ライフサイエンスコーパス: phosphorylation state

1 induce cell death in tobacco, independent of phosphorylation state.

2 d to intracellular RyRs, as well as in Kv2.1 phosphorylation state.

3 l biosynthesis and morphogenesis through its phosphorylation state.

4 gth regulatory function are regulated by its phosphorylation state.

5 The activity of Spo0A depends on its phosphorylation state.

6 entail more than its regulation of the NS5A phosphorylation state.

7 merization and did not influence the cofilin phosphorylation state.

8 t of the chemotaxis machinery, CheA, and its phosphorylation state.

9 n factor whose activity is regulated via its phosphorylation state.

10 the number and length of acyl chains and its phosphorylation state.

11 tution with unlabeled PLB, regardless of its phosphorylation state.

12 interact directly with Spo0A to control its phosphorylation state.

13 whose structure is dependent on its tyrosine phosphorylation state.

14 HeLa cells results in alterations in the CTD phosphorylation state.

15 ansition between modes, depending on the LCC phosphorylation state.

16 to the spatiotemporal control of the protein phosphorylation state.

17 ated with high-dose CAF regardless of ErbB-2 phosphorylation state.

18 icient spatial and temporal control of their phosphorylation state.

19 mediated regulation of CAST depends on NFI's phosphorylation state.

20 s constitutively monomeric regardless of its phosphorylation state.

21 at is accompanied by dramatic changes in its phosphorylation state.

22 es to the environment as a function of their phosphorylation state.

23 ntractile modulator, regardless of cMyBP-C's phosphorylation state.

24 availability of Robo3 without affecting its phosphorylation state.

25 h DAT conformation biases and changes in DAT phosphorylation state.

26 es LLPS and does so under the control of its phosphorylation state.

27 1 by the 20S proteasome is controlled by its phosphorylation state.

28 coded by DNM1L) is inactive, as shown by its phosphorylation state.

29 separating substrate peptides with different phosphorylation states.

30 aling pathways leading to alteration of Cx43 phosphorylation states.

31 n the critical Thr-X-Tyr region in different phosphorylation states.

32 al influence of CXCR4/ACKR3 interactomes and phosphorylation states.

33 encoding forms of CaMKII mimicking different phosphorylation states.

34 -terminal region of cMyBP-C in its different phosphorylation states.

35 on of mutations, or modification of receptor phosphorylation states.

36 ssing that are associated with different CTD phosphorylation states.

37 a similar cross-species response in protein phosphorylation states 5 and 25 min after exposure to st

38 refore tested the hypothesis that Tm and its phosphorylation state affect the rate at which single ac

39 Hsp70 complexes have been implicated in tau phosphorylation state and amyloid precursor protein (APP

40 he H. pylori transcriptome for RNAs whose 5'-phosphorylation state and cellular concentration are gov

41 ated mice had a significant reduction in its phosphorylation state and insoluble fraction, which spec

42 s that enable simultaneous monitoring of the phosphorylation state and intracellular trafficking of C

43 regulator of Sct1p activity by affecting the phosphorylation state and overexpression level of Sct1p.

44 mal Scc2 function requires modulation of its phosphorylation state and suggest that scc2 phosphomimet

45 y shown that NFI activity depends on the NFI phosphorylation state and that calcineurin phosphatase d

46 ions upstream of sigma(T) by controlling the phosphorylation state and thus anti-anti-sigma activity

47 se A (PKA) activity directly controlled both phosphorylation state and tracer coupling.

48 This pathway controls Elo2 phosphorylation state and VLCFA synthesis.

49 domain constructs differed substantially in phosphorylation states and catalytic competency, suggest

50 Upon examining phosphorylation states and expression levels of proteins

51 The ability to assay early tau phosphorylation states and perform high-quality immunoel

52 TOR complex-specific subunit composition and phosphorylation state, and found abnormal mTOR expressio

53 at the mTORC1 is regulated in its abundance, phosphorylation state, and localization in coordination

54 synapses have distinctive stoichiometry and phosphorylation state, and respond differently to pertur

55 ve to wild-type cells was an increase in the phosphorylation state, and thus activation, of activated

56 rasensitive or switchlike responses in their phosphorylation state are not expected because the modif

57 construct, demonstrating that changes in tau phosphorylation state are not required to suppress or en

58 d that the Rex-2 C terminus and its specific phosphorylation state are required for stability and opt

59 as a fibrogenic factor independently of its phosphorylation state, as demonstrated by the increased

60 Adenylate phosphorylation state assays and mitochondrial respirato

61 of data points per day on proteins and their phosphorylation state at individual sites.

