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1 ey contribute to disease risk have yet to be pinpointed.
2 that underpins the adult outcome of ADHD was pinpointed.
7 ribe progression through the CME pathway and pinpoint a cargo-sensitive regulatory transition point t
11 regulation of diurnal metabolic rhythms and pinpoint a key mechanism by which the microbiota control
12 ly induced seizure model can be leveraged to pinpoint a new target for seizure control: VIP interneur
14 ory domain of sigma subunit, and potentially pinpoint a novel target for development of new antibacte
15 GAT2 enzymes with each other, allowing us to pinpoint a region that dramatically affects the specific
17 hways associated with AD neuropathology, and pinpoint a specific functional gene module underlying se
18 ynamic clamp, we show that it is possible to pinpoint a specific gene variant that modulates pain sig
20 ynamic clamp, we show that it is possible to pinpoint a specific variant of another gene, KCNQ in thi
21 and X-ray crystallography analyses, we have pinpointed a critical node within the complex dynamic co
24 olgi dispersal in several cancer cell lines, pinpointing a possible link between drug-induced toxicit
25 models of encoding and retrieval dynamics by pinpointing a specific contextual factor that differenti
26 within the circuitry associated with reward pinpoints a novel region that controls the expression of
27 egrative epigenomic characterization further pinpoints a recurrent hypomethylated enhancer of CCAAT/e
29 y p21 dynamics in the cell-fate decision and pinpoints a source of proliferative cancer cells that ca
30 iple 100pico-liter (pL) volume droplets with pinpoint accuracy into a single diatom frustule with dim
31 , turtles did not home to small islands with pinpoint accuracy, but rather overshot and/or searched f
35 ith known synergistic molecules allows us to pinpoint additional molecule combinations that also act
40 ed, and further study on one peptide (PepB2) pinpointed an asparagine residue necessary for CPP activ
42 omplexity of the JA gene regulatory network, pinpoints and validates previously unknown regulators, a
43 n macaques, as opposed to human imaging data pinpointing area V3B/kinetic occipital area (V3B/KO).
44 residues threonine-154 and tyrosine-310 were pinpointed as being involved in binding CoA-conjugated p
45 nets of Darwinian evolution, while privately pinpointing aspects of Darwin's views of inheritance tha
46 lease of Gd(DTPA)(2-) stimulated by HIFU was pinpointed at the HIFU focal point in 3-D space in a tis
47 new mechanistic information about TORC2 and pinpoint Avo3 as pivotal for TORC2 PM localization and a
48 ver, causative mutations can be difficult to pinpoint because variants frequently map to genes with n
49 patch at the 30s region of its sequence, as pinpointed by computational results and site-directed mu
50 ential energy surface features around 1 were pinpointed by convergent focal point analysis targeting
52 initiator of cognitive pathology in AD, and pinpoint calcium dysregulation mediated by NgRs and T-ty
53 Our genetic interaction and imaging studies pinpoint cAMP signaling as a key downstream effector for
55 ferentiation and knockdown keratinocytes, we pinpointed candidate bioactive lipid subspecies as diffe
56 s with exome sequencing within our colony to pinpoint candidates likely to mediate the effect of sele
62 biological conditions on a global scale, and pinpoint characteristic ribosome occupancy patterns at s
63 emains unexplained, and leverage this gap to pinpoint characteristics of weakly decoded sentences and
64 ers cause multifaceted immunosuppression and pinpoint circulating factors as a target of intervention
65 strand-specific analysis of the data allowed pinpointing CodY-binding sites at close to single-nucleo
67 s, but also important local differences, and pinpoint critical research priorities to enable evidence
69 R), provides an extraordinary opportunity to pinpoint crucial regulators and target genes responsible
71 pproaches should provide increasing power to pinpoint discrete associations potentially useful toward
72 mphasize recent advances in therapeutics and pinpoint disease-associated variants that remain poorly
74 e genetic architecture of the MHC region and pinpoints disease associations that are due to different
76 tions, the ordering temperature is harder to pinpoint due to potential local lattice variations that
81 plausible underlying disease mechanisms and pinpointed ETS2 as a potential causal gene for chr21q22
83 r approach represents an exciting new way to pinpoint factors driving adaptation, enabling a clearer
