ライフサイエンスコーパス: photoreceptor

1 pair kinesin-driven ciliary transport in the photoreceptor.

2 photoreactivity of these two closely related photoreceptors.

3 ting the dark adaptation of rod but not cone photoreceptors.

4 and efficient synaptic transmission in cone photoreceptors.

5 Ex data sets to study the unique splicing of photoreceptors.

6 ns of the retina that form synapses with rod photoreceptors.

7 ure with severe malformations in the area of photoreceptors.

8 tinal ganglion cells and a large fraction of photoreceptors.

9 essential for the viability and function of photoreceptors.

10 upply route from the choriocapillaris to the photoreceptors.

11 ted with the visual pigments of rod and cone photoreceptors.

12 the G protein-coupled receptor rhodopsin in photoreceptors.

13 ith lysosome-like structures observed in the photoreceptors.

14 animals with more than three types of color photoreceptors.

15 scribe the localization of PDLIM1 in chicken photoreceptors.

16 ted with the visual pigments of rod and cone photoreceptors.

17 pes but not significantly in Muller cells or photoreceptors.

18 ion and selective failure to regenerate cone photoreceptors.

19 of which are preferentially expressed in rod photoreceptors.

20 r renewal by phagocytosis of the tips of the photoreceptors.

21 tially general strategy to convert RTKs into photoreceptors.

22 dle- (M-) and long- (L-) wave sensitive cone photoreceptors [2].

23 tly change the relative activity of M- and L-photoreceptors [5, 6].

24 he form of a horizontal streak of higher rod photoreceptor (~80,000 rods mm(-2) ) and ganglion cell (

25 the proper formation of the outer segment of photoreceptors, a modified cilium.

26 , several recent studies utilizing triggered photoreceptor ablation have shown adaptive responses in

27 ity, and restrict the light that reaches the photoreceptor according to ambient light intensities.

28 he transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina.

29 , as both destabilize the active form of the photoreceptor and thermosensor phytochrome B (phyB).

30 on and primary, nonapoptotic degeneration of photoreceptors and a role for apoptosis in secondary deg

31 e retina by populations of neurons including photoreceptors and bipolar cells.

32 tina, which provide inhibitory feedback onto photoreceptors and contribute to image processing.

33 An array of photoreceptors and intricate signaling pathways allow pl

34 oes not localize to the subapical regions of photoreceptors and Muller glial cells; rather, it locali

35 nd structural changes at the level of single photoreceptors and neurons.

36 ertain defects in the differentiation of the photoreceptors and other retinal neurons by influencing

37 We show that cone photoreceptors and P-type pathway bipolar cells are tigh

38 physiology, the pigment epithelium supports photoreceptors and participates in their renewal by phag

39 plied to study the light-induced response of photoreceptors and photoenzymes in vitro Here, we establ

40 ess, vitamin A aldehyde is shepherded within photoreceptors and retinal pigment epithelial cells to f

41 nitor cells at birth and ectopic presence of photoreceptors and secondary neurons upon maturation sug

42 derstand the interaction between the hAM and photoreceptors and suggest that photoreceptor regenerati

43 l types, including Muller glia, rod and cone photoreceptors, and bipolar cells.

44 We tested this idea in Xenopus laevis photoreceptors, and found that transgenic expression of

45 asets revealed predominant expression in rod photoreceptors, and immunostaining demonstrated RIMS2 lo

46 ational dysregulation that ultimately drives photoreceptor apoptosis and an inflammatory reactive gli

47 Combined, these fate changes suggest that photoreceptors are a default fate outcome in OTX2+ cells

48 Photoreceptors are highly specialized sensory neurons wi

49 Photoreceptors are important for light sensing and downs

50 While various makers for photoreceptors are present in the cavefish inner segment

51 s and vision loss.SIGNIFICANCE STATEMENT The photoreceptors are specialized neurons that drive photot

52 ntributing to the differentiation pathway of photoreceptors are targets of the miR-183 cluster, and t

53 In order to understand how photoreceptors are tilted inside the eye, we used comput

54 However, blue light-responsive photoreceptors are, in principle, considered inadequate

55 ain continuous rod function and support cone photoreceptors as well although its throughput has to be

56 culating quantum catch for N. oerstedii's 12 photoreceptors associated with chromatic vision, we foun

57 revealed hyperreflective aberrations within photoreceptor-associated bands.