62 We quantified the phosphorylation state at multiple sites of the tau prote

63 Neuronal activity regulates the phosphorylation states at multiple sites on MeCP2 in pos

64 C proteins, involves a cyclic progression of phosphorylation states at Ser431 and Thr432 of KaiC.

65 in-C with its binding partners vary with its phosphorylation state, binding predominantly to myosin w

66 However, Ca(2+), pH, and the phosphorylation state can regulate Cx32 gap junction cha

67 ctly interacted with SREBP-2 and altered its phosphorylation state, causing an increase in SREBP-2 bi

68 These tau phosphorylation state changes are uniquely associated wi

69 The LeETR4 phosphorylation state closely paralleled ripening progre

70 th Tau (2N4R) in Sf9 cells in a well defined phosphorylation state containing up to approximately 20

71 a repetitive heptad sequence (YSPTSPS) whose phosphorylation states coordinate eukaryotic transcripti

72 We show that neither enzymatic activity nor phosphorylation state correlate with the ability to tran

73 Also, CTD interacts with host proteins in a phosphorylation state-dependent manner.

74 tate may modulate core protein functions but phosphorylation state-dependent viral or host interactio

75 E in a cell cycle-dependent manner, and its phosphorylation state dictates its interaction with TopB

76 t is required for motility, and its putative phosphorylation state dictates the ability of CtrA to ac

77 Kv2.1 phosphorylation site, we find that the phosphorylation state differs between Kv2.1 clusters on

78 Regardless of its phosphorylation state, downregulation of Flt1 also inhib

79 e we also examined the beta3 subunit and its phosphorylation state during internalization.

80 were present simultaneously, melanophilin's phosphorylation state enforced track selection of the Ra

81 er, and activator of transcription 1 (STAT1) phosphorylation state, followed by profound apoptosis of

82 Finally, we observe changes in individual phosphorylation states following a small molecule screen

83 C's regulatory N-terminal domains in defined phosphorylation states for protein-protein interaction s

84 Independently of its phosphorylation state, GRA7 associates with the rhoptry

85 1 synaptic localization, its effect on AMPAR phosphorylation state has not been explored.

86 n virion secretion, we have analyzed the CTD phosphorylation state in complete (containing the genomi

87 its elevated expression affects the nephrin phosphorylation state in diabetes.

88 on in AKT and mTOR protein expression and/or phosphorylation state in dorsolateral prefrontal cortex

89 y, we demonstrate the importance of the CrzA phosphorylation state in regulating growth, conidiation,

90 ents and quantification of their 5'-terminal phosphorylation state in wild-type and mutant cells.

91 determine the concentrations of all four PLB phosphorylation states in pig cardiac tissue, with and w

92 ce supports changes in alternative splicing, phosphorylation state, interaction with tubulin, and sel

93 serine/threonine-proline (S/T-P) sites whose phosphorylation state is known to regulate CTD functions

94 The dynamic nature of the erbB1 phosphorylation state is shown by monitoring activation

95 ind that the network of possible binding and phosphorylation states is composed of over 1000 members.

96 It remains unknown how the CTD phosphorylation state may modulate core protein function

97 a membrane (PM) expression of InsP(3)R-1 and phosphorylation state mutant InsP(3)R-1 to study how thi

98 protein microarrays were used to profile the phosphorylation state of 108 epitopes on 82 distinct sig

99 where a kinase and phosphatase regulate the phosphorylation state of a common substrate, and coupled

100 on effects can be reproduced by changing the phosphorylation state of a single residue: GluN2B Ser-11

101 in the cellular levels of TIP influence the phosphorylation state of a specific protein substrate of

102 A heterotrimer, PP2A(Ppp2r2d), regulates the phosphorylation state of AMP kinase by dephosphorylating

103 There were no marked differences in the phosphorylation state of AMP-activated protein kinase, A

104 The phosphorylation state of AMPAR subunits is one mechanism

105 ent with BBR did not significantly alter the phosphorylation state of AMPK in both the liver and adip

106 Unexpectedly, we found that the phosphorylation state of an evolutionarily conserved Cdk

107 lyses show that PTPRG activation affects the phosphorylation state of at least 31 signaling proteins.

