fatty acid oxidation (FAO) with subs

36 arcinoma consumes citrate to power oxidative phosphorylation and fuel lipogenesis, enabling tumour pr

37 cells with LDL reduces BMP-9-induced SMAD1/5 phosphorylation and gene expression and silencing of CAV

38 ile that reflects a combination of oxidative phosphorylation and glycolysis.

39 , the two mutant viruses induced lower STAT1 phosphorylation and grew to 2-log-higher titers than wil

40 T158A mice show decreased level of GSK-3beta phosphorylation and increased level of beta-catenin phos

41 7 activation can occur independent of T-loop phosphorylation and is thus exclusively MAT1-dependent b

42 kappaB transcription-activating group P65 by phosphorylation and nuclear translocation.

43 Besides, decreased hypothalamic STAT3-phosphorylation and Pomc expression were found after twe

44 LRP6 of the Wnt signalosome to enhance LRP6 phosphorylation and potentiate Wnt-beta-catenin signalin

45 These results suggest that PKA-mediated phosphorylation and PP1/PP2A-dependent dephosphorylation

46 ps, an effect associated with increased JNK2 phosphorylation and reduced myosin light chain (MLC(20)

47 Pnhd activity was accompanied by Erk phosphorylation and required FGF and Nodal but not Wnt s

48 counteracting GSK3beta-directed threonine 58 phosphorylation and subsequent FBXW7-mediated proteasoma

49 esses: myeloid cell differentiation, protein phosphorylation and synaptic signaling.

50 ikely due to suppression of thrombin-induced phosphorylation and thereby inactivation of Cofilin1, an

51 that extensive erythrocyte membrane protein phosphorylation and ubiquitination are involved in SCD p

52 tion involving the histone variant H3.3, its phosphorylation, and both the recruitment and the ejecti

53 r PNNs, interacts with TRKB and inhibits its phosphorylation, and chondroitinase treatment or deletio

54 inly conducted via acylation, glycosylation, phosphorylation, and deamidation.

55 Phosphorylation, and thereby activation, of response reg

56 contribution of equilibrium fluctuations to phosphorylation, as evaluated by the ability to predict

57 We demonstrate unequivocally that Katanin phosphorylation at a single residue is necessary and suf

58 Moreover, JNK mediated phosphorylation at an evolutionarily more recent site di

59 influx and inhibits KCC-mediated efflux via phosphorylation at conserved, shared motifs.

60 Phosphorylation at other sites is required for PopP2 but

61 onal bouton by PKC-induced calcium-dependent phosphorylation at Ser-41 (pGAP-43).

62 d that AMP-activated protein kinase-mediated phosphorylation at Ser-99 promotes TET2 stability and in

63 ts on the channel conferred by PKA-dependent phosphorylation at serine-465.

64 ti-apoptotic Bcl-2 by demonstrating that its phosphorylation at serine-70 functions as a redox sensor

65 nantly phosphorylated at multiple sites, yet phosphorylation at specific tyrosines is variable and on

66 oteasomal degradation after meiosis, whereas phosphorylation at the other sites only inhibits Katanin

67 ariable and only a subset of receptors share phosphorylation at the same site, even with saturating l

68 uire the kinase activity of DNA-PKcs and its phosphorylation at the T2609 cluster.

69 bility is regulated through phosphorylation: phosphorylation at Thr58 signals degradation while Ser62

70 This implies that abnormal phosphorylations at certain sites may not affect the ext

71 Conversely, phosphorylation-blocking substitutions at these sites en

72 y confirmed the role of Fam20C itself in OPN phosphorylation, but also revealed that phosphorylation

73 Notably, OSCA1.3 and its phosphorylation by BIK1 are critical for stomatal closur

74 SYP-1 phosphorylation by CDK-1 occurs just before meiotic onse

75 this pseudophosphatase functions in tyrosine phosphorylation by competing with active phosphatases fo

76 pathway involving direct HDAC5 tyrosine 642 phosphorylation by focal adhesion kinase (FAK), a HDAC5

77 mpetitors attenuated YAP1 recruitment to and phosphorylation by LegK7.

78 e bearing a Speg(3A) mutation to prevent its phosphorylation by PKB display cardiac dysfunction.

