ライフサイエンスコーパス: picornavirus

1 -OC43, but not encephalomyocarditis virus, a picornavirus.

2 enza virus, paramyxovirus, dengue virus, and picornavirus.

3 than the mature capsid, unlike in any other picornavirus.

4 genomic characterization of the first canine picornavirus.

5 rans-complementable function for 3CD for any picornavirus.

6 with the Theiler's murine encephalomyelitis picornavirus.

7 terovirus 8, Seneca Valley virus, and simian picornavirus.

8 ng infection with poliovirus, the prototypic picornavirus.

9 thway for hepatoviruses that is unique among picornaviruses.

10 hanism, being assembled differently to other picornaviruses.

11 common mechanism that targets these related picornaviruses.

12 own to effectively limit infectivity of many picornaviruses.

13 initiation for both plant- and animal-hosted picornaviruses.

14 ting a pathogenic role for this new group of picornaviruses.

15 ew strategies for targeting therapies to all picornaviruses.

16 or gene function, except by comparison with picornaviruses.

17 a phospholipase essential for entry of other picornaviruses.

18 e gene sequence of SePV-1 and those of other picornaviruses.

19 ovide transient stability to a number of the picornaviruses.

20 for this interaction are provided for three picornaviruses.

21 -3Dpol complex that extrapolates well to all picornaviruses.

22 change of genetic elements between different picornaviruses.

23 gainst several classes of viruses, including picornaviruses.

24 to interpret experiments with CVB3 and other picornaviruses.

25 K2, WASL, and NCK1, in infection by multiple picornaviruses.

26 K1 comprise a pathway important for multiple picornaviruses.

27 nome release, as is the case in many related picornaviruses.

28 g of the life cycle of sapelovirus and other picornaviruses.

29 egrin binding motifs are found in some other picornaviruses.

30 , perhaps explored early in the evolution of picornaviruses.

31 netic position of the tentatively named seal picornavirus 1 (SePV-1) as an outlier to the grouping of

32 Furthermore, we found that multiple picornavirus 3A proteins copurify with the Golgi adaptor

33 EMO for cleavage has been observed only with picornavirus 3C proteases (3C(pro)) and coronavirus 3CL(

34 ural analysis of non-covalent complexes of a picornavirus 3C(pro) with peptide substrates.

35 In this review, we focus on picornaviruses, a family of positive-strand RNA viruses,

36 that hepatitis A virus (HAV), a hepatotropic picornavirus, ablates type 1 IFN responses by targeting

37 ary processes by which DAF was selected as a picornavirus accessory receptor.

38 ses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that consti

39 nterspecies and intraspecies transmission of picornaviruses among NHP, we collected fecal specimens f

40 also cleaved by 3C or 3C-like proteinases of picornavirus and artertivirus.

41 Detection of picornavirus and bacteria was associated with an additiv

42 new virus is most closely related to the Eel picornavirus and can be assigned to the genus Potamipivi

43 hea, has a genomic organization typical of a picornavirus and encodes a 2,469-amino-acid polyprotein

44 One pediatric case, with picornavirus and influenza A coinfection, visited 3 diff

45 Compared to picornaviruses and adenoviruses, the engineered VSVs wer

46 esents new information about receptor use by picornaviruses and highlights the importance of attainin

47 sequences within the genomic RNAs of certain picornaviruses and is required for viral translation.

48 netic divergence of SePV-1 compared to other picornaviruses and its mix of characteristics relative t

49 unctionally similar to cre elements of other picornaviruses and likely involved in templating VPg uri

50 ogenetic analysis places HAV between typical picornaviruses and the insect viruses.

51 lect its position as a link between 'modern' picornaviruses and the more 'primitive' precursor insect

52 virus, human metapneumovirus, adenoviruses, picornaviruses, and coronaviruses.

53 support divergent evolution of nodaviruses, picornaviruses, and tetraviruses from a common ancestor

54 Picornaviruses are a leading cause of human and veterina

55 Few drugs targeting picornaviruses are available, making the discovery of an

56 mechanism of RNase-protected RNA transfer in picornaviruses are discussed.

