ライフサイエンスコーパス: piriform

1 or olfactory nucleus (AON), to contribute to piriform activity is not known.

2 Anterior piriform adrenergic blockade prevented acquisition of si

3 habenula, striatum, amygdala, the cingulate, piriform and entorhinal cortex, and in cerebellum, notab

4 ng to examine the representation of odors in piriform and in two downstream areas, the orbitofrontal

5 Also, the piriform and insular cortices displayed strong PIST labe

6 racing to demonstrate a critical role of the piriform and orbitofrontal cortices in relapse to opioid

7 se to these odors in the olfactory (anterior piriform and orbitofrontal) cortices and emotion-relevan

8 egions (dentate gyrus, hippocampal area CA1, piriform and parietal cortices) at 6 and 12 months of ag

9 Curiously, the piriform and somatosensory cortices were more vulnerable

10 a distributive pattern of projections to the piriform and stereotyped projections to the amygdala pro

11 educed in the hippocampus and somatosensory, piriform, and entorhinal cortices of all three strains o

12 ed BDNF expression in the frontal, parietal, piriform, and entorhinal cortices, increased NT-3 expres

13 emble patterns in perirhinal, orbitofrontal, piriform, and insular cortices.

14 ons as indexed by a reduction in overlap for piriform Arc(+) pyramidal neurons after training.

15 e similar as indexed by increased overlap in piriform Arc-expressing (Arc(+)) pyramidal neurons.

16 clofen, a GABA(B) agonist known to attenuate piriform associative inputs, interfered with within-cate

17 This circuitry may shape the ensembles of piriform cells that encode odorant identity.

18 dal cell connections across the rat anterior piriform cortex (aPC) and found a pronounced gradient of

19 Ensemble activity patterns in anterior piriform cortex (APC) and orbitofrontal cortex (OFC) ref

20 P(+)) cells within the CC, Ctx, and anterior piriform cortex (aPC) and used prelabeling with 5-ethyny

21 Layer 2 principal neurons in the anterior piriform cortex (APC) can be divided into 2 subtypes: se

22 NMDA receptor (NMDAR) number in the anterior piriform cortex (aPC) in rat induced by a 10 min pairing

23 he first time that adrenoceptors in anterior piriform cortex (aPC) must be engaged for adult rats to

24 ded neural ensemble activity in the anterior piriform cortex (aPC) of rats performing an odor mixture

25 rivation is in the highly excitable anterior piriform cortex (APC) of the brain.

26 examines synaptic plasticity in the anterior piriform cortex (aPC) using ex vivo slices from rat pups

27 f IAA deficiency requires an intact anterior piriform cortex (APC), but does it act alone?

28 striction, we hypothesized that the anterior piriform cortex (APCx) and the olfactory tubercle (OTu)

29 The largest changes were in the piriform cortex (before: 47.7 +/- 1.4 ms; 18-24 h: 82.3

30 tion, the analysis of neural circuits in the piriform cortex (PC) demonstrated the importance of not

31 ng from the association fiber (AF) system in piriform cortex (PC) make axodendritic synapses on granu

32 nic synapses (AASs) in brain slices from the piriform cortex (PC) of mice.

33 inhibitory and glutamatergic neurons in the piriform cortex (PC) of mice.

34 n adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination

35 ation of cortical association fibers (AF) in piriform cortex (PC).

36 ct regions: olfactory bulb (OB) and anterior piriform cortex (PC).