79 Activation of AMPK requires phosphorylation by the liver kinase B1 or by the Ca(2+)/

80 ated by ERK1/2, which in turn suppresses its phosphorylation by ULK1.

81 binding, beta-arrestin2 recruitment, ERK1/2 phosphorylation, cAMP inhibition) and in vivo (anxiety-l

82 cluding MAPKs, in turn regulated by multiple phosphorylation cascades.

83 This compromised oxidative phosphorylation, causing severe oxidative stress.

84 ed CXCR4 agonist activity as measured by ERK phosphorylation, chemotaxis, and G(i/o)-mediated cAMP in

85 ptor gamma coactivator 1-alpha and oxidative phosphorylation complex II and III were significantly lo

86 ecific nuclear-encoded subunits in oxidative phosphorylation complexes I and V increased in CLPP2 kno

87 Our data indicate that Y155 phosphorylation constitutes a novel regulatory mechanism

88 d region (C-IDR), remaining disordered after phosphorylation, contains the secondary eIF4E-binding si

89 MAF1 represses Pol III transcription and how phosphorylation controls this process.

90 , but there were no differences in oxidative phosphorylation coupling efficiency or membrane potentia

91 this inhibitory phosphorylation in vivo, new phosphorylation-deficient p53-S180A knock-in mice were g

92 ti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF

93 together, these data suggest that rhodopsin phosphorylation/dephosphorylation modulates the recovery

94 -stream effectors, including DOCK2 and ELMO1 phosphorylation, destabilise the auto-inhibited state to

95 cetylated chromatin, respectively, and BRD4S phosphorylation diminishes BRD4 condensation.

96 Scar/WAVE phosphorylation does not require ERK2 in Dictyostelium o

97 e-465 as the site that elicits PKA-dependent phosphorylation effects on SK2 channel function.

98 d mitochondrial function, of which oxidative phosphorylation emerged as the top-most enriched pathway

99 s, we built a mathematical model for the eS6 phosphorylation (eS6-P) control circuit.

100 we present evidence that deficiency for this phosphorylation event prevents condensin II release from

101 This phosphorylation event reduced eIF2alpha binding to PERK

102 Kinase-mediated phosphorylation events within peripheral blood mononucle

103 Thus, ERK2-mediated PFAS phosphorylation facilitates the increase in nucleic acid

104 ative phosphoproteomics we identified unique phosphorylation fingerprints for each kinase, including

105 surveillance state, microglia use oxidative phosphorylation for their energy supply, but rely on the

106 , we provide genetic evidence that eIF2alpha phosphorylation has a protective role in CMT1B Schwann c

107 tween glycolysis and mitochondrial oxidative phosphorylation has been implicated in macrophage polari

108 Ngamma-response along with STAT-1 and STAT-4 phosphorylation in 29 HCV-infected LTx-recipients and 17

109 We showed that MCP-1 induces Src phosphorylation in a similar time frame and that the MCP

110 However, analyses of HK phosphorylation in biochemical assays in vitro suggest n

111 oxygen species (ROS) levels and Src protein phosphorylation in CD34(+) cells.

112 flicting results regarding the extent of Tau phosphorylation in cells.

113 itro suggest negative cooperativity, whereby phosphorylation in one protomer of the dimer inhibits ph

114 CRK9 depletion also caused a loss of phosphorylation in RPB1, the largest subunit of RNA poly

115 Oxidative phosphorylation in the presence of substrates for ETC an

116 demonstrate the importance of phospholemman phosphorylation in the regulation of vascular tone and B

117 lation in one protomer of the dimer inhibits phosphorylation in the second protomer, leading to ~50%

118 To explore the role of this inhibitory phosphorylation in vivo, new phosphorylation-deficient p

119 N enhances the effects of cocaine on protein phosphorylation, including ERK/MAPK-targets like gephyri

120 In cells Ser429 phosphorylation increases MDM2 autoubiquitination and de

121 G2/M DDR that evolves slowly and involves a phosphorylation-independent proteolytic pathway.

122 , and ferredoxin-dependent transport-coupled phosphorylation indicated anaerobic acetogenesis was cen

