ライフサイエンスコーパス: phylloquinone

1 s A(0) (a monomeric chlorophyll a) and A(1) (phylloquinone).

2 g(-1) cholecalciferol, and ND-54.4 mug g(-1) phylloquinone).

3 oquinone and 96.2% with 6.6% RSD for labeled phylloquinone.

4 n average of 4.7 pmol mg(-1) fresh weight of phylloquinone.

5 n of both C=O groups of one electron reduced phylloquinone.

6 carbonyl (C=O) modes of neutral and reduced phylloquinone.

7 thm (Ln)-nmol/L-unit increase in circulating phylloquinone.

8 les that contain unlabeled and (18)O-labeled phylloquinone.

9 dict this behavior for a C=O mode of neutral phylloquinone.

10 um is therefore due to a C=O mode of neutral phylloquinone.

11 e non hydrogen bonded C(1)=O mode of neutral phylloquinone.

12 nt change in the orientation of the measured phylloquinone.

13 r saline, both of which contained 154 microg phylloquinone.

14 ntify other loci contributing to circulating phylloquinone.

15 ors participate in the absorption of dietary phylloquinone.

16 ied as potential determinants of circulating phylloquinone.

17 he strength of the H-bond to the PsaA-branch phylloquinone.

18 haracteristic of asymmetric H-bonding to the phylloquinone.

19 (FW)), tocopherols (214 +/- 60 ug/g FW) and phylloquinone (18 +/- 2 ug/g FW).

20 102+/-20 nmol x h/L for the lipid group for phylloquinone; 38.6+/-7.5 nmol x h/L for the saline grou

21 dult men and women by dietary restriction of phylloquinone (40 microg/d, days 1-11) and by administra

22 ommended daily intake per 75 g serving: 100% phylloquinone, 63% ascorbic acid, 2.7% thiamine, and 97%

23 sphatidylcholine films, and were assigned to phylloquinone, A(1) (E(m) = -0.54 V) and iron-sulfur clu

24 omeric chlorophyll electron acceptor (A0), a phylloquinone (A1), and three [4Fe-4S] clusters (FX/A/B)

25 dy sheds new light on the orientation of the phylloquinone acceptors in their binding pockets in PS I

26 In postmenopausal women, phylloquinone administration is not associated with chan

27 ate to isochorismate for the biosynthesis of phylloquinone, an essential cofactor for photosynthetic

28 e lack of a significant difference in plasma phylloquinone and %ucOC between the 2 groups after eithe

29 ative standard deviation (RSD) for unlabeled phylloquinone and 96.2% with 6.6% RSD for labeled phyllo

30 hat menadione is a catabolic product of oral phylloquinone and a major source of tissue menaquinone-4

31 determination of both unlabeled and labeled phylloquinone and can be applied to bioavailability stud

32 In conclusion, dietary intakes of phylloquinone and dihydrophylloquinone, but not menaquin

33 phans (W693) is predicted to be close to the phylloquinone and has been implicated in the interaction

34 egerin was associated positively with plasma phylloquinone and inversely with %ucOC.

35 ive was to compare the biological effects of phylloquinone and its hydrogenated form, dihydrophylloqu

36 A1 binding site and that the reincorporated phylloquinone and its immediate protein environment, in

37 ulations in which the C4=O carbonyl group of phylloquinone and its methyl-less analogue are hydrogen

38 eutral" infrared difference spectra for both phylloquinone and its methyl-less analogue.

