ライフサイエンスコーパス: picolinate

1 te undergoes a second redox cycle to produce picolinate.

2 n of a novel class of densely functionalized picolinates.

3 otide binding motif in competition with FAD, picolinate (0.07 mol/mol of nikD) and an unknown picolin

4 converts piperideine 2-carboxylate (P2C) to picolinate, a key component of the nonribosomal peptide

5 C results in the stoichiometric formation of picolinate, accompanied by the reduction of 2 mol of oxy

6 zation of piperideine-2-carboxylate (P2C) to picolinate, an essential component of nikkomycin antibio

7 n "aromatic cage" that surrounds the ring in picolinate and its precursors.

8 (LLBs) based on pyclen-bearing pai-extended picolinate antennas were synthesized and demonstrated we

9 Picolinate as a chelation-assisted leaving group could b

10 their corresponding wild-type genes restored picolinate auxin sensitivity.

11 oci that conferred significant resistance to picolinate auxins such as picloram, yet had minimal cros

12 ved for complexes of the reduced enzyme with picolinate, benzoate, or 1-cyclohexenoate, a 1-deaza-P2C

13 th a pK(a) of 7.4, identical to the pK(a) of picolinate bound to the enzyme.

14 It was discovered that the enzyme with picolinate bound was reduced at a rate similar to that w

15 d is eliminated upon mixing nikD with excess picolinate but not by a reversible unfolding procedure t

16 ISTANT30) that are specifically resistant to picolinates, but not to other auxins.

17 The byproduct, ethyl 2-picolinate can be used to install the picolinamide DG in

18 elator platforms derived of triazamacrocycle picolinates, capable of stably incorporating three clini

19 ) arene complexes [(eta(6)-arene)Os(4-methyl-picolinate)Cl] that differ only in their arene ligands a

20 this question, we used a novel member of the picolinate class of synthetic auxins that is structurall

21 The nutritional dietary supplement chromium picolinate, [Cr(pic)(3)], has gained much notoriety as a

22 sly reported that the micronutrient chromium picolinate (CrP), with long-standing cardiovascular bene

23 pe (bidentate, mono-anionic) ligands such as picolinate dramatically stabilize these nickel(IV) speci

24 plements were identified: chitosan, chromium picolinate, Ephedra sinica, Garcinia cambogia, glucomann

25 alyst for the hydrolysis of the coordinating picolinate ester 11, following Michaelis-Menten kinetics

26 Release of picolinate from Tyr258Phe is 100-fold faster than turnov

27 t into the mechanisms of plant resistance to picolinate herbicides and also shed light on the possibl

28 pic30 mutants are selectively insensitive to picolinate herbicides, while pic30-3 is also defective i

29 be further oxidized by nikD or converted to picolinate in a nonenzymic reaction.

30 produce an isomer that could be oxidized to picolinate in a reaction that satisfies known steric con

31 dation of piperideine-2-carboxylate (P2C) to picolinate in a remarkable aromatization reaction compri

32 ersible unfolding procedure that removes the picolinate-like compound, ruling out both compounds as t

33 linate (0.07 mol/mol of nikD) and an unknown picolinate-like compound.

34 esolution HPLC method, capable of separating picolinate, nicotinate and isonicotinate, was developed

35 the observed 4-electron oxidation of P2C to picolinate occurs via a mechanism involving two successi

36 mumol Cr/d (924 micrograms Cr/d) as chromium picolinate or a low-chromium placebo for 12 wk while eng

37 3-3.5 mumol as chromium chloride or chromium picolinate) or placebo (0.1 mumol Cr) and weight trainin

38 from a rigid bispyclen platform possessing a picolinate pendant arm, formed a stable and inert Mn(II)

39 oss-bridged cyclam derivative containing two picolinate pendant arms are kinetically inert in very ha

40 f four [V(V)O(2)L(2)](-) complexes, with L = picolinate (pic), 5-cyanopicolinate (picCN), 3-aminopyra

41 ryliodonium reagent to an anionic nickel(II)-picolinate precursor.

42 mides were successfully coupled with various picolinate salts under mild conditions in yields up to 9

43 saturation was decreased more with chromium picolinate supplementation (24%) than with chromium chlo

44 Chromium picolinate supplementation did not influence these respo

45 These data suggest that high-dose chromium picolinate supplementation for 12 wk did not influence h

46 This study examined the effects of chromium picolinate supplementation on hematologic indexes and se

47 ranges and were unchanged by either chromium picolinate supplementation or resistive training.

48 ged by either resistive training or chromium picolinate supplementation.

49 Picolinate, the product of the physiological catalytic r

50 2) 1.92 micromol (100 microg) Cr as chromium picolinate two times per day, or 3) 9.6 micromol (500 mi

51 ators, L(4b) and L(4c), bearing two specific picolinate two-photon antennas (tailor-made for each tar

52 N amination of benzylic and related aromatic picolinates under conditions mild enough to modify polyf

53 he analogous reactions with PicAuCl2 (Pic =2-picolinate) were found to proceed by selective 1,3-acylo

54 pon the rate of reduction in the presence of picolinate with a pK(a) of 7.4, identical to the pK(a) o

55 C-Glycosylation reactions of glycosyl picolinates with allyltrimethylsilane or silyl enol ethe