ライフサイエンスコーパス: pigmentation

1 y of the borders, and presence of additional pigmentation.

2 on defects, and/or heavy trabecular meshwork pigmentation.

3 melanocyte reservoir for both hair and skin pigmentation.

4 model for the stepwise emergence of betalain pigmentation.

5 to be involved in melanosome maturation and pigmentation.

6 ng of teeth, and three genes associated with pigmentation.

7 their polypeptide composition and partly by pigmentation.

8 n potentially be used to repopulate skin for pigmentation.

9 ATP as a signaling molecule that stimulates pigmentation.

10 s pleiotropic effects on eye, hair, and skin pigmentation.

11 es contribute to the wide variation in human pigmentation.

12 egulatory paradigm for fine-tuning patterned pigmentation.

13 y that exhibited reduced cspA expression and pigmentation.

14 unologically compromised mice skin to regain pigmentation.

15 es, but cry2 has a predominant role in fruit pigmentation.

16 s; and reflectometry to measure erythema and pigmentation.

17 ved in melanosome transportation and feather pigmentation.

18 n in current-day D. santomea does not affect pigmentation.

19 asthma, diabetes, body mass index (BMI), and pigmentation.

20 al melanoma subtype is uniquely unrelated to pigmentation.

21 effects of pituitary hormones on puberty and pigmentation.

22 eptor, has a crucial role in human and mouse pigmentation.

23 primary melanomas scored for histopathologic pigmentation.

24 ); of these, 13 tumors (26%) showed variable pigmentation.

25 shape of the skeleton as well as defects in pigmentation.

26 tic subterranean habitats have lost all body pigmentation.

27 e of differentiated melanocytes and for hair pigmentation.

28 zes the chemistry and role of astaxanthin in pigmentation.

29 had prior primary melanomas also scored for pigmentation.

30 light responses are linked to phylogeny and pigmentation.

31 tions to discover new genes influencing skin pigmentation.

32 of this analog still led to significant skin pigmentation.

33 that are significantly associated with skin pigmentation.

34 enerate mature melanocytes for hair and skin pigmentation.

35 hite allele causes a nearly complete loss of pigmentation.

36 nd simultaneous development of lopsided body pigmentation.

37 fluence in carotenoid accumulation and fruit pigmentation.

38 TDO in squid embryos efficiently eliminated pigmentation.

39 KU due to the redox environment generated by pigmentation.

40 MYB11) are also involved in petal background pigmentation.

41 ting climate warming may additionally impact pigmentation.

42 liorate UV stress by increasing UV-absorbing pigmentation.

43 he photochemical reflectance index, and leaf pigmentation.

44 ompensates for loss of SLC45A2 expression in pigmentation.

45 re, supporting a thermoregulatory role of UV pigmentation.

46 an hair follicle growth, differentiation and pigmentation.

47 s, including a loss or reduction of eyes and pigmentation.

48 est as high levels of persistent anthocyanin pigmentation.

49 Significant secondary phenolic pigmentation (11 times the cellular content of chlorophy

50 patients with incident melanomas scored for pigmentation, 527 had prior primary melanomas also score

51 Regulation of carotenoid pigmentation 695 IV.

52 yellow-white dots (57.1% [32/56]), nummular pigmentation (85.7% [48/56]), torpedo-like lesions (10.7

53 we tested eight herbal extracts for their co-pigmentation ability with aronia anthocyanins.

54 e hyper-producing strain by comparing colony pigmentation against colonies transformed with native Ph

55 There are a number of red hair/low pigmentation alleles of MC1R; we found that together the

56 Pigmentation allows animals to absorb light from biolumi

57 Pigmentation also affects floral thermoregulation, sugge

58 ight is required for Vitamin D synthesis and pigmentation, although it is plausible that longer visib

59 ripheral monocyte response in the retina nor pigmentation, although peripheral CX3CR1(+) and CCR2(+)

60 longed sun exposure as surrogate measures of pigmentation among 49,323 white women in the Nurses' Hea

61 nfirm the association of rs1426654 with skin pigmentation among South Asians, consistent with previou

62 Decreased levels of pigmentation and aureolysin (Aur) activity in the yjbH m

63 eron, yjbIH, resulted in decreased levels of pigmentation and aureolysin (Aur) activity relative to t

64 hyphal growth, sexual reproduction, melanin pigmentation and conidiogenesis.

