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1 vative of the alkaloid camptothecin bound to phytosphingosine.
2 oth to D-ribo-phytosphingosine and L-arabino-phytosphingosine.
3 could be suppressed by exogenous addition of phytosphingosine.
4 yzes the conversion of dihydrosphingosine to phytosphingosine.
5  by exogenous addition of the sphingoid base phytosphingosine.
6 lates the generation of a specific subset of phytosphingosine.
7 atalyzes conversion of dihydrosphingosine to phytosphingosine.
8  and dihydrosphingosine and no activity with phytosphingosine.
9 esis of phytoceramide from palmitic acid and phytosphingosine.
10 orting a derivative of camptothecin bound to phytosphingosine.
11 e absence of exogenous dihydrosphingosine or phytosphingosine.
12  in the accumulation of the long chain base, phytosphingosine.
13 ted in the synthesis of l-xylo and l-arabino phytosphingosines.
14 mixture of N-hydroxyhexacosanoyl C18 and C20 phytosphingosines.
15                   Phosphatidic acid (PA) and phytosphingosine 1-phosphate (phyto-S1P) both are lipid
16 , such as dihydrosphingosine 1-phosphate and phytosphingosine 1-phosphate, have also been implicated
17 ing sphingosine 1-phosphate (1a), and D-ribo-phytosphingosine 1-phosphonate (2), the isosteric phosph
18            An asymmetric synthesis of d-ribo-phytosphingosine (1) was achieved by utilizing the ProPh
19 the isosteric phosphonate analogue of D-ribo-phytosphingosine-1-phosphate (2a), were synthesized star
20        Our data show for the first time that phytosphingosine-1-phosphate (PHS-1-P) is present at a l
21                   Phosphatidic acid (PA) and phytosphingosine-1-phosphate (phyto-S1P) have both been
22 d bases, such as sphingosine-1-phosphate and phytosphingosine-1-phosphate (phytoS1P) are used in plan
23 dienine [d18:2]), hydroxyceramide and LCB-P (phytosphingosine-1-phosphate [t18:0-P] and 4-hydroxy-8-s
24                   Importantly, we found that phytosphingosine-1-phosphate, similar to S1P, regulates
25 further support of these findings, exogenous phytosphingosine (10 microM) was found to induce transie
26 do ester 8 via alpha-azidolactone 9 afforded phytosphingosine 1a.
27 od for the preparation of D-ribo- and L-lyxo-phytosphingosines (1a,b, respectively) and phytoceramide
28                 By using a similar approach, phytosphingosine 1b was synthesized.
29 her with an improved synthesis of (2S,3S,4S)-phytosphingosine (2), are described.
30 -O-isopropylidene-d-glycerate (4) and D-ribo-phytosphingosine (3), respectively.
31 phosphonate analogue of the aminotriol lipid phytosphingosine (3), together with an improved synthesi
32 e we show that, in Saccharomyces cerevisiae, phytosphingosine, a putative sphingolipid second messeng
33 on to a synthesis of 4-deoxy-4-fluoro-L-xylo-phytosphingosine and 4-deoxy-4-fluoro-L-lyxo-phytosphing
34 high occurrence of very-long-chain moieties; phytosphingosine and 4-hydroxy-8-sphingenine were the pr
35                                    Using [3H]phytosphingosine and [3H]inositol-labeled yeast sphingol
36 e 2-fold increase in ceramide containing C18-phytosphingosine and a 5-fold increase in ceramide conta
37        We propose that heat stress increases phytosphingosine and activates ubiquitin-dependent prote
38 reases were seen in two sphingoid bases, C20 phytosphingosine and C20 dihydrosphingosine, which incre
39 ecursors such as the long chain bases (LCBs) phytosphingosine and dihydrosphingosine also suppressed
40 ional studies implicated the sphingoid bases phytosphingosine and dihydrosphingosine as the likely me
41 nd two endogenous yeast sphingoid backbones, phytosphingosine and dihydrosphingosine, were found to b
42 ivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphin
43 l ketone allowed rapid access both to D-ribo-phytosphingosine and L-arabino-phytosphingosine.
44 ng-chain sphingosine or 22-carbon long-chain phytosphingosine and nonhydroxy fatty acids (P < .05) an
45 s an enzyme that phosphorylates sphingosine, phytosphingosine and other sphingoid long-chain bases.
46 ificity for phosphorylated long-chain bases, phytosphingosine and sphingosine.