58 this mosaic grows by mitotic addition of new photoreceptors at the rim of the hemispheric retina, top

59 c horizontal cell refinement and presynaptic photoreceptor axon growth.

60 tion of muscle cells tightly associated with photoreceptor axons at stereotyped positions in both uni

61 that OTX2 is required for the generation of photoreceptors, but also for repression of specific reti

62 Degeneration of photoreceptors caused by excessive illumination, inherit

63 loss of transducin in rd10 mice also led to photoreceptor cell death in darkness.

64 in-coupled receptor is causing light-induced photoreceptor cell death in rd10 mice.

65 Photoreceptor cell death is the ultimate cause of vision

66 In rd10 mice, photoreceptor cell death occurs with exposure to normal

67 sregulation is thought to cause rod and cone photoreceptor cell death.

68 rogressive disease involving RPE atrophy and photoreceptor cell degeneration.

69 ve outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hund

70 l1 disruption caused abnormal positioning of photoreceptor cell nuclei early in development.

71 Additionally, four weekly IVIs increased the photoreceptor cell number in the retinae of Rho(P23H/+)

72 visual photopigments are housed within these photoreceptor cells and are sensitive to a wide range of

73 is constitutive activity can desensitize rod photoreceptor cells and lead to night blindness.

74 orrelated with a significant preservation of photoreceptor cells at 4 and 10 weeks PI.

75 in coexpressed with rhabdomeric-opsin in eye photoreceptor cells bearing both microvilli and cilia in

76 ve units expressed multiple opsins, while UV photoreceptor cells expressed single opsins; 2) most of

77 r a new way for maintaining and regenerating photoreceptor cells in neurodegenerative diseases.

78 Photoreceptor cells in the eyes of Bilateria are often c

79 ations in dogs characterised by depletion of photoreceptor cells in the retina, which ultimately lead

80 This rule is broken by rod photoreceptor cells of nocturnal mammals, in which the t

81 f photoreceptive units (e.g., assemblages of photoreceptor cells).

82 bit signs of retinal stress and rapidly lose photoreceptor cells.

83 based photosensitive organelle of Drosophila photoreceptor cells.

84 of 11-cis-retinal that can be marshalled in photoreceptor cells.

85 sponse during visual signaling in vertebrate photoreceptor cells.

86 ution, and possible plasticity of animal eye photoreceptor cells.

87 Evolution to GA is heralded by early local photoreceptor changes and drusen accumulation, detectabl

88 segment layer with a concomitant increase in photoreceptor cilia length.

89 We demonstrate that C2orf71/PCARE (photoreceptor cilium actin regulator) can interact with

90 both the visual system and non-image-forming photoreceptors contribute to circadian clock resetting.

91 Rod and cone photoreceptors convert light into electrochemical signal

92 aic pattern of hexagonal shapes representing photoreceptors could not be resolved in most pathologic

93 Furthermore, the photoreceptor count was assessed.

94 ied ncRNA profiling to identify rod and cone photoreceptor CREs from wild-type and mutant mouse retin

95 the clock protein TIMELESS by the blue light photoreceptor Cryptochrome is considered the main mechan

96 of adjacent photoreceptor outer segments and photoreceptor death, which eventually led to decline of

97 causes shortening of the outer segments and photoreceptor death.

98 f/f(CRX-Cre)) ] exhibited rapid, early-onset photoreceptor degeneration and functional decline charac

99 that her9 is upregulated during chronic rod photoreceptor degeneration and regeneration in adult zeb

100 We did not observe any photoreceptor degeneration in either heterozygous or hom

101 Characterized by progressive photoreceptor degeneration in the central retina, diseas

102 Photoreceptor degeneration is the most common cause of b

103 ensitive mouse model of acute stress-induced photoreceptor degeneration recapitulates the epigenetic

104 esented retinal pigment epithelium (RPE) and photoreceptor degeneration which was similar to the adva

105 ption of the retinal pigment epithelium, (3) photoreceptor degeneration, and (4) absence of other sig

106 We examined the role of Ca(2+) in photoreceptor degeneration, assessing the activation pat

107 etween decreased chromatin accessibility and photoreceptor degeneration, thereby elucidating a potent

108 ed electroretinograms (ERGs) and progressive photoreceptor degeneration, which is presumed to be driv

109 al therapies to both improve vision and slow photoreceptor degeneration.