65 and pummelo with marked differences in fruit pigmentation and content of xanthophylls esters, showed

66 t it is essential for multicellular conidial pigmentation and development in a plant endophytic fungu

67 showed moderate to heavy trabecular meshwork pigmentation and either Krukenberg spindle or transillum

68 ye, further supporting PMEL's role in ocular pigmentation and function.

69 muralis), which differ in orange and yellow pigmentation and in their ecology and behavior, are virt

70 ells deeper inside the colony have increased pigmentation and larger photosystem II antenna size.

71 e stem cells (MSCs), play a critical role in pigmentation and melanoma.

72 ck to the P. fici DeltaPfmaE mutant restored pigmentation and multicellular adherence of the conidia.

73 r investigating the mechanisms that regulate pigmentation and neurogenesis.

74 twin sister has normal iris architecture and pigmentation and never received any pitcher plant inject

75 ed no significant association between nigral pigmentation and nigral dopamine transporter density.

76 utations have previously been shown to cause pigmentation and ocular defects in animals, this researc

77 Echinoderms display a vast array of pigmentation and patterning in larval and adult life sta

78 mentation of SSB01 cultures causes a loss of pigmentation and photosynthetic activity, disorganizatio

79 These studies identified changes in pigmentation and protease activity in response to YjbIH

80 ht a central role for MC1R palmitoylation in pigmentation and protection against melanoma.

81 e melanin-containing organelles that provide pigmentation and protection from solar UV radiation to t

82 Skin pigmentation and receipt of vasopressors were not associ

83 strain with the wild-type SNF2 gene restored pigmentation and recovered the strong antifungal activit

84 les (MAC) are the most frequent cause of lip pigmentation and sometimes difficult to differentiate fr

85 rlap in the genetic factors influencing skin pigmentation and tanning response.

86 ed with LM or LMM: (1) asymmetric follicular pigmentation and targetlike structures, and (2) round, l

87 , reinforcing the importance of nevogenesis, pigmentation and telomere maintenance, together with ide

88 skin xanthophores, which mediate red/yellow pigmentation and trafficking, but not in tissues associa

89 al images minimized the impact of background pigmentation and vascularization.

90 acid is critical in establishing asymmetric pigmentation and, via cross-talk with thyroid hormones,

91 aureus that display small colonies, reduced pigmentation, and decreased hemolysis and/or coagulase a

92 intrinsic tumor vascularity, increased tumor pigmentation, and decreased tumor thickness with synchro

93 l development, the TI antibody response, fur pigmentation, and intestinal homeostasis in mice.

94 ent, body size and morphology, skin and hair pigmentation, and keratinization.

95 , Cdc42 null mice displayed a severe loss of pigmentation, and melanoblasts showed cell-cycle progres

96 osses that segregate for colour, banding and pigmentation, and several other unlinked shell phenotype

97 tinctive, genetically programmed patterns of pigmentation, and the recessive k1 mutation can epistati

98 Changes in tumor size, pigmentation, and vascularity; incidence of iris neovasc

99 cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability.

100 ne declines will display larger increases in pigmentation; and third, taxa with anthers exposed to am

101 uced structure, photophysical properties, co-pigmentation, antioxidant properties, glycosylation and

102 tic factors controlling circadian rhythm and pigmentation are also involved in the development of myo

103 ticipate in the patterning of the carapacial pigmentation as both the migratory neural crest cells an

104 D) is an autosomal-dominant disorder of skin pigmentation associated with mutations in keratin 5 (KRT

105 by improving facial lines, wrinkles and skin pigmentation associated with photo-ageing.

106 paring with modern populations, we find that pigmentation-associated loci have undergone strong popul

107 Strongest association with skin pigmentation at 19p13 was observed for an Y182H missense

108 Keloids had a significant reduction in pigmentation at 21.3%.

109 in Abd-B aligned with the duration of setal pigmentation at the pupal-adult transition.

