ライフサイエンスコーパス: physical dependence

1 ay in mediating ethanol withdrawal symptoms (physical dependence).

2 propensity to induce reward or aversion and physical dependence.

3 without producing cannabimimetic effects or physical dependence.

4 similar to wild-type mice but fewer signs of physical dependence.

5 limited by the development of tolerance and physical dependence.

6 eliciting signs or symptoms of tolerance or physical dependence.

7 tially reduced antinociceptive tolerance and physical dependence.

8 nt the development of morphine tolerance and physical dependence.

9 awal signs, indicative of the development of physical dependence.

10 to morphine and attenuated morphine-induced physical dependence.

11 sses the development of opioid tolerance and physical dependence.

12 ays independent of these factors can mediate physical dependence.

13 changes may be involved in the expression of physical dependence.

14 eptive tolerance and the subsequent onset of physical dependence.

15 t appear to elicit opioid-like withdrawal or physical dependence.

16 lated with a reduction in the development of physical dependence.

17 s in the development of opiate tolerance and physical dependence.

18 hout dependence), versus symptoms related to physical dependence.

19 he ventral tegmental area (VTA); and induced physical dependence.

20 alcohol consumption, alcohol-induced ataxia, physical dependence after chronic alcohol exposure, and

21 awal hyperalgesia is a reliable indicator of physical dependence after chronic morphine treatment.

22 nol treatment (12 days) sufficient to induce physical dependence also did not shift sensitivity or ma

23 The development of physical dependence and addiction disorders due to misus

24 chronic use, opiates can produce tolerance, physical dependence and addiction.

25 are expressed as adverse effects, including physical dependence and compulsive drug-seeking behavior

26 clarify complex mechanisms underlying opioid physical dependence and opioid addiction.

27 L-NAC and L-NACme prevent the acquisition of physical dependence and overcome acquired dependence to

28 ich stem from an intricate interplay between physical dependence and psychological vulnerabilities.

29 udies have demonstrated that galanin affects physical dependence and rewarding actions associated wit

30 On the other hand, both physical dependence and tolerance were suppressed at MDA

31 SC, contributes to the development of opioid physical dependence and withdrawal effects.

32 diction treatment to date have addressed the physical dependence and withdrawal that accompany addict

33 leus is involved in the expression of opiate physical dependence and withdrawal, and has been charact

34 ), a noradrenergic nucleus, is implicated in physical dependence and withdrawal, whereas the ventral

35 delayed tolerance, and exacerbated morphine physical dependence and withdrawal.

36 repeated use is known to produce tolerance, physical dependence, and addiction; these properties lim

37 8) in morphine-induced analgesia, tolerance, physical dependence, and conditioned place preference, w

38 f addictive drugs: sensitization, tolerance, physical dependence, and euphoria/elation.

39 phine, elicited no respiratory depression or physical dependence, and only limited inhibition of gast

40 , chronic opioids cause analgesic tolerance, physical dependence, and opioid addiction, common clinic

41 olerance can be genetically dissociated from physical dependence, and thus provide a genetic framewor

42 symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to

43 We evaluated lack of reinforcing effect, physical dependence, and withdrawal of REL-1017 in Sprag

44 ratory depression, significant constipation, physical dependence, and, perhaps most important, reinfo

45 genetic background show attenuated signs of physical dependence, as measured by the classic signs of

46 tenuates development of opioid tolerance and physical dependence, as previously shown to occur during

47 as alcohol withdrawal syndrome, craving and physical dependence, as well as extrahepatic alcohol-rel

48 naloxone-precipitated withdrawal-jumping in physical dependence assays.

49 g effects of morphine and led to exacerbated physical dependence, but also reduced their sensitivity

50 to its acute analgesic effects, and profound physical dependence by sustained activation of these rec

51 se patterns were associated with symptoms of physical dependence (eg, withdrawal or tolerance).