110 rhodopsin levels in Prcd-KO retina prior to photoreceptor degeneration.

111 ype BALB/c mice susceptible to light-induced photoreceptor degeneration.

112 on of the RPE, and (3) evidence of overlying photoreceptor degeneration.

113 d - rod bipolar cell signaling following rod photoreceptor degeneration.

114 leading to persistent visual function during photoreceptor degenerative disease.

115 Photoreceptor density in 2-month old pomgnt1 mutant reti

116 Mean parafoveal photoreceptor density was 14 988 cells/mm(2) (standard d

117 ated horizontal visual streak with increased photoreceptor density, with additional local maxima in w

118 We also observed a dorsoventral asymmetry in photoreceptor density, with greater density in the ventr

119 The activity and survival of retinal photoreceptors depend on support functions performed by

120 icantly enhanced Ryr2 expression in cultured photoreceptor-derived Weri-Rb1 cells.

121 previously undescribed role for Her9/Hes4 in photoreceptor differentiation, maintenance, and survival

122 genetically encoded Ca(2+) indicator in the photoreceptor ER.

123 Toc159 protein import receptors have active photoreceptors, even though the mutant fails to induce t

124 a light-induced rise in cytosolic Ca(2+) in photoreceptors exposed to Ca(2+)-free solutions.SIGNIFIC

125 work in opposition, such that PRDM1 promotes photoreceptor fate and VSX2 bipolar cell fate.

126 comes, whereas double gene targeting favored photoreceptor fate.

127 In mammalian retinas, rod and cone photoreceptors form selective synaptic connections with

128 t inactivating rhodopsin signaling protected photoreceptors from degeneration suggesting that the pat

129 to RetGC, a process essential for protecting photoreceptors from degeneration.

130 eas others perforated the retina, separating photoreceptors from the retinal pigment epithelium.

131 l-field electroretinogram and found impaired photoreceptor function and retina-based alterations most

132 ndria are known to play an essential role in photoreceptor function and survival that enables normal

133 S) to the outer segment (OS) is critical for photoreceptor function and vision.

134 Aberrant photoreceptor function or morphogenesis leads to blindin

135 posure to ML-265 did not result in decreased photoreceptor function or survival under baseline condit

136 eveal that MCU is dispensable for vertebrate photoreceptor function, consistent with its low expressi

137 a expression, the db/db mice had reduced rod photoreceptor function.

138 ase 6beta (Pde6beta), involved in modulating photoreceptor functions.

139 wing a posteriorly located retinal area with photoreceptor: ganglion cell convergence as low as 39:1.

140 rstanding the physiological requirements for photoreceptor homeostasis and the factors that drive mic

141 cone photoreceptors that has major roles in photoreceptor homeostasis as well as retinoid and polyun

142 Here, we investigated the role of ERdj5 in photoreceptor homeostasis in vivo by using an Erdj5 knoc

143 e identified 58 cell types within 6 classes: photoreceptor, horizontal, bipolar, amacrine, retinal ga

144 ted with epigenetic profiles of rod and cone photoreceptors, identified thousands of candidate rod- a

145 In mice, OPN5 is a known photoreceptor in the retina(3) and skin(4) but is also e

146 sh inner segments, the outer segments of the photoreceptors in cavefish are missing from the earliest

147 onserved photoreaction characteristic of CRY photoreceptors in plants and some non-plant species.

148 sducin signaling did not prevent the loss of photoreceptors in rd10 mice reared under normal light co

149 rcuit until they themselves are inhibited by photoreceptors in response to dimming, thus providing a

150 microtomography, we reconstructed models of photoreceptors in situ and extracted estimated angular a

151 Cone photoreceptors in the retina enable vision over a wide r

152 on factors that can physically interact with photoreceptors, including phytochromes and cryptochromes

153 he therapy and two weeks after acute loss of photoreceptor input in the living animal.