84 capability should - in the future - help to pinpoint factors that play an essential role in cell mig
85 of Rab3 vesicles in these navigating axons, pinpointing Fignl1/Kif1bbeta as a dynein speed limiter c
87 Formula: see text] significance level and we pinpointed four genes, ESR1, PHB, RYR3, GRIK2, that are
88 upled the assay to saturation mutagenesis to pinpoint functional regions within an enhancer, which we
90 in diverse tumor types, it is challenging to pinpoint FUS specifications that may elicit the desired
92 diversity, the model described in this paper pinpoints geographic areas and clades most urgently requ
95 mulations that targeted prevention, where we pinpoint high-level spread using a coalescence measureme
96 base pair content across long genomes and to pinpoint hotspots of well-defined RNA structures, a meth
97 s the killing of bacteria on the surface and pinpoints how the critical colony size depends on key pa
98 nalyses show the efficiency of the screen to pinpoint human cancer drivers altered by non-genetic mec
99 nt datasets of small and long RNA sequencing pinpointed immune cell subsets pivotal to these response
100 eover, deviations from these predictions may pinpoint impacted sites and aid in future response effor
101 er nonsteady state compared to steady state, pinpointing important overlooked breeding targets for im
102 of heterogeneous conformational dynamics and pinpoints important motions that, potentially, can be co
105 We argue that recent advances are at last pinpointing individual enzyme and transporter genes that
106 hereby define small inhibitory regions, even pinpointing individual residues with critical functional
107 by application of lidocaine to the DRG, thus pinpointing intermittent failure of spike propagation as
109 nneled through the Ras1/2 GTPase is delayed, pinpointing its time scale and its contribution to the d
110 rent survival of tagged birds and managed to pinpoint key aspects and drivers of tagging effects.
111 States spatial and temporal climate data to pinpoint key driving parameters for solar desiccant driv
112 ntifies hotspots of tumor mtDNA mutations to pinpoint key mitochondrial functions in pediatric malign
113 scale comparative multicondition analyses to pinpoint key phenotypic differences between bacterial pa
115 r comparative approach is a powerful tool to pinpoint key regulators of the viral-host interplay and
117 omplex with different gluco-oligosaccharides pinpointed key residues in binding sites located in the
118 of the system through gamma-Proteobacteria, pinpointing key evolutionary events that led to the mach
119 D) simulations in lipid bilayers are used to pinpoint likely lipid-protein interactions, which can be
124 , and how transcriptomic approaches can help pinpoint mechanisms underlying genetic risk for psychiat
125 ore importantly, a transfer entropy analysis pinpoints media coverage on firearm control policies as
128 lar composition of endometriosis lesions and pinpoints metabolic markers that may provide new knowled
131 eostasis in poststroke immune responses, and pinpointed multiple affected pathways, which opens new v
135 on was not found during a three-minute rest, pinpointing neural synchrony to social interactions amon
136 20) catalog these redistributed proteins and pinpoint nonsense-mediated decay as a therapeutic target
138 -analysis of clinical gut-microbiome studies pinpointed numerous disease associations for the newly i
141 opy-number increases (genomic amplification) pinpoint oncogenic driver genes and therapeutic targets
142 and chromatin immunoprecipitation sequencing pinpointed oncogenic transcriptional amplification media
143 protein expression data, did not allow us to pinpoint one PGE2-G lipase, and rather support the invol
144 the MRgHIFU-stimulated cargo release can be pinpointed, opening up an opportunity for future image-g
149 ion resistance against Enterobacteriaceae to pinpoint possible control points for curbing their sprea
150 dy, we used FUMA, a GWAS annotation tool, to pinpoint potential causal variants and genes from the la
151 ion detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations in colo
152 hip between proteins and tissue function and pinpoint potential pathways of biotechnological relevanc
153 scape of PD transcriptomic networks but also pinpoints potential key regulators of PD pathogenic path
154 in the Ras processing and MAPK pathways and pinpoint PREX1 as an AML-specific activator of MAPK sign
156 isual areas, and establish novel methods for pinpointing pulsed transmission schemes in neural data.
