ライフサイエンスコーパス: photoreactive

1 e compound highly oxidizing and particularly photoreactive.

2 g is greater when the phagosome contents are photoreactive.

3 wherein the linkers between the two opposing photoreactive 1,8-diazaanthracene units are connected to

4 complete transporter for petrobactin (PB), a photoreactive 3,4-catecholate siderophore produced by ma

5 silicon oxide surfaces were derivatized with photoreactive 3-(hydroxymethyl)naphthalene-2-ol (NQMP) m

6 We have substituted photoreactive 5-iododeoxypyrimidines into the DNA oligon

7 Photoreactive 5-iodouridines were incorporated into the

8 A photoreactive Abeta(1-40) ligand was synthesized by subs

9 s at the margins, and then a dNMP carrying a photoreactive adduct was added to the 3'-hydroxyl group.

10 zophenone)thiophosphate] (AMPS-Succ-BP) as a photoreactive ADP analogue.

11 Previous studies used the photoreactive affinity label 3-[3H]azido-2-methyl-5-meth

12 In addition, photoreactive agent-treated monolayers of retinal microv

13 Furthermore, [gamma-(32)P]8-azido ATP, a photoreactive agonist, was effectively cross-linked to P

14 cting substructure for LPA and as a possible photoreactive alkylating agent for the LPA receptor(s).

15 (F(4)N(3)Bzoxy-AP), a general anesthetic and photoreactive allopregnanolone analog that is a potent G

16 urthermore, using co-immunoprecipitation and photoreactive amino acid cross-linking, we found that AD

17 Using a photoreactive amino acid incorporated into proteins, we

18 f a substance P (SP) analogue containing the photoreactive amino acid p-benzoyl-l-phenylalanine (Bpa)

19 we are using analogues of SP containing the photoreactive amino acid p-benzoyl-L-phenylalanine (Bpa)

20 ifically replaced by the genetically encoded photoreactive amino acid p-benzoylphenylalanine (Bpa).

21 Reciprocally, Hexim1 is cross-linked by a photoreactive amino acid replacing Cdk9 W193, a tryptoph

22 resulted in the incorporation of 125I at the photoreactive amino acid residue, yielding probes of hig

23 ctors that interact with TBP, the nonnatural photoreactive amino acid rho-benzoyl-phenylalanine (BPA)

24 f the peptide ligand at a site distal to the photoreactive amino acid.

25 ANQX, a photoreactive AMPA receptor antagonist, is an important

26 ligonucleotides, each of which contained the photoreactive analog 4-thiodeoxythymidine (4-thioT) at a

27 ript could be further elongated, placing the photoreactive analog at internal positions in the RNA.

28 t, 4-azido-2-nitrophenyl phosphate (ANPP), a photoreactive analog of pNPP, was used as a probe of the

29 Here, we use a photoreactive analog of propofol (2-isopropyl-5-[3-(trif

30 ing sites in a muscle-type nAChR by use of a photoreactive analog of propofol, 2-isopropyl-5-[3-(trif

31 interactions, we prepared a fully functional photoreactive analog of PTHrP, [Ile5,Bpa23,Tyr36]PTHrP-(

32 ynylphenyl) barbituric acid (S-mTFD-MPPB), a photoreactive analog of the convulsant barbiturate S-MPP

33 Azietomidate is a photoreactive analog of the general anesthetic etomidate

34 photoadduction of azi-m-propofol (aziPm), a photoreactive analog of the general anesthetic propofol.