154 avelength-sensitive opsin transcript; 3) the photoreceptors involved in spatial, motion, and polariza

155 This photoreceptor is the first system discovered so far, to

156 E STATEMENT The death of retinal neurons and photoreceptors is a leading cause of vision loss.

157 Temporal contrast detected by rod photoreceptors is channeled into multiple retinal rod pa

158 resolution afforded by a dense array of cone photoreceptors is preserved in the retinal output by a r

159 The continual responsiveness of these photoreceptors is then sustained by regeneration process

160 trastructural analysis demonstrates that rod photoreceptors lacking PRCD display disoriented and dysm

161 ransporter with strong expression within the photoreceptor layer in the retina.

162 Eyes with GA had significantly reduced photoreceptor layer thickness; but similar nerve fiber l

163 g characteristics: (1) atrophy of the foveal photoreceptor layer with or without associated subretina

164 All eyes exhibited thinning of photoreceptor layers, despite intact retinal pigment epi

165 foveal hypoplasia, quantitative parameters (photoreceptor length, OS length, FDI), and PL VA were ob

166 1; OS length: r = 0.65; F = 7.94, P < 0.008; photoreceptor length: r = 0.65; F = 7.94, P < 0.008).

167 r visual system to electrical stimuli in the photoreceptor-less retina that warrant further mechanist

168 transformation of these cells to neuron- and photoreceptor-like cells, which are associated with the

169 e the transformation of fibroblasts into rod photoreceptor-like cells.

170 mitochondrial metabolic state and attenuate photoreceptor loss in a model of retinitis pigmentosa, t

171 Photoreceptor loss is the final common endpoint in most

172 inal levels, qAF and NIR-AF intensities, and photoreceptor loss were consistent with the clinical pre

173 tive disease that leads to blindness through photoreceptor loss.

174 ght-induced RPE cellular damage preceded the photoreceptors loss.

175 Similar to cancer cells, photoreceptors maintain pyruvate kinase muscle isoform 2

176 vation of the largest PDFME via lamina organ photoreceptors maintains PDF release orchestrating phase

177 at the intracellular environment affects LOV photoreceptor mechanisms in general.

178 Retinal rod and cone photoreceptors mediate vision in dim and bright light, r

179 Trafficking of photoreceptor membrane proteins from their site of synth

180 n alternative pathway for Ca(2+) uptake into photoreceptor mitochondria.

181 either good (photoreceptors seen), average (photoreceptor mosaic cannot be visualized clearly, retin

182 etinas of nonmammalian vertebrates have cone photoreceptor mosaics that are often organized as highly

183 In the extracellular space between photoreceptors, Muller glial processes were identified.

184 orded sustained RET activation and prevented photoreceptor neuron loss in the retina.

185 We generated a pan-retinal and rod photoreceptor neuron-specific conditional KO mouse lacki

186 eals that many disc membranes in Prcd-KO rod photoreceptor neurons are irregular, containing fewer rh

187 Photoreceptor neurons are surrounded by an extracellular

188 proteins in the development and function of photoreceptor neurons in the retina.

189 Short green-sensitive photoreceptor neurons of the compound eye terminated in

190 Long UV-sensitive compound eye photoreceptor neurons terminated in medulla layer ME2 wi

191 e morphogenesis of terminally differentiated photoreceptor neurons.

192 tion with the progressive differentiation of photoreceptor neurons.

193 vel, and promising, therapeutic strategy for photoreceptor neuroprotection.

194 he penetration of outer limiting membrane by photoreceptor nuclei and Muller cell microvilli could mi

195 istae remodeling; therefore, we examined the photoreceptors of a heterozygous Opa1 knockout mouse mod

196 Suction electrode recordings from individual photoreceptors of both mutant lines showed normal flash

197 alization of outer segment proteins, whereas photoreceptors of F45L mice were normal.

198 ork in the literature describing the retinal photoreceptors of T. s.

199 a the largest PDFME entrained by extraocular photoreceptors of the lamina organ.

200 xpression of opsin photopigments in the cone photoreceptors of the mouse retina provides an excellent

201 Rod and cone photoreceptors of the retina are responsible for the ini

202 We have identified the photoreceptors of Trachemys scripta elegans, an intensel

203 Cone photoreceptors, OFF-midget bipolar cells (P pathway), OF

204 e progression as well as its contribution to photoreceptor OS disc morphogenesis, we generated a Prcd

205 en process is operational at the base of the photoreceptor OS where the PCARE module and actin coloca

206 ation (PRCD) is a small protein localized to photoreceptor outer segment (OS) disc membranes.