157 can inform future microbiome-based therapy, pinpointing putative intervention targets for manipulati
160 ranslated-region tethered function assays to pinpoint RBPs that regulate RNA stability or translation
163 ap can be customized with expression data to pinpoint regulated subnetworks and druggable molecules.
164 combines ChIP with exonuclease treatment to pinpoint regulatory elements in DNA with high precision,
166 folded and unfolded states of a protein can pinpoint residues of critical importance that should be
167 sequencing (WGS) can support surveillance by pinpointing resistance mechanisms and uncovering transmi
168 g novel ALS genes, the new analyses not only pinpoint risk regions in known genes but also highlight
169 ymous variants in known epilepsy genes, thus pinpointing risk factors of disease from non-coding sequ
170 11,808 controls of diversified populations, pinpoints risk regions of ALS genes, including SOD1, NEK
172 in THADA mutant flies rescues their obesity, pinpointing SERCA as a key effector of THADA function.
178 sed to investigate peripheral mechanisms and pinpoint specific gene variants that modulate pain signa
179 s in the peripheral nervous system (PNS) and pinpoint specific genes that are major contributors to p
180 aspects of fluorescent protein knock-ins and pinpoint specific improvements and perspectives, like th
182 or closers of local chromatin accessibility, pinpointing specific cis-regulatory elements where bindi
183 We relate this work to recent progress that pinpoints specific determinants of TAR recognition by: (
184 le preparation of a late stage intermediate, pinpoint stereocontrol around the tricyclic skeleton, an
191 uated total reflection infrared spectroscopy pinpointed that magnesium carbonate precipitation begins
193 e reagent pair EDC/GEE, are used together to pinpoint the binding sites of rifamycin SV, doxycycline,
194 f each organ quantitatively will allow us to pinpoint the cause of the low tumor delivery efficiency.
196 e products using microbial factories and can pinpoint the contributions of microorganisms to planetar
197 gions may underlie the psychedelic state and pinpoint the critical role of the serotonin 2A and 1A re
199 The derivatization reaction was performed to pinpoint the double bond positions in diacylglyceryltrim
202 on archaeal T4P structures, and allows us to pinpoint the evolutionary divergence of bacterial T4P, a
203 provided by trajectory inference, or fail to pinpoint the exact types of differential expression.
204 we used magnetoencephalography in humans to pinpoint the factors underlying the beta-band modulation
207 tic, bioinformatic and functional studies to pinpoint the genetic drivers underlying their renal and
209 conservation units for gray reef sharks and pinpoint the isolation and vulnerability of their French
210 ng into supracrystals as a model system, and pinpoint the key role of surface fluctuation in shaping
211 es released after photoactivation as well as pinpoint the location at which uncaging of the molecules
212 UVPD (CID/UVPD) approach was implemented to pinpoint the location of both double bond and cyclopropy
214 uoroscopy-guidance in a rat model of RIPF to pinpoint the location of the endomicroscope during FE im
216 se four methods are mutually supportive, and pinpoint the locations of the spin labels on the duplexe
217 rough metabolic gene expression analysis, we pinpoint the loss of squalene monooxygenase expression a
218 intermediates and transition states helps to pinpoint the main factors controlling the selectivity.