39 ted the methylation step in the synthesis of phylloquinone and led to the accumulation of 2-phytyl-1,

40 Better vitamin K status (high plasma phylloquinone and low %ucOC) was associated with lower b

41 Observational studies have shown that both phylloquinone and menaquinone intake might reduce cardio

42 ing the dithiotreitol-dependent reduction of phylloquinone and menaquinone into their respective quin

43 Vitamin K (as phylloquinone and menaquinones) is an essential cofactor

44 Vitamin K occurs in the diet as phylloquinone and menaquinones.

45 cyanobacteria and plastids, co-occurrence of phylloquinone and plastoquinone-9 has driven the evoluti

46 neutral infrared difference spectra for both phylloquinone and plastoquinone-9, it is shown that such

47 between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated

48 t as photosynthetic pigments; plastoquinone, phylloquinone and ubiquinone (all of which contain long

49 Changes in plasma phylloquinone and vitamin K1-2,3-epoxide were no differe

50 aB are pi-stacked with the head group of the phylloquinones and are H-bonded to Ser692PsaA and Ser672

51 hat connects the binding environments of the phylloquinones and FX.

52 ouplings attributed to the 2-methyl group of phylloquinone, and (iii) the orientation of Q(-) in the

53 naphthoquinone is in the same orientation as phylloquinone, and out-of-phase, spin-echo modulation sp

54 nd Cmax values for alpha-carotene, lycopene, phylloquinone, and retinyl palmitate.

55 essing and the absorption of 1) carotenoids, phylloquinone, and tocopherols in salad vegetables and 2

56 w that undercarboxylated osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid ex

57 hlorophyll a molecules (in three pairs), two phylloquinones, and a [4Fe-4S] cluster arranged in two p

58 ve previously assigned to a C:-O mode of the phylloquinone anion in WT A1(-)/A1 FTIR DS down-shifts a

59 tic resonance (EPR) signal attributed to the phylloquinone anion radical (A(1)(-)) can be observed ei

60 ymmetric vibration of both C=O groups of the phylloquinone anion should display exactly this behavior

61 BLT1 also decreased phylloquinone apical efflux by approximately 80%.

62 Carotenoids, tocopherols and phylloquinone are highly valued in vegetables due to the

63 group, the C=O/C-:O modes of neutral/reduced phylloquinone are indeed expected to be upshifted by at

64 ons indicate that two, structurally distinct phylloquinones are photoaccumulated.

65 icles that were incubated in the presence of phylloquinone, are found to be very similar to those obt

66 ifference in the relative bioavailability of phylloquinone, as evidenced by the lack of a significant

67 Phylloquinone-associated decreases in CAC progression we

68 Dietary phylloquinone at baseline was significantly lower in sub

69 Associations with circulating phylloquinone at P < 1 x 10(-6) were then evaluated in a

70 morphism (SNP) associations with circulating phylloquinone at P < 1 x 10(-6), including a functional

71 ant association was observed for circulating phylloquinone at the genome-wide significance level of 5

72 ution of unlabeled ((16)O) and (18)O-labeled phylloquinone back into the A(1) binding site in menB ph

73 indicates that we were able to reincorporate phylloquinone back into the A1 binding site and that the

74 g concentrations of ascorbic acid, thiamine, phylloquinone, beta-carotene, lutein, zeaxanthin, total

75 ort to identify amino acid residues near the phylloquinone binding sites, all tryptophans and histidi

76 quinone radical observed by EPR occupies the phylloquinone-binding site containing PsaA-Trp(693).

77 , genes that encode for proteins involved in phylloquinone biosynthesis can be deleted.

78 Populus ICS primarily functions in phylloquinone biosynthesis, a process that can be sustai

79 that the Arabidopsis enzymes are involved in phylloquinone biosynthesis.

80 cies of cyanobacteria cluster with predicted phylloquinone biosynthetic genes.

81 hotosystem (PS) I quinone acceptor, A(1), in phylloquinone biosynthetic pathway mutants are described

82 has a weak side chain cleavage activity for phylloquinone but a strong prenylation activity for mena

83 e in the PS I variant is fully occupied with phylloquinone, but the absence of methyl hyperfine coupl

84 700-A(1) cores shows that the replacement of phylloquinone by plastoquinone-9 induces a decrease in t

85 that when intravenously administered in mice phylloquinone can enter into tissues but is not converte

86 In these subjects the fraction of plasma phylloquinone carried by LDLs and by HDLs increased prog

87 nificantly differ across plasma (dp)ucMGP or phylloquinone categories.