207 F220C mice exhibited minor disruptions of photoreceptor outer segment dimensions without any mislo

208 opment with lack of a foveal pit and no cone photoreceptor outer segment lengthening.

209 essential for the formation of rod and cone photoreceptor outer segments (OS).

210 in RPE further prompted the loss of adjacent photoreceptor outer segments and photoreceptor death, wh

211 ithelium (RPE), a cell layer adjacent to the photoreceptor outer segments, form the well-established

212 polar cells (BCs), which filter and transmit photoreceptor output to the inner retina, are among the

213 s a spatio-chromatic receptive field for fly photoreceptor outputs, with a color opponent center and

214 tors using selective recovery of activity in photoreceptor pairs.

215 urthermore, in the peripheral retinal parts, photoreceptors (particularly the outer segments) were no

216 rod pathways that ultimately connect to cone photoreceptor pathways via Cx36 gap junctions or via che

217 s not required for retinal morphogenesis and photoreceptor patterning.

218 Regulation of photoreceptor phosphodiesterase (PDE6) activity is respo

219 The photoreceptor phototropin2 (phot2) mediates the chloropl

220 Light responses mediated by the photoreceptors play crucial roles in regulating differen

221 Molecular decision-makers of photoreceptor (PRC) membrane organization and gene regul

222 The images showed possible photoreceptor presence over the hAM membrane.

223 cused on determining the number of different photoreceptors present in the retina of G. australis and

224 se chronological order, but how exactly cone photoreceptor production is restricted to early stages r

225 he long-range signaling capabilities of this photoreceptor protein.

226 Blue light using flavin (BLUF) photoreceptor proteins are critical for many light-activ

227 Here, we show that photoreceptors (PRs) of diseased individuals display inc

228 rosthetic implants, which aim to bypass lost photoreceptors (PRs).

229 Restoration of some photoreceptor reflectivity and intact RPE after SDD regr

230 the hAM and photoreceptors and suggest that photoreceptor regeneration may occur.

231 Also projecting to the antRNs are inhibitory photoreceptor relay interneurons.

232 eration of sensory neuronal subtypes such as photoreceptors remains a challenge.

233 ll-tolerated as protein fusion partners, are photoreceptors requiring simultaneous photoactivation to

234 e number of labs now using iPSCs to generate photoreceptor, retinal pigmented epithelial (RPE), and-m

235 In turn, photoreceptor ribbon synaptic structure depends on the c

236 se variant, rhodopsin was sequestered to the photoreceptor rod inner segment layer with a concomitant

237 sed on structures identified as either good (photoreceptors seen), average (photoreceptor mosaic cann

238 invite the suggestion that modifications of photoreceptor signals activate a plastic post-receptoral

239 ecorrelation and dimensionality reduction of photoreceptor signals while retaining maximal chromatic

240 ptor-interacting protein-like 1 (AIPL1) is a photoreceptor-specific chaperone that stabilizes the eff

241 AIPL1 is a photoreceptor-specific co-chaperone that interacts with

242 erexpression are sufficient to activate many photoreceptor-specific exons in HepG2 liver cancer cells

243 e loss of MSI1 and MSI2 prevented the use of photoreceptor-specific exons in transcripts critical for

244 d the function of the protein encoded by the photoreceptor-specific gene C2orf71, which is mutated in

245 ssociated with the expression of neuron- and photoreceptor-specific markers in human retinal pigment

246 ceptors using a mcu(-/-) zebrafish and a rod photoreceptor-specific Mcu(-/-) mouse.

247 Photoreceptor-specific Stx3 knockouts [Stx3 (f/f(iCre75)

248 unresolved, recent studies suggest that the photoreceptor-specific tetraspanin, peripherin-2/rds (P/

249 d role for ATOH7 expression in regulation of photoreceptor specification during late retinogenesis.