108 by TPX2 is catalytically active and that the phosphorylation state of Aurora-A is an inaccurate surro

109 The phosphorylation state of B2AR dictates its partitioning

110 The phosphorylation state of beta2-syntrophin allosterically

111 d sensors resulting in the modulation of the phosphorylation state of BfiS in a growth-mode-dependent

112 uces prosurvival signaling by increasing the phosphorylation state of both Aurora and IKK kinases and

113 s study, we provide detailed analyses on the phosphorylation state of BRCA1 by cyclin D1/cdk4 complex

114 However, the link between the phosphorylation state of CaMKII and the agonist-triggere

115 n basal c-Src activity, but it increased the phosphorylation state of Cav-1.

116 ics screening approach, we characterized the phosphorylation state of CDCP1 across a panel of breast

117 many response regulators, we found that the phosphorylation state of ComE does not likely play a rol

118 between CpsD and CpsC was observed, and the phosphorylation state of CpsD influenced the subsequent

119 physiology has focused on how changes in the phosphorylation state of CREB regulate the timing proces

120 The phosphorylation state of Cx35 at two regulatory phosphor

121 In the saline-control group, the basal phosphorylation state of DARPP-32 at Threonine-34 site (

122 Altering the phosphorylation state of each protein causes correspondi

123 The phosphorylation state of fascin at S39, a PKC site, cont

124 ify the mechanisms involved, we examined the phosphorylation state of focal adhesion kinase (Fak)(Ser

125 atin decondensation, RNA processing, and the phosphorylation state of fundamental cell cycle proteins

126 We demonstrate that RetS modulates the phosphorylation state of GacS by a direct and specific i

127 ne increases AMPAR current by modulating the phosphorylation state of GluA1 which is dependent on alp

128 ession of GluN3A-containing receptors to the phosphorylation state of GluN3A subunits, and provides a

129 The phosphorylation state of heptapeptide repeats within the

130 JIL-1 is the major kinase controlling the phosphorylation state of histone H3S10 at interphase in

131 and was associated with an alteration in the phosphorylation state of HuR.

132 e II (Pol II) correlates with changes to the phosphorylation state of its large subunit C-terminal do

133 hase and anaphase that are determined by the phosphorylation state of its Mde4 subunit.

134 pose tissue as indicated by reduction of the phosphorylation state of JNK1 and the mRNA levels of pro

135 y, BBR treatment significantly decreased the phosphorylation state of JNK1 in both hepatoma H4IIE cel

136 and KaiC--that generates oscillations in the phosphorylation state of KaiC.

137 exes with stoichiometries that depend on the phosphorylation state of KaiC.

138 alled CNSProfile) to identify changes in the phosphorylation state of key neuronal phosphoproteins ev

139 We also demonstrate that although the phosphorylation state of Kv2.1 is also shaped by the act

140 his is achieved through redox control of the phosphorylation state of light-harvesting antenna comple

141 Surprisingly, the phosphorylation state of melanophilin was instead import

142 SEPW1 silencing did not change the phosphorylation state of MKK4 but increased total MKK4 p

143 The phosphorylation state of MpkA was determined post exposu

144 The phosphorylation state of MSL10 also regulated its abilit

145 We show that MSMEG_5437 influences the phosphorylation state of MSMEG_6129.

146 Impaired activity correlated with the phosphorylation state of MTHFR, with more severe mutatio

147 It causes dose-dependent reductions in the phosphorylation state of multiple proteins downstream of

148 nt nitric oxide synthesis by influencing the phosphorylation state of neuronal nitric oxide synthase.

149 (GFAP) genes in MG cells is dependent on the phosphorylation state of NFI, with hypophosphorylation o

150 tor sensitivity regulation in Drosophila The phosphorylation state of Orco (S289) is altered in an od

151 phosphorylation has to precede the change of phosphorylation state of other serine residues.

