ライフサイエンスコーパス: piperidine ring

1 reductive amination sequence that closes the piperidine ring.

2 olysis reaction stereoselectively formed the piperidine ring.

3 henyl group located on the 4-position of the piperidine ring.

4 al cyclization sequence introduces the final piperidine ring.

5 nteractions to control the conformation of a piperidine ring.

6 oducts containing only fused pyrrolidine and piperidine rings.

7 hydroxyl group into the C-4 position on the piperidine ring (10e) resulted in a substantial decrease

8 uents, (3) introducing unsaturation into the piperidine ring, (4) ring-opening or eliminating the pip

9 try between the 3- and 4-substituents in the piperidine ring, a trans-crotyl or allyl substituent on

10 (phenylalkyl)amine series indicates that the piperidine ring and alkyl chain substitutions common to

11 udies indicated that the sulfonyl group, the piperidine ring and benzothiazole were the key component

12 at placing substituents at position 3 of the piperidine ring and position 4 of the pyridine could all

13 g a hydroxy group onto the 4-position of the piperidine ring and the beta-carbon of the N-alkyl space

14 t one additional methylene group between the piperidine ring and the polar group in the 3alpha-substi

15 l modifications, including introduction of a piperidine ring and varied N-alkyl substitutions enhance

16 ne ring, (4) ring-opening or eliminating the piperidine ring, and (5) removing the piperidino N-methy

17 itrogen, the lack of a 2-methyl group in the piperidine ring, and either no substitution or hydroxyl

18 Incorporation of the lipophilic piperidine ring appears to confer a moderate effect on t

19 -hydroxy substituent axially oriented to the piperidine ring (C9beta-hydroxy) was a mu-agonist about

20 mations (pyridone ring-forming desaturation, piperidine ring cleavage, and redox-neutral isomerizatio

21 clization to form the hydroindole system and piperidine ring closure through a stereocontrolled aldol

22 Bicyclic-substituted piperidine ring derivatives of naphthalene antagonist 1,

23 he stereomutation of such piperidines is the piperidine ring flip and not nitrogen inversion or rotat

24 A 2,4,6-trisubstitited piperidine ring forms the core of the quinolizidine segm

25 membered bicyclic aryl rings attached to the piperidine ring had a marked impact on these effects.

26 The role of the piperidine ring in neutralizing Asp-351 was addressed us

27 ses include oxidative C-C bond cleavage of a piperidine ring in the core structure of the obscurine i

28 ain between the arene and tosyl group on the piperidine ring is proposed to rationalize the greater s

29 c nitrogen, by adding a fluorine atom to the piperidine ring, leading to 3-(4-fluoropiperidin-3-yl)-2

30 ectrostatic interaction between the ORG27569 piperidine ring nitrogen and K3.28(192) that is importan

31 y the optimal spacing and orientation of the piperidine ring nitrogen relative to the benzimidazole.

32 umerous attempts toward the formation of the piperidine ring of 1 from vinyl iodide 56 were made and

33 Ring size reduction of the central piperidine ring of lobelane yielded pyrrolidine analogue

34 hydroxy substituent was introduced into the piperidine ring of one of our disubstituted lead analogu

35 clash of the modified C386 residue with the piperidine ring of SR141716A and/or disruption of an aro

36 y unknown enzymatic C-C bond cleavage in the piperidine ring of the alkaloid scaffold, resembling an

37 nverse interaction of amino acid 351 and the piperidine ring of the antiestrogen side chain of raloxi

38 y step was employed to construct the central piperidine ring of the iminosugar and the C-glycosidic s

39 cement of the carboxylate group at C2 in the piperidine ring of the inhibitors causes electrostatic d

40 bered ring to the conformationally mobile D'-piperidine ring provided an isolated atropisomer 81a, wh

41 l ether substituent on the 5-position of the piperidine ring provided ultrapotent inhibitor 38 (DH376

42 complex noviose sugar with readily available piperidine rings resulted in approximately 100 fold incr

43 loaddition to accommodate the formation of a piperidine ring (ring B of daphnilactone B).

44 The piperidine ring size of potent, competitive P2Y(14)R ant

45 clic tropane ring system with the monocyclic piperidine ring system or an acyclic aminoalkylene chain

46 piperazine with either a homopiperazine or a piperidine ring system was well tolerated at DAT (K(i) r

47 33 different organocations derived from the piperidine ring system.

48 1 antagonists based on the 4,4-disubstituted piperidine ring system.

49 rrect relative stereochemistry about the bis(piperidine) ring system.

50 ands, cyTPA and 1-isocyTPQA, which feature a piperidine ring that provides a structurally rigid backb

51 e and (ii) introduction of a fluorine in the piperidine ring to reduce its basicity, resulting in att

52 f enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed, intramolecula

53 med then precipitates the contraction of the piperidine ring via C2-C3 bond cleavage, and the resulti

54 7 indicated that the benzylated six-membered piperidine ring was disordered and exposed to solvent.

55 A C2-symmetric piperidine ring was incorporated in the ligand as the ni

56 rigid carbocyclic structure and an attached piperidine ring which is free to rotate were synthesized

57 ene derivative replacing the nitrogen on its piperidine ring with a carbon to form cyclohexane.

58 precedented level of substitution to provide piperidine rings with adjacent tetrasubstituted carbon a