250 interest in colour processing in Drosophila, photoreceptor spectral sensitivity measurements have yet

251 e propose a working model in which perturbed photoreceptor states cause microglial dominant migration

252 Each photoreceptor subtype was shown to have a specific spati

253 phenotypes with mutants of the phytochrome B photoreceptor, such as delayed seed germination in the d

254 ted States and globally, is a disease of the photoreceptor support system involving the retinal pigme

255 Previous studies suggest that long-term photoreceptor survival and retinal health is in part rel

256 factors that drive microglia to best promote photoreceptor survival has important implications for th

257 hat O-mannosyl glycosylation is required for photoreceptor survival in zebrafish.

258 ed for neuroprotective modalities to improve photoreceptor survival.

259 ect of ERdj5 ablation on retinal function or photoreceptor survival.

260 melatonin receptor, is incompatible with rod photoreceptor survival.

261 ty of arrestin-1 monomer, ensuring long-term photoreceptor survival.SIGNIFICANCE STATEMENT Visual arr

262 1.4 L-type channels for the formation of rod photoreceptor synapses in the retina.

263 We wanted to know whether photoreceptor terminals could directly contact pigment-d

264 ese color opponent signals arise as early as photoreceptor terminals.

265 dulla correlating with projection regions of photoreceptor terminals.

266 entifies a violet light-sensitive deep brain photoreceptor that normally suppresses BAT thermogenesis

267 tons of the light interact with rod and cone photoreceptors that are present in the neural retina.

268 y expressed protein secreted by rod and cone photoreceptors that has major roles in photoreceptor hom

269 caused by mutations in RHO expressed in rod photoreceptors that provide vision in dim ambient light.

270 is CRB1 isoform is the only one expressed by photoreceptors, the affected cells in CRB1 disease.

271 etina and this enabled us to reconstruct how photoreceptors tilt in an intact eye.

272 refore relates the structural changes in the photoreceptor to the underlying neurological function of

273 relay the excitatory feedforward drive from photoreceptors to amacrine and ganglion cells.

274 ass of interneurons that modulate input from photoreceptors to retinal ganglion cells (RGCs), renderi

275 m CNTF treatments caused further declines of photoreceptor transcription factors accompanied by marke

276 h wild type mice, including reduction of key photoreceptor transcription factors Crx, Nrl, and rod ph

277 odel incorporating the principal features of photoreceptor transduction.

278 tified synapse in the mouse retina, the cone photoreceptor type 4 bipolar cell (BC4) synapse, and sho

279 for the determination of the density of each photoreceptor type were made in wholemount retinas.

280 To recognize and count the different photoreceptor types, we labeled them with a combination

281 Cryptochrome (CRY) photoreceptors undergo photoresponsive homo-oligomerizat

282 s phototransduction and energy metabolism in photoreceptors using a mcu(-/-) zebrafish and a rod phot

283 direct interactions between inner and outer photoreceptors using selective recovery of activity in p

284 The severe impact on early rod photoreceptor viability may signify a previously underes

285 odules engineered from the Neurospora crassa photoreceptor Vivid by orthogonalizing the homodimerizat

286 The cristae structure in the Opa1 (+/-) photoreceptors was not greatly affected, but the mitocho

287 lar alterations in the Ca(2+) economy of the photoreceptors, we believe that we have identified the k

288 of visual arrestin-1 oligomerization in rod photoreceptors, we expressed mutant arrestin-1 with seve

289 AOSLO) images of foveal capillaries and cone photoreceptors were acquired in a subset of children to

290 s in the flash responses of the two kinds of photoreceptors, which were likely during evolution to ha

291 odDeltaBsg mice showed a progressive loss of photoreceptors, while ConeDeltaBsg mice did not display

292 wavelength-sensitive opsin (lws) in red cone photoreceptors, while in retinal pigment epithelium (RPE

293 due to a distributed network of extraocular photoreceptors whose fields of view are restricted by ch

294 are also part of a widespread superfamily of photoreceptors with diverse spectral and biochemical pro

295 five spectrally and morphologically distinct photoreceptors, with the potential for complex color vis

296 we were able to observe the presence of the photoreceptors within the angioid streaks, differentiate

297 Microglia dendrites extended between photoreceptors within two hours of induction, withdrew t

298 Preventing the secondary loss of cone photoreceptors would preserve central visual acuity and

299 nset, precursor regions were associated with photoreceptor zone thinning (P = 0.007) and interdigitat

300 respectively), and loss or disruption of the photoreceptor zone, ellipsoid zone, and retinal pigment