ライフサイエンスコーパス: pigment epithelial cell

1 eavage before internalization by the retinal pigment epithelial cell.

2 e the proliferative potential of the retinal pigment epithelial cell.

3 D) attributed to anteriorly migrated retinal pigment epithelial cells.

4 ytes, retinal endothelial cells, and retinal pigment epithelial cells.

5 e stress on the UPP in cultured human retina pigment epithelial cells.

6 itis and that IL-22 can affect human retinal pigment epithelial cells.

7 types, human trabecular meshwork and retinal pigment epithelial cells.

8 scopy for IFT88-mEOS4b in live human retinal pigment epithelial cells.

9 generation of rod photoreceptors and retinal pigment epithelial cells.

10 CD mRNA expression in cultured human retinal pigment epithelial cells.

11 horylation in TGF-beta-treated human retinal pigment epithelial cells.

12 ber at the population level in human retinal pigment epithelial cells.

13 ascular complex, surrounded by FasL+ retinal pigment epithelial cells.

14 support functions usually adopted by retinal pigment epithelial cells.

15 ll-to-cell spread in polarized human retinal pigment epithelial cells.

16 erior retinal blood vessels and some retinal pigment epithelial cells.

17 so stimulated proliferation of human retinal pigment epithelial cells.

18 egument protein were tested in human retinal pigment epithelial cells.

19 y reveals sporadic degeneration of scattered pigment epithelial cells.

20 upregulates IL-8 and CCL2 levels in retinal pigment epithelial cells.

21 ilitator of Best1 is demonstrated in retinal pigment epithelial cells.

22 cytes and increase in circularity of retinal pigment epithelial cells.

23 entration (IC(5)(0)) of 20 mug/mL in retinal pigment epithelial cells.

24 nesis and a cytoprotective agent for retinal pigment epithelial cells.

25 and reduced cathepsin D activity in retinal pigment epithelial cells.

26 inal capillary endothelial cells and retinal pigment epithelial cells.

27 f increased iron on the functions of retinal pigment epithelial cells.

28 gamma, to increase CFH expression in retinal pigmented epithelial cells.

29 man leukemia cells, HL-60, and human retinal pigmented epithelial cells.

30 through the transdifferentiation of the iris-pigmented epithelial cells.

31 d vessels surrounded by proliferated retinal pigmented epithelial cells.

32 lated from mammalian endothelial and retinal pigmented epithelial cells.

33 rms fewer atypical fibers with human retinal pigmented epithelial cells.

34 In this disorder, retinal pigment epithelial cells, abandon their attachment to Br

35 Over time, the Mreg(-/-) mouse retinal pigment epithelial cells accumulate the lipofuscin compo

36 n had a moderate effect on enhancing retinal pigmented epithelial cell adhesion and migration on norm

37 ing spontaneously immortalized human retinal pigment epithelial cells (adult retinal pigment epitheli

38 O-2s protect human neuroblastoma and retinal pigmented epithelial cells against hydroxyl radicals in

39 Retinal pigment epithelial cells and cells in the inner retina,

40 a novel, high Mr protein from human retinal pigment epithelial cells and endothelial cells by affini

41 se-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were

42 4F2hc or b(0,+)AT and rBAT in human retinal pigment epithelial cells and in COS-1 cells.

43 debris by monocytes/macrophages and retinal pigment epithelial cells and is capable of producing an

44 be required for viral replication in retinal pigment epithelial cells and microvascular endothelial c

45 ls, whereas AdV5-GFP transduced only retinal pigment epithelial cells and occasional photoreceptors a

46 gment changes indicative of reactive retinal pigment epithelial cells and photoreceptor degeneration.

47 The RPE65 protein is located in the retinal pigment epithelial cells and plays an important role in

48 cular, retrolental tissue containing retinal pigment epithelial cells and remnants of the hyaloid vas

49 teinase (MMP) inhibitory activity in retinal pigment epithelial cells and resulted in increased secre

50 eration depend on a loss of ClC-2 in retinal pigment epithelial cells and Sertoli cells, respectively

51 od outer segment-challenged, control retinal pigment epithelial cells and zif-268, AP-1, AP-2, or tis

52 AT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts all-trans

53 In 2 wk, we generated both retinal pigmented epithelial cells and self-forming neural retin

54 n Muller cells (rMCs), primary mouse retinal pigment epithelial cells, and astrocytes.

