ライフサイエンスコーパス: pigmentary

1 AUC in the detection of large drusen (0.94), pigmentary abnormalities (0.93), and late AMD (0.97).

2 cuity loss included foveal scarring (44.3%), pigmentary abnormalities (27.9%), and foveal GA (11.5%).

3 0.742 vs. 0.696; kappa 0.601 vs. 0.517) and pigmentary abnormalities (accuracy 0.890 vs. 0.813; kapp

4 To comprehend the role of pigmentary abnormalities (PA) and GA in AMD, the authors

5 ence of structural AMD biomarkers, including pigmentary abnormalities (PAs), pigment epithelium detac

6 en volume, reticular pseudodrusen (RPD), and pigmentary abnormalities (PAs).

7 5% confidence interval (CI): 1.02, 1.14) and pigmentary abnormalities (RR = 1.09, 95% CI: 1.04, 1.14)

8 er, being a current smoker, as well as focal pigmentary abnormalities and large drusen (>125 mum) wer

9 gression to late-stage AMD, similar to focal pigmentary abnormalities and large drusen.

10 at CFH may play a role in the development of pigmentary abnormalities and may modify the progression

11 lesions of larger drusen (>125 microns) and pigmentary abnormalities and the incidence of any ARM we

12 in the nasal and inferior quadrants, whereas pigmentary abnormalities associated with age-related mac

13 Persons with large drusen or with pigmentary abnormalities associated with at least medium

14 of age; vessel attenuation, RPE atrophy and pigmentary abnormalities at 14 months, which progressed

15 We report a case study on models for retinal pigmentary abnormalities in the Beaver Dam Eye Study.

16 amination of the 11 eyes revealed drusen and pigmentary abnormalities in the central macula and no ev

17 Ciliary body cysts and retinal pigmentary abnormalities may also be markers of NF1.

18 hology seems to lie with dry eye disease and pigmentary abnormalities of various ocular structures, e

19 progression (age, drusen volume on OCT, and pigmentary abnormalities on CFP; all P >= 0.205).

20 sence of any size drusen and the presence of pigmentary abnormalities or by the presence of large-siz

21 Persons with no visible drusen or pigmentary abnormalities should be considered to have no

22 medium drusen (>/= 63-<125 mum), but without pigmentary abnormalities thought to be related to AMD, s

23 in eyes with both medium drusen and retinal pigmentary abnormalities was 4-fold higher than that in

24 l, large drusen, soft indistinct drusen, and pigmentary abnormalities were more likely to develop in

25 the superior or temporal quadrants, whereas pigmentary abnormalities were most likely to occur in th

26 n from medium size drusen to large drusen or pigmentary abnormalities within the central 1500-microm

27 ng individual AMD risk factors (drusen size, pigmentary abnormalities) for each eye and then calculat

28 ermediate drusen, extensive small drusen, or pigmentary abnormalities), or group 3 (large drusen or e

29 was related to ARM (specifically to retinal pigmentary abnormalities), whereas total carbohydrate in

30 adjustment for confounders of drusen volume, pigmentary abnormalities, and age.

31 macular regions (extramacular drusen score), pigmentary abnormalities, and disease staging were also

32 ustment for the confounders of baseline age, pigmentary abnormalities, and drusen volume.

33 ardenburg syndrome, which involves deafness, pigmentary abnormalities, and facial characteristics inc

34 m annual visits were graded for soft drusen, pigmentary abnormalities, and late AMD.

35 The relationships of retinal drusen, retinal pigmentary abnormalities, and macular degeneration to ag

36 fam(EKO) mice exhibited severe HF dystrophy, pigmentary abnormalities, and telogen-like condensed der

37 ome typically manifests with congenital iris pigmentary abnormalities, but careful inspection can rev

38 gment dystrophy and in tvrm5 mice, including pigmentary abnormalities, focal thickening and elevated

39 n in the diet were related to lower odds for pigmentary abnormalities, one sign of early ARM (odds ra

40 The development of foveal scar, pigmentary abnormalities, or GA contributed to most of t

41 acular degeneration, any type of drusen with pigmentary abnormalities, or soft indistinct drusen with

42 ted high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD),

43 ho usually do not have conspicuous drusen or pigmentary abnormalities.

44 drusen and between zinc and the incidence of pigmentary abnormalities.

45 CFPs were also graded for the presence of pigmentary abnormalities.

46 raphs were used to grade for the presence of pigmentary abnormalities.

47 iduals who had dilated eye exams had retinal pigmentary abnormalities.

