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1 vative of the alkaloid camptothecin bound to phytosphingosine.
2 oth to D-ribo-phytosphingosine and L-arabino-phytosphingosine.
3 could be suppressed by exogenous addition of phytosphingosine.
4 yzes the conversion of dihydrosphingosine to phytosphingosine.
5 by exogenous addition of the sphingoid base phytosphingosine.
6 lates the generation of a specific subset of phytosphingosine.
7 atalyzes conversion of dihydrosphingosine to phytosphingosine.
8 and dihydrosphingosine and no activity with phytosphingosine.
9 esis of phytoceramide from palmitic acid and phytosphingosine.
10 orting a derivative of camptothecin bound to phytosphingosine.
11 e absence of exogenous dihydrosphingosine or phytosphingosine.
12 in the accumulation of the long chain base, phytosphingosine.
13 ted in the synthesis of l-xylo and l-arabino phytosphingosines.
14 mixture of N-hydroxyhexacosanoyl C18 and C20 phytosphingosines.
16 , such as dihydrosphingosine 1-phosphate and phytosphingosine 1-phosphate, have also been implicated
17 ing sphingosine 1-phosphate (1a), and D-ribo-phytosphingosine 1-phosphonate (2), the isosteric phosph
19 the isosteric phosphonate analogue of D-ribo-phytosphingosine-1-phosphate (2a), were synthesized star
22 d bases, such as sphingosine-1-phosphate and phytosphingosine-1-phosphate (phytoS1P) are used in plan
23 dienine [d18:2]), hydroxyceramide and LCB-P (phytosphingosine-1-phosphate [t18:0-P] and 4-hydroxy-8-s
25 further support of these findings, exogenous phytosphingosine (10 microM) was found to induce transie
27 od for the preparation of D-ribo- and L-lyxo-phytosphingosines (1a,b, respectively) and phytoceramide
31 phosphonate analogue of the aminotriol lipid phytosphingosine (3), together with an improved synthesi
32 e we show that, in Saccharomyces cerevisiae, phytosphingosine, a putative sphingolipid second messeng
33 on to a synthesis of 4-deoxy-4-fluoro-L-xylo-phytosphingosine and 4-deoxy-4-fluoro-L-lyxo-phytosphing
34 high occurrence of very-long-chain moieties; phytosphingosine and 4-hydroxy-8-sphingenine were the pr
36 e 2-fold increase in ceramide containing C18-phytosphingosine and a 5-fold increase in ceramide conta
38 reases were seen in two sphingoid bases, C20 phytosphingosine and C20 dihydrosphingosine, which incre
39 ecursors such as the long chain bases (LCBs) phytosphingosine and dihydrosphingosine also suppressed
40 ional studies implicated the sphingoid bases phytosphingosine and dihydrosphingosine as the likely me
41 nd two endogenous yeast sphingoid backbones, phytosphingosine and dihydrosphingosine, were found to b
42 ivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphin
44 ng-chain sphingosine or 22-carbon long-chain phytosphingosine and nonhydroxy fatty acids (P < .05) an
45 s an enzyme that phosphorylates sphingosine, phytosphingosine and other sphingoid long-chain bases.
48 molecular species of dihydrosphingosines and phytosphingosines and their 1-phosphates with carbon cha
49 t increase in C20-dihydrosphingosine and C20-phytosphingosine, and a more stable 2-fold increase in c
50 ion of high levels of dihydrosphingosine and phytosphingosine, and accumulation of medium-chain ceram
51 d by glucosylsphingosine, lysosphingomyelin, phytosphingosine, and primary alkylamines with >10 carbo
52 ined phosphorus, mannosylinositol, inositol, phytosphingosines, and fatty acids in a molar ratio of 2
53 lar amounts of phosphorus, mannosylinositol, phytosphingosines, and fatty acids; their composition an
54 d equimolar amounts of phosphorus, inositol, phytosphingosines, and fatty acids; their composition an
55 t abundant long chain bases were C18 and C20 phytosphingosines, and the most abundant fatty acids wer
56 tant accumulates ceramide when fed exogenous phytosphingosine as expected for a strain lacking IPC sy
57 ha-anomeric sugars conjugated to an acylated phytosphingosine base, required presentation by antigen-
58 ulans Sur2 homolog BasA is also required for phytosphingosine biosynthesis but is also essential for
59 ngosine, N,N'-dimethyl sphingosine (DMS) and phytosphingosine but not dihydrosphingosine or sphingosi
61 amides containing nonhydroxy fatty acids and phytosphingosines (Cer[NP]) increased, whereas ceramides
62 While introduction of the amide-motif in the phytosphingosine chain is tolerated for CD1d binding and
64 her demonstrated that oral administration of phytosphingosine decreased inflammation in a mouse model
65 at erg26-1 cells had decreased levels of the phytosphingosine-derived ceramides that are the direct p
68 4p and Lcb3p to generate a localized pool of phytosphingosine distinct from phytosphingosine generate
69 phytosphingosine and 4-deoxy-4-fluoro-L-lyxo-phytosphingosine, each in five steps from Garner's aldeh
73 nt to cell cycle arrest induced by exogenous phytosphingosine, indicating that Cln3 acts downstream o
75 ne and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymorphonuclear leukocyte (P
76 centration of C18-dihydrosphingosine and C18-phytosphingosine, more than a 100-fold transient increas
77 mounts of sphingosine alpha-hydroxyceramide, phytosphingosine non-hydroxyceramide, and 1-O-acylcerami
79 s were observed for four lipid markers, with phytosphingosine ([P]) levels being significantly lower
80 trated elevated dihydrosphingosine (DHS) and phytosphingosine (PHS) levels, and consistent with this
81 -) auxotrophs was more strongly inhibited by phytosphingosine (PHS) than was growth of Trp+ strains,
83 ong chain bases dihydrosphingosine (DHS) and phytosphingosine (PHS), and further saw that VPA increas
84 re we show that dihydrosphingosine (DHS) and phytosphingosine (PHS), two major sphingoid bases of fun
89 erase, a key enzyme in generating endogenous phytosphingosine, prevents proteolysis during heat stres
90 nting metabolites were thus identified, with phytosphingosine showing the most effective anti-inflamm
91 thesis that allows swift modification of the phytosphingosine side chain by amidation of an advanced
92 Acetylsphingosine, N-acetylphytosphingosine, phytosphingosine, sphingosine, and dihydrosphingosine, b
95 atalyzes the second step in the synthesis of phytosphingosine, the long chain base found in yeast sph
99 e sphinganines are more easily accessed than phytosphingosines, which should facilitate SAR studies.
100 was a derivative of camptothecin binding to phytosphingosine, wich that is inserted into the hydroph