57 Picornaviruses are genetically and antigenically highly

58 Picornaviruses are important animal and human pathogens

59 Picornaviruses are responsible for a range of human and

60 Picornaviruses are simple models for such viruses, and i

61 denoviruses, vesicular stomatitis virus, and picornaviruses as well as nonreplicating lentiviral and

62 nfected 3D(pol) transgenic mice with another picornavirus, as well as an alphaherpesvirus and a rhabd

63 possible without RNA encapsidation and that picornavirus assembly may involve an inward radial colla

64 Enterovirus 71 is a picornavirus associated with fatal neurological illness

65 In the second strategy, a picornavirus autoprocessing element was used to separate

66 investigate possible transmission of enteric picornaviruses between humans and NHP, we collected feca

67 e to determine the crystal structures of the picornavirus bovine enterovirus 2 (BEV2) and the cytopla

68 viruses, such as flaviviruses, alphaviruses, picornaviruses, bunyaviruses, and coronaviruses.

69 t MDA-5 is crucial for sensing infections by picornaviruses, but there have been no studies on the ro

70 se activity could also be produced for other picornaviruses by immunization with immature particles.

71 cornavirus-like supercluster, which includes picornaviruses, caliciviruses, and coronaviruses.

72 Diverse picornaviruses can trigger multiple human maladies, yet

73 molecular explanation for the transition of picornavirus capsid conformations and demonstrate distin

74 Nonetheless, our results demonstrate that picornavirus capsid expansion is possible without RNA en

75 sential factor for folding and maturation of picornavirus capsid proteins.

76 ution structure of a Fab molecule bound to a picornavirus capsid.

77 Picornaviruses carry a small number of proteins with div

78 Human enterovirus 71 is a picornavirus causing hand, foot, and mouth disease that

79 s (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cau

80 n infection with coxsackievirus B3 (CVB3), a picornavirus closely related to poliovirus.

81 the polyhedrin subunits are more similar to picornavirus coat proteins than to the polyhedrin of cyt

82 oot-and-mouth disease virus (FMDV) and other picornaviruses comprise five major domains H-L.

83 Fifty-two picornaviruses comprising 10 distinct serotypes were det

84 Picornaviruses constitute a large group of viruses compr

85 iratory syncytial virus, rhinoviruses, other picornaviruses, coronaviruses 229E and OC43, parainfluen

86 eport demonstrated that infection by another picornavirus (coxsackievirus B3) causes SRp20 to relocal

87 in templating VPg uridylylation as in other picornaviruses, despite its significantly larger size an

88 ed with encephalomyocarditis virus (EMCV), a picornavirus detected by MDA5 and LGP2 but not RIG-I.

89 erotypes, in the zoo population, only 15% of picornaviruses detected in NHP were of human origin.

90 nthropic NHP in Bangladesh where 100% of the picornaviruses detected were of human serotypes, in the

91 12, EV115, and SV19 accounted for 88% of all picornaviruses detected.

92 Other cargo, including a closely related picornavirus, did not exhibit similar motility.

93 Picornaviruses disrupt nucleocytoplasmic trafficking pat

94 To compare picornavirus diversity between humans and NHP, the same

95 the structures illustrate that, similarly to picornaviruses, DWV forms alternate particle conformatio

96 nvestigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with al

97 phenotypically characterised mutants of the picornavirus, echovirus 7, in which these parameters wer

98 Optimal resistance to infection with picornavirus encephalomyocarditis virus is known to requ

99 Many related picornaviruses encode a single copy but uniquely the FMD

100 Several viruses, including the RNA picornaviruses, encode factors that alter nuclear transp

101 assigned as a new species (HRV-C) within the picornavirus Enterovirus genus.

102 es were found in 52 of 386 patients (13.4%); picornavirus (enteroviruses [n = 14], rhinovirus [n = 5]

103 It remains unexplained why picornaviruses evolutionarily conserve the wasteful prod

104 It differs radically from other picornaviruses, existing in an enveloped form and being

105 e mechanisms by which separate genera of the picornavirus family achieve this shutoff differ.