48 vioral, cognitive, motor, bone, cardiac, and pigmentary abnormalities.

49 rmalities, or soft indistinct drusen without pigmentary abnormalities.

50 rkers, respectively, based on drusen and AMD pigmentary abnormalities.

51 ection can reveal additional posterior uveal pigmentary abnormalities.

52 d be differentiated: type 1 with mild, focal pigmentary abnormalities; type 2 characterized by multif

53 tinct/reticular drusen or coexisting retinal pigmentary abnormality and soft distinct drusen in eyes

54 al (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates.

55 difficult include the presence of drusen and pigmentary alteration, a fundus in which choroidal vesse

56 rately capturing erythema, inflammation, and pigmentary alterations in skin of color, specific lighti

57 g with drusen (particularly soft drusen) and pigmentary alterations in the macular region.

58 Visible light (VL) can induce pigmentary alterations, especially in dark-skinned indiv

59 s could drive complex immune, epidermal, and pigmentary alterations.

60 racteristics, and their association with any pigmentary alterations.

61 ck to skin features, providing insights into pigmentary and auditory features.

62 icate that MC1R protects by a combination of pigmentary and non-pigmentary effects in vivo and that w

63 and potency of the response to alpha-MSH in pigmentary and nonpigmentary cells suggest this to be a

64 and glutathione peroxidase (GPx) activity in pigmentary and nonpigmentary cells.

65 cluding radiation protection, UV-protection, pigmentary and structural color productions, and thermor

66 the intricate biophotonic interplay between pigmentary and structural coloration elements tightly co

67 global) to determine how transitions between pigmentary and structural colours influence speciation d

68 This was true of both pigmentary and structurally colored plumage patches.

69 a diagnosis that denotes the coexistence of pigmentary and vascular birthmarks of specific types, ac

70 higher risk of failure for pseudoexfoliative/pigmentary, angle closure, uveitic, and normal tension s

71 haracterized by deafness in association with pigmentary anomalies and various defects of neural crest

72 10 alleles in mice exhibit aganglionosis and pigmentary anomalies typical of a subset of HSCR patient

73 B6] exhibit highly variable craniofacial and pigmentary anomalies.

74 lanocyte stimulating hormone (alpha-MSH) has pigmentary, anti-inflammatory, antipyretic, and general

75 nation of lymph and glandular emission, with pigmentary cell filtering in the skin.

76 l patients without grossly visible drusen or pigmentary change (n = 15; age range, 60-95 years).

77 proteins as the tumors become amelanotic, a pigmentary change associated with ongoing malignant prog

78 Senile reticular pigmentary change was the predominant peripheral change

79 fundus appearance was graded for drusen and pigmentary change, using stereo color photographs.

80 the presence of nGA included the presence of pigmentary changes (odds ratio [OR], 16.84; 95% confiden

81 o was legally blind, had peripheral nummular pigmentary changes (stage 4).

82 Finally, 1 eye demonstrated peripheral pigmentary changes and clustered atrophic lesions resemb

83 fundus photography these included localized pigmentary changes and on OCT imaging an ellipsoid zone

84 are associated with a more severe degree of pigmentary changes and retinal disruption than those loc

85 Both drusen of 125 mum or more and pigmentary changes at baseline were significant risk fac

86 Pigmentary changes at the level of the RPE occur early i

87 Examination of pigmentary changes by spectrophotometry revealed that th

88 cence was seen in 70.8% of eyes, and new RPE pigmentary changes developed in 56.2% of eyes.

89 nts with normal fundus, TLR, or asymptomatic pigmentary changes had a continuous ellipsoid zone on OC

90 Fundus examination revealed macular pigmentary changes in all 7 patients, corresponding to a

91 .9% of participants with drusen >125 mum and pigmentary changes in both eyes.

92 greatly enhance our appreciation of dynamic pigmentary changes in human or animal skin over time and

93 vision loss who presented bilateral retinal pigmentary changes in posterior pole and midperiphery.

94 ere was a 60% increased detection of retinal pigmentary changes in surgical eyes.

95 f which one was possibly related to RGX-314: pigmentary changes in the macula with severe vision redu

96 manifestations, but it can also present with pigmentary changes in the retina.

97 pplicability of RCM to detecting UVR-induced pigmentary changes in this model.