37 Hyperactive odor-evoked activity in the piriform cortex (PCX) and increased OB-PCX functional co

38 s, we found that 26% of neurons in the mouse piriform cortex (PCX) display modulation in firing to ca

39 The piriform cortex (PCX) is the largest component of the ol

40 s well as local field potentials in the MDT, piriform cortex (PCX), and OFC in rats performing a two-

41 In the piriform cortex (PCx), spatially dispersed sensory input

42 electrophysiological recordings in anterior piriform cortex (PCx), we assessed how cortical neurons

43 ociated with increased Fos expression in the piriform cortex (Pir) neurons projecting to the OFC, but

44 A), dorsomedial striatum (DMS) and olfactory piriform cortex (PIR).

45 ut the olfactory tubercle (OT) and posterior piriform cortex (pPC) are candidates for decoding reward

46 e-associated astrocytes" (SAAs) in posterior piriform cortex (PPC) are unique by virtue of a direct a

47 ributed ensemble activity in human posterior piriform cortex (PPC) coincides with perceptual ratings

48 resentations of the odor target in posterior piriform cortex (PPC) gave way to poststimulus represent

49 Retrograde tracing from the OB or posterior piriform cortex (PPC) showed that the APC projects to th

50 apse with neurons distributed throughout the piriform cortex [7-10].

51 obust interhemispheric asymmetry in anterior piriform cortex activity that emerges during specific st

52 nput from the anterior olfactory nucleus and piriform cortex already by the second week.

53 dy calyx, the insect analog of the mammalian piriform cortex and a center for associative memory.

54 le to functionally isolate defined inputs to piriform cortex and assess their potential to activate o

55 cross brain regions, and particularly in the piriform cortex and cortical amygdala.

56 reased theta-specific phase coupling between piriform cortex and hippocampus.

57 ated by odor-evoked connectivity between the piriform cortex and insula, a region involved in integra

58 imaging in the mouse, we show that both the piriform cortex and its sensory inputs from the olfactor

59 d with a direct monosynaptic pathway linking piriform cortex and OFC.

60 However, the LEC also projects back to the piriform cortex and olfactory bulb.

61 ible changes in odor-evoked fMRI activity in piriform cortex and orbitofrontal cortex (OFC).

62 ns that resembled neurogliaform cells of the piriform cortex and provided feedforward inhibition of t

63 e, only C. sociabilis had OTR binding in the piriform cortex and thalamus and V1aR binding in the olf

64 etween the hippocampus and the amygdala, the piriform cortex and thalamus between stress-resistant an

65 idual glomeruli in the olfactory bulb to the piriform cortex and the cortical amygdala.

66 w that spatial ensemble activity patterns in piriform cortex are closely linked to the perceptual mea

67 rceptual codes of odour quality in posterior piriform cortex are degraded in patients with Alzheimer'

68 The orbitofrontal cortex (OFC) and piriform cortex are involved in encoding the predictive

69 lly to reach the ventral pallium deep to the piriform cortex at E14.5 in the mouse.

70 ion-invariant neurons are overrepresented in piriform cortex but not in olfactory bulb mitral and tuf

71 dy further explored LEC feedback to anterior piriform cortex by examining how LEC top-down input modu

72 bitrarily chosen subpopulation of neurons in piriform cortex can elicit different behavioral response

73 Steady-state interhemispheric anterior piriform cortex coherence is reduced during the initial

74 reduced microgliosis in the hippocampus and piriform cortex compared with T2(+/+)PS mice.

75 njection, the anterior olfactory nucleus and piriform cortex displayed a high alpha-synuclein patholo

76 al stimuli to sensory representations in the piriform cortex during odor-driven social learning.

77 We now report that OPCs in adult murine piriform cortex express low levels of doublecortin, a ma

78 evated baseline, spontaneous activity in the piriform cortex extends the dynamic range of odor repres

79 The piriform cortex had the strongest correlation between th

80 Together these findings suggest that human piriform cortex has access to olfactory content in the t

81 Cholinergic modulation within the piriform cortex has long been proposed to serve importan

82 To determine whether OPCs in the piriform cortex have inherently different physiological

83 In recordings from anterior piriform cortex in awake behaving mice, we found that ne

84 ur study suggests a causal role of posterior piriform cortex in differentiating olfactory objects.

85 ative descriptions of the olfactory bulb and piriform cortex in six mammals using stereology techniqu

86 nd olfactory-related oscillations within the piriform cortex in vivo.