35 When cross-linked to alphaLbeta2, the photoreactive analog of THI0019 remained an agonist, con

36 N(6)-dATP and its photoreactive analogs AB-dATP and DB-dATP were successfu

37 iazirynylphenyl)barbituric acid (mTFD-MPAB), photoreactive analogs of 2-ethyl 1-(phenylethyl)-1H-imid

38 Previously, using photoreactive analogs of etomidate ([(3)H]azietomidate)

39 Photoreactive analogs of PTH singularly substituted with

40 The interactions of a photoreactive analogue of benzoylcholine, 4-azido-2,3,5,

41 In order to address this question, a photoreactive analogue of cisplatin, PtBP(6), was used t

42 Here, we report the synthesis of a photoreactive analogue of echistatin (a 49-amino acid pe

43 ynthesis of photo-leucine, a diazirine-based photoreactive analogue of leucine, and demonstrate its i

44 A nonhydrolyzable GTP photoreactive analogue, azidoanilido [alpha-32P]GTP (AAG

45 The first synthesis of two photoreactive analogues of the lipid mediator and second

46 Combining both photoreactive and inert polycations in the same film yie

47 -CN-riboflavin and 8-CN-FMN were found to be photoreactive and need to be protected from exposure to

48 and quadruplet codons including fluorescent, photoreactive and redox active amino acids, glycosylated

49 midate and a barbiturate, [(3)H]R-mTFD-MPAB, photoreactive anesthetics that bind with high selectivit

50 demonstrate that the relative populations of photoreactive anti-parallel and non-photoreactive parall

51 The ApP is fused to a small photoreactive antibody-binding domain (pAbBD) that can b

52 lar crystal of a rigid monomer bearing three photoreactive arms, photopolymerization of the crystalli

53 f thymidine in the major groove of DNA using photoreactive aryl azides attached to deoxyuridine by va

54 n of biological cysteine-Au(I) adducts and a photoreactive Au(I) complex that produces a covalent bon

55 Affinity mapping using photoreactive AVG analogs identified the interface of po

56 Significantly, the photoreactive azide of IAS is positioned on the phenyl r

57 In addition to N(3)RdUTP, which has a photoreactive azido group 9 A from the uridine base, we

58 irus capsid-derived peptide ligand bearing a photoreactive azido group was specifically bound by and

59 romethyldiazirinylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and stereosel

60 ect to a damaged DNA site was assessed using photoreactive base analogues within specific DNA substra

61 ions in K(+) solution, whereas a potentially photoreactive basket conformation is favored in Na(+) so

62 pha subunit specifically photolabeled by the photoreactive batrachotoxin derivative was identified by

63 developed photoaffinity probes containing a photoreactive benzophenone derivative, p-benzoylphenylal

64 pic label in the choline methyl groups and a photoreactive benzophenone in the long-chain base, may b

65 This ligand contains a photoreactive benzophenone moiety attached to the side c

66 oy a synthetic signal peptide containing the photoreactive benzoylphenylalanine to efficiently and sp

67 t proteins interacting preferentially with a photoreactive BER intermediate can be selected from the

68 Photoreactive BH3 helices mapped both triggering and aut

69 abricated through patterning with light in a photoreactive binary blend of crosslinking acrylate and

70 Two fluorophores bound with a short photoreactive bridge are fascinating structures and rema

71 While the use of photoreactive cages to investigate the influence of subs

72 levels of singlet oxygen, produced either by photoreactive chemicals or high light treatment, induces

73 rn California Bight by measuring retinal-the photoreactive chromophore essential for rhodopsin functi

74 erdin, found in most mammalian tissues, as a photoreactive chromophore.

75 BODIPY photocages are photoreactive chromophores that release covalently linke

76 Recently, we developed a photoreactive "clickable" probe, SAHA-BPyne, to report o

77 The most photoreactive CNTs exhibited comparable photoreactivity

78 However, the use of photoreactive coloured organic compounds is the optimal

79 rface itself is photochemically inert, while photoreactive component is present in the solution.

80 The hydrophobic photoreactive compound 3-trifluoromethyl-3-(m-[125I]iodo

81 Subsequent activation of the photoreactive compound by a specific wavelength of light

82 The photoreactive compound incorporated into the block copol

83 Photoreactive compounds are important tools in life scie

84 Microbial reworking also produces photoreactive compounds, with potential implications for

85 ar features (elemental ratios and mass) with photoreactive compounds.

