ライフサイエンスコーパス: phosphorylcholine

1 lyzed by sphingomyelinases into ceramide and phosphorylcholine.

2 -choline-labelled cell walls was shown to be phosphorylcholine.

3 lyzed by sphingomyelinases into ceramide and phosphorylcholine.

4 A fraction of these antibodies bound to free phosphorylcholine.

5 m infected rats and shown to be specific for phosphorylcholine.

6 5'-thymidine monophosphate and p-nitrophenyl phosphorylcholine.

7 acterial cell wall polysaccharide component, phosphorylcholine.

8 encoding for antibodies targeting bacterial phosphorylcholine.

9 dum lipid showed that the target of M131 was phosphorylcholine.

10 ecognition of ES-62 by target cells, because phosphorylcholine, a common pathogen-associated molecula

11 ice, anti-phosphatidylcholine Abs, like anti-phosphorylcholine Abs, contain few N-additions, and have

12 is and A. actinomycetemcomitans include anti-phosphorylcholine (alpha-PC) and beta2-glycoprotein-1-de

13 age cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was selected for testin

14 ) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the

15 nzyme that hydrolyzes sphingomyelin (SPM) to phosphorylcholine and ceramide.

16 is first used to hydrolyze sphingomyelin to phosphorylcholine and ceramide.

17 o their equivalent 1H NMR spectra, e.g., for phosphorylcholine and phosphorylethanolamine.

18 e phospholipase A(2) inhibitor oleyloxyethyl phosphorylcholine and the CYP450 inhibitor ketoconazole.

19 ned that recognize simultaneously the hapten phosphorylcholine and the self antigen double-stranded D

20 phosphatase then generates choline from the phosphorylcholine, and the newly formed choline is then

21 ytidine diphosphate-choline as the donor for phosphorylcholine, AnkX catalyzes the transfer of phosph

22 Abs against phosphorylcholine (anti-PC) and Abs against malondialdeh

23 ss contain higher concentrations of IgG anti-phosphorylcholine (anti-PC) than sera from healthy subje

24 ollowed using the chromophoric p-nitrophenyl-phosphorylcholine as a model substrate.

25 romol/min.mg toward 1-palmitoyl-sn-glycero-3-phosphorylcholine at pH 8.0 and 40 degrees C, correspond

26 The Au-phosphorylcholine (Au-PC) probes exhibit 'super-stealth'

27 entity with antibodies from the classic anti-phosphorylcholine B-cell clone, T15, which protect again

28 Therefore, the potential of phosphorylcholine-based vaccination strategies as a nove

29 Phosphorylcholine-based zotarolimus-eluting stents had l

30 fore, our findings do not support a role for phosphorylcholine-bearing antigens in immune defense aga

31 Antibodies specific for phosphorylcholine-bearing proteins of L1 larvae first ap

32 infection with T. spiralis were specific for phosphorylcholine-bearing proteins.

33 n are based on poly(2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methac

34 em is based on poly[2-(methacryloyloxy)ethyl phosphorylcholine]-block-[2-(diisopropylamino)ethyl meth

35 d the serum levels of NAbs against bacterial phosphorylcholine but not oxidized low-density lipoprote

36 ce mounted robust antibody responses against phosphorylcholine, but not protein, determinants compare

37 g, and that pchP and other genes involved in phosphorylcholine catabolism are necessary to stimulate

38 pendent manner, and binding was inhibited by phosphorylcholine (ChoP) and choline.

39 the additional LPS phase variable structures phosphorylcholine (ChoP) and sialic acid.