87 Inactivation of piriform cortex increased odor responsiveness and pairwi

88 assium changes demonstrates that SLEs in the piriform cortex initiate in the superficial layer 1 lack

89 Pyramidal cells in piriform cortex integrate sensory information from multi

90 Finally, post-training disruption of piriform cortex intracortical association fiber synapses

91 An interesting finding is the absence of the piriform cortex involvement in young male rats and the c

92 gamma oscillations in the vStr LFP and that piriform cortex is an important driver of gamma-band osc

93 trated that a reduction in plasticity in the piriform cortex is associated with a selective impairmen

94 cells across major cortical subdivisions of piriform cortex is lacking.

95 These observations demonstrate that the piriform cortex is sufficient to elicit learned behavior

96 d, odor-distinctive patterns of responses in piriform cortex layer 2 principal cells: Approximately 1

97 the peculiar organization of the superficial piriform cortex layers, which are characterized by unmye

98 Both right and left piriform cortex local field potential activities were re

99 oligodendrocytes (OLs), whereas those in the piriform cortex may also generate neurons.

100 activity during slow-wave states within the piriform cortex may be shaped by recent olfactory experi

101 learning until mastery, suggesting that each piriform cortex may contribute something unique to odour

102 cell fate and later to specify layer II/III piriform cortex neuronal identities.

103 We found that the overall spike rates of piriform cortex neurons (PCNs) were sensitive to the rel

104 Piriform cortex neurons from E14.5 mutant embryos displa

105 ng how LEC top-down input modulates anterior piriform cortex odor evoked activity in rats.

106 robust odor representations in the anterior piriform cortex of adult rats when odor was associated w

107 However, neurotoxicity in the piriform cortex of immature females treated for 60days a

108 on resets the phase of delta oscillations in piriform cortex prior to odor arrival.

109 The piriform cortex provides an ideal system to address this

110 However, piriform cortex pyramidal cells also receive dense intra

111 espread and broadly tuned than excitation in piriform cortex pyramidal cells.

112 enhanced intrinsic neuronal excitability of piriform cortex pyramidal neurons, and in their excitato

113 are primarily located in the in the adjacent piriform cortex rather than in the vStr itself, providin

114 ve suggested a model in which neurons of the piriform cortex receive convergent input from random col

115 n to provide direct evidence that neurons in piriform cortex receive convergent synaptic input from d

116 The olfactory bulb (OB) and piriform cortex receive dense cholinergic projections fr

117 lt CNS-though rare, neuron production in the piriform cortex remains a possibility.

118 ves dorsal olfactory bulb input, whereas the piriform cortex samples the whole olfactory bulb without

119 Here we used patch-clamp recordings in rat piriform cortex slices to examine cellular mechanisms th

120 istent with an auto-associative function for piriform cortex supported by recurrent circuitry.

121 onic synapse are significantly higher in the piriform cortex than in the neocortex.

122 bulb and sends an associative projection to piriform cortex that has potential roles in the state-de

123 tiple relays in a network extending from the piriform cortex through the hippocampus can be different

124 fMRI data for a node within the ipsilateral piriform cortex to be important for seizure modulation i

125 We introduced channelrhodopsin into the piriform cortex to characterize these intrinsic circuits

126 dendrites and that feedback projections from piriform cortex to olfactory bulb interneurons are a sou

127 hereas cingulate cortex and to a less extent piriform cortex were affected preferentially by the CIV

128 DCX and PSA-NCAM immunoreactive cells in the piriform cortex were quantified as measures of plasticit

129 put/output curves for two connections in the piriform cortex were similar to those for the LPP, where

130 Odor representations in anterior piriform cortex were sparser than typical in adult rat a

131 o-active neurons that are distributed across piriform cortex without any apparent spatial organizatio

132 a tecta, and anterior olfactory tubercle and piriform cortex