106 For the picornavirus family member poliovirus, a number of funct

107 In the picornavirus family of nonenveloped RNA viruses, the req

108 ted by the finding that viral proteases from picornavirus family specifically targeted MOV10 as a pos

109 nanosecond timescale of four RdRps from the picornavirus family that exhibit 30-74% sequence identit

110 that coxsackievirus, an enteric virus in the picornavirus family, also relies on microbiota for intes

111 Rhinovirus (RV), a ssRNA virus of the picornavirus family, is a major cause of the common cold

112 f the rhinovirus genus, which belongs to the picornavirus family, which includes clinically and econo

113 Unlike other picornaviruses, FMDV-induced autophagosomes did not colo

114 Here, we show that the picornavirus foot-and-mouth disease virus (FMDV) induces

115 he integrated stress response.IMPORTANCE The picornavirus foot-and-mouth disease virus (FMDV) is a no

116 ructures involved in genome packaging in the picornavirus foot-and-mouth disease virus (FMDV).

117 Like other viruses, the picornavirus foot-and-mouth disease virus (FMDV; genus A

118 equences involved in genome packaging of the picornavirus foot-and-mouth disease virus.

119 Unlike other picornaviruses, for which there is strong evidence that

120 heiler's murine encephalitis virus (TMEV), a picornavirus from which it was derived.

121 ce analysis was used to identify a subset of picornaviruses from multiple genera that contain 5' UTR

122 es of viruses representing each of the major picornavirus genera (Enterovirus, Rhinovirus, Aphthoviru

123 the evolution of serotypes within different picornavirus genera, large-scale analysis of recombinati

124 These properties were shared with other picornavirus genera, such as the parechoviruses and erbo

125 ecies assignments in enteroviruses and other picornavirus genera.

126 The picornavirus genome must act as a template for both tran

127 tein complex that catalyzes this key step in picornavirus genome replication.

128 A novel picornavirus genome was sequenced, showing 42.6%, 35.2%,

129 The 5'-untranslated regions (5' UTRs) of picornavirus genomes contain an internal ribosomal entry

130 P2 is required for translation initiation on picornavirus genomes with type I internal ribosome entry

131 cre or oriI) found at different locations in picornavirus genomes.

132 The replication of picornaviruses has been described to cause fragmentation

133 between that of insect viruses and mammalian picornaviruses, HAV is enigmatic in its origins.

134 Picornaviruses have 3' polyadenylated RNA genomes, but t

135 Picornaviruses have a peptide termed VPg covalently link

136 All picornaviruses have a protein, VPg, covalently linked to

137 Picornaviruses have both asexual and sexual RNA replicat

138 sexual RNA replication mechanisms.IMPORTANCE Picornaviruses have both asexual and sexual RNA replicat

139 Picornaviruses have some of the highest nucleotide subst

140 Many viruses, including picornaviruses, have the potential to infect the central

141 Unlike other picornaviruses, hepatitis A virus (HAV) is cloaked in ho

142 tify the lipid-modifying enzyme PLA2G16 as a picornavirus host factor that is required for a previous

143 be required for the replication of multiple picornaviruses; however, it is unclear whether a physica

144 f HeLa cells during infection by yet another picornavirus (human rhinovirus 16).

145 ed, identifying the first sequence-confirmed picornavirus in a marine mammal.

146 We subsequently detected zebrafish picornavirus in publicly available sequencing data from

147 Asymptomatic presence of picornavirus in the neonatal airway is a potent activato

148 the maintenance and transmission of diverse picornaviruses in Bangladesh.