40 tal choline into lipopolysaccharide (LPS) as phosphorylcholine (ChoP) as well as the phase variation

41 Incorporated choline is in the form of phosphorylcholine (ChoP) based on the reactivity with th

42 Phosphorylcholine (ChoP) can be found in all life forms.

43 The phase-variable structure phosphorylcholine (ChoP) confers susceptibility to human

44 dergoes phase variation in expression of the phosphorylcholine (ChoP) epitope, a structure present on

45 In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP

46 Phosphorylcholine (ChoP) is a common surface feature of

47 Phosphorylcholine (ChoP) is a component of the teichoic

48 Phosphorylcholine (ChoP) is a potential candidate for a

49 Phosphorylcholine (ChoP) is an antigenic component on th

50 that the LOS from H. haemolyticus contained phosphorylcholine (ChoP) less frequently than the LOS fr

51 irway infection models, we demonstrated that phosphorylcholine (ChoP) moieties that are shared by PAF

52 tures found within NTHi LOS suggested that a phosphorylcholine (ChoP) moiety was involved in adherenc

53 CRP binds to phosphorylcholine (ChoP), a constituent of eukaryotic me

54 Haemophilus influenzae, express cell-surface phosphorylcholine (ChoP), a ligand for the receptor for

55 in both licl, required for the expression of phosphorylcholine (ChoP), and lic2, a putative galactosy

56 c-1, which is required for the expression of phosphorylcholine (ChoP), is the best characterized and

57 ct express an unusual prokaryotic structure, phosphorylcholine (ChoP), on their cell surface.

58 Here, we demonstrated that the phosphorylcholine (ChoP)-containing outer membrane prote

59 ental sources onto its lipopolysaccharide as phosphorylcholine (ChoP).

60 Thus, PAFr shepherds phosphorylcholine-containing bacterial components such a

61 sly demonstrated that one such molecule, the phosphorylcholine-containing glycoprotein ES-62, acts to

62 Here we demonstrate that ES-62, a phosphorylcholine-containing glycoprotein released by th

63 cribed a filarial nematode-derived, secreted phosphorylcholine-containing glycoprotein, ES-62, with i

64 d not react with red blood cells, which have phosphorylcholine-containing lipids in their exterior me

65 Phosphorylcholine-containing secreted products (phosphor

66 enzyme activity are positively regulated by phosphorylcholine degradation products, including glycin

67 for the capsular polysaccharide (PPS14), the phosphorylcholine determinant of the cell wall C-polysac

68 ntigen-binding activities to haptens such as phosphorylcholine, dextrans, fructofuranans, or dinitrop

69 SNPE) headgroup, while the other contained a phosphorylcholine (DiC(6)SNPC) headgroup.

70 is study, we demonstrate the presence of the phosphorylcholine epitope on the lipopolysaccharides (LP

71 sphorylcholine-containing secreted products (phosphorylcholine-ES) are also released by human filaria

72 coccal pce gene encoding for a teichoic acid phosphorylcholine esterase (Pce), an enzymatic activity

73 ococcal surface proteins, and the catalytic (phosphorylcholine esterase) activity is localized on the

74 ibitor 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine (ET-18-OCH3), or by using small interf

75 o be inert toward platelets, but it bound to phosphorylcholine exposed after oxidation triggered by a

76 extracts of C. elegans' microsomes transfer phosphorylcholine from L-alpha-dipalmitoyl phosphatidylc

77 o-BMA) with blood were diminished due to the phosphorylcholine functionalities of the hydrogel, which

78 search Laboratory antigen that also contains phosphorylcholine, further indicating the specificity of

79 yelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes.

80 ions, attributed to the copious zwitterionic phosphorylcholine groups for protein-adsorption resistan

81 For PEDOT functionalized with zwitterionic phosphorylcholine groups, higher levels of intermediate

82 Our data indicate that the phosphorylcholine head group is essential for antigenici

83 id recognize lysophosphatidylcholine and the phosphorylcholine head group.

84 esence of an sn-2-oleoyl group; 2), that the phosphorylcholine headgroup independently increases mole

85 n synthesis, we successfully prepared poly(L-phosphorylcholine homoserine) with controlled chain leng

86 s lacking type IV pili, the protease, or the phosphorylcholine hydrolase are not defective for intrac

87 ., protease, acid phosphatase, p-nitrophenol phosphorylcholine hydrolase, lipase, phospholipase A, an

88 lytic enzymes metalloprotease, p-nitrophenol phosphorylcholine hydrolase, lipase, phospholipase A, an

89 pase, a phospholipase A, and a p-nitrophenyl phosphorylcholine hydrolase.