86 the form 3 conformation is not the principal photoreactive conformation, and that G-quadruplexes in K

87 K(+) solution are dynamic and able to access photoreactive conformations more easily than in Na(+) so

88 the kinase, we used the heterobifunctional, photoreactive cross-linker N-5-azido-2-nitrobenzoyloxysu

89 ural amino acid p-benzoyl-L-phenylalanine, a photoreactive cross-linker, we mapped interactions betwe

90 Dendrimers functionalized with photoreactive cross-linkers were internalized by HeLa ce

91 pRNAs were used to position an azidophenacyl photoreactive cross-linking agent specifically at a stra

92 We have used a sensitive photoreactive cross-linking assay to explore the substra

93 action, Tim23p molecules containing a single photoreactive cross-linking probe were imported into mit

94 spondin and fibrinogen were identified using photoreactive cross-linking to an albumin-(serotonin)(6)

95 domain, we implemented unnatural amino acid photoreactive crosslinking to the alveolin domain and id

96 Two new photoreactive dATP analogs, N(6)-[4-azidobenzoyl-(2-amin

97 A novel photoreactive deoxycytidine analog, 4-[N-(p-azidobenzoyl

98 Another photoreactive deoxyuridine analog was made that containe

99 nity labeling using the previously described photoreactive deoxyuridine analog, 5-[N-(pazidobenzoyl)-

100 A photoreactive derivative of famotidine has been synthesi

101 illary gland membranes with a radioiodinated photoreactive derivative of SP, p-benzoyl-L-phenylalanin

102 es of covalent attachment of radioiodinated, photoreactive derivatives of SP containing p-benzoyl-L-p

103 Photoreactive derivatives of the general anesthetic etom

104 We used a panel of photoreactive derivatives to identify the site of action

105 Using photoreactive Dewar benzene 3,4,5,6-tetramethyl-1,2-dica

106 chors having a clickable alkynyl group and a photoreactive diazirine group attached to the GPI glucos

107 escribed preliminary studies on the use of a photoreactive diazirine-containing amino acid to cross-l

108 he resting channel [3H]DAF is bound with its photoreactive diazo group oriented toward deltaVal-269.

109 Using photoreactive DNA containing 5-iodo-dUMP in defined posi

110 To create the photoreactive DNA probe in situ, DNA substrates containi

111 Using photoreactive DNA probes, we provide evidence that withi

112 ge of soils using viability PCR based on the photoreactive DNA-intercalating dye propidium monoazide(

113 cene is shown, without relying on additional photoreactive dopants or alignment layers.

114 todynamic therapy (PDT), the activation of a photoreactive drug in tumor tissue with visible light, i

115 mer units present limited accessibility to a photoreactive dye.

116 because the singlet oxygen produced by these photoreactive dyes compromised ocular cellular, humoral,

117 In contrast, covalent attachment of the photoreactive ethidium analog to DNA resulted in marked

118 Here, we used a radiolabeled, photoreactive etomidate analog ([(3)H]azietomidate), whi

119 We report here that TDBzl-etomidate, a photoreactive etomidate analog, acts as a positive allos

120 Previously, photoreactive etomidate analogs identified two equivalen

121 Photoreactive etomidate derivatives labeled alphaMet-236

122 lly cross-linked to the damaged DNA when the photoreactive FAP-dCMP (exo-N-{2-[N-(4-azido-2,5-difluor

123 sly shown to exist primarily in the proposed photoreactive form 3 conformation than the sequence show

124 ectively, indicating that these are the most photoreactive fractions of DOM.

125 oAffinity Bits), which utilizes a library of photoreactive fragments to covalently capture fragment-p

126 In this report, we utilize novel photoreactive fusion inhibitors and photoaffinity labeli

127 been facilitated by using drugs developed as photoreactive GABAAR modulators.