123 ding to Cav-1 as well as Src-dependent Cav-1 phosphorylation, indicating the importance of CSD in the

124 In contrast, BGLF2 did not inhibit STAT1 phosphorylation induced by IFN-gamma.

125 It blocked STAT1 tyrosine phosphorylation induced either by type I IFN or overexpr

126 ecular dynamics indicates that Aurora B S227 phosphorylation induces conformational changes and this

127 We find that first, if phosphorylation induces local changes in the flexibility

128 of allogeneic T cell-driven GVHD, oxidative phosphorylation is a main driver of Treg suppressor func

129 Reversible protein phosphorylation is an essential post-translational modif

130 Multisite phosphorylation is an important mechanism of post-transl

131 ame and that the MCP-1-induced Pyk2 tyrosine phosphorylation is controlled by the Src family kinase.

132 However, the function of phosphorylation is controversial and the mechanism of an

133 The extent of phosphorylation is heterogeneous, up to ~20 phosphates p

134 The total accumulation of phosphorylation is reduced by about half when either of

135 ides direct cellular evidence that transient phosphorylation is required for CAP1 functions in both a

136 gene expression, its crosstalk with protein phosphorylation is vital for cell signaling.

137 In the absence of S533 phosphorylation, it was proposed that another inflammaso

138 ion at Thr58 signals degradation while Ser62 phosphorylation leads to its stabilization and functiona

139 different basal and BCR stimulation-induced phosphorylation levels of downstream signaling proteins.

140 n to gel-like condensates and SRPK1-mediated phosphorylation likely helps open up such structures to

141 Failure of eIF2B to sense eIF2 phosphorylation likely leads to unregulated unfolded pro

142 Phosphorylation makes cyclin L2 amenable to cellular deg

143 In zebrafish, SerRSS101D/S241D, a phosphorylation-mimicry mutant, cannot suppress VEGFA ex

144 ptors containing ITAM, ITIM or ITSM tyrosine phosphorylation motifs to the promiscuous cell-surface p

145 get, the CDK inhibitor Sic1, contains linear phosphorylation motifs, docking sites, and phosphodegron

146 sized to regulate BER during CSR, as the AID phosphorylation mutant, AID(S38A), cannot interact with

147 A phosphorylation network is essentially a causal network,

148 Phosphorylation occurred independently of beta(1)-AR act

149 s eIF4E-dependent translation in MPs through phosphorylation of 4E-BP1.

150 Phosphorylation of a conserved threonine motif (T788/T78

151 Here, we report that phosphorylation of a specific tyrosine residue in STING

152 toplasmic tail inhibits the protein kinase C phosphorylation of a threonine and is associated with pr

153 K regulation of ferroptosis to AMPK-mediated phosphorylation of acetyl-CoA carboxylase and polyunsatu

154 Furthermore, phosphorylation of AGO2(Y393) disrupts both the wild-typ

155 Phosphorylation of AID at serine 38 was previously hypot

156 tients with T- or B-cell CAEBV had increased phosphorylation of Akt and S6 in NK cells, but no increa

157 2 receptors and the subsequent PKA-dependent phosphorylation of alpha3GlyRs within the intracellular

158 nt activation of IGPR-1, in turn, stimulates phosphorylation of AMP-activated protein kinase, which l

159 howed pro-apoptotic sensitization by reduced phosphorylation of BAD.

160 Depletion of PP4-complex subunits increases phosphorylation of both Ser666 and the CTR, and promotes

161 in tumor cells was strongly associated with phosphorylation of CDCP1 and PKCdelta (CDCP1_ pY743(+) a

162 udies demonstrated substantial inhibition of phosphorylation of CHK1, the downstream ATR substrate.