110 Association of histopathologic pigmentation between incident and prior melanomas was an

111 pathways previously shown to be involved in pigmentation biology.

112 ins may have an important role, not only for pigmentation but also in astringency.

113 FMO3 activity is essential for larval pigmentation, but in juveniles and adults, loss of FMO3

114 between self-reported hearing loss and skin pigmentation by using hair color, skin tanning ability,

115 ations, we show how the architecture of skin pigmentation can vary across humans subject to different

116 AF mutation into that of DPN, with increased pigmentation, cell volume and nuclear cyclin D1 levels.

117 , we assessed melanoma risks associated with pigmentation characteristics and other phenotypes, and w

118 nstrate that MC1R variants are important for pigmentation characteristics in Hispanics and that carri

119 ion study for variants associated with human pigmentation characteristics two coding variants of TPC2

120 ns between MC1R genetic risk groups and some pigmentation characteristics were identified.

121 suggesting that cspA is downstream to Spx in pigmentation control.

122 grew faster and larger, and presented darker pigmentation; corals fed at the highest light levels gre

123 very during early development, the degree of pigmentation could be finely controlled.

124 This evidence suggests that egg pigmentation could play an important role in thermoregul

125 or taxa with anthers enclosed within petals, pigmentation declined with increases in temperature, sup

126 rest disorder, Myo10(tm2/tm2) mice exhibited pigmentation defects (white belly spots) and simple synd

127 repeats (CRISPR)-Cas9 method caused profound pigmentation defects and enlarged anterior segments in t

128 in the melanocyte lineage results in severe pigmentation defects in dorsal and ventral regions of th

129 ypoplasia and optic nerve misrouting without pigmentation defects.

130 exhibit delays in melanoblast migration and pigmentation defects.

131 knockout in plants, which include growth and pigmentation deficiency, global transcriptomic changes a

132 rmal and mechanical cutaneous sensitivity is pigmentation dependent.

133 Pigmentation differences are explained by extremely dive

134 to South Asian populations, who behold huge pigmentation diversity.

135 eful to identify the genetic architecture of pigmentation, due to their high genotypic and phenotypic

136 tical twin sister who maintained normal iris pigmentation during the entire course.

137 Tested compounds provoked different co-pigmentation effect, manifested by hyperchromic and bato

138 -3-rutinoside resulted in the most stable co-pigmentation effect.

139 20, 40, 60, 80 and 100 degrees C), on the co-pigmentation effects, stoichiometric ratio (n), the equi

140 ts suffer from tissue ochronosis: dark brown pigmentation, especially of joint cartilage, leading to

141 Cole disease is a genodermatosis of pigmentation following a strict dominant mode of inherit

142 iagnosed with ROP and 39.4% had light fundus pigmentation (FP).

143 or polymorphism to the genomic region of the pigmentation gene Agouti, previously linked to introgres

144 N. vitripennis, we targeted a conserved eye pigmentation gene cinnabar, generating several independe

145 conidial pigmentation mutants, a new fungal pigmentation gene cluster, which contains Mr-Pks1, Mr-Et

146 ation regulatory pathway, and that all three pigmentation genes exercise feedback regulation of conid

147 We expect our approach to deliver new pigmentation genes when applied to genome-wide associati

148 hoxa13a being of particular interest and to pigmentation genes where itgb1, involved in the melanoph

149 the association of two previously known skin pigmentation genes, SLC24A5 (minimum p = 2.62 x 10(-14),

150 h American warblers to highlight the role of pigmentation genes-involved in melanin and carotenoid pr

151 aA and Mr-WetA regulates expression of these pigmentation genes.

152 Our meta-analysis of skin pigmentation GWAS in recently admixed populations provid

153 recent follow-up studies a role for TPC2 in pigmentation has been further confirmed.