128 first asymmetric synthesis of novel, potent photoreactive gamma-secretase inhibitors 2 and 3 has bee

129 on two-step protocols that first introduce a photoreactive group and then generate a reactive interme

130 ditions of direct UV light activation of the photoreactive group at 312 nm.

131 In this paper, a photoreactive group at the N-terminus of the RGD-ligand

132 he oligodeoxyribonucleotide as an additional photoreactive group did not increase the photo-cross-lin

133 th different protein targets in cells, (2) a photoreactive group for UV light-induced covalent cross-

134 ntact site for an echistatin analogue with a photoreactive group in position 45, near the C-terminus

135 ted by 365 nm UV light, activates the nearby photoreactive group in the BER intermediate resulting in

136 Depending on the location of the photoreactive group in the primer, the distribution of t

137 The arylazido photoreactive group is then activated through energy tra

138 pha(V)beta(3)-ligand possessing a C-terminal photoreactive group was photo-cross-linked within beta(3

139 , an analog of THI0019 modified to contain a photoreactive group was used to demonstrate that when cr

140 es outstanding inhibitor potency, a suitable photoreactive group, and tritium at high specific activi

141 ional glycosylatable peptides containing two photoreactive groups and found that these were linked to

142 described the use of small molecules bearing photoreactive groups and latent affinity handles as full

143 These are based on diazirine photoreactive groups and sulfoxide as the MS-labile link

144 e synthetic origin of the polyester, the way photoreactive groups are introduced and organized within

145 Photoreactive groups have enabled chemists to activate b

146 The reactivity of photoreactive groups in solution often departs from thei

147 In addition, we introduced photoreactive groups in the multilayer, which rendered t

148 The probes are equipped with two photoreactive groups to allow photoliberation (uncaging)

149 ffinity labeling, we attached four different photoreactive groups to DNA and examined their ability t

150 ze, chemical properties, and availability of photoreactive groups.

151 Here, we synthesize and characterize a photoreactive GTP affinity probe that covalently photocr

152 borated by an increased incorporation of the photoreactive GTP analog [gamma-32P]GTP azidoanilide int

153 hile enabling the direct installation of the photoreactive handle.

154 Photoreactive heterotrifunctional chemical cross-linking

155 A three-dimensional bulk photoreactive hydrogel eliminates manual blotting.

156 me photobleaching, which makes granules more photoreactive, increased the effects of blue light.

157 A photoreactive inhibitor, [alpha-(32)P]-8-azidoadenosine

158 We find that photoreactive IR probes are not compatible with OPTIR.

159 This work reports a luminescent and photoreactive iron(II) complex, the first performant gro

160 Toward this aim, we use a photoreactive, irreversible antagonist of AMPA receptors

161 iant rests on reactivity differences between photoreactive ketone groups in specific chemical environ

162 We designed and synthesized photoreactive ligands and used them for photoaffinity la

163 These photoreactive ligands are based on cyclo Ac-[Cys-Asn-Dmt

164 studies in our laboratory using radiolabeled photoreactive ligands suggested that the steroid binding

165 This results in synthesis of a photoreactive long patch base excision repair (BER) inte

166 Rac1 mutants were fused to the photoreactive LOV (light oxygen voltage) domain from pho

167 epsilon-(5-azido-2-nitrobenzoyl)-lysyl-tRNA, photoreactive lysine residues would be incorporated in t

168 ess in the development of advanced nanoscale photoreactive, magnetic and multifunctional materials ap

169 water, suggesting differential recoveries of photoreactive moieties by solid phase extraction.

170 owth were likely driven by the production of photoreactive moieties through the heterotrophic transfo

171 t distance being less than the length of the photoreactive moiety attached to the ligand.