152 which plays a major role in restricting the phosphorylation state of p107 and inducing its activatio

153 While the phosphorylation state of p107 is very sensitive to force

154 The phosphorylation state of p38 mitogen activated protein k

155 Together, these studies identify the phosphorylation state of PACS-2 Ser437 as a molecular sw

156 This interaction is dependent on the phosphorylation state of PDH.

157 microwave fixation was used to preserve the phosphorylation state of phosphoproteins in brains of DF

158 Intriguingly, HIV-1 infection modulates the phosphorylation state of Pin1, enhancing its ability to

159 The phosphorylation state of pocket proteins during the cell

160 Although FTY720 altered the phosphorylation state of protein kinase B and p38, our d

161 ng that active site inhibitors stabilize the phosphorylation state of protein kinases B/Akt and C.

162 The phosphorylation state of proteins involved in translatio

163 ellular signaling networks by regulating the phosphorylation state of proteins.

164 tivated using a PAR2-agonist peptide and the phosphorylation state of PTEN, and the activities of PTE

165 However, PP5 and ERK activity regulates the phosphorylation state of Raf1 kinase, an upstream activa

166 diated ubiquitination of Rds2 depends on the phosphorylation state of Rds2, suggesting a cross-talk b

167 leled ripening progress, suggesting that the phosphorylation state of receptors is implicated in ethy

168 Alteration in the phosphorylation state of receptors is likely to be an in

169 modulate the output of TCSs by affecting the phosphorylation state of response regulators.

170 ation and RNA degradation are coupled to the phosphorylation state of RNA polymerase II's repeat doma

171 APII remained at the transcription site, the phosphorylation state of RNAPII was unaltered, and the t

172 RssB-sigma(S) in solution, regardless of the phosphorylation state of RssB.

173 Thus, NMDA-R activation alters the phosphorylation state of S783 and acts as a molecular sw

174 Our results suggest that the phosphorylation state of Sec2p can direct a switch in it

175 Environmental signals may modulate the phosphorylation state of sensor kinases (SK).

176 ion of ADAM17 in this pathway depends on the phosphorylation state of Ser-811 in its cytoplasmic doma

177 f unphosphorylated AMII, irrespective of the phosphorylation state of Ser639.

178 (long-term depression (LTD)) as well as the phosphorylation state of Ser831 and Ser845 sites at the

179 n and Ras transformation are mediated by the phosphorylation state of serine 727.

180 The phosphorylation state of serine 776 is also crucial for

181 tic acid is believed to be able to mimic the phosphorylation state of serine, while alanine is a comm

182 hed by GSK3 inhibitors, and dependent on the phosphorylation state of serine-154.

183 Our results suggest that the phosphorylation state of serines is likely an essential

184 array analysis revealed small changes in the phosphorylation state of several components of the Akt s

185 egulation of DAT does not correlate with the phosphorylation state of several well-studied MAP kinase

186 We also assessed alterations in the phosphorylation state of SFK targets, including GluN2A a

187 uitination of Snf1 affects the stability and phosphorylation state of Snf1, thereby affecting Snf1 ki

188 hibited partial defects in regulation of the phosphorylation state of Snf1.

189 of Wapl activity, which is controlled by the phosphorylation state of Sororin.

190 e had a substantial and common effect on the phosphorylation state of specific actin, tubulin and myo

191 The phosphorylation state of Spo0A is controlled by a multi-

192 d more specifically to the regulation of the phosphorylation state of Spo0F, a key regulatory protein

193 The phosphorylation state of SynI by Cdk5 at site 7 is regul

194 The phosphorylation state of SypE appears to regulate these

195 S264D phosphomutants, we determined that the phosphorylation state of TAF7 at S264 influences the lev

196 essing 5LO had a significant increase in the phosphorylation state of tau at S396 and S396/S404, as r

197 kinesin-1 and that this is dependent on the phosphorylation state of tau.

198 o the mechanisms involved, we determined the phosphorylation state of the activation loop residues Se

199 icial induction of sigma(B), analysis of the phosphorylation state of the anti-anti-sigma factor RsbV

200 We could show that during drug arrest the phosphorylation state of the APC changes, indicating tha

201 However, whether the phosphorylation state of the APC/C is important for its

202 emble of these results demonstrates that the phosphorylation state of the Bnip3 LIR signals either th

203 ase II (Pol II) is controlled in part by the phosphorylation state of the C-terminal domain (CTD) of

204 or secretion of empty virions.IMPORTANCE The phosphorylation state of the C-terminal domain (CTD) of

205 that generates circadian oscillations in the phosphorylation state of the clock protein KaiC.