149 Here we identified two novel picornaviruses in fecal specimens of ring-tailed lemurs

150 ogenic positive-sense RNA enteroviruses, and picornaviruses in general, transport multiple virions en

151 Cadicivirus (CDV) is unique amongst picornaviruses in having a dicistronic genome with inter

152 Picornaviruses in the cardiovirus genus express a unique

153 Picornaviruses, including Coxsackievirus B3 (CVB3), are

154 s afflicted annually with diseases caused by picornaviruses, including myocarditis, aseptic meningiti

155 d antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of md

156 samples obtained during an acute, moderate, picornavirus-induced exacerbation and 7 to 14 days later

157 Although picornaviruses infect most mammals, infection of a compa

158 Host translation shutoff induced in picornavirus-infected cells is a well-known phenomenon.

159 While using ISRIB to investigate the ISR in picornavirus-infected cells, we observed that ISRIB resc

160 Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2D(

161 Picornavirus infection can cause Golgi fragmentation and

162 showed that hippocampal injury during acute picornavirus infection in mice is associated with calpai

163 that apoptosis of hippocampal neurons during picornavirus infection is a cell-autonomous event trigge

164 mediator of hippocampal injury during acute picornavirus infection of the brain.

165 cating that neuronal cell death during acute picornavirus infection of the CNS occurs in a non-cell-a

166 Cognitive deficits associated with CNS picornavirus infection result from injury and death of n

167 Among the many genes induced by picornavirus infection was a large set encoding guanosin

168 e knowledge of the host factors required for picornavirus infection would facilitate antiviral develo

169 In a picornavirus infection, both an infectious and a noninfe

170 During picornavirus infection, several cellular proteins are cl

171 the viral genomic RNA replication steps of a picornavirus infection.

172 useful for neuroprotection during acute CNS picornavirus infection.

173 In contrast, many neurovirulent picornavirus infections are acute and transient, with ra

174 e more recent studies that have revealed how picornavirus infections impact the RNA metabolism of the

175 lighting a system for studying the spread of picornavirus infections within and between individuals.

176 nism of SRp20 cellular redistribution during picornavirus infections, and they provide additional ins

177 Picornavirus internal ribosomal entry site (IRES)-mediat

178 ccine candidates based on the insertion of a picornavirus internal ribosome entry site (IRES) sequenc

179 We therefore sought to determine whether the picornavirus IRES could be engineered into VSV to attenu

180 functional initiation codon in type I and II picornavirus IRES.

181 The major classes of picornavirus IRESs (Types 1 and 2) have distinct structu

182 Picornavirus IRESs are classified into four structurally

183 Therefore, our data reveal how picornavirus IRESs use eIF4E-dependent and -independent

184 ffers fundamentally from initiation on these picornavirus IRESs.

185 do not occur in the two principal groups of picornavirus IRESs.

186 line helix structure, not seen previously in picornaviruses is present at the C terminus of VP1, a po

187 main present in Seneca valley virus (SVV), a picornavirus, is dispensable for IRES activity, while th

188 ell-surface receptors are bound by different picornaviruses, it is unclear whether common host factor

189 on that this conformation is conserved among picornaviruses led us to examine the role of this residu

190 taxonomic affinity is uncertain as it has a picornavirus-like cassette of enzymes for virus replicat

191 The picornavirus-like deformed wing virus (DWV) has been dir

192 arge training data set of 284 representative picornavirus-like genomic sequences with defined host or

193 cently defined and rapidly growing family of picornavirus-like RNA viruses called the Dicistroviridae

194 at a single virus or multiple viruses in the picornavirus-like supercluster by targeting 3Cpro or 3CL

195 sense RNA viruses can be classified into the picornavirus-like supercluster, which includes picornavi

196 e most commonly detected sequences were from picornaviruses, making up 59 to 88% of all viral reads,

197 e mammalian system and may shed light on how picornaviruses may have evolved between plant and animal

198 cessfully complete their replication cycles, picornaviruses modify several host proteins to alter the

199 Picornavirus mRNAs contain IRESs that sustain their tran

200 Due to their small genome size, picornaviruses must utilize host proteins to mediate cap

201 ein, is covalently attached to the 5' end of picornavirus negative- and positive-strand RNAs.