172 The GSTABP-G features a photoreactive moiety for UV-induced covalent binding to

173 ne or alters the protein interface so that a photoreactive moiety is brought closer to the cap struct

174 solid-state reaction kinetics suggests that photoreactive molecular crystals may be useful for gener

175 t a photomechanical response and motility of photoreactive molecular crystals.

176 Photoreactive molecules have been conjugated to TFOs to

177 the interaction of SecA with ribosome-bound photoreactive nascent chains in the absence of trigger f

178 le to determine chemical dynamics in complex photoreactive networks.

179 sed of two pyridyl-amide arms connected by a photoreactive nitrophenyl group.

180 al crosslinking strategy that incorporates a photoreactive, non-natural amino acid, p-benzoyl-l-pheny

181 of native and minimal hammerheads containing photoreactive nucleobases 6-thioguanosine, 2,6-diaminopu

182 es in vivo labeling of nascent RNAs with the photoreactive nucleosides 4-thiouridine (4SU) or 6-thiog

183 The photoreactive nucleotide 4-thiothymidine (4ST) incorpora

184 her a phenylazide or phenyldiazirine and the photoreactive nucleotide is then enzymatically incorpora

185 sslinks in E.coli occur because of unusually photoreactive nucleotides at particular locations in the

186 Photoreactive nucleotides containing an aryl azide (AB-d

187 5 S rDNA was engineered with photoreactive nucleotides incorporated at different site

188 nthetic supercoiled DNA substrate containing photoreactive nucleotides.

189 concept of "crystal microbots", realized by photoreactive organic crystals capable of prolonged dire

190 ortance of TU in templating the olefins in a photoreactive orientation in the crystalline state.

191 Each contains a photoreactive p-benzoyl-phenylalanyl (Bpa) residue in cl

192 Four PTH analogues, containing a single photoreactive p-benzoylphenylalanine (Bpa) residue in po

193 tions of photoreactive anti-parallel and non-photoreactive parallel conformers of the ring-open form

194 A photoreactive peptide is synthesized that affinity-label

195 f appropriately posttranslationally modified photoreactive peptide probes of isoprene function.

196 oss-linking experiments were performed using photoreactive peptides containing the YDSI motif and pur

197 By genetically incorporating photoreactive phenyl azide, the fluorescent properties o

198 Benzoylphenylalanine, a photoreactive phenylalanine analog that can be incorpora

199 of Mg(2+), ADP, and orthovanadate (V(i)), a photoreactive phosphate analog with a trigonal bipyramid

200 RNATyr gene was extensively probed by use of photoreactive phosphodiesters, deoxyuridines, and deoxyc

201 -induced switching of the formal charge of a photoreactive polycation resulted in repulsive interlaye

202 Photoreactive polyelectrolyte multilayers (PEMs) that di

203 r guideline to develop afterglow probes from photoreactive polymers.

204 rom intracellular accumulation of undigested photoreactive POS lipids.

205 f which spans positions 24-26; together, the photoreactive positions flank the RGD motif.

206 d by the extent of decreased labeling by the photoreactive probe 3-(trifluoromethyl)-3-(m- [125I]iodo

207 receptor structure, we used the hydrophobic photoreactive probe 3-trifluoromethyl-3-(m-[(125)I]iodop

208 In addition, a single photoreactive probe incorporated at a unique site in act

209 A photoreactive probe was incorporated into a nascent chai

210 A photoreactive probe was incorporated into the middle of

211 For each photoreactive probe, labeled sites were identified by am

212 eavage products bear the membrane-restricted photoreactive probe, proof that surface-cleaved TNF has

213 We now demonstrate, using peptides with a photoreactive probe, that this binding is strengthened s

214 ving the design and synthesis of a clickable photoreactive probe, we demonstrated specific labeling o

215 ibe a suite of S-adenosyl homocysteine (SAH) photoreactive probes and their application in chemical p

216 n of a complementary pair of bio-orthogonal, photoreactive probes based on the polyunsaturated scaffo

217 future development of click chemistry-based photoreactive probes for the in situ analysis of additio

218 intermediate of ppalphaF was generated with photoreactive probes incorporated into the mature portio

219 tization technique that leverages the unique photoreactive properties of unsaturated lipids to reveal

220 es, the ferric form of cupriachelin exhibits photoreactive properties.