90 natural antibodies and specific tolerance to phosphorylcholine immunogens that normally recruit prote

91 ically elevated levels of diacylglycerol and phosphorylcholine in the absence of growth factors.

92 oyl-2-(5,6-epoxyisoprostane E2)-sn-glycero-3-phosphorylcholine increase interleukin-8 (IL-8) synthesi

93 d 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine induce endothelial cells to synthesize

94 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synt

95 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine induced a rapid yet sustained activati

96 Soluble phosphorylserine but not phosphorylcholine inhibits substrate cleavage.

97 Phosphorylcholine is a common epitope in antigens of bac

98 Phosphorylcholine is an important bioactive adduct to th

99 factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a major primary and secondary mess

100 palmitoyl-2-epoxyisoprostane E2-sn-glycero-3-phosphorylcholine) is the most active lipid in OxPAPC th

101 lysaccharide antibody unmasked the bacterial phosphorylcholine ligand, allowing for increased adheren

102 u(25) molecular clusters functionalized with phosphorylcholine ligands (AuPC, ~2 nm in size) as a pre

103 ted primarily to the strong hydration of the phosphorylcholine-like monomers that make up the robustl

104 anied by enhanced inward movement of several phosphorylcholine lipid probes and was associated with e

105 zed a genetic locus lic that is required for phosphorylcholine metabolism in S. pneumoniae.

106 l-eluted fractions contained a huge range of phosphorylcholine-modified structures with up to three a

107 in (SM) in mammalian cells by transferring a phosphorylcholine moiety from phosphatidylcholine to cer

108 surface proteins noncovalently bound to the phosphorylcholine moiety of the cell wall of Streptococc

109 bsence of adsorbed kininogens because of its phosphorylcholine moiety.

110 modified posttranslationally at Ser(76) by a phosphorylcholine moiety.

111 ic explanation for the abnormal responses to phosphorylcholine observed in Btk-deficient mice, and in

112 (CBPs) that are non-covalently bound to the phosphorylcholine of the teichoic acid.

113 yi, strongly supporting the concept that the phosphorylcholine oligosaccharide biosynthetic enzymes a

114 The biosynthesis in vitro of phosphorylcholine oligosaccharides in Caenorhabditis ele

115 d key components: melittin and oleyloxyethyl phosphorylcholine (OOPC).

116 The small molecule phosphorylcholine, or choline phosphate (ChoP), is used

117 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholip

118 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholip

119 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) and, specifically, the compo

120 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) on osteogenic signaling indu

121 dized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (Ox-PAPC), activates endothelial cells

122 dized-1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (Ox-PAPC), found in atherosclerotic le

123 h as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) and its constituents 1-palmyt

124 n of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) generates a group of bioactiv

125 es of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) in bronchioalveolar lavage fl

126 zed 1- palmitoyl-2-arachidonoyl-sn-3-glycero-phosphorylcholine (OxPAPC) on chemokine expression and l

127 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC), a component of minimally mod

128 ch as 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (OxPAPC), have been shown to inhibit s

129 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC), which has been shown to accu

130 e II-dependent exoenzymes is a p-nitrophenol phosphorylcholine (p-NPPC) hydrolase whose activity is o

131 ipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (PAPC), which then induced the stress-

132 obacillus actinomycetemcomitans, one bearing phosphorylcholine (PC) (strain D045D-40) and one devoid

133 The zwitterions phosphorylcholine (PC) and phosphoethanolamine (PE) are

134 Abs specific for phosphorylcholine (PC) are known to contribute to the im

135 Antibodies reactive with phosphorylcholine (PC) are ubiquitous in human sera, but

136 ute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsu

137 , specific for two determinants on R36A, the phosphorylcholine (PC) determinant of C-polysaccharide a

138 ococcal surface protein A (PspA) and for the phosphorylcholine (PC) determinant of C-polysaccharide,

139 n of the display of the virulence-associated phosphorylcholine (PC) epitope on the LOS in response to

140 oniae and house dust mite (HDM) bear similar phosphorylcholine (PC) epitopes.