202 nonenveloped," recent studies show that some picornaviruses, notably hepatitis A virus (HAV; genus He

203 us, and encephalomyocarditis virus (EMCV), a picornavirus of the Cardiovirus genus, was completely in

204 une mediators was found in the neonates with picornavirus (P < .0001; partial least square discrimina

205 e involvement of predicted RNA structures in picornavirus packaging and offers a readily transferable

206 n uncoating intermediate for the major human picornavirus pathogen CAV16, which reveals VP1 partly ex

207 Translation of picornavirus plus-strand RNA genomes occurs via internal

208 The structures of multiple picornavirus polymerase elongation complexes suggest tha

209 myelitis virus, duck hepatitis virus 1, duck picornavirus, porcine teschovirus, porcine enterovirus 8

210 Crystal structures of all picornavirus RdRps exhibit a template-nascent RNA duplex

211 87 mutants also agree with similar data from picornavirus RdRps.

212 Picornaviruses rearrange cellular membranes to form cyto

213 is similar to "A" particles encountered when picornaviruses recognize a potential host cell before ge

214 Picornavirus regulatory sequences mediating cell type-sp

215 tiviral target for drug discovery.IMPORTANCE Picornaviruses remain an important family of human and a

216 Although picornaviruses replicate exclusively in the cytoplasm of

217 The picornavirus replication complex comprises a coordinated

218 dentifies a previously undescribed aspect of picornavirus replication complex structure-function and

219 Picornavirus replication is critically dependent on the

220 Picornavirus replication is known to cause extensive rem

221 Because recombination is a natural aspect of picornavirus replication, we hypothesized that some feat

222 Infection of mammalian cells by picornaviruses results in the nucleocytoplasmic redistri

223 oxsackievirus, human rhinoviruses, and other picornaviruses reveal a putative template RNA entry chan

224 A 3' poly(A) tail is a common feature of picornavirus RNA genomes and the RNA genomes of many oth

225 Although picornavirus RNA genomes contain a 3'-terminal poly(A) t

226 In particular, we show that picornavirus RNA recombination counteracts the negative

227 There are two protein primers involved in picornavirus RNA replication, VPg, the viral protein of

228 have shown that transgenic mice expressing a picornavirus RNA-dependent RNA polymerase (RdRP) outside

229 longation of positive- and negative-stranded picornavirus RNA.

230 lays an essential role in the replication of picornavirus RNA.

231 VPg linkage to the 5' ends of picornavirus RNAs requires production of VPg-pUpU.

232 cis-acting replication element (CRE) within picornavirus RNAs serves as a template for the uridylyla

233 vivin separately, or together linked by a 2A picornavirus self-cleaving peptide, into Ag-responding C

234 Comparison of the picornavirus serotypes detected in NHP specimens with th

235 es in the diversification process generating picornavirus serotypes that contribute to understanding

236 quence evolution generating diversity within picornavirus serotypes, in which neutral or purifying se

237 uncoating intermediate particles of several picornaviruses show limited expansion and some increased

238 ecombination contributes to the formation of picornavirus species groups and the emergence of circula

239 combination is important in the formation of picornavirus species groups and the ongoing evolution of

240 Sexual RNA replication shapes picornavirus species groups, contributes to the emergenc

241 eptor interactions that are conserved across picornavirus species.

242 The picornavirus structural proteins VP0, VP1, and VP3 are b

243 Picornaviruses, such as encephalomyocarditis virus (EMCV

244 replication, and other steps of infection by picornaviruses, such as human rhinovirus, coxsackievirus

245 CPMV), a plant virus that is a member of the picornavirus superfamily, is increasingly being used for

246 ified novel viral sequences belonging to the picornavirus superfamily, the Reoviridae, Parvoviridae,

247 -dependent RNA replication mechanisms render picornaviruses susceptible to error catastrophe, an over

248 Encephalomyocarditis virus (EMCV) is a picornavirus that can cause paralysis, diabetes, and myo

249 Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver disease worldwide.