88 her measures of vitamin K status (ie, plasma phylloquinone concentration and percentage of ucOC) did

89 Vitamin K status [plasma phylloquinone concentration and percentage of undercarbo

90 Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, wa

91 After supplementation, serum phylloquinone concentration increased approximately 10-f

92 At baseline, the mean serum phylloquinone concentration was lower in the young than

93 for the causal relation between circulating phylloquinone concentrations and risk of type 2 diabetes

94 Plasma phylloquinone concentrations declined 82% with dietary p

95 Plasma phylloquinone concentrations determined by LC-fluorescen

96 meal for the measurement of plasma lipid and phylloquinone concentrations in plasma and lipoprotein s

97 usly measure unlabeled and deuterium-labeled phylloquinone concentrations in plasma specimens using h

98 Plasma phylloquinone concentrations increased significantly wit

99 Plasma phylloquinone concentrations peaked at 6 h.

100 They add to the evidence that vitamin K1/phylloquinone concentrations vary markedly between geogr

101 Low circulating phylloquinone concentrations were associated with an inc

102 For both younger and older adults, plasma phylloquinone concentrations were higher (P < 0.001) and

103 ne-specific alkaline phosphatase (BSAP), and phylloquinone concentrations were measured at baseline a

104 s, which was assessed with the use of plasma phylloquinone concentrations, the degree of under-gamma-

105 usly found to be associated with circulating phylloquinone concentrations.

106 ly higher, and the proximal intestine mucosa phylloquinone content 4 h after gavage was increased in

107 was fed throughout both cycles; however, the phylloquinone content of one of the cycles was increased

108 y reduced DHNA-CoA thioesterase activity and phylloquinone content, establishing in vivo evidence tha

109 This approach was validated for phylloquinone, cyclosporine, testosterone undecanoate, c

110 A mixed diet containing 100 micrograms phylloquinone/d was fed throughout both cycles; however,

111 lower for each additional intake of 100 mug phylloquinone/d.

112 ted for 5 d with either broccoli (377 microg phylloquinone/d; broccoli diet) or phylloquinone-fortifi

113 -dwelling postmenopausal women received 1 mg phylloquinone daily for 12 mo (experimental group), and

114 n received a placebo daily for 1 wk and then phylloquinone daily for 3 wk: 500, 1000, and 2000 micro

115 photosensitivity to high light associated to phylloquinone deficiency in cyanobacteria.

116 ts contain only ~40% of wild-type amounts of phylloquinone, demonstrating that VTE5 and FOLK both con

117 f structural assignments and measurements of phylloquinone-derived menadione using high resolution MS

118 In comparison with phylloquinone, dihydrophylloquinone was less absorbed an

119 at certain C=C/C-:C modes of neutral/reduced phylloquinone do not shift upon replacement of the methy

120 KORC1, the Arabidopsis enzyme did not reduce phylloquinone epoxide, and was resistant to inhibition b

121 the fully adjusted model, dietary intakes of phylloquinone (for quartile 4 vs. quartile 1, hazard rat

122 77 microg phylloquinone/d; broccoli diet) or phylloquinone-fortified oil (417 microg/d; oil diet).

123 Phylloquinone, found in dark-green vegetables and certai

124 lder adults, the relative bioavailability of phylloquinone from a vegetable with that of a fortified

125 olled study evaluated the bioavailability of phylloquinone from an intravenous lipid emulsion.

126 suggest that the relative bioavailability of phylloquinone from vegetables is lower than that from a

127 ignificantly differ according to circulating phylloquinone [fully adjusted HR (95% CI) relative to >1

128 ial dilutions of either unlabeled or labeled phylloquinone gave correlation coefficients (R) of 0.999

129 prenoids, such as chlorophylls, tocopherols, phylloquinone, gibberellins, and carotenoids.