163 AZD1775 induced phosphorylation of DNA-PK, protecting cells from replica

164 U3 activates purified DNA-PK and triggers phosphorylation of DNA-PKcs at T2609.

165 reased stemness and tumorspheres by reducing phosphorylation of EGFR family proteins, ERK, FAK, and C

166 We show that inhibitory phosphorylation of eIF2alpha (P-eIF2alpha), a conserved

167 nism for translation inhibition involved the phosphorylation of eIF2alpha, surprisingly mediated by e

168 riggered the integrated stress response, via phosphorylation of eIF2alpha, thus linking these pathway

169 H with both HBV particles and Pam3Cys led to phosphorylation of ERK (extracellular signal-regulated k

170 Phosphorylation of Escherichia coli CheY protein transdu

171 Conversely, genetically reducing phosphorylation of eukaryotic initiation factor 2alpha i

172 cause RLBs did not require protein kinase R, phosphorylation of eukaryotic translation initiation fac

173 hosphoproteomics identify an ITGA2-dependent phosphorylation of focal adhesion kinase and mitogen-act

174 d hepatic insulin sensitivity with increased phosphorylation of FOXO1, reduced expression of PEPCK, a

175 w here that this interaction is regulated by phosphorylation of Frizzled3 at T598 and can be regulate

176 iffness of the microenvironment also induces phosphorylation of gammaH2AX-positive foci.

177 Decades of research have shown how phosphorylation of glutamate receptors mediates protein

178 d acetylation of histones and with increased phosphorylation of H2AX and CHK1, suggesting the modulat

179 Phosphorylation of HDAC7 by the CaMK group member salt-i

180 able by immunofluorescence microscopy, using phosphorylation of histone-variant H2AX (gamma-H2AX) to

181 se signals then leads to activity-associated phosphorylation of IFN regulatory factor-3.

182 ha in vitro, which correlated with decreased phosphorylation of IFN regulatory factory 7 (IRF7) and N

183 d by autophagy stimuli and that it catalyzes phosphorylation of IGPR-1 at Ser(220) The subsequent act

184 olesterol (7-DHC) could specifically promote phosphorylation of IRF3 (not TBK1) and enhance type I in

185 Channel activation is achieved by phosphorylation of its regulatory (R) domain by cAMP-dep

186 Mechanistically, phosphorylation of JMJD3 at Thr-1044 by FGF21 signal-act

187 it remains unknown whether heterogeneity in phosphorylation of key structural proteins alters tissue

188 ate transitions are driven by changes in the phosphorylation of light harvesting complex II (LHCII),

189 er, the TNF-alpha, IL-17A, and IL-22-induced phosphorylation of MAPK and JAK-STAT pathways, and activ

190 Next, we found that activin A regulates phosphorylation of NMDA receptor (NMDAR) subunit GluN2B

191 gain-of-function change, allowing increased phosphorylation of NRAS to enhance melanocyte transforma

192 Kinases are the enzymes that catalyze the phosphorylation of other proteins in a target-specific m

193 In addition, phosphorylation of PCK1 at Ser90, INSIG1 at Ser207 and I

194 lorectal cancer cells, FL3 treatment blocked phosphorylation of PHB1 at Thr258, resulting in its nucl

195 Reversible phosphorylation of Pol II and accessory factors helps or

196 lly, we demonstrate that PDGFRbeta-initiated phosphorylation of PRAS40 is required for TGFbeta-induce

197 Expression and phosphorylation of proteins in the mechanistic target of

198 In contrast, the phosphorylation of RPA by ATR is only detected at TTS, w

199 iation of CCTalpha from the NE and increased phosphorylation of S319.

200 Phosphorylation of Ser(16) was disrupted by the cardiomy

201 In addition, we show that phosphorylation of Ser(3) may be an additional mechanism

202 naling and independent of muscarinic-induced phosphorylation of Ser-239 in vasodilator-stimulated pho

203 2+/PKC, respectively, and further identified phosphorylation of serine 240 on p115 RhoGEF by PKC to b

204 A significant decrease in phosphorylation of signal transducer and activator of tr

205 of SS, inhibition of BMP6 signaling reduced phosphorylation of SMAD1/5/8 in the mouse submandibular

206 PKB-mediated phosphorylation of SPEG activates its second kinase-doma

207 We found that increased phosphorylation of T654 EGFR correlates with increased e

208 t compromise the mitotic checkpoint, nor the phosphorylation of the Aurora B kinetochore substrates H

209 tion in the second protomer, leading to ~50% phosphorylation of the available sites in dimers.