154 Our understanding of the genetics of skin pigmentation has been largely skewed towards populations

155 While genetic regulators of pigmentation have been well studied in human and animal

156 in the yellow gene, named for its effects on pigmentation, have been known to reduce male mating succ

157 and contributed to the evolution of betalain pigmentation, highlighting the significance of upstream

158 ar to characterize the genetic basis of skin pigmentation in admixed populations (N = 2,104).

159 ll other loci, variants associated with dark pigmentation in Africans are identical by descent in Sou

160 MFSD12, a gene recently associated with skin pigmentation in Africans.

161 results introduce an unprecedented source of pigmentation in amphibians and highlight the potential r

162 We present a GWAS of skin pigmentation in an admixed sample from Cuba (N = 762).

163 he genetic variation at OCA2 to variation in pigmentation in areas beyond Europe.

164 make large contributions to the loss of body pigmentation in D. santomea.

165 expression have created the possibility that pigmentation in different sections of the petal can evol

166 Abd-B is required for pigmentation in Drosophila yakuba, the sister species of

167 de in paleontology with respect to resolving pigmentation in fossil material.

168 Skin pigmentation in humans and coat color in fleece-producin

169 Despite the wide range of skin pigmentation in humans, little is known about its geneti

170 ho have ocular features of albinism and skin pigmentation in keeping with their familial background p

171 unction that, when suppressed, causes darker pigmentation in mice and humans(3,4).

172 The regulation of site-specific pigmentation in reconstructs used for skin grafting is i

173 anscription factors required for anthocyanin pigmentation in the berry skin.

174 Mendelian blue locus, which abolishes yellow pigmentation in the budgerigar.

175 ologs arose during the evolution of betalain pigmentation in the core Caryophyllales and later experi

176 anscription of ooxB-lacZY, resulting in blue pigmentation in the presence of X-gal.

177 ) is clinically characterized by the loss of pigmentation in the skin, hair, and iris.

178 yoVa:melanosome interaction is important for pigmentation in vivo.

179 These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pig

180 tion (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20q13 and 22q12).

181 Genes involved in pigmentation, including those for the metabolism of chlo

182 Pigmentation increased in 32 tumors (64%), decreased in

183 Globally, the extent of petal UV pigmentation increased significantly across taxa by ~2%

184 ey were fed (RAS-B modified to RAS+B), their pigmentation increased, and their oral discs readily exp

185 er declines in ozone displayed more dramatic pigmentation increases.

186 This post-treatment increase in cellular pigmentation induced a significant increase in PAI signa

187 Skin pigmentation is a complex trait that varies largely amon

188 Rather, baseline skin pigmentation is a complex, polygenic trait in the KhoeSa

189 nd confirmed previous findings, showing that pigmentation is a critical determinant of skin aging.

190 To test whether clofazimine-induced skin pigmentation is due to CLDI formation, we synthesized a

191 We demonstrate that skin pigmentation is highly heritable, but known pigmentation

192 pigmentation phenotypes, we demonstrate that pigmentation is more complex than previously assumed, wi

193 esults suggest that clofazimine-induced skin pigmentation is not due to clofazimine precipitation and

194 As a role for Csf1r signaling in pigmentation is not observed in mammals or birds, it is

195 Spore pigmentation is very common in the fungal kingdom.

196 clofazimine bioaccumulation results in skin pigmentation, its most common side effect.

197 tion using the perceived biological basis of pigmentation leads to enhanced genetic association and p

198 nor adverse event, with a 3.53% treated-vein pigmentation length for group 1 and 7.09% for group 2, w

199 We also infer considerable variation in pigmentation levels in Europe by circa 6000 BC.

200 ctions to uncover global responses in floral pigmentation linked to ozone and climate change.

201 tion between both colour/banding, and colour/pigmentation loci are zero, incomplete penetrance and ep

202 pigmentation is highly heritable, but known pigmentation loci explain only a small fraction of the v

203 Both pigmentation loci showed evidence for divergent selectio

204 we identify canonical and non-canonical skin pigmentation loci, including near SLC24A5, TYRP1, SMARCA

205 e Bayesian LMMs provide evidence for two new pigmentation loci: one for eye color (AHRR) and one for

206 melanoma, thereby reducing the expression of pigmentation markers.