206 The sensor transmitter module controls the phosphorylation state of the cognate-response-regulator

207 Pef1 and PP4 control the phosphorylation state of the cohesin kleisin Rad21.

208 lead to either LTP or LTD, depending on the phosphorylation state of the control point, T305/T306.

209 Furthermore, the phosphorylation state of the CTD regulates capsid assemb

210 i knockdown of dCDK12 in S2 cells alters the phosphorylation state of the CTD, reducing its Ser2 phos

211 ng to this site was clearly modulated by the phosphorylation state of the downstream and non-overlapp

212 of TPX2 binding, which is independent of the phosphorylation state of the enzyme.

213 mployed Phos-tag methods to characterize the phosphorylation state of the Escherichia coli response r

214 endocytosis is attributed to a change in the phosphorylation state of the GluR1 at Ser(845) as morphi

215 A and activation of PKC increased the serine phosphorylation state of the HCN1 protein.

216 regulator KaiA to act on KaiC depends on the phosphorylation state of the hexamer and that KaiA and K

217 hat this complex is primarily defined by the phosphorylation state of the integrin C-terminal Tyr(759

218 n transduced via the kinases controlling the phosphorylation state of the master regulator Spo0A.

219 ral phenotypes of tao mutations and that the phosphorylation state of the microtubule-binding protein

220 The phosphorylation state of the mini-titin twitchin control

221 tivation of m-calpain, without affecting the phosphorylation state of the protease.

222 sensor kinase/phosphatase that modifies the phosphorylation state of the regulator PhoP in response

223 y of a sensor or other proteins to alter the phosphorylation state of the regulator.

224 f the exon 3,4,5,6 cassette of Casp9 via the phosphorylation state of the RNA splicing factor SRp30a

225 th myosin were inactive, irrespective of the phosphorylation state of the serines in the nonhelical t

226 f any, energy input and is controlled by the phosphorylation state of the thick filament-associated m

227 Mih1 directly modulates the phosphorylation state of the Vps26 retromer subunit; mut

228 The phosphorylation state of this motif determines delta-cat

229 ions in deadenylation are independent of the phosphorylation state of three serines known to regulate

230 These data suggest that DEP-1 can modify the phosphorylation state of tight junction proteins and pla

231 irulence factor production was linked to the phosphorylation state of transcriptional regulator BvgA.

232 ents, including regulation of the levels and phosphorylation state of translation factors.

233 Moreover, we show that the phosphorylation state of Treslin at Ser-1000 is importan

234 R activity was verified by a decrease in the phosphorylation state of two mTOR targets, 70-kDa riboso

235 Finally, our analyses revealed that the phosphorylation state of two Z-disc kinases (striated mu

236 This rescue is dependent on the phosphorylation state of WIPI2B at the isolation membran

237 Thus, the phosphorylation state of Y1357 can function as a molecul

238 ess and low during sleep, and changes in the phosphorylation states of AMPARs, CamKII and GSK3beta ar

239 Large-scale studies of the dynamic phosphorylation states of cell signaling systems have be

240 The phosphorylation states of cPLA(2) and p38 MAP kinase and

241 eraction site of CRMP-2 and examined whether phosphorylation states of CRMP-2 affected the interactio

242 Hence, the phosphorylation states of EIN and HPr shift the binding

243 tation (ChIP) to examine the acetylation and phosphorylation states of histones H3 and H4 on Zp and R

244 transcription was regulated by the tyrosine phosphorylation states of HoxA9 and HoxA10.

245 Furthermore, distinct phosphorylation states of HuR differentially regulate tr

246 Neocortical absence of HuR alters the phosphorylation states of initiation and elongation fact

247 Modulation of phosphorylation states of ion channels is a critical ste

248 ivity of PTP1B can cause large shifts in the phosphorylation states of its regulatory targets.

249 , decreased insulin signaling, increased the phosphorylation states of JNK and NFkappaB p65, and enha

250 This interaction depends upon the phosphorylation states of klp9p and ase1p.

251 ts resulted a dose-dependent increase in the phosphorylation states of many proteins.