98 e analysis, it proposes a hypothesis for the pigmentary changes in this rare autosomal recessive EBS

99 ndings consistent with ochronosis, including pigmentary changes of the ear and mild degenerative dise

100 ts suggest that PG mediate post-inflammatory pigmentary changes through modulation of melanocyte dend

101 Asymptomatic pigmentary changes were seen in the inferior retinal per

102 the blind spot), ocular findings (paucity of pigmentary changes with no sign of vitreous inflammation

103 , 68% had drusen of 125 mum or more, 36% had pigmentary changes, 10% had both drusen of 125 mum or mo

104 : cobblestone, 19% versus 30%; and reticular pigmentary changes, 25% versus 33%, respectively.

105 , 10% had both drusen of 125 mum or more and pigmentary changes, and 17% had only RPD in their fellow

106 fibrotic changes, 48 eyes (11.5%) with mild pigmentary changes, and 43 eyes (10.3%) showing a vitell

107 HFs, decreased anagen HF proliferation, hair pigmentary changes, and decreased hair width and length.

108 east 1 large druse ( 125 um), and/or retinal pigmentary changes, and eAMD in the fellow eye.

109 , nevus, drusen, enlarged cup-to-disc ratio, pigmentary changes, and other).

110 es, reticular pseudodrusen, senile reticular pigmentary changes, cobblestone degeneration, and FAF ab

111 dus initially showed a pallid optic disc and pigmentary changes, developing thereafter retinal lacuna

112 showed dilated and tortuous retinal vessels, pigmentary changes, incomplete vascularization of periph

113 s also were graded for AMD features (drusen, pigmentary changes, late AMD) to generate person-based A

114 ups based on fundus characteristics (drusen, pigmentary changes, late AMD, and subretinal drusenoid d

115 ith selective Ranbp2 ablation in RPE develop pigmentary changes, syncytia, hypoplasia, age-dependent

116 The 4 youngest patients had no fundus pigmentary changes, with the rest of the patients presen

117 tation and discusses the pathogenesis of the pigmentary changes.

118 ddition, older patients more commonly showed pigmentary changes.

119 subclinical characteristics such as TLR and pigmentary changes.

120 nd all scars (100%, 95% CI, 49.9-100) showed pigmentary changes.

121 progression to GA, in addition to drusen and pigmentary changes.

122 ities, and the remainder (29%) showing minor pigmentary changes.

123 nding to a fair response on average (26%-50% pigmentary clearance).

124 unduscopic examination revealed perivascular pigmentary clumping and atrophic changes radiating from

125 le regulatory coordination of structural and pigmentary coloration.

126 l]) melanocytosis is a congenital periocular pigmentary condition that can lead to the development of

127 Zebrafish morphants for either gene develop pigmentary defects and severe craniofacial abnormalities

128 amptodactyly, and other digital deformities; pigmentary defects on the face and scalp; and multiple f

129 cription factor SOX10 is associated with the pigmentary deficiencies of Waardenburg syndrome (WS) and

130 terised by distinct bands of circumferential pigmentary degeneration in the peripheral retina and dev

131 inopathy and retinal pigmentation as well as pigmentary degeneration.

132 A pigmentary demarcation line was noted extending the nasa

133 ral retina, accompanied by bone spicule-like pigmentary deposits and a reduced or absent electroretin

134 scribe the development of diffuse preretinal pigmentary deposits in 12 eyes after surgery for complic

135 -1), an autosomal recessive disorder causing pigmentary dilution, visual disturbances, bleeding diath

136 ulopathy is an acquired, progressive retinal pigmentary disease associated with oral PPS use.

137 abnormalities has been detected in patterned pigmentary disease.

138 or GNA11 lead to a spectrum of vascular and pigmentary diseases including Sturge-Weber syndrome, in

139 at interest pharmaceutically (as therapy for pigmentary diseases) and cosmeceutically (e.g., to desig

140 their functions are associated with various pigmentary diseases; however, many remain to be identifi

141 stigated the etiology of X-linked reticulate pigmentary disorder (XLPDR), a primary immunodeficiency

142 Melasma is a pigmentary disorder characterized by hyperpigmented patc

143 Vitiligo, an acquired pigmentary disorder of unknown origin, is the most frequ

144 The deafness-pigmentary disorder Waardenburg Syndrome Type 2 is cause

145 A total of 50% of respondents had at >=1 pigmentary disorder: solar lentigo (13,192 [27.5%]), axi

146 wounds (16 [18.4%]), neoplasms (10 [11.5%]), pigmentary disorders (10 [11.5%]), signs of torture/viol

147 ow the development of novel therapeutics for pigmentary disorders and bring new insights into the imm

148 rldwide survey provides important data about pigmentary disorders and their strong impact on affected

149 Pigmentary disorders are a common finding in primary car

150 Pigmentary disorders are prevalent around the world, but

151 ermatologic conditions in skin of color, and pigmentary disorders is needed.