141 modified (MDA-modified) LDL (MDA-LDL) or the phosphorylcholine (PC) headgroup of oxidized phospholipi

142 Phosphorylcholine (PC) is a classic T-independent Ag tha

143 olecular clusters (Au(25)) functionalized by phosphorylcholine (PC) ligands for NIR-II fluorescence i

144 tigators have demonstrated that HDMs express phosphorylcholine (PC) moieties.

145 e show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs)

146 d toward oxidation-specific epitopes such as phosphorylcholine (PC) that arise during disease-driven

147 he biology of nematodes is the attachment of phosphorylcholine (PC) to carbohydrate.

148 ominated by Abs to oxidation-associated Ags, phosphorylcholine (PC), a head group that becomes expose

149 Because phosphorylcholine (PC), a major haptenic component of te

150 Examination of the IgG2 response to phosphorylcholine (PC), a response thought to be mainly

151 In mice, antibodies directed against phosphorylcholine (PC), an epitope present on the cell w

152 ked conjugation with a simple hapten such as phosphorylcholine (PC), induces more efficient T cell st

153 to the bacterial cell wall C-PS determinant, phosphorylcholine (PC), relative to Ig responses to the

154 ntibodies against the small-molecule epitope phosphorylcholine (PC), we show in multiple mouse models

155 Using this method, we compared the phosphorylcholine (PC)- and polycation-based binding act

156 was not associated with shifts in levels of phosphorylcholine (PC)- or pneumococcal capsular polysac

157 cture of this product was determined to be O-phosphorylcholine (PC)-AEA.

158 tans are variable with respect to display of phosphorylcholine (PC)-bearing antigens.

159 We have previously shown that ES-62, a phosphorylcholine (PC)-containing glycoprotein secreted

160 XCL13(-/-) mice are deficient in preexisting phosphorylcholine (PC)-specific antibodies and in their

161 Phosphorylcholine (Pc)-substituted glycans were also fou

162 ulates the production of natural Abs against phosphorylcholine (PC).

163 phenotypes by virtue of covalently attached phosphorylcholine (PC).

164 rface protein A [PspA])- and polysaccharide (phosphorylcholine [PC] determinant of teichoic acid)-spe

165 that are fully functionalized with desirable phosphorylcholine, PC, groups.

166 on period was incorporated into tissue [14C] phosphorylcholine (PCh) and [14C]phosphatidylcholine (Pt

167 odes manufacture various carbohydrate-linked phosphorylcholine (PCh)-containing molecules, including

168 Phosphorylcholine (PCho) is added to some LOS forms in a

169 e the result of phase-variable expression of phosphorylcholine (PCho) such that MAb 5G8 reacted only

170 ghout the biofilm, while variants expressing phosphorylcholine (PCho) were found within the biofilm.

171 ffected by phase variation was identified as phosphorylcholine (PCho), which is linked to the primary

172 f LOS glycoforms, including those containing phosphorylcholine (PCho).

173 ccharides containing sialic acid (NeuAc) and phosphorylcholine (PCho).

174 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine (PEIPC) and 1-palmitoyl-2-(5-oxovalero

175 oyl-2-(5,6-epoxyisoprostane E2)-sn-glycero-3-phosphorylcholine (PEIPC), accumulated in macrophages in

176 PC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine (PGPC), on Cx43 expression and phospho

177 C) and 1- palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine (PGPC), which are present in OxPAPC, M

178 phospholipids is hydrolyzed by a periplasmic phosphorylcholine phosphatase, PchP.