250 Senecavirus A (SVA) is a picornavirus that causes acute vesicular disease (VD), t

251 3' untranslated region (UTR) of an oncolytic picornavirus that causes lethal myositis in tumor-bearin

252 Enterovirus 71 (EV71) is a picornavirus that causes outbreaks of hand, foot, and mo

253 particles of human enterovirus 71 (EV71), a picornavirus that causes severe neurological disease in

254 Our study describes a naturally occurring picornavirus that elicits strong antiviral responses in

255 Senecavirus A (SVA) is an emerging picornavirus that has been recently associated with an i

256 ive zebrafish revealed a naturally occurring picornavirus that induced a canonical interferon-mediate

257 titis A virus (HAV) is an hepatotropic human picornavirus that is associated only with acute infectio

258 01) is a conditionally replication-competent picornavirus that is not pathogenic to normal human cell

259 omyelitis virus (TMEV) is a highly cytolytic picornavirus that persists in the mouse central nervous

260 r's murine encephalomyelitis virus (TMEV), a picornavirus that, in some strains of mice, results in p

261 Cardioviruses comprise a genus of picornaviruses that cause severe illnesses in rodents, b

262 -one from a coronavirus and the other from a picornavirus-that have independently acquired the abilit

263 dancy with similar motifs derived from human picornaviruses, the motif is likely to operate by direct

264 In the case of poliovirus and several other picornaviruses, these membranes are derived from subvers

265 he replication of FMDV and potentially other picornaviruses through ribonucleoprotein complex formati

266 RNA recombination is a common mechanism for picornaviruses to counteract and avoid error catastrophe

267 ability of the 3A protein from 18 different picornaviruses to form a complex with PI4KIIIbeta by aff

268 Importance: The ability of replicating picornaviruses to influence the function of the secretor

269 the arsenal of poliovirus and perhaps other picornaviruses to overcome host defense mechanisms.

270 A viruses range from subtle (nodaviruses and picornaviruses) to dramatic (tetraviruses and togaviruse

271 itions in densely populated Bangladesh favor picornavirus transmission, resulting in a high rate of i

272 ebacks, the impact of Threespine Stickleback picornavirus (TSPV) on the fish biology should be invest

273 w species, dubbed the Threespine Stickleback picornavirus (TSPV).

274 ignaling attenuates SRPK activity to enhance picornavirus type 1 IRES translation and favor PVSRIPO t

275 Picornavirus Type 1 IRESs comprise five principal domain

276 ised questions about the prevalence of these picornavirus types in the community, the extent of HRV d

277 Many picornaviruses use IgG-like receptors that bind in the v

278 Picornaviruses use internal ribosome entry sites (IRESs)

279 attachment suggests that this branch of the picornaviruses uses a different mechanism of genome enca

280 tion; however, it is not known whether other picornaviruses utilize SRp20 as an ITAF and direct its c

281 rovides insight into the architecture of the picornavirus VPg uridylylation complex.

282 , MDA5, a PRR thought to recognize primarily picornaviruses, was required for recognition of MHV.

283 Picornaviruses were detected in 58 neonates (10.2%) and

284 Picornaviruses were detected in 78 of 677 (11.5%) NHP fe

285 s were positive for a picornavirus, while no picornaviruses were detected in samples from capped lang

286 The picornaviruses were detected in the stools of >40% of AF

287 doubled the number of infections identified; picornaviruses were the most frequent in patients of all

288 ainfluenza, respiratory syncytial virus, and picornavirus) were examined in the Canadian Asthma Prima

289 ion of FMDV replicons, which is unlike other picornaviruses where a single 3B can be used for both ci

290 Coxsackievirus B3 (CVB3) is a picornavirus which causes myocarditis and pancreatitis a

291 Given the precedent for other picornaviruses which use terminal sialic acids (SAs) as

292 These range from the tiny polio picornavirus, which has only 7kb of RNA genetic code tha

293 Indeed, even in flaviviruses and picornaviruses, which showed the lowest ratios among the

294 ns, or hamadryas baboons were positive for a picornavirus, while no picornaviruses were detected in s

295 Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine c

296 coalescent analyses of VP1 regions from four picornaviruses with 22 published VP1 rates to produce th

297 ively block replication of distantly related picornaviruses with minimal toxicity to cells.

298 ited during infection with several different picornaviruses, with consequences likely to have signifi

299 e protein-RNA linkage generated by different picornaviruses without impairing the integrity of viral

300 if could be functionally replaced with known picornavirus YX-AUG motifs and is predicted to function