221 x-formation oligonucleotides attached with a photoreactive psoralen molecule (psoTFO) can be used to

222 Photoreactive psoralens can form interstrand crosslinks

223 we designed and radioiodinated a bioactive, photoreactive PTH agonist, (125)I-[Nle(8,18),Lys13(epsil

224 The photoreactive PTH(1-34) analogue K27 contains a benzophe

225 annel receptor site 2, was localized using a photoreactive radiolabeled batrachotoxin derivative to c

226 has led to the search for sequence-specific photoreactive reagents that can produce more genotoxic l

227 Our goal was to generate competent photoreactive receptors that can be cross-linked to beta

228 Photoreactive repair (PR) of cyclobutane pyrimidine dime

229 Transcription had no effect on photoreactive repair in transcribed and downstream regio

230 ith nearly all conserved residues within the photoreactive retinal-binding pocket in the membrane-emb

231 The newly designed tagged photoreactive RGD-containing ligands display an affinity

232 s-linking analysis of interactions between a photoreactive RNase MRP substrate and the Saccharomyces

233 Upon excitation to the photoreactive S(2)(L(a)) state, a favorable redistributi

234 ization that photoinduced bending of slender photoreactive single crystals is surprisingly common has

235 zation with photocleavable moieties or using photoreactive small-molecule ligands.

236 e has been obtained that at equilibrium, the photoreactive SP analogue (125)I-[D-Tyr(0)]Bpa(3)SP cova

237 In this study, a second photoreactive SP analogue, Bpa(4)-SP, in which the Bpa r

238 the triplet excited state is univocally the photoreactive state leading to exo/endo carbazole deriva

239 ggests a polar transition state and the S(1) photoreactive state.

240 chemoproteomic strategy that uses clickable, photoreactive sterol probes in combination with quantita

241 sequences are inserted between a hydrophobic photoreactive styrylpyrene unit and a hydrophilic polyme

242 y the demonstration several years ago that a photoreactive substrate analogue, azido-Q, covalently la

243 photocatalytically oxidized into a series of photoreactive substrates that underwent photolysis or ad

244 Thus, dual-wavelength-driven photoreactive systems (reactions that require or utilize

245 ween the murine mdr1b P-glycoprotein and two photoreactive Taxol analogues have been mapped by a comb

246 ne of the ammine ligands was replaced with a photoreactive tethered aryl azide ligand.

247 Derivatized SWCNTs were significantly more photoreactive than derivatized MWCNTs.

248 ence, *[LAuX](n) oligomeric species are more photoreactive than monomeric species.

249 We further show that N-H imines are more photoreactive than N-substituted imines, a distinction p

250 in the labeling of L27 from the 3' end of a photoreactive tRNA at the ribosomal P site.

251 , we describe the genetic incorporation of a photoreactive Uaa into the pore of an inwardly rectifyin

252 Monomers were synthesized by connecting two photoreactive units, either sorbic acids (monomer I) or

253 problem, we demonstrate the application of a photoreactive unnatural amino acid (UAA) crosslinking sy

254 glutamate receptor by genetically encoding a photoreactive unnatural amino acid (UAA).

255 sed amber codon suppression to introduce the photoreactive unnatural amino acid p-benzoyl-l-phenylala

256 We show, using a photoreactive, unnatural amino acid, that Asf1 tail resi

257 elies on a photopatternable (blue light) and photoreactive (UV light) polyacrylamide gel.

258 e, thus opening an avenue to design advanced photoreactive wavelength-controlled systems for applicat