130 no difference in CAC progression between the phylloquinone group and the control group; the mean (+/-

131 367), there was less CAC progression in the phylloquinone group than in the control group (P = 0.03)

132 16-19% lower among participants with plasma phylloquinone >=0.50 nmol/L (n = 2421) compared to those

133 Participants with <=0.5 nmol/L circulating phylloquinone had an adjusted 19% higher risk of all-cau

134 sfer, involving both the PsaA- and PsaB-side phylloquinones, has been the source of some controversy.

135 ) Q(-) has a larger g-anisotropy than native phylloquinone, (ii) Q(-) does not display the prominent

136 of eight carotenoids, four tocopherols, and phylloquinone in 26 green leafy vegetables (GLV) commonl

137 bond is to tie up the C(4) carbonyl group of phylloquinone in a H-bond so as to prevent protonation a

138 ifferent from that seen with the infusion of phylloquinone in a saline solution.

139 We measured vitamin K1/phylloquinone in duplicate in 95 composite samples using

140 ings support a potential beneficial role for phylloquinone in glucose homeostasis in men and women.

141 mutants contain plastoquinone-9 rather than phylloquinone in the A(1) site and show altered rates of

142 imated to be 50 to 60 mV more oxidizing than phylloquinone in the A(1) site, which translates to a lo

143 In menG mutant PS I, phylloquinone in the A1 binding site is replaced with an

144 (11 men and 15 women) aged 20-78 y received phylloquinone in the amount of either 1.43 or 50 microg/

145 s, highlighting the importance of sufficient phylloquinone in the human diet.

146 zation pattern shows that the orientation of phylloquinone in the PS I complexes is identical to that

147 site with an orientation similar to that of phylloquinone in the wild type, and (iii) has spectrosco

148 from the spin polarization is that of native phylloquinone in the wild type.

149 olvement of both the PsaA- and the PsaB-side phylloquinones in photosystem I electron transport.

150 tionally representative data for vitamin K1 (phylloquinone) in horticultural commodities.

151 With the infusions, plasma phylloquinone increased in both groups (P = 0.001).

152 Phylloquinone intake (median: 45 microg/d) was not consi

153 icant interactions between the E4 allele and phylloquinone intake and BMD or hip fracture.

154 nd longitudinal associations between dietary phylloquinone intake and type 2 diabetes in elderly subj

155 We conclude that dietary phylloquinone intake is associated with reduced risk of

156 A daily phylloquinone intake of approximately 1000 micro g is re

157 ciation and evaluate the impact of increased phylloquinone intake on cardiovascular and other health

158 Higher phylloquinone intake was associated with greater insulin

159 by using a food-frequency questionnaire, and phylloquinone intake was estimated by using the USDA dat

160 Phylloquinone intake was not associated with fasting ins

161 otal body, lumbar spine, and hip and dietary phylloquinone intake were measured annually for 4 y.

162 ed by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circ

163 ho decreased or did not change the amount of phylloquinone intake.

164 Dietary and supplemental phylloquinone intakes were assessed by using a food-freq

165 Vitamin K1 (phylloquinone) intestinal absorption is thought to be me

166 These findings raise the question whether phylloquinone is absorbed and delivered to tissues in it

167 It is therefore surprising that each phylloquinone is hydrogen bonded at the C(4) position to

168 When the biosynthesis of phylloquinone is inhibited in Synechocystis sp. PCC 6803

169 An adult daily intake of about 100 microg of phylloquinone is recommended for the maintenance of hemo

170 cterium Synechocystis sp. PCC 6803, in which phylloquinone is replaced by plastoquinone-9 with a low

171 Phylloquinone is the one-electron carrier at the A(1) si

172 t photosystem 1 particles in the presence of phylloquinone, it was shown in another study that phyllo

173 ha-tocopherol (E), gamma-tocopherol (E), and phylloquinone (K1) by LC-MS/MS.