179 ymeric immunoglobulin receptor, or cell wall phosphorylcholine/platelet-activating factor receptor.

180 vely loaded into poly(2-methacryloyloxyethyl phosphorylcholine)-poly(2-(diisopropylamino)ethyl methac

181 antiproliferative agent, zotarolimus, and a phosphorylcholine polymer may provide similar angiograph

182 antiproliferative agent, via a biocompatible phosphorylcholine polymer on a cobalt alloy thin-strut s

183 0 or 200 microg per stent)-coated BiodivYsio phosphorylcholine polymer stents versus uncoated stents

184 rolimus-eluting coronary stents (ZES) with a phosphorylcholine polymer versus sirolimus-eluting stent

185 Compared with SES, treatment with a phosphorylcholine polymer-based ZES is associated with s

186 1-Palmitoyl-2- (5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) and 1- palmitoyl-2-glutaroyl-s

187 ives, 1-palmitoyl-2-oxovaleroyl-sn-glycero-3-phosphorylcholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn

188 g 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC), are active components of mini

189 s 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC).

190 The phosphorylcholine product is the first to leave the acti

191 suggested that only a small fraction of the phosphorylcholine-related antibody response against T. s

192 The phosphorylcholine released by PlcH activity on phospholi

193 ), an enzymatic activity capable of removing phosphorylcholine residues from the cell wall teichoic a

194 on vascular endothelial cells and binding of phosphorylcholine residues on pneumococcal cell wall to

195 tein (Cbp) family are noncovalently bound to phosphorylcholine residues on the surface of Streptococc

196 the bacterial cell wall, specifically by the phosphorylcholine residues which serve as anchors for su

197 In contrast, the IgG anti-phosphorylcholine response, although also dependent on C

198 ce, including decreased serum IgM, poor anti-phosphorylcholine responses, and slightly reduced number

199 nylcholine (1-O-hexadec-1'-enyl-sn-glycero-3-phosphorylcholine), resulting in the production of a neu

200 with radiolabeled serine, palmitic acid, and phosphorylcholine revealed that the ultraviolet B-induce

201 While poly(L-phosphorylcholine serine) was found to be unstable upon

202 ckness and total biomass and reduced surface phosphorylcholine, similar to a luxS mutant.

203 active Stat3, and increased reactivity with phosphorylcholine, similar to murine peritoneal B-1a and

204 ly demonstrated peritoneal B-1a cell-derived phosphorylcholine-specific and total IgM moves away from

205 d adjuvant in augmenting polysaccharide- and phosphorylcholine-specific IgG responses.

206 in protective levels of polysaccharide- and phosphorylcholine-specific IgG.

207 Monoclonal phosphorylcholine-specific IgG2c failed to protect rats

208 activated by TLR7 or TLR9 agonists produced phosphorylcholine-specific IgM.

209 heterogeneous with respect to its degree of phosphorylcholine substitution in both O-6-positions.

210 Because it is thought that phosphorylcholine substitution of oligosaccharides modul

211 cal concentration of phospholipid containing phosphorylcholine, suggesting that the epitope has both

212 to the pathogen-associated molecular pattern phosphorylcholine that results in the uptake of bacteria

213 und called Lipidure (2-Methacryloyloxy ethyl phosphorylcholine) that is up to 40X less expensive than

214 rary of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflamm

215 e that is cross-reactive with both dsDNA and phosphorylcholine, the dominant hapten on the pneumococc

216 horylcholine, AnkX catalyzes the transfer of phosphorylcholine to Rab1 in a filamentation-induced by

217 egradation, and transfer of their headgroup, phosphorylcholine, to SMs.

218 dized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine), was identified in a co-regulated gro

219 of oxidized LDL, including OxPLs containing phosphorylcholine, whereas immunization with viable thym

220 rmal immune responses against Ags, including phosphorylcholine, which confer protection against Strep

221 Functional polymers with sulfobetaine or phosphorylcholine zwitterions as pendent groups are demo