55 idual cells, such as photoreceptors, retinal pigment epithelial cells, and blood cells in the retinal

56 orphogenetic protein-4 expression in retinal pigment epithelial cells, and both bone morphogenetic pr

57 cell lines including hepatoma cells, retinal pigment epithelial cells, and keratinocytes as well as i

58 hree cell types: dermal fibroblasts, retinal pigment epithelial cells, and vascular endothelial cells

59 We disrupted CETN2 in human retinal pigmented epithelial cells, and despite having intact ce

60 including lung and skin fibroblasts, retinal pigmented epithelial cells, and endometrial stromal fibr

61 cally localized to renal medulla and retinal pigmented epithelial cells, and it was prominent in neur

62 as readily observed in the dedifferentiating pigmented epithelial cells, and the levels of expression

63 Retinal pigment epithelial cells appear to demonstrate a distinc

64 acrophages and directed migration of retinal pigment epithelial cells are annexin A2-dependent, and s

65 ofuscin granules isolated from human retinal pigment epithelial cells are examined by using steady-st

66 pofuscin pigments that accumulate in retinal pigment epithelial cells are implicated in the etiology

67 beam radiation, retinal ganglion and retinal pigment epithelial cells are preserved while choroidal e

68 Our results indicate that retinal pigment epithelial cells are the initial site of insult

69 ic factor IL-1beta strongly, whereas retinal pigment epithelial cells are the main source of VEGF-A.

70 ed epithelial cells, such as ARPE-19 retinal pigmented epithelial cells, are poorly infected by labor

71 he effects of UVA radiation on Human retinal pigment epithelial cell (ARPE-19) growth and protein exp

72 Retinal pigment epithelial cells (ARPE-19 and B6-RPE07) were sti

73 Human retinal pigment epithelial cells (ARPE-19) and rat neurosensory

74 on the ability of immortalized human retinal pigment epithelial cells (ARPE-19) to regulate complemen

75 ion of lipid rafts in cultured human retinal pigment epithelial cells (ARPE-19) was studied by confoc

76 Human retinal pigment epithelial cells (ARPE-19) were cultured either

77 Retinal pigment epithelial cells (ARPE-19) were cultured for 18

78 lls (RGC-5), and serum-starved human retinal pigment epithelial cells (ARPE-19) were exposed to 2, 4,

79 , and peroxynitrite) for human adult retinal pigment epithelial cells (ARPE-19) were quantified by me

80 Retinal pigment epithelial cells (ARPE-19) were transduced with

81 ized NORPEG, a novel gene from human retinal pigment epithelial cells (ARPE-19), in which its express

82 e experimental model, and from human retinal pigment epithelial cells (ARPE-19).

83 dysbiotic Pg-strains to invade human-retinal pigment epithelial cells(ARPE-19), their survival, intra

84 ) is exported out of the adult human retinal pigment epithelial cells (ARPE19) packaged in exosomes.

85 retinoid pigments that accumulate in retinal pigment epithelial cells as lipofuscin are associated wi

86 ence in normal human fibroblasts and retinal pigment epithelial cells, as ectopic expression of the t

87 ds human primary blood leukocytes or retinal pigment epithelial cells at effective concentrations; pr

88 as an oxidative stressor leading to retinal pigment epithelial cell atrophy.

89 e life span of human fibroblasts and retinal pigment epithelial cells beyond senescence without causi

90 bovine retinal pericytes (BRPs) and retinal pigment epithelial cells (BRPECs) were evaluated by dete

91 crophages, choroidal fibroblasts and retinal pigment epithelial cells, but also on the expression of

92 that tenascin-C is anti-adhesive for retinal pigmented epithelial cells, but after integrin activatio

93 nner nuclear layer, ganglion cell layer, and pigmented epithelial cells, but not in photoreceptors.