252 Usually, monitoring the phosphorylation states of MAP kinases in vitro requires

253 restin enable arrestin to recognize plethora phosphorylation states of numerous GPCRs, contributing t

254 However, the levels of the four phosphorylation states of PLB (U-PLB, P16-PLB, P17-PLB,

255 tions, the statistical relationships between phosphorylation states of proteins may be disrupted, mak

256 ical roles for Tyr(1) in differentiating the phosphorylation states of Ser(2)/Ser(5) of CTD in RNA po

257 These factors are targeted to specific phosphorylation states of the CTD that predominate at di

258 The separation of two different phosphorylation states of the Dam1 complex, generated fr

259 C1 and 2) and the subcomplexes and different phosphorylation states of the Dam1 complex.

260 complexes without affecting dimerization or phosphorylation states of Trk.

261 is study, we measured protein expression and phosphorylation states of UPR sensor pathway proteins in

262 the rat to investigate the effect of Ser-129 phosphorylation state on dopaminergic neuron pathology.

263 The effects of combinations of possible phosphorylation states on protein kinase activity are di

264 rative study of the effects of combinatorial phosphorylation states on protein kinase conformational

265 differential effects of phospholamban (PLB) phosphorylation states on the activity of the sarcoplasm

266 ent, there is a compensatory increase in the phosphorylation state or expression level of the other m

267 eded to evaluate whether alterations in PAK1 phosphorylation states, or alterations in protein expres

268 a group of proteins whose concentrations and phosphorylation states oscillate with daily periodicity

269 s across the dimer interface can communicate phosphorylation states over 25 A from the activation loo

270 Multiplexed NMR profiling of reporter phosphorylation states provides unique advantages for ki

271 y with the core protein depending on its CTD phosphorylation state, pulldown assays were performed us

272 ylcyclopropene rapidly influenced the LeETR4 phosphorylation state rather than protein abundance.

273 s suggest that the Cav1 expression level and phosphorylation state regulates fluid phase endocytosis

274 In contrast, the phosphorylation state, represented by phosphor-mimetic m

275 play a role in the modulation of ion channel phosphorylation states required for hyperalgesia.

276 Depletion of BAF or perturbing its phosphorylation state results not only in nuclear envelo

277 q patterns specific for different Pol II CTD phosphorylation states reveal weak co-transcriptional sp

278 that 50 different phosphopeptides had their phosphorylation state significantly altered by ABA over

279 ividual hexamers make a shorter cycle in the phosphorylation state space, which compensates for the s

280 ate Nox5 on Thr494 and Ser498 as detected by phosphorylation state-specific antibodies.

281 was analyzed within 30 min of hunting using phosphorylation state-specific CREB (pCREB) and CREB ant

282 -L1 molecules were associated with the STAT3 phosphorylation state, suggesting a causal link.

283 ause of challenges in isolating a particular phosphorylation state; surprising little effort on this

284 ase II (Pol II) large subunit cycles through phosphorylation states that correlate with progression t

285 repression through the alteration of Pol II phosphorylation states, thereby contributing to our unde

286 that Hsp110 plays a critical function in tau phosphorylation state through maintenance of efficient P

287 homimetic mutation, thus linking the Thr-592 phosphorylation state to the control of SAMHD1 dNTPase a

288 wever, the ability of CaMKII and its various phosphorylation states to control spine size has not bee

289 The distribution of different PLM phosphorylation states to different pools may be explain

290 These results show that each PLB phosphorylation state uniquely alters Ca(2+) homeostasis

291 bodies was controlled by changes in peptide phosphorylation state using a kinase/phosphatase enzyme

292 activity of ICSBP is influenced by tyrosine phosphorylation state, we hypothesized that mutations in

293 ulator functions are often affected by their phosphorylation state, we investigated how phosphorylati

294 onship between the mobility of Rad54 and its phosphorylation state, we performed fluorescence recover

295 In both LVH and sham hearts, all phosphorylation states were significantly populated, but

296 mingly minor one, can dramatically alter its phosphorylation state, which is significant because trun

297 associated with an abnormal membrane protein phosphorylation state, with destabilization of the membr

298 h pPKRm and pPKRd are heterogeneous in their phosphorylation states, with an average of 9 or 10 phosp

299 ences of inactivating Plk4 or perturbing its phosphorylation state within its Slimb-recognition motif

300 gap junctions can exist in widely different phosphorylation states within a single neuron, implying