210 ase-II) protein-expression, CaMKII-dependent phosphorylation of the cardiac RyR2 (ryanodine-receptor

211 We show that phosphorylation of the cytoplasmic domain of p14 trigger

212 machinery to slow down protein synthesis via phosphorylation of the eukaryotic initiation factor (eIF

213 Phosphorylation of the FAK family member Pyk2 at tyrosin

214 imulations on eight BAK1 mod-forms involving phosphorylation of the four activation-loop threonine re

215 Activation of TrkC by Nt-3 resulted in phosphorylation of the Igf1R on activating tyrosine resi

216 Phosphorylation of the inhibitory tyrosine of SFKs was a

217 membrane domain and to inhibit CD40-induced phosphorylation of the kinases Lyn and protein kinase C-

218 AMP-activated protein kinase, which leads to phosphorylation of the major pro-autophagy proteins ULK1

219 Phosphorylation of the N-terminal domain of the huntingt

220 In the present study, we show that phosphorylation of the newly introduced Thr residue expl

221 Phosphorylation of the p.Y783 residue is essential for t

222 We show that the phosphorylation of the RNA-DNA binding protein fused in

223 phase chromosomes through Aurora-B-dependent phosphorylation of the SAF-A DNA-binding domain; failure

224 ocal compaction of the disordered chain upon phosphorylation of these mostly singly phosphorylated si

225 (BCR) induced both expression of IFITM3 and phosphorylation of this protein at Tyr20, which resulted

226 Cdk1 can downregulate Hsp70 function through phosphorylation of this site, with potential costs to ov

227 ociated DeltaArg(14) mutation, implying that phosphorylation of Thr(17) by CaMKII may become crucial

228 Upon phosphorylation of Thr55, cooperativity is abolished and

229 TRPC1 and PKCdelta interactions and phosphorylation of TRPC1 induced by store depletion were

230 en TRPC1 and PKCdelta and PKCdelta-dependent phosphorylation of TRPC1.

231 we show that the GATOR2 complex controls the phosphorylation of TSC2, which is essential for TSC exch

232 Phosphorylation of UPF1 occurs in its unstructured N- an

233 ated vesicle tethering, are required for the phosphorylation of Vac17 in its Myo2 binding domain.

234 timulation but does not significantly affect phosphorylation of Zap70 (zeta chain of T cell receptor-

235 tool for identifying and quantifying protein phosphorylation on a global scale.

236 permeable to Ca(2+), and that BIK1-mediated phosphorylation on its N terminus increases this channel

237 urs isothermally and is governed by tyrosine phosphorylation on LAT.

238 To understand the effects of multisite phosphorylation on the plant protein kinase brassinoster

239 To test the potential role of phosphorylation on the structure and function of CHT7, w

240 meric Galphai with RTKs, and facilitates the phosphorylation on two tyrosines located within the inte

241 ergy generation processes, such as oxidative phosphorylation (OXPHOS).

242 l motility, DNA repair, immune response, two phosphorylation pathways, and a randomized gene sets.

243 phosphorylation and the more complex antenna phosphorylation patterns in C. reinhardtii compared to A

244 The complex phosphorylation patterns of the LHCII trimers and of the

245 ing proteins and, thus, differing downstream phosphorylation patterns.

246 ational modifications including SUMOylation, phosphorylation, persulfidation and acetylation.

247 MYC stability is regulated through phosphorylation: phosphorylation at Thr58 signals degrad

248 oid-related orphan receptor alpha (RORalpha) phosphorylation plays a pivotal role in sulfotransferase

249 r complex composed of 12 HSP27 dimers with a phosphorylation pocket flanked by serine residues betwee

250 uples the import of carbohydrates with their phosphorylation prior to metabolism and has been linked

251 ons to empower an N-to-C terminally directed phosphorylation process.