174 the 11 subjects supplemented with 50 microg phylloquinone/kg, plasma lipoproteins were isolated by s

175 samples spiked with between 0.5 and 32 nmol phylloquinone/L gave average recoveries of 96.7% with 5.

176 -rich lipoproteins are the major carriers of phylloquinone, LDL and HDL may carry small fractions of

177 space narrowing (JSN) per quartile of plasma phylloquinone level for each joint, adjusting for correl

178 nts with each feature per quartile of plasma phylloquinone level.

179 creased significantly with increasing plasma phylloquinone levels (P<or=0.03 for all).

180 creased significantly with increasing plasma phylloquinone levels (PR decreased from 1.0 to 0.6, P=0.

181 For example, as plasma phylloquinone levels rose, the PR for hand OA decreased

182 l/L (n = 2421) compared to those with plasma phylloquinone <0.50 nmol/L (adjusted HRs: 0.50, 0.99 nmo

183 be seedling lethal, to contain no detectable phylloquinone (< 0.1 pmol mg(-1) fresh weight) compared

184 , our study supports that higher circulating phylloquinone may be causally related with lower risk of

185 justment for confounders, dietary intakes of phylloquinone, menaquinones, and total vitamin K, assess

186 ly associated with warfarin dose and altered phylloquinone metabolism.

187 More specifically, calculations on a phylloquinone model molecule with the C(4)=O group hydro

188 A phylloquinone molecule (2-methyl, 3-phytyl, 1, 4-naphtho

189 A phylloquinone molecule (2-methyl-3-phytyl-1,4-naphthoqui

190 hotosystem I from plants and cyanobacteria a phylloquinone molecule, called A1, functions as the seco

191 d with (3)P700 are observed, indicating that phylloquinone occupies the A1 site in all of the reconst

192 further understand the potential benefits of phylloquinone on bone acquisition in growing children.

193 idose warfarin and of dietary restriction of phylloquinone on hemostasis and vitamin K nutritional st

194 This could indicate that phylloquinones on both the PsaA and PsaB branches are in

195 ctron transfer, involving only the PsaA-side phylloquinone or bi-directional electron transfer, invol

196 10 d of repletion (200 microg/d) with either phylloquinone or dihydrophylloquinone.

197 ) and with the A(1) binding site occupied by phylloquinone or plastoquinone-9.

198 olism), COL22A1, CDO1, CTNAA2, and CYP4F2 (a phylloquinone oxidase), respectively.

199 By specifically labeling only the phylloquinone oxygen atoms we are able to identify bands

200 ciation of the 5q22.3 locus with circulating phylloquinone (P < 0.05).

201 provide a supplemental amount of 150 microg phylloquinone per day in addition to that present natura

202 none was defined by the difference in plasma phylloquinone, percentage serum undercarboxylated osteoc

203 Interruption of the phylloquinone (PhQ) biosynthetic pathway by interposon m

204 tion that the oxidation rates of the reduced phylloquinone (PhQ) cofactor differ by an order of magni

205 Phylloquinone (PhQ) plays a unique role in photosynthesi

206 sting of a pair of chlorophylls (Chls) and a phylloquinone (PhQ).

207 We measured phylloquinone (PK) and menaquinone (MK) -4 to -10 in che

208 ped for the analysis of vitamin K compounds: phylloquinone (PK) and menaquinones (MK-n).

209 ve LC-ESI-MS/MS method for quantification of phylloquinone (PK), and menaquinones (MK) 4-10 in food u

210 ection and quantification by LC-ESI-MS/MS of phylloquinone (PK), menaquinone-4 (MK-4), menaquinone-7

211 , particularly MK4, than the dietary form of phylloquinone (PK).

