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1                           Injection of alpha-pifithrin, a p53 antagonist, inhibited PGC apoptosis and
2 survival in cardiomyocytes were inhibited by Pifithrin-a, a p53 inhibitor, suggesting that Lats2 stim
3 when Eftud2-mutant embryos were treated with Pifithrin-a, an inhibitor of P53.
4 with an unconventional neuroregulatory drug, pifithrin-a.
5                            The p53 inhibitor pifithrin abolished the SFN-induced increase in transpor
6                                              Pifithrin alpha (PFTalpha) is a chemical compound isolat
7 ferroptosis in hESCs, which is suppressed by pifithrin alpha.
8 tified the tetrahydrobenzothiazole analogue, pifithrin-alpha (2), as a p53 inhibitor that was effecti
9 l animals or wild-type p53 mice treated with pifithrin-alpha (a p53 blocker) were irradiated (five 10
10                     A 24-h pretreatment with pifithrin-alpha (and continuing in the presence of insul
11 th after tGCI, we intravenously administered pifithrin-alpha (PFT).
12 ibitors of the tumor suppressor protein p53, pifithrin-alpha (PFT-alpha) and Z-1-117, are highly effe
13                   The p53-specific inhibitor pifithrin-alpha (PFT-alpha) significantly reduced the ex
14                              A p53 inhibitor pifithrin-alpha (PFT-alpha) was administered to stroke r
15 otective activity of the previously reported pifithrin-alpha (PFT-alpha, 1), various derivatives and
16                                              Pifithrin-alpha (PFTalpha) was originally thought to be
17                         Inhibition of p53 by pifithrin-alpha blocked STAT3 activation and the express
18 tream target of Rig-G, and p53 inhibition by pifithrin-alpha caused abrogation of tumor-suppressive e
19                                              Pifithrin-alpha completely suppressed DOX-induced activa
20                 Acute inhibition of p53 with pifithrin-alpha in wild-type mice mimicked the observati
21 -Ala-Asp-fluoromethylketone or p53 inhibitor pifithrin-alpha markedly prevented mitochondrial release
22                               The effects of pifithrin-alpha on p53 included inhibition of transcript
23                         Inhibition of p53 by pifithrin-alpha or by RNA interference prevented mitocho
24                            The p53 inhibitor pifithrin-alpha or p53 siRNA prevented both cisplatin-in
25                          Repressing p53 with pifithrin-alpha or small interfering RNA increased ERK p
26         Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either
27  short-term treatment with the p53 inhibitor Pifithrin-alpha partially and transiently rescued the my
28                   Furthermore, p53 inhibitor pifithrin-alpha partially nullified the suppressive effe
29 n these neurons, and inhibition of p53 using pifithrin-alpha prevented the apoptosis.
30 , the inhibition of p53 by the p53 inhibitor pifithrin-alpha protected against PA-induced apoptosis.
31 stent with activation of AP-1 and NF-kappaB, pifithrin-alpha was also able to enhance the UV-induced
32                                              Pifithrin-alpha was protective when given up to 14 h aft
33 either by administration of a p53 inhibitor (pifithrin-alpha), or by crossing Foxe3-/- mice with p53-
34                       Inhibition of p53 with pifithrin-alpha, a cell permeable p53 inhibitor, had sim
35 ions in p53 as well as in cells treated with pifithrin-alpha, a chemical inhibitor of p53 that decrea
36                                 Injection of pifithrin-alpha, a chemical inhibitor of p53, into pregn
37                      In utero treatment with pifithrin-alpha, a p53 inhibitor, rescued the hemorrhage
38 during cisplatin treatment was attenuated by pifithrin-alpha, a pharmacological inhibitor of p53, whi
39                                              Pifithrin-alpha, a specific inhibitor of p53, mimicked t
40 vity was confirmed using antisense c-myc and pifithrin-alpha, a specific inhibitor of p53.
41 treatment of mouse epidermal Cl41 cells with pifithrin-alpha, an inhibitor for p53-dependent transcri
42 ficiency, caused by germ-line mutation or by pifithrin-alpha, an inhibitor of p53-dependent apoptosis
43                                              Pifithrin-alpha, an inhibitor of the tumor suppressor pr
44 g inhibitors of p53-dependent transcription, pifithrin-alpha, and a genetic approach (overexpressing
45                         Inhibition of p53 by pifithrin-alpha, attenuates citral-mediated apoptosis.
46 systemic administration of the p53 inhibitor pifithrin-alpha, compared with untreated controls.
47 eath was provided by use of a p53 inhibitor, pifithrin-alpha, in organotypic slice cultures of mouse
48                           The p53 inhibitor, pifithrin-alpha, is able to attenuate the effect of prot
49  for p53 was tested using the p53 inhibitor, pifithrin-alpha, or using stable transfectants of a v-MY
50                               This compound, pifithrin-alpha, protected mice from the lethal genotoxi
51 t of pol eta(-/-) mice with a p53 inhibitor, pifithrin-alpha, reduced adipocyte senescence and attenu
52                       Perturbation of p53 by pifithrin-alpha, RNA interference, or genetic deletion p
53    We utilized the small molecule inhibitor, pifithrin-alpha, to inhibit p53 signaling, and nutlin-3a
54 ce the apoptosis of LNCaP cells treated with pifithrin-alpha, which prevents p53 accumulation, or of
55 f macrophages in the kidneys of p53(-/-) and pifithrin-alpha-treated mice after ischemic injury were
56             Ischemic kidneys of p53(-/-) and pifithrin-alpha-treated mice also showed reduced express
57 nally, models of peritonitis in p53(-/-) and pifithrin-alpha-treated mice confirmed the anti-inflamma
58 n p53(-/-) primary microglial cultures or in pifithrin-alpha-treated microglial BV2 cells.
59 ession of miR-192-5p were also suppressed by pifithrin-alpha.
60  of p53, and these effects were inhibited by pifithrin-alpha.
61 +UV) could be reversed by the p53 inhibitor, pifithrin-alpha.
62 prazosin, BMY 7378, apocynin, SB 202190, and pifithrin-alpha.
63 evidence was obtained using a p53 inhibitor, pifithrin-alpha.
64 y repair, and this binding was suppressed by pifithrin-alpha.
65  with the compound nutlin-3 and prevented by pifithrin-, an inhibitor of p53 activation.
66 ciency of p53 or pharmacologic inhibition by pifithrin impairs thrombus resolution and is associated
67        We also identified a novel CA binder, pifithrin-micro, which could not have been identified by
68  the mitochondrial translocation of p53 with pifithrin mu prevents the formation of p53/Bak complexes
69 elective for the inward-facing state) and/or pifithrin-mu (an HSP70 inhibitor) restored folding of, a
70  the heat shock protein 70 (HSP70) inhibitor pifithrin-mu such that endoplasmic reticulum export of a
71                               Noribogaine or pifithrin-mu treatment supported hDAT delivery to the pr
72 y this flow-through fraction is inhibited by pifithrin-mu, a small molecule inhibitor of Hsp70, sugge
73  ligand noribogaine and the HSP70 inhibitor, pifithrin-mu.
74 g flies were treated with noribogaine and/or pifithrin-mu.
75 efficacy of administering the small-molecule pifithrin (PFT)-mu, an inhibitor of mitochondrial p53 ac
76      However, the laboratory that discovered pifithrin recently reported that the compound also inhib
77 ion of DAT activity by the pharmacochaperone pifithrin-u was mutation-specific.
78 s-infected cells, which could be reversed by pifithrin-u, a p53-heat shock protein 70 (HSP70) signali