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1 nt and abundance of the proteins Bassoon and Piccolo.
2 ughput scRNA-seq data in an R package called Piccolo.
3  selectively with the zinc finger domains of Piccolo.
4 olocalized with another active zone protein, Piccolo.
5 shRNA-mediated knockdown to demonstrate that Piccolo, a multidomain protein of the active zone cytoma
6                                              Piccolo, a presynaptic active zone protein, is best know
7                     Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cyto
8                             We now show that piccolo/aczonin, a recently described active-zone protei
9                                              Piccolo and bassoon are highly homologous multidomain pr
10                                 Furthermore, Piccolo and Bassoon are necessary for ELKS2/CAST to leav
11 gi network on a common vesicle that requires Piccolo and Bassoon for its proper assembly.
12                   However, core CAZ proteins Piccolo and Bassoon have long been believed exclusive to
13                        Thus, we propose that piccolo and bassoon play a redundant role in synaptic ve
14 loss of the presynaptic active zone proteins Piccolo and Bassoon triggers the loss of synaptic vesicl
15 at the destruction of SVs in boutons lacking Piccolo and Bassoon was associated with the induction of
16            Despite a nearly complete loss of piccolo and bassoon, however, we still did not detect an
17 ted presynaptic autophagy in boutons lacking Piccolo and Bassoon, providing insights into the molecul
18 To unmask potentially redundant functions of piccolo and bassoon, we thus acutely knocked down expres
19  homology to vertebrate active zone proteins Piccolo and RIM.
20 nuation of the active-zone proteins Bassoon, Piccolo, and CAST/Erc2.
21 additionally led to loss of Munc13, Bassoon, Piccolo, and RIM-BP, indicating disassembly of the activ
22  presynaptic active zone, including bassoon, piccolo, and RIM1.
23 n electrophysiological phenotype in cultured piccolo- and bassoon-deficient neurons in either GABAerg
24                                  Bassoon and Piccolo are active zone specific cytosolic proteins esse
25 n the ribbon-associated proteins Bassoon and Piccolo are disrupted, and few intact ribbons are presen
26 nal 165 amino acids of the Yng2 component of Piccolo are sufficient with Esa1 to specifically act on
27                                  Bassoon and Piccolo are two high molecular weight components of the
28 fied the N-terminal proline-rich Q domain in Piccolo as a region that interferes with clathrin-mediat
29 ngs demonstrate a novel role for Bassoon and Piccolo as critical regulators of presynaptic ubiquitina
30                     Our results suggest that Piccolo, as a structural protein of the CAZ, may serve t
31                        Our studies show that Piccolo, Bassoon, and ELKS2/CAST exit the trans-Golgi ne
32 nsport of three crucial synaptic components, Piccolo-bassoon Transport Vesicles (PTVs), Synaptic Vesi
33 nalyses reported here also indicate that the Piccolo-Bassoon transport vesicles leaving the Golgi may
34 a sandwiched Bassoon puncta and aligned in a Piccolo-Bassoon-Piccolo structure in adult NMJs.
35                              Ca(2+) binds to piccolo by virtue of its C(2)A-domain via an unusual mec
36 he distinct Ca(2+)-binding properties of the piccolo C(2)A- domain are mediated by an evolutionarily
37       The unusual Ca(2+)-binding mode of the piccolo C(2)A-domain reveals that C(2)-domains are mecha
38               The low Ca(2+) affinity of the piccolo C(2)A-domain suggests that piccolo could functio
39 from the Pclo gene, reported to lack >95% of Piccolo, continue to express multiple Piccolo isoforms.
40 e sorting at synapses providing hints to how Piccolo contributes to developmental and psychiatric dis
41 ty of the piccolo C(2)A-domain suggests that piccolo could function in short-term synaptic plasticity
42 ypoplasia Type 3 are also exhibited by these Piccolo deficient animals.
43 electrophysiology and electron microscopy of piccolo-deficient synapses failed to uncover a major phe
44 ynaptic vesicle clustering in double bassoon/piccolo-deficient synapses.
45                       Our studies define the Piccolo determinants sufficient to assemble its three su
46 its three subunits into a complex as well as Piccolo determinants sufficient to specifically acetylat
47                                      Work by Piccolo et al. shows that the Tet1 and Tet2 hydroxylases
48                              Boutons lacking Piccolo exhibit enhanced activity-dependent Synapsin1a d
49 study, we use interference RNAs to eliminate Piccolo expression from cultured hippocampal neurons to
50 he ribbon synapse-specific splice variant of Piccolo, for shaping the ribbon structure.
51    Together, these data suggest that loss of Piccolo function in patients with PCH3 could be involved
52 logous protein Bassoon, which indicates that Piccolo has a unique role in coupling the mobilization o
53  Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocere
54                 We find that boutons lacking Piccolo have deficits in the Rab5/EEA1 dependent formati
55 -associated protein that is colocalized with Piccolo in nerve terminals of hippocampal primary neuron
56                         Here, we address how Piccolo inactivation in rat neurons adversely affects sy
57 e synaptic ribbon specific splice variant of Piccolo, interacts with RIBEYE, the main component of sy
58 t and recruitment of the active zone protein Piccolo into nascent synapses.