47                         LCBK1 phosphorylates phytosphingosine and thereby promotes stomatal immunity
48 molecular species of dihydrosphingosines and phytosphingosines and their 1-phosphates with carbon cha
49 t increase in C20-dihydrosphingosine and C20-phytosphingosine, and a more stable 2-fold increase in c
50 ion of high levels of dihydrosphingosine and phytosphingosine, and accumulation of medium-chain ceram
51 d by glucosylsphingosine, lysosphingomyelin, phytosphingosine, and primary alkylamines with >10 carbo
52 ined phosphorus, mannosylinositol, inositol, phytosphingosines, and fatty acids in a molar ratio of 2
53 lar amounts of phosphorus, mannosylinositol, phytosphingosines, and fatty acids; their composition an
54 d equimolar amounts of phosphorus, inositol, phytosphingosines, and fatty acids; their composition an
55 t abundant long chain bases were C18 and C20 phytosphingosines, and the most abundant fatty acids wer
56 tant accumulates ceramide when fed exogenous phytosphingosine as expected for a strain lacking IPC sy
57 ha-anomeric sugars conjugated to an acylated phytosphingosine base, required presentation by antigen-
58 ulans Sur2 homolog BasA is also required for phytosphingosine biosynthesis but is also essential for
59 ngosine, N,N'-dimethyl sphingosine (DMS) and phytosphingosine but not dihydrosphingosine or sphingosi
60                                  Addition of phytosphingosine bypasses the requirement for serine pal
61 amides containing nonhydroxy fatty acids and phytosphingosines (Cer[NP]) increased, whereas ceramides
62 While introduction of the amide-motif in the phytosphingosine chain is tolerated for CD1d binding and
63                                          The phytosphingosine-containing alpha-galactosylceramides (a
64 her demonstrated that oral administration of phytosphingosine decreased inflammation in a mouse model
65 at erg26-1 cells had decreased levels of the phytosphingosine-derived ceramides that are the direct p
66                         Both enzymes can use phytosphingosine, dihydrosphingosine, or sphingosine as
67            Ceramides and the sphingoid bases phytosphingosine, dihydrosphingosine, sphingosine, and s
68 4p and Lcb3p to generate a localized pool of phytosphingosine distinct from phytosphingosine generate
69 phytosphingosine and 4-deoxy-4-fluoro-L-lyxo-phytosphingosine, each in five steps from Garner's aldeh
70 a 5-fold increase in ceramide containing C20-phytosphingosine following heat stress.
71 lized pool of phytosphingosine distinct from phytosphingosine generated by Sur2p.
72 ng 3-ketosphinganine, dihydrosphingosine, or phytosphingosine in the growth medium.
73 nt to cell cycle arrest induced by exogenous phytosphingosine, indicating that Cln3 acts downstream o
74                                              Phytosphingosine-induced proteolysis requires multiubiqu
75 ne and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymorphonuclear leukocyte (P
76 centration of C18-dihydrosphingosine and C18-phytosphingosine, more than a 100-fold transient increas
77 mounts of sphingosine alpha-hydroxyceramide, phytosphingosine non-hydroxyceramide, and 1-O-acylcerami
78 e APP1 transcription, whereas treatment with phytosphingosine or ceramides does not.
79 s were observed for four lipid markers, with phytosphingosine ([P]) levels being significantly lower
80 trated elevated dihydrosphingosine (DHS) and phytosphingosine (PHS) levels, and consistent with this
81 -) auxotrophs was more strongly inhibited by phytosphingosine (PHS) than was growth of Trp+ strains,
82                                              Phytosphingosine (PHS), a sphingoid long chain base, is
83 ong chain bases dihydrosphingosine (DHS) and phytosphingosine (PHS), and further saw that VPA increas
84 re we show that dihydrosphingosine (DHS) and phytosphingosine (PHS), two major sphingoid bases of fun
85                         LCBK1 phosphorylates phytosphingosine (PHS).
86  of the two major long chain bases is called phytosphingosine (PHS).
87       When cells were treated with exogenous phytosphingosine (PHS, 20 microm) or structurally simila
88 chain sphingoid bases dihydrosphingosine and phytosphingosine (Phyto-Sph).
89 erase, a key enzyme in generating endogenous phytosphingosine, prevents proteolysis during heat stres
90 nting metabolites were thus identified, with phytosphingosine showing the most effective anti-inflamm
91 thesis that allows swift modification of the phytosphingosine side chain by amidation of an advanced
92 Acetylsphingosine, N-acetylphytosphingosine, phytosphingosine, sphingosine, and dihydrosphingosine, b
93         Saturated long-chain fatty acids and phytosphingosine supplementation rescue the cell-cycle d
94    Its immunological activity resided in the phytosphingosine tail of the ligand.
95 atalyzes the second step in the synthesis of phytosphingosine, the long chain base found in yeast sph
96                            Both ceramide and phytosphingosine, the primary sphingoid base present in
97 hingosine kinases (SPHKs) that phosphorylate phytosphingosine to generate phyto-S1P.
98                                              Phytosphingosine was resolved as a sharp peak with the a
99 e sphinganines are more easily accessed than phytosphingosines, which should facilitate SAR studies.
100  was a derivative of camptothecin binding to phytosphingosine, wich that is inserted into the hydroph