94 that IL-22 can affect primary human retinal pigment epithelial cells by decreasing total tissue resi

95 manipulation of integrin function in retinal pigment epithelial cells can restore their adhesion and

96 ed against the noncancerous ARPE-19 (retinal pigment epithelial cells) cell line, in order to evaluat

97 al College of Surgeons-p+ dystrophic retinal pigment epithelial cells challenged with rod outer segme

98 try showed subfoveal accumulation of retinal pigment epithelial cells, collagen, and vimentin, disrup

99 ta1 localizes to the basal aspect of retinal pigment epithelial cells colocalizing with the basal lam

100 structures stained with these dyes included pigment epithelial cells, cone outer segments, and Mulle

101 e hypothesis that blue light is toxic to non-pigmented epithelial cells, confluent cultures of human

102 We conclude that iris pigment epithelial cells constitutively express cell sur

103 pic expression of ngn2 in nonneural, retinal pigment epithelial cell culture triggered de novo genera

104 Retinal pigment epithelial cell cultures prepared from RCS and c

105 key role of oxidative stress-induced retinal pigment epithelial cell death and secondary photorecepto

106 x hours following irradiation of rat retinal pigment epithelial cells delays DNA repair and suppresse

107 s uses two different routes to enter retinal pigmented epithelial cells, depending on the cell type i

108 r (CNTF), a combination of BDNF and CNTF, or pigment epithelial cell-derived growth factor (PEDF) mig

109 Retinal pigment epithelial cells did not stain for iNOS.

110 presumptive neural retina, without affecting pigmented epithelial cell differentiation.

111 and transiently increased in normal retinal pigment epithelial cells during rod outer segment phagoc

112 n the stimulation of fibroblasts and retinal pigment epithelial cells during the formation of choroid

113 drusen deposition is associated with retinal pigmented epithelial cell dysfunction and degeneration o

114 expression in cultures of non-neural retinal pigment epithelial cells elicited transdifferentiation i

115 oaded nanotube were non-cytotoxic to retinal pigment epithelial cells even at a concentration of 200

116 MREG-deficient human and mouse retinal pigment epithelial cells exhibit diminished activity of

117 Human retinal pigment epithelial cells exposed to superoxide or hydrog

118 Cloned retinal pigment epithelial cells expressed the IGF-1 transgene a

119 Evaluation of retinal pigment epithelial cell extracts derived from E-FABP nul

120 L localizes to the primary cilium of retinal pigment epithelial cells, fibroblasts and kidney tubular

121 LEDGF1-326 also increased retinal pigment epithelial cell FluoSphere uptake to 140 +/- 10%

122 ombospondin and incubated with human retinal pigment epithelial cells for 3 hours.

123 ngle-cell atlas of immune, glial and retinal pigment epithelial cells from adult mouse retina before

124 Retinal pigment epithelial cells from normal and RCS rats were g

125 It has been shown that allografts of retinal pigment epithelial cells from normal perinatal rats have

126 Retinal pigment epithelial cell heights were measured on light a

127 portance of alpha1beta1 integrin for retinal pigment epithelial cell homeostasis and retinal health w

128 Glucose consumption of HRECs, human retinal pigment epithelial cells (HRPEs), and human Muller cells

129 ls, Muller cells, photoreceptors and retinal pigment epithelial cells in a spatial arrangement simila

130 improved survival of retinal endothelial and pigment epithelial cells in conjunction with reduced str

131 senescence-associated phenotypes in retinal pigment epithelial cells in culture.

132 gocytosis and lysosomal functions of retinal pigment epithelial cells in the aged RPE/choroid.

133 is and unique suppressive mechanisms used by pigment epithelial cells in the eye.

134 raphic) atrophy frequently occurs in retinal pigment epithelial cells in the human disease, age-relat

135 Reoxygenation of human retinal pigment epithelial cells in vitro and ocular reperfusion

136 ow that B(e)P is a toxicant to human retinal pigment epithelial cells in vitro.