207 patial scale, we find evidence that eggshell pigmentation may have been shaped by thermoregulatory ne

208 However, sparse dorsal pigmentation means that these frogs are better described

209 By analysing a series of conidial pigmentation mutants, a new fungal pigmentation gene clu

210 n to four other genes within the D. santomea pigmentation network, three of which have evolved expres

211 The co-pigmentation of black chokeberry (Aronia melanocarpa) an

212 cessive inherited condition that affects the pigmentation of eyes, hair and skin.

213 ating success are mediated by its effects on pigmentation of male-specific leg structures called sex

214 ecrease melanin synthesis and prevent normal pigmentation of resulting skin grafts.

215 sociation scan in >6,000 Latin Americans for pigmentation of skin and eyes.

216 Gonioscopy revealed moderate pigmentation of the angle and a concave configuration of

217 actor (CgsMYB12) responsible for anthocyanin pigmentation of the basal region ('cup') in the petal of

218 analyses involving the variants that affect pigmentation of the iris argue that the derived allele o

219 s spectroscopic analyses and observe lighter pigmentation of the large parascapular spines, consisten

220 Pigmentation of the skin and hair represents the result

221 between age, type and severity of glaucoma, pigmentation of the trabecular meshwork (PTM), total ene

222 nificant relationships were observed between pigmentation of the ventral nigral tier with striatal do

223 Overall, these results suggest that pigmentation of this animal is genetically determined an

224 -lacZY, resulting in readily visualized blue pigmentation on ABM agar medium supplemented with X-gal

225 on OCTA and most often did not correspond to pigmentation on CFP.

226 ifferences in the following features: lesion pigmentation on CFPs corresponding to hypoautofluorescen

227 exposure favors larger areas of UV-absorbing pigmentation on petals, which protects pollen from UV-da

228 oss, retinal nerve fiber layer thinning, and pigmentation onto the retinal surface.

229 ix progenitors that regulate hair growth and pigmentation, partly by creating an SCF-dependent niche

230 ifferent genes thought to be involved in the pigmentation pathway(s) of larvae and grew the embryos t

231 n has been central to the evolution of petal pigmentation patterning in C. gracilis ssp. sonomensis.

232 tation rates resulting in many variations of pigmentation patterning in harlequin flowers of Phalaeno

233 Petal pigmentation patterning is widespread in flowering plant

234 Formation of periodic pigmentation patterns 696 V.

235 We show that specific pigmentation patterns from its diverse repertoire are se

236 the evolution of the remarkable diversity of pigmentation patterns in flowers.

237 n India has a profound influence on the skin pigmentation patterns of the subcontinent.

238 rotenoid biosynthesis, formation of periodic pigmentation patterns, developmental genetics of corolla

239 rchids contain dark purple spots and various pigmentation patterns, which appeared as a new color in

240 exhibit visually striking spotted or striped pigmentation patterns.

241 e entire body glow, thereby backlighting the pigmentation patterns.

242 embling a global survey of quantitative skin pigmentation phenotypes, we demonstrate that pigmentatio

243 arby GRM5 gene have an independent effect on pigmentation, possibly through regulation of gene expres

244 neuromelanin remains dependent on detectable pigmentation, rather than direct quantification of neuro

245 The co-pigmentation reactions involving anthocyanins of sour ch

246 ) were determined.The strongest immediate co-pigmentation reactions were observed at 960 mg/L, being

247 Losses of floral pigmentation represent one of the most common evolutiona

248 ntury resulted in elevated UV incidence, but pigmentation responses to this aspect of global change h

249 OCT differed significantly among the groups, pigmentation, retinal fibrosis, shape, retinal vessel pa

250 alterations in melanocyte development and in pigmentation signaling pathways.

251 ency, Wnt signaling, melanocyte development, pigmentation signaling, and protein ubiquitination, besi

252 our and banding loci and more loosely linked pigmentation, spread band and punctate loci.