212 ent of eight vitamin K vitamers, vitamin K1 (phylloquinone; PK) and vitamin K2 (menaquinones; MK-4 to

213 Phylloquinone postprandial response was also significant

214 In vivo, the phylloquinone postprandial response was significantly hi

215 tocopherol synthesis are completely but, for phylloquinone production, only partially derived from ge

216 We propose that in the absence of phylloquinone, PS I recruits plastoquinone-9 into the A(

217 tigated using site-directed mutations in the phylloquinone (QK) and FX binding regions of Synnechocys

218 These observations indicate that the A(1)(-) phylloquinone radical observed by EPR occupies the phyll

219 ectra, a difference spectrum associated with phylloquinone reduction (A(1)(-) - A(1)) has been calcul

220 ue to a C=O/C-:O mode of the neutral/anionic phylloquinone, respectively.

221 iated with C=C/C-:C modes of neutral/reduced phylloquinone, respectively.

222 a metabolic unit, 15 young adults were fed a phylloquinone-restricted diet (10 microg/d) for 15 d fol

223 -type design, 13 healthy volunteers eating a phylloquinone-restricted diet for 35 d were randomly ass

224 or percentage ucOC concentrations during the phylloquinone-restricted diet or during the period of di

225 The mean value for PIVKA-II during the phylloquinone-restricted diet significantly increased 5.

226 combination of omeprazole treatment and the phylloquinone-restricted diet significantly reduced PIVK

227 one concentrations declined 82% with dietary phylloquinone restriction (P < 0.05) and were not signif

228 002) and resorption (P = 0.08) after dietary phylloquinone restriction and repletion, respectively.

229 ribute to vitamin K nutriture during dietary phylloquinone restriction, but not enough to restore nor

230 yperfine coupling of the methyl group on the phylloquinone ring, whereas the S692CPsaA mutation cause

231 To investigate the environment of the phylloquinone secondary electron acceptor A(1) within th

232 were randomly assigned to receive placebo or phylloquinone supplementation (250, 375, 500, and 1000 m

233 In substudy A, %ucOC decreased with phylloquinone supplementation (P < 0.0001); a greater re

234 entrations between participants who received phylloquinone supplementation and those who did not.

235 mma-carboxylation as assessed by response to phylloquinone supplementation and to evaluate the effect

236 Phylloquinone supplementation decreased %ucOC dose-depen

237 ntrations and 2) the effect of daily 500 mug phylloquinone supplementation for 3 y on cytokine concen

238 Phylloquinone supplementation increases osteocalcin gamm

239 Phylloquinone supplementation reduced serum osteocalcin

240 Phylloquinone supplementation reduced serum osteocalcin

241 Phylloquinone supplementation slows the progression of C

242 Randomized phylloquinone supplementation trials are needed to furth

243 h 10 by fortifying corn oil in the diet with phylloquinone (supplemented diet).

244 AC (Agatston score > 10), those who received phylloquinone supplements had 6% less progression than d

245 bidopsis mutants deficient in early steps of phylloquinone synthesis do not become autotrophic and ar

246 4-dihydroxy-2-naphthoate, an intermediate in phylloquinone synthesis downstream of the OSB-CoA ligase

247 other evidence suggests that the enzymes of phylloquinone synthesis from isochorismate may form a co

248 enzoyl-coenzyme A (OSB-CoA) ligase acting in phylloquinone synthesis.

249 hat VTE5 and FOLK both contribute in part to phylloquinone synthesis.

250 esult, knockout cells contained 13-fold less phylloquinone than their wild-type counterparts and disp

251 ntified a plastidial pool of non-photoactive phylloquinone that could be involved in additional cellu

252 otosystem I (PS I) contains two molecules of phylloquinone that function as electron transfer cofacto

253 In addition, phylloquinone that has asymmetrically hydrogen bonded ca

254 s, each consisting of two chlorophylls and a phylloquinone, that potentially link the primary electro

255 Levels of plasma phylloquinone (the primary form of vitamin K) had previo

256 ssociated with concentrations of circulating phylloquinone, the primary circulating form of vitamin K

257 aphthoquinone in the biosynthetic pathway of phylloquinone, the secondary electron acceptor in photos

