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1 in which each of the linking arms contains a piperazine ring.
2 nzyl moiety, respectively, on the piperidine/piperazine ring.
3  in this series included an aryl-substituted piperazine ring, a varying alkyl chain linker (C3-C5), a
4              Modifications to the piperidine/piperazine ring ablated inhibitory activity, suggesting
5 omatic hydrophobic moieties connected to the piperazine ring and bioisosteric replacement of the arom
6 he scaffold, we have maintained the original piperazine ring and introduced four different functional
7 (SAR) of the aromatic ring linked to the N-4-piperazine ring confirmed the superiority of 2-pyridine
8 ing-containing buffers (e.g., Mops, Mes) and piperazine ring-containing zwitterionic buffers (e.g., P
9 e report that conformational constraint of a piperazine ring converts a mu opioid receptor (MOR) anta
10 e linker between the oxime group and the N-1-piperazine ring displayed the best profile.
11 roup adjacent to either nitrogen atom of the piperazine ring (e.g. 25 and 27) was not well tolerated.
12 f the benzene ring after the cleavage of the piperazine ring (e.g., CIP product with m/z 280) is desc
13 DNA binding drug Hoechst 33258, in which the piperazine ring has been replaced by an amidinium group
14 example, analogues prepared by replacing the piperazine ring in the GBR structure with an N, N'-dimet
15                      The substitution of the piperazine ring in the GBR structure with other diamine
16 alkyl chain between the phenyl group and the piperazine ring influenced binding affinity and selectiv
17 s via direct functionalization of the intact piperazine ring is described.
18 ridine ring and the terminal nitrogen of the piperazine ring, leading to compound (4S)-4-[({4-[4-(met
19 6 (generated from the destruction of the CFC piperazine ring) maintained 41%, 44%, and 30% of the ant
20 rein a 4-(alkylamino)piperidine replaces the piperazine ring of the BHAPs.
21                   Evidence suggests that the piperazine rings of the H1 side-by-side complex are capa
22 e incorporated at the central bridge region (piperazine ring) of GBR 12935.
23  sulfonamide group at the 1N-position of the piperazine ring to fill the S1' pocket of the enzyme, an
24 e) is attached to the distal nitrogen of the piperazine ring via alkyl chains of varying lengths or d
25 CIP oxidation proceeds through an opening of piperazine ring via N-dealkylation.
26 on spacer between the hydroxyl group and the piperazine ring was essential for enantioselectivity, an
27 n of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial
28 ), which differed by the substitution on the piperazine ring where the piperazine of LDK1203 and LDK1
29  to form a five-ring compound with a central piperazine ring, which was characterized by electrospray