219 ne central goal in molecular evolution is to pinpoint the mechanisms and evolutionary forces that cau
220 ological characterizations were performed to pinpoint the mechanisms by testing hypotheses related to
223 regions within multispecies microbiomes can pinpoint the molecular mechanisms that play key roles in
229 and power) are still too bluntly defined to pinpoint the precise biophysical link between ventilatio
230 overstory and multiple understory) and also pinpoint the required density for reasonable tree segmen
231 dentified, and structure-guided GusR mutants pinpoint the residues essential for DNA binding and gluc
234 e and chromatin immunoprecipitation analyses pinpoint the UPR as a broad-spectrum compensatory respon
236 s subtilis and Saccharomyces cerevisiae have pinpointed the biomolecules that oxidants can damage and
240 ome sequencing, mining of electronic records pinpointed the origin of the outbreak as a single patien
242 , our reconstructed transcriptional networks pinpointed the precise timing from naive to formative pl
244 ial 10 s of the IEDDA reaction, we precisely pinpointed the subcellular locations of endogenous PLD a
245 n of the C-termini between classes precludes pinpointing the analogous residues in Class 1 enzymes by
246 associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been ch
247 riants with complex traits and diseases, but pinpointing the causal variant(s) among those in tight l
248 ve trait loci interspersed across the genome pinpointing the chorismate-tyrosine pathway as a regulat
250 tability, and cell internalization pathways, pinpointing the high sensitivity of stability-activity r
251 tive neuroscience of human memory retrieval, pinpointing the neural chronometry underlying successful
252 biological approaches has been essential to pinpointing the origins of amphibian-parasitizing chytri
253 ur chemical-genetic screening strategies for pinpointing the physiologically relevant targets of chem
254 mapped confirmed previous findings, now also pinpointing the potentially affected regulatory elements
255 y functional and ab initio levels of theory, pinpointing the predominance of London dispersion intera
260 ation to allele-specific copy-number changes pinpoints the common ancestor to a point prior to chemot
263 resolution model of the CXCR4-CXCL12 complex pinpoints the interaction determinants and reveals the o
264 interactions between MCU and EMRE as well as pinpoints the juxtamembrane loop of MCU and extended lin
265 Well finding using aeromagnetic surveys pinpoints the location of steel-cased wells, detecting b
266 that UQ interacts with phenylalanine 211 and pinpoints the location of the binding site in the interf
267 onally, but how the Microprocessor machinery pinpoints the locations of short precursor miRNA sequenc
269 e site poised for catalysis of APOBEC3A, but pinpoints the residues that confer specificity towards C
276 re made for mice after neutrophil depletion, pinpointing this cell type as the source of the reactive
277 icient to induce ferroptosis in human cells, pinpointing this omega-6 PUFA as a conserved metabolic i
278 ational analysis of full-length proteins, we pinpoint three amino acids in TRPM3 and their interactin
280 nally conserved Rab11 genes, we were able to pinpoint three specific amino acid residues that may be
284 cell-type-specific regions of open chromatin pinpointed two TAL1-bound endothelial enhancers, which w
287 complementary use of iPSCs and mouse models pinpoint unique cellular mechanisms by which EIF4A3 muta
288 Interactions with specific nucleoporins were pinpointed using FLIM-FRET for measuring protein-protein
289 r results demonstrate RADAR can successfully pinpoint variants, both somatic and germline, associated
290 genome, and great strides have been made in pinpointing variations in these repetitive sequences usi
291 he nuclear proteome during infection, we can pinpoint vital components required for immunity or susce
294 erlied the abnormal phenotypic expansion and pinpointed when lineage choice events occurred during di
296 smission heterogeneity is present, and 2) to pinpoint where in a phylogeny high-level spread is occur
298 identify electron-density redistribution and pinpoint why the TS for guanosine 5'-triphosphate (GTP)
299 , and therefore allows their locations to be pinpointed with precision that achieves the Cramer-Rao l
300 dual molecular ruthenium catalysts have been pinpointed within growing polynorbornene, thereby reveal