253 nd the related ultraviolet response and skin pigmentation standing out as a shared pathway, perhaps a

254 train 531Ad) and cells with normal levels of pigmentation (strain 531Ac), respectively.

255 Although most floral pigmentation studies have focused on how pigment intensi

256 In vivo pigmentation study shows high potency and short duration

257 s that reverted from betalain to anthocyanin pigmentation, such as Caryophyllaceae.

258 ould be caused by a flat object with varying pigmentation, such as wallpaper, or differential light r

259 tting this versatile model remain elusive in pigmentation systems.

260 arvae resulted in a phenotype with scattered pigmentation that mimicked human DDD.

261 tic reduction in proteolysis, hemolysis, and pigmentation that was fully complementable.

262 score (P = 0.0009), and improvements in scar pigmentation, thickness, surface roughness, and mechanic

263 NX13, TYRP1, and UVRAG) associated with skin pigmentation, three of which already have been reported

264 s, mainly involving in biomineralization and pigmentation through functional enrichment.

265 ession of either TSC1 or TSC2 causes reduced pigmentation through mTORC1 activation, which results in

266 f embryos in the sea urchin, is required for pigmentation throughout the life stages of this sea urch

267 e map variation in basal forewing red-orange pigmentation to a locus centred around the gene ventral

268 cument a rapid phenotypic response of floral pigmentation to anthropogenic climatic change, suggestin

269 allelic F374 variant restores only moderate pigmentation to SLC45A2-deficient melanocytes due to rap

270 ts ranging from lactase persistence, to skin pigmentation, to hypoxic response, to arsenic tolerance.

271 first directly estimate natural selection on pigmentation traits and an underlying pigment locus, Ago

272 proportions proposed to represent differing pigmentation types, such as pheomelanin, eumelanin, and

273 ng MC1R signalling, which triggers increased pigmentation, ultraviolet-B-induced G1-like cell cycle a

274 Genetic evidence indicates that the light pigmentation variant at SLC24A5 was introduced into East

275 Here, we investigate skin pigmentation variation in a cohort of 1,167 individuals

276 enes have been directly associated with skin pigmentation variation in humans, leading to its charact

277 ecause of genetic variation affecting normal pigmentation variation in humans.

278 (OCA4) and polymorphisms are associated with pigmentation variation, but the localization, function,

279 The co-pigmentation was accompanied by a magnification of color

280 to 2017 to test whether change in UV floral pigmentation was associated with altered ozone and tempe

281 Additional pigmentation was found in 5 patients (20.8%).

282 Intermolecular co-pigmentation was investigated for the first time for fer

283 Within the Parkinson's disease group, nigral pigmentation was lower in the ventral tier as compared t

284 Pigmentation was the most common minor adverse event, wi

285 pendently generated mutants that had altered pigmentation was verified.

286 Since MITF also induces pigmentation, we hypothesize that macrometastatic succes

287 ations in the characterization of human iris pigmentation, we introduce a fully automated approach th

288 ng the potential practical application of co-pigmentation, we tested eight herbal extracts for their

289 r cohort of white women, surrogates for skin pigmentation were not associated with risk of hearing lo

290 and qualitative effects of intermolecular co-pigmentation were studied by adding chlorogenic and rosm

291 ls, pseudocereals and legumes), differing in pigmentation, were screened for their phenolic profiles,

292 Ectothermal reptiles have internal pigmentation, which is not seen in endothermal birds and

293 Skin pigmentation, which is regulated by the melanocortin 1 r

294 absorption is increased 50-fold by phenolic pigmentation, while glacier algal chloroplasts positione

295 ested three predictions: first, UV-absorbing pigmentation will increase temporally and be correlated

296 ve analysis identified a higher frequency of pigmentation with hypoautofluorescence, full-thickness r

297 The visual fading of A. terreus conidial pigmentation with the subculturing, revealing the biosyn

298 as flat, small, well-circumscribed areas of pigmentation with varying degrees of central hypopigment

299 and the homoplastic distribution of betalain pigmentation within Caryophyllales.

300 SH-NH2 is ideal for inducing short-term skin pigmentation without sun for melanoma prevention.