152 Multiple related deafness-pigmentary disorders result from mutations in genes that

153 lerosis and neurofibromatosis type 1 are two pigmentary disorders that have had many changes in their

154 essed the worldwide prevalence and impact of pigmentary disorders through an online survey of 48,000

155 cations on the management of photoaggravated pigmentary disorders, the proper use of sunscreens, and

156 drial Ca2+ uptake for clinical management of pigmentary disorders.

157 ividuals, and exacerbate photodermatoses and pigmentary disorders.

158 lies the pathophysiology of neurological and pigmentary disorders.

159 lanocyte survival and manifestations of skin pigmentary disorders.

160 in order to further study their function in pigmentary disorders; however, due to the lack of specif

161 Patients with open-angle glaucoma including pigmentary dispersion syndrome and pseudoexfoliation syn

162 the posterior iris that occurs in eyes with pigmentary dispersion syndrome.

163 were composed of IOL decentration and tilt, pigmentary dispersion within the anterior segment and on

164 were composed of IOL decentration and tilt, pigmentary dispersion within the anterior segment and on

165 s, iris thinning and atrophy, synechiae, and pigmentary dispersion within the trabecular meshwork.

166 residual signs, adverse reactions, including pigmentary disturbance and skin atrophy, complications s

167 ypically seen in adults, 4 patients had mild pigmentary disturbance or white dots along the arcades,

168 expression levels and predominantly involved pigmentary disturbances of the abdomen, hindpaws, and ta

169 clude the grossly visible macular drusen and pigmentary disturbances typical of age-related macular d

170 ors) with grossly visible macular drusen and pigmentary disturbances were either wholemounted for pho

171 thway and reveal how coat-color patterns and pigmentary diversity have been shaped by recent selectio

172 ocortin 1 receptor (Mc1r) gene contribute to pigmentary diversity in natural populations of fish, bir

173 tects by a combination of pigmentary and non-pigmentary effects in vivo and that when MC1R function i

174 e that a functional Mc1r is required for the pigmentary effects of Agouti, and suggest that Agouti pr

175 In particular, it remains unclear whether pigmentary effects of the MC1R can account for all of th

176 nse through induction of cAMP and downstream pigmentary enzymes.

177 yer (mONL), photoreceptors (PR), and retinal pigmentary epithelium (RPE).

178 Obtaining pigmentary function in autologous skin grafts is a curre

179 e associated with the expression of relevant pigmentary genes in human melanocyte cultures.

180 for failure were pseudoexfoliation glaucoma/pigmentary glaucoma (HR = 1.641, P = .004), primary angl

181 ma suspects, ocular hypertension (OR, 1.55), pigmentary glaucoma (OR, 1.56), and pseudoexfoliative gl

182 Pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) are presumed to be inherited in

183 Pigmentary glaucoma (PG) is a common glaucoma subtype th

184 gresses to elevated intraocular pressure and pigmentary glaucoma (PG).

185 (NTG), pseudoexfoliative glaucoma (PXG), and pigmentary glaucoma (PG).

186 sis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG).

187 DS) is a well-known entity which can lead to pigmentary glaucoma (PG).

188 ucoma (POAG), normal-tension glaucoma (NTG), pigmentary glaucoma (PIGM), and pseudoexfoliation glauco

189 Secondary pigmentary glaucoma accompanying the implantation of a f

190 ed a series of cases who developed secondary pigmentary glaucoma after cataract operations.

191 eyes of 10 patients who developed secondary pigmentary glaucoma after foldable IOLs implantation in

192 and the pathway(s) by which it progresses to pigmentary glaucoma are not known.

193 he long-term outcomes of eyes with secondary pigmentary glaucoma associated with the implantation of

194 e involved in IL-18 mediated pathogenesis of pigmentary glaucoma in the eyes of DBA/2J mice.

195 DBA/2J (D2) mice develop a form of pigmentary glaucoma involving iris pigment dispersion (I

196 Pigmentary glaucoma is a significant cause of human blin

197 Pigmentary glaucoma is one of the most common forms of s

198 somes may play a part in the pathogenesis of pigmentary glaucoma observed in these mice.