252 In addition, the hypothesis that (de)phosphorylation processes drive the disease process resu

253 ly, we demonstrate that chABC increases TRKB phosphorylation (pTRKB), while PNN component aggrecan at

254 Our data reveal effector-triggered and phosphorylation-regulated conformational changes within

255 as to test the hypothesis that phospholemman phosphorylation regulates vascular tone in vitro and tha

256 Furthermore, VAMP8-mediated STAT1 phosphorylation required the presence of TRIM6.

257 by nuclear translocation of c-Jun, enhanced phosphorylation (Ser73), and AP-1/DNA-binding in respons

258 t certain sites may not affect the extent of phosphorylation significantly and do not represent hyper

259 ng-range CheY allosteric network between D57 phosphorylation site and the FliM(N) interface, namely t

260 tional ECT2 BRCT domain and the UBF1 Ser-412 phosphorylation site are required for UBF1-mediated ECT2

261 meostatic upscaling can be gated by a single phosphorylation site on the GluA2 subunit.

262 howed modified fibrillation that depended on phosphorylation site.

263 titative data for 10,000 proteins and 55,000 phosphorylation sites (p-sites) from 125 CCLs.

264 Moreover, we identified regulated phosphorylation sites in numerous proteins that function

265 luated by the ability to predict Ser/Thr/Tyr phosphorylation sites in the disordered proteome.

266 f thousands of proteins, phosphoproteins and phosphorylation sites specific to each tissue source, to

267 We identified >6,000 protein phosphorylation sites that can be used to infer >1,500 k

268 Among the 12 TIM phosphorylation sites we identified, at least two of the

269 TOR complex-specific subunit composition and phosphorylation state, and found abnormal mTOR expressio

270 as a fibrogenic factor independently of its phosphorylation state, as demonstrated by the increased

271 ause of challenges in isolating a particular phosphorylation state; surprising little effort on this

272 ivity of PTP1B can cause large shifts in the phosphorylation states of its regulatory targets.

273 The effects of combinations of possible phosphorylation states on protein kinase activity are di

274 d expression of UCP3, AAC1, or AAC2, and PDH phosphorylation status did not differ between the nitrit

275 However, the phosphorylation status of a kinase does not always refle

276 conjugates, precluding the evaluation of the phosphorylation status of signaling proteins across diff

277 fect its activity state without changing its phosphorylation status.

278 ount of insoluble monomeric alpha-syn or its phosphorylation status.

279 n, couples the conformational switch and the phosphorylation step, resulting in the rapid generation

280 vels of posttranslational control, including phosphorylation, SUMOylation, and ubiquitination.

281 he free Lck pool showed more activating Y394 phosphorylation than the coreceptor-bound Lck pool.

282 or (AMPAR) and NMDA receptor (NMDAR) subunit phosphorylation that likely contribute to increased rece

283 However, impeding PERK-phosphorylation through the administration of GSK2656157

284 Our results reveal that SarA undergoes host phosphorylation to recruit a STAT3-activating complex, c

285 t activating mutations do not require p.Y783 phosphorylation to stimulate downstream NFkappaB, NFAT,

286 The dual phosphorylation triggers ERG recognition and degradation

287 We show that activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerizat

288 ism for efficient inhibition of beta-catenin phosphorylation upon Axin recruitment to the Wnt recepto

289 information, is triggered by transient Snt1 phosphorylation upon cell cycle arrest.

290 e but detect the failure to counteract STAT1 phosphorylation upon IFN-I pretreatment, resulting in ne

291 human Tau mutant (hTau-P301L), the hTau S199 phosphorylation was ameliorated as GSK3beta phosphorylat

292 BDNF-evoked glutamate release and synapsin phosphorylation was attenuated within DS synapses, but e

293 OPN phosphorylation, but also revealed that phosphorylation was essential for OPN secretion.

294 atic vessels, myosin light chain 20, MLC(20) phosphorylation was increased in these vessels.

295 phosphorylation was ameliorated as GSK3beta phosphorylation was regained.

296 s receptor-dependent effect, as well as CREB phosphorylation, was blocked by a construct derived from

297 nflammatory gene activation, including NF-kB phosphorylation, were notably reduced.

298 ve RhoC increased heat shock factor 1 (HSF1) phosphorylation, which induced the heat shock protein 90

299 sociated with MST1 activation and UNC5B T428 phosphorylation, which is accompanied by YAP reduction a

300 cetylation and subsequently attenuated STAT1 phosphorylation, which may at least partially contribute

301 on of ROS by hydrogen peroxide increased Src phosphorylation, while ROS reduction by N-acetyl cystein