59                                              Piccolo is a high molecular weight component of the acti
60                                              Piccolo is a high molecular weight multi-domain protein
61 alysis of its primary structure reveals that Piccolo is a multidomain zinc finger protein structurall
62                                              Piccolo is a novel component of the presynaptic cytoskel
63                                              PICCOLO is a phase II, global, open-label, single-arm tr
64                      Our analysis shows that Piccolo is critical for the recycling and maintenance of
65                           Our data show that Piccolo is not required for glutamatergic synapse format
66                        These data imply that Piccolo is required for the normal development, maturati
67                        Our results show that Piccolo is transported to nascent synapses on an approxi
68 95% of Piccolo, continue to express multiple Piccolo isoforms.
69                           Here, we generated piccolo knockin/knockout mice that either contain wild-t
70 olo mutant mice were viable and fertile, but piccolo knockout mice exhibited increased postnatal mort
71  down expression of bassoon in wild-type and piccolo knockout neurons.
72 uncated (partial knockout), or <5% levels of piccolo (knockout).
73     We have characterized recently generated Piccolo KO (Pclo(gt/gt) ) rats.
74                              Our analysis of Piccolo KO rats supports this hypothesis, formally demon
75                          Loss of Bassoon and Piccolo leads to the aberrant degradation of multiple pr
76                             In contrast, the Piccolo levels in NMJs from aged mice were comparable to
77 d for new genetic models with which to study Piccolo loss of function.
78                 These features indicate that Piccolo may act to scaffold proteins involved in synapti
79                                          All piccolo mutant mice were viable and fertile, but piccolo
80 t least two multiprotein complexes, NuA4 and Piccolo NuA4 (picNuA4), and its essential function is be
81 , Ybf2/Sas3, Sas2, Tip60 family HAT complex, Piccolo NuA4 (picNuA4).
82  this cysteine (C304A) in Esa1 or within the piccolo NuA4 complex yielded an enzyme that was catalyti
83 Widom 601" sequence were acetylated with the Piccolo NuA4 complex, which acetylates mainly H4 N-termi
84 entify the Gcn5- and Esa1-containing ADA and Piccolo NuA4 complexes as bona fide crotonyltransferases
85  spectrometry analysis revealed that ADA and Piccolo NuA4 crotonylate lysines in the N-terminal tails
86  suggest that the acetylation of histones by Piccolo NuA4 disturbs not only the structure of a nucleo
87 the Esa1-containing Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex.
88 histone H4, and also to nucleosomal DNA when Piccolo NuA4 interacts with the nucleosome.
89                                              Piccolo NuA4 is an essential yeast histone acetyltransfe
90 ce neither region identified is required for Piccolo NuA4 to bind to nucleosomes and yet both are nee
91 mology domain of Epl1 play critical roles in Piccolo NuA4's ability to act on the nucleosome.
92                                        While Piccolo NuA4's catalytic subunit Esa1 alone is unable to
93 the Gcn5-Ada2-Ada3 (ADA) and Esa1-Yng2-Epl1 (Piccolo NuA4) histone acetyltransferase complexes have t
94  member Esa1, and its physiological complex (piccolo NuA4), steady-state kinetic analyses revealed a
95 sitively regulate the activities of NuA4 and Piccolo NuA4.
96  indicate the encoded proteins may represent Piccolo orthologs.
97 aptic active zone, such as bassoon (BSN) and piccolo (PCLO).
98 ifferent types of retinal ribbon synapses in Piccolo/Piccolino-deficient male and female rats, we sho
99                      These data suggest that Piccolo plays a role in the trafficking of synaptic vesi
100 omains that resemble the PXXP motif of human Piccolo proteins, which bind SH3 domains in proteins inv
101                                              Piccolo puncta sandwiched Bassoon puncta and aligned in
102                                Utilizing the Piccolo Q domain as bait in a yeast two-hybrid screen, w
103 (CLA-1) based on homology to the AZ proteins Piccolo, Rab3-interactingmolecule (RIM)/UNC-10 and Fife.
104 reactive for presynaptic proteins, including piccolo, Rab3C, vesicular glutamate transporter 2, and c
105                       These data reveal that Piccolo regulates neurotransmitter release by facilitati
106   Our data demonstrate the conservation of a Piccolo-related protein in invertebrates and identify cr
107  GTPase deficient Rab5 or the Znf1 domain of Piccolo restores the size and recycling of SV pools.
108          We previously identified Drosophila Piccolo-RIM-related Fife, which regulates neurotransmiss
109     Here, we present the identification of a piccolo-rim-related gene in invertebrates, together with
110 e Esa1 chromodomain plays a critical role in Piccolo's ability to distinguish between histones and nu
111 bassoon, clarinet, flute, French horn, oboe, piccolo, saxophone, trombone, trumpet, and tuba) or sing
112 soon puncta and aligned in a Piccolo-Bassoon-Piccolo structure in adult NMJs.
113 ckin), approximately 60% decreased levels of piccolo that is C-terminally truncated (partial knockout
114 owever, the chromodomain is not required for Piccolo to bind to nucleosomes, suggesting a role for th
115                          Results: Of the 696 PICCOLO trial patients in the irinotecan-vs-irinotecan w
116 anned retrospective biomarker study from the PICCOLO trial, which tested the addition of panitumumab
117 at either contain wild-type levels of mutant piccolo unable to bind Ca(2+) (knockin), approximately 6
118 Siah1, an interacting partner of Bassoon and Piccolo whose activity is negatively regulated by their
119 tecan, and ciclosporin in colorectal cancer (PICCOLO) with with the a priori hypothesis that high tum
120                                          The Piccolo zinc fingers were found to interact with the dua

 
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