258 zymes of the biosynthetic pathway leading to phylloquinone, the secondary electron acceptor of photos

259 se, respectively, prevented the synthesis of phylloquinone, thereby confirming the participation of t

260 Before administration of the placebo or phylloquinone, total osteocalcin, ucOC, glucose, and ins

261 Phylloquinone uptake by Caco-2 cells was saturable and w

262 Phylloquinone uptake was then measured ex vivo using mou

263 ndercarboxylated osteocalcin (ucOC)], plasma phylloquinone, urinary gamma-carboxyglutamic acid, and p

264 e the only organisms capable of synthesizing phylloquinone (vitamin K for vertebrates), which they us

265 sary step to form the naphthoquinone ring of phylloquinone (vitamin K(1) ).

266 ated the causal relation between circulating phylloquinone (vitamin K(1)) concentrations and type 2 d

267 ctive of this study was to determine whether phylloquinone (vitamin K(1)) intake and biochemical indi

268 Phylloquinone (vitamin K(1)) is a bipartite molecule tha

269 Phylloquinone (vitamin K(1)) is a lipophilic compound pr

270 udy assessed the ability of various doses of phylloquinone (vitamin K(1)) to facilitate osteocalcin g

271 th available measures of fasting circulating phylloquinone (vitamin K-1) and confirmed CVD events and

272 luated the associations of dietary intake of phylloquinone (vitamin K-1), menaquinones (vitamin K-2),

273 Phylloquinone (vitamin K1) and menaquinones (vitamin K2

274 characterize the absorption and transport of phylloquinone (vitamin K1) by plasma lipoproteins.

275 Low phylloquinone (vitamin K1) intake is a potential risk fa

276 Mice have the ability to convert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K

277 The objective was to determine the effect of phylloquinone (vitamin K1) supplementation on CAC progre

278 Serum phylloquinone (vitamin K1) was measured in 296 participa

279 Dietary intakes of phylloquinone (vitamin K1), menaquinones (vitamin K2), a

280 ses when vitamin K status is low, and plasma phylloquinone (vitamin K1), which decreases when vitamin

281 ylquinone (including tocopherol [vitamin E], phylloquinone [vitamin K] and plastoquinone) metabolism

282 as assessed by serial measurements of plasma phylloquinone, vitamin K1-2,3-epoxide.

283 s formulated to contain different amounts of phylloquinone was assessed in nine healthy subjects aged

284 ring the postprandial phase, > 53% of plasma phylloquinone was carried by the triacylglycerol-rich li

285 The relative bioavailability of phylloquinone was defined by the difference in plasma ph

286 Phylloquinone was extracted from plasma using hexane, fu

287 Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP

288 Plasma phylloquinone was inversely associated with NTx and oste

289 Circulating phylloquinone was measured by using reversed-phase high-

290 Circulating phylloquinone was measured in a central laboratory from

291 likely for C=O/C-:O modes of neutral/anionic phylloquinone, we have used density functional theory to

292 able concentrations of unlabeled and labeled phylloquinone were 0.05 and 0.08 pmol/injection, respect

293 ally predicted concentrations of circulating phylloquinone were associated with lower risk of type 2

294 phytosterols, squalene, cholecalciferol and phylloquinone were developed using HPLC-DAD-FLD.

295 e greatest mean concentrations of vitamin K1/phylloquinone were found in kale (565 mug/100 g), baby s

296 hydroxyvitamin D2, 25-hydroxyvitamin D3, and phylloquinone) were 25, 17, and 0.33 nM, respectively, w

297 ron transfer from the secondary acceptor A1 (phylloquinone) were measured in mutants using time-resol

298 4-mutant plants were also able to synthesize phylloquinone when provided with 1,4-dihydroxy-2-naphtho

299 oquinone, it was shown in another study that phylloquinone will displace plastoquinone-9 in the A(1)

300 d to evaluate the association of circulating phylloquinone with incident CVD and all-cause mortality