52 in adolescents is related to development of physical dependence, ethnicity, impulsivity, affective d

53 ity (hazard ratio, 2.28; p < 0.001), pre-ICU physical dependence (hazard ratio, 2.00; p < 0.001), ris

54 dity (hazard ratio, 1.59; p = 0.02), pre-ICU physical dependence (hazard ratio, 2.29; p < 0.001), ris

55 ression and anxiety), pain hypersensitivity, physical dependence, immune markers, and the gut microbi

56 Chronic MAGL blockade also caused physical dependence, impaired endocannabinoid-dependent

57 ide effects such as ethanol potentiation and physical dependence in animal models.

58 antagonist rimonabant precipitated signs of physical dependence in mice treated chronically with a g

59 Chronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism and ne

60 d neuronal inhibition but also contribute to physical dependence, including withdrawal after abrupt c

61 pears that tolerance can be dissociated from physical dependence, indicating a role for PKC and PKA t

62 mumol/kg, IV), prevent acquisition of acute physical dependence induced by twice-daily injections of

63 stance for normal functioning and develops a physical dependence leading to compulsive and repetitive

64 Moreover, NNTA produced neither significant physical dependence nor place preference in the ED50 dos

65 delta opioid receptors in the tolerance and physical dependence of mu opioid receptor agonists, we h

66 In contrast, monkeys did not show physical dependence on BU08028.

67 ndicate that tPA mediates the development of physical dependence on ethanol by regulating NR2B-contai

68 Computational genetic analyses of physical dependence on morphine across 23 mouse strains

69 morphine-induced analgesia and tolerance and physical dependence on morphine arise have been the subj

70 inergic pathways, these results suggest that physical dependence on morphine can be suppressed to a s

71 us system--in development and maintenance of physical dependence on morphine in the mouse spinal cord

72 Interestingly, the signs of physical dependence on morphine in the transgenic mice d

73 eased GABA release frequency correlated with physical dependence on morphine measured by counting som

74 administration, the monkeys developed acute physical dependence on morphine, as manifested by precip

75 ry in these strains after the induction of a physical dependence on morphine.

76 he spinal cord contributes to development of physical dependence on morphine.

77 n is thought to represent certain aspects of physical dependence on nicotine.

78 ell as loss of place-preference activity and physical dependence on this opioid.

79 anxiolysis, and the elicitation of signs of physical dependence on withdrawal.

80 reatment, sufficient to induce tolerance and physical dependence, on GABAA receptor function was stud

81 reatment, sufficient to induce tolerance and physical dependence, on N-methyl-D-aspartate (NMDA) rece

82 xA does not depress respiration or result in physical dependence or reward behavior, suggesting it ac

83 ansport mechanism or that the development of physical dependence (or the inhibition of abstinence-ind

84 reatment, sufficient to induce tolerance and physical dependence, probably does not lead to readily d

85 The modest physical dependence produced by Delta9-THC as well as it

86 ce more slowly than morphine, showed limited physical dependence, respiratory depression, constipatio

87 Older age, pre-ICU comorbidities, pre-ICU physical dependence, severity of illness at ICU admissio

88 antly attenuated (P<0.05) the development of physical dependence, shown by an attenuated withdrawal s

89 -4-ones were active in an acute electroshock physical dependence side effect assay in mice precluding

90 pal FIN given only during the development of physical dependence significantly increased EtOH withdra

91 e analgesia was not altered, and neither was physical dependence to chronic morphine.

92 rocesses, responsible for the acquisition of physical dependence to fentanyl.

93 of tests to assess analgesia, tolerance, and physical dependence to morphine.

94 gonucleotide also reduced the development of physical dependence to opiates, based on attenuation of

95 using the warm-water tail immersion test and physical dependence was evaluated by quantifying/scoring

96 he expected tolerance response, whereas less physical dependence was observed than with chronic morph

97 elf-administration, analgesic tolerance, and physical dependence, we hypothesize that decreased melan

98 mice; however, development of tolerance and physical dependence were greatly reduced.

99 l syndrome, indicative of the development of physical dependence, when they were tested in cocaine- (

100 rphine tolerance and reward without altering physical dependence, whereas the exon 4-associated trunc