137 racrine biological activity in human retinal pigment epithelial cells in vitro.

138 roximately 40% of the animals and in retinal pigmented epithelial cells in 4 animals.

139 Retinal pigmented epithelial cells in the eye produce retinyl es

140 tracellular iron on the functions of retinal pigment epithelial cells, in vitro ARPE-19 cells were tr

141 ignificantly activated by hypoxia in retinal pigment epithelial cells, indicating that ERK5 regulatio

142 embly compartments in differentiated retinal pigment epithelial cells, infected AmEpCs made dispersed

143 The role of AMPK in retinal pigment epithelial cell inflammatory response is address

144 Following retinal pigment epithelial cell injury, transplanted microglia d

145 results suggest that manipulation of retinal pigment epithelial cell integrins through integrin activ

146 doses of light with NACA maintained retinal pigment epithelial cell integrity and prevented outer nu

147 etected in the conditioned medium of retinal pigment epithelial cells, interphotoreceptor matrix, and

148 nduced pluripotent stem cell-derived retinal pigment epithelial cells (iPSC-RPE).

149 neration, and transplantation of new retinal pigment epithelial cells is an attractive strategy to pr

150 Integrity of retinal pigment epithelial cells is necessary for photoreceptor

151 Thus, SCD expression in retinal pigment epithelial cells is regulated by retinoic acid,

152 ated that the developmental potential of the pigmented epithelial cells is not completely restricted;

153 Retinal pigment epithelial cells isolated from dystrophic RCS ra

154 Thus, in retinal pigment epithelial cell layers, rapamycin decreased nucl

155 to the ganglion, inner nuclear, and retinal pigment epithelial cell layers.

156 id phenylalanine (Phe) between human retinal pigment epithelial cell line (ARPE-19) and tachyzoites o

157 ndothelial growth factor (VEGF) in a retinal pigment epithelial cell line (ARPE-19) and to determine

158 tubular cell line (TEC) and a human retinal pigment epithelial cell line (ARPE-19).

159 Knockdown of Tgifs in a human retinal pigment epithelial cell line also increased EVI5L expres

160 utamate transporter xc- in the human retinal pigment epithelial cell line ARPE-19 and in retina from

161 xpression was inhibited in the human retinal pigment epithelial cell line ARPE-19 by siRNA.

162 y of differentiation in vitro of the retinal pigment epithelial cell line ARPE-19 has been previously

163 e transporter (x(c)(-)) in the human retinal pigment epithelial cell line ARPE-19, clone the light ch

164 We next used the human retinal pigment epithelial cell line RPE-1 as a model system and

165 After introducing a retinal pigment epithelial cell line to the subretinal space ear

166 We used in this study a retinal pigment epithelial cell line, ARPE- 19 and exposed it to

167 n the present study, using the human retinal pigment epithelial cell line, ARPE-19.

168 In addition, the retinal pigment epithelial cell line, RPE-Neo was used as a heal

169 man telomerase reverse transcriptase-retinal pigment epithelial cell line, we show that RanGTP, a sma

170 bs against BADrUL131-Y4 CMV in adult retinal pigment epithelial cell line-19 human epithelial cells;

171 cysteine and expressed in the human retinal pigment epithelial cell line.

172 III myosin, MYO3A, from retina and a retinal pigment epithelial cell line.

173 Confluent cultures of a human retinal pigmented epithelial cell line (ARPE-19) were deprived o

174 gulate the expression of VEGF in the retinal-pigmented epithelial cell line ARPE-19.

175 s this question we established human retinal pigment epithelial cell lines expressing wild type or S1

176 mRNAs in mouse and human retinas and retinal pigment epithelial cell lines.

177 erstanding of the adverse effects of retinal pigment epithelial cell lipofuscin.

178 Retinal pigment epithelial cell malfunction is a causative featu

179 in the skate but not the rat retina, retinal pigment epithelial cells may be an alternative source of

180 Thus, FasL expressed on retinal pigment epithelial cells may control the growth and deve

181 gocytosis of extracellular matrix by retinal pigment epithelial cells may represent a novel mechanism

182 2 to the cell surface, thus enabling retinal pigment epithelial cell migration following injury; our

183 were blood-borne macrophages and not retinal pigment epithelial cells nor Muller glia.

184 f N5-methyltetrahydrofolate in human retinal pigment epithelial cells occurs exclusively through the

185 ent materials, called lipofuscin, in retinal pigment epithelial cells of the aging retina is most pro

186 After lens removal, the pigment epithelial cells of the dorsal, but not the vent

187 After lens removal, the pigmented epithelial cells of the dorsal iris proliferat

188 ing melanocytes, mast cells, osteoclasts and pigmented epithelial cells of the eye.

189 (BMs) serve as attachment sites for retinal pigment epithelial cells on Bruch's membrane and Muller

190 Our experiments reveal that in retinal pigment epithelial cells, only a fraction of PINK1 becom

191 gration in (hTERT)-immortalizedRPE1 (retinal pigment epithelial) cells over long timescales.

192 of such a process is transdifferentiation of pigmented epithelial cells (PECs) to lens cells during l

193 Human retinal pigment epithelial cells play a pivotal role in supplyin

194 Subconfluent retinal pigment epithelial cells preferentially phagocytose FN o

195 anes of CMV-infected polarized human retinal pigment epithelial cells propagated on permeable filter

196 mations in photoreceptor (RDH12) and retinal pigment epithelial cells (RDH11).

197 cell line as well as human and mouse retinal pigment epithelial cells resulted in killing of T. gondi

198 protein levels, and inducing MYCN in retinal pigmented epithelial cells resulted in CHK1 phosphorylat

199 Microarray measurements in retinal pigment epithelial cells revealed 36 genes regulated by

200 caused replication defects in rhesus retinal pigment epithelial cells: Rh01 (an HCMV TRL1 orthologue)

201 The results suggest that in retinal pigment epithelial cells, rod outer segment-specific pha

202 The retinal pigment epithelial cell (RPE cell) layer protects the ph

203 cence (NIR-AF) provided evidence for retinal pigment epithelial cell (RPE) involvement.

204 ry activity, it also participates in retinal pigment epithelial cell (RPE) mediated activation of mac

205 and differentiated these cells into retinal pigment epithelial cells (RPE) to study the mechanisms o

206 scopic deposits on the basal side of retinal pigment epithelial cells (RPE), an early feature in DHRD

207 ogram light peak (LP), lipofuscin in retinal pigment epithelial cells (RPE), and fluid- and debris-fi

208 lium; and primary cultures of bovine retinal pigment epithelial cells (RPE), pericytes (RPC), and end

209 microvascular endothelial cells and retinal pigment epithelial cells (RPE).

210 plasma membrane protein expressed in retinal pigment epithelial cells (RPE).

211 r of blue-light-induced apoptosis in retinal pigment epithelial cells (RPE).

212 nvolving photoreceptors and adjacent retinal pigment epithelial cells (RPE).

213 complex set of reactions in adjacent retinal pigment epithelial cells (RPE).

214 uman skin fibroblasts (BJ-hTERT) and retinal pigment epithelial cells (RPE-hTERT) retain normal growt

215 ion in mouse retinal cells and human retinal pigmented epithelial cells (RPE) through STAT1-mediated

216 dDeltaBsg), cones (ConeDeltaBsg), or retinal pigment epithelial cells (RPEDeltaBsg).

217 thy and that smooth muscle cells and retinal pigment epithelial cells secrete HGF in the eye.