199 a bleb-related infection to be diagnoses of pigmentary glaucoma or juvenile glaucoma, history of ble

200 itiates and/or amplifies the pathogenesis of pigmentary glaucoma requires further investigation.

201 f IL-18 participation in the pathogenesis of pigmentary glaucoma should provide approaches for develo

202 A PRS for IOP also differentiated pigmentary glaucoma status; a PRS for VCDR did not.

203 e pathophysiology of angle-closure glaucoma, pigmentary glaucoma, and a variety of other anterior seg

204 ary glaucoma other than pseudoexfoliative or pigmentary glaucoma, angle closure, previous incisional

205 e precedes the onset of clinical evidence of pigmentary glaucoma, implying a pathogenic role of infla

206 the DBA/2J mouse as an animal model of human pigmentary glaucoma, we demonstrated for the first time

207 th primary open-angle, pseudoexfoliation, or pigmentary glaucoma, who failed a first trabeculectomy a

208 sd mice are a suitable alternative model for pigmentary glaucoma.

209 d mutations resulting in chronic age-related pigmentary glaucoma.

210 n process is involved in this mouse model of pigmentary glaucoma.

211 nosomes, causing iris disease and subsequent pigmentary glaucoma.

212 igment production may be beneficial in human pigmentary glaucoma.

213 osomal protein genes may contribute to human pigmentary glaucoma.

214 al pattern of pigmentation between different pigmentary groups.

215 Here, we validate pigmentary hematite ("pigmentite") as a proxy indicator

216 Three patients had nummular pigmentary lesions along the arcades as typically seen i

217 cts including linear or whorled atrophic and pigmentary lesions, striated hyperkeratosis, coarse lust

218 alone, and drive melanoma development within pigmentary lesions.

219 ethnic origins and in melanocytes of various pigmentary levels.

220 Melanins are pigmentary macromolecules found throughout the biosphere

221 estations of dominant cerebellar ataxia with pigmentary macular dystrophy, a review of the pathogenes

222 All 6 eyes demonstrated a pigmentary maculopathy ranging from mild to pronounced.

223 tients because of bilateral media opacities, pigmentary maculopathy was present in 32 of 65 patients

224 rs that has been linked to poorly understood pigmentary maculopathy.

225 varian failure; short stature; hearing loss; pigmentary maculopathy; and renal tubular dysfunction.

226 phototoxicity, and lower protection by "non-pigmentary" MC1R effects.

227 C1R variants, and suggest an alternative non-pigmentary mechanism whereby MC1R variants could modify

228 melanoma development and progression via non-pigmentary mechanisms.

229 Distinct pigmentary microenvironments are created as the HF cycle

230 using northern and western blots, and their pigmentary modulating activities were demonstrated.

231 e the way toward elucidating the etiology of pigmentary mosaicism and highlight the role of RHOA in h

232 the most frequent abnormalities being focal pigmentary mottling and chorioretinal atrophy or scarrin

233 y induced by trauma, as well as mild diffuse pigmentary mottling on the trunk and proximal limbs.

234 that the same variants can cause either the pigmentary or vascular phenotypes alone, and drive melan

235 halopathy with axonal spheroids" (HDLS) and "pigmentary orthochromatic leukodystrophy" (POLD), disord

236 oganoid is a mouse coat-color mutation whose pigmentary phenotype and genetic interactions resemble t

237 s are of key significance in determining the pigmentary phenotype and response to ultraviolet radiati

238 onserved signaling gradient into a conserved pigmentary phenotype has been radically altered in the c

239 Pigmentary phenotype is a key determinant of an individu

240 Pigmentary phenotype is genetically complex and at a phy

241 Genome-wide association studies on pigmentary phenotypes provide a pool of candidate geneti

242 A cohort of 166 CMN subjects underwent pigmentary phenotyping, with MC1R genotyping in 113.

243 hat different mechanisms are involved in the pigmentary responses of the skin to different types of U

244 l of the retinal pigment epithelium (clumped pigmentary retinal degeneration).

245 utosomal recessive disorder characterized by pigmentary retinal degeneration, sensorineural hearing l

246 ccompanied by ocular cystinosis-foveoschisis-pigmentary retinal dystrophy complex.

247 editary retinal dystrophy), 362.74 + H35.52 (pigmentary retinal dystrophy), 362.76 + H35.54 (dystroph

248 d by multiple clinical features that include pigmentary retinal dystrophy, polydactyly, obesity, deve

249 ted with ocular cystinosis, foveoschisis and pigmentary retinal dystrophy.