218 ic protein-4 may interact to promote retinal pigment epithelial cell senescence and that bone morphog

219 ent mild oxidative stress can induce retinal pigment epithelial cell senescence through p53-p21(Cip1/

220 Retinal pigment epithelial cell signals also changed dramaticall

221 lymers were shown to be non-toxic to retinal pigment epithelial cells, studies of drug release using

222 The canonical visual cycle in retinal pigment epithelial cells supplies 11cRAL at low rates.

223 lture supernatants of astrocytes and retinal pigment epithelial cells support the CD8 autoreactive T

224 via VEGF receptors expressed on the retinal pigment epithelial cells that drive this disease, VEGF's

225 he ciliary epithelium in the eye consists of pigmented epithelial cells that express the alpha1beta1

226 In human fetal retinal pigment epithelial cells, there is an early induction of

227 transfected into embryonic or mature chicken pigment epithelial cells, these cells adopt a neuronal m

228 were induced to undergo apoptosis by retinal pigment epithelial cells through a Fas-FasL interaction.

229 tion greatly enhanced the ability of retinal pigment epithelial cells to adhere to tenascin-rich wet

230 ing that ngn2 can instruct nonneural retinal pigment epithelial cells to differentiate toward retinal

231 shepherded within photoreceptors and retinal pigment epithelial cells to facilitate retinoid traffick

232 fective in improving the efficacy of retinal pigment epithelial cell transplantation in wet age-relat

233 e secretion of angiogenic factors by retinal pigmented epithelial cells under normoxic, hypoxic, and

234 in wild-type and TP53 knockout human retinal pigment epithelial cells using a focused dual guide RNA

235 alphaB is secreted from human adult retinal pigment epithelial cells via microvesicles (exosomes), i

236 LEDGF1-326 increased human retinal pigment epithelial cell viability from 48.3 +/- 5.6 to 1

237 holinos, we found that proliferation of iris pigment epithelial cells was dramatically reduced both i

238 hic Royal College of Surgeons-p+ rat retinal pigment epithelial cells was studied in primary cell cul

239 Notably, using polarized adult retinal pigment epithelial cells, we show that the secretion of

240 Human retinal pigment epithelial cells were cultured on an impermeable

241 ARPE-19 retinal pigment epithelial cells were depleted of their mitochon

242 Yellow staining of detached pigment epithelial cells were rare.

243 Human retinal pigment epithelial cells were transfected in vitro with

244 Human retinal pigment epithelial cells were treated with various combi

245 Retinal pigment epithelial cells were visible in patient 3 where

246 ut not in regions with scotomas, and retinal pigment epithelial cells were visible in regions without

247 Iris pigment epithelial cells, when cultured at high densitie

248 taset obtained on differentiation of retinal pigment epithelial cells where 399 proteins were quantif

249 ns in photoreceptors and in adjacent retinal pigment epithelial cells where all-trans-retinol is isom

250 egments and to the apical surface of retinal pigment epithelial cells where it might be involved in t

251 l cells, and Muller cells as well as retinal pigment epithelial cells, whereas AdV5-GFP transduced on

252 of primary cilia in mouse IMCD3 and retinal pigment epithelial cells, which could be rescued by inhi

253 pically central retina) composed of modified pigment epithelial cells, which we hypothesize to be the

254 ipofuscin pigment A2E accumulates in retinal pigment epithelial cells with age and is particularly ab

255 scent lipofuscin that accumulates in retinal pigment epithelial cells with age may contribute to an a

256 orescent pigments that accumulate in retinal pigment epithelial cells with aging and in some retinal

257 E, a fluorophore that accumulates in retinal pigment epithelial cells with aging and in some retinal

258 In vitro treatments of human retinal pigment epithelial cells with CEP-dipeptide or CEP-HSA d

259 e observed in human liver, lens, and retinal pigment epithelial cells with increasing concentrations

260 e transcriptome of immortalized human retina pigment epithelial cells with inducible MYCN activation.

261 ysis, increased after stimulation of retinal pigment epithelial cells with LPS or poly(I:C), indicati

262 Treatment of human retinal pigment epithelial cells with NACA protected against oxi

263 is, we altered the GSSG:GSH ratio in retinal pigment epithelial cells with the thiol-specific oxidant

264 tively, we find that transduction of retinal pigmented epithelial cells with alpha9 integrin, a tenas

265 e actin (SMA) expression in adjacent retinal pigment epithelial cells, with subsequent formation of a