250 lcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) congenital contractures

251 phthalmoparesis, mitochondrial myopathy, and pigmentary retinopathy also had autoimmune polyglandular

252 Ocular findings previously described a pigmentary retinopathy and atrophy that now can be expan

253 egia at clinical presentation, hearing loss, pigmentary retinopathy and extrapyramidal features.

254 essive diseases characterized by progressive pigmentary retinopathy and sensorineural hearing loss.

255 alcium deposits, cutaneous photosensitivity, pigmentary retinopathy and/or cataracts, and sensorineur

256 (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine

257 syndrome, Goldman-Favre syndrome and clumped pigmentary retinopathy in humans, allelic disorders caus

258 and serous retinal detachments, a unilateral pigmentary retinopathy mimicking retinitis pigmentosa, n

259 Pigmentary retinopathy rate was 36.56% (95% CI 24.61-50.

260 The affected eye in unilateral pigmentary retinopathy shows a progressive loss of perip

261 yndrome, Goldman-Favre syndrome, and clumped pigmentary retinopathy that is also associated with an a

262 Pigmentary retinopathy was less prominent in the superio

263 report a case of bilateral nanophthalmos and pigmentary retinopathy with angle closure glaucoma and o

264 Fundoscopy showed fundus features of pigmentary retinopathy with atrophic macular lesions.

265 abnormalities, such as cleft lip and palate, pigmentary retinopathy, and multiple tubular stenoses (e

266 tic neuropathy, ophthalmoplegia with ptosis, pigmentary retinopathy, and retrochiasmal visual loss.

267 alcium deposits; cutaneous photosensitivity; pigmentary retinopathy, cataracts, or both; and sensorin

268 cessive Bardet-Biedl syndrome (BBS; obesity, pigmentary retinopathy, polydactyly, hypogonadism, renal

269 ome (BBS) which is characterized by obesity, pigmentary retinopathy, polydactyly, renal abnormalities

270 sorder with the primary features of obesity, pigmentary retinopathy, polydactyly, renal malformations

271 sorder with the primary features of obesity, pigmentary retinopathy, polydactyly, renal malformations

272 recessive disorder characterized by obesity, pigmentary retinopathy, polydactyly, renal malformations

273 ted neurodegeneration (PKAN), which leads to pigmentary retinopathy, progressive dystonia and other a

274 white flashes in 15 patients with unilateral pigmentary retinopathy.

275 ment epithelium that manifests clinically as pigmentary retinopathy.

276 nces, bull's eye maculopathy, and peripheral pigmentary retinopathy.

277 odulation as a response to therapies against pigmentary skin disorders, skin aging, as well as skin c

278 and expression level of ATM correlated with pigmentary status in canities-affected hair follicles.

279 ate MC1R genotype to phenotype, by measuring pigmentary status using categorical scales.

280 o improve the phenotypic assessment of human pigmentary status.

281 on due to PAX3 mutations causes the auditory-pigmentary symptoms in at least some individuals with WS

282 m by which PAX3 mutations cause the auditory-pigmentary symptoms in WS1/WS3 remains to be explained.

283 help to identify additional unknown deafness-pigmentary syndrome mutations in human kindred and permi

284 ired to properly reconstitute the melanocyte pigmentary system following injury.

285 Harlequin is a pigmentary trait of the domestic dog that is controlled

286 en, we examined the associations between (i) pigmentary traits and (ii) reactions to sun exposure and

287 skin, but the relative contribution to these pigmentary traits in heterozygotes, homozygotes and comp

288 that might cause iris inflammation or even a pigmentary-type of glaucoma.

289 and eventual depletion of hair follicle (HF) pigmentary unit (HFPU) melanocytes and their local proge

290 Whereas the HF pigmentary unit ages quickly, its epithelial stem cell (

291 ase activity, and HMB45 expression in the HF pigmentary unit and altered HF melanocyte morphology in

292 chanisms of the remodeling of the follicular pigmentary unit during HF anagen-catagen-telogen transit

293 The fate of the hair follicle pigmentary unit during the cyclical involution of anagen

294 of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, k

295 duced catagen display similar changes in the pigmentary unit.

296 sm that can explain several aspects of human pigmentary variation and show how polymorphism of essent

297 fied other loci that appear to contribute to pigmentary variation.

298 ework, can contribute significantly to human pigmentary variation.

299 agouti protein may not play a role in human pigmentary variation.

300 The only gene known to exert an effect on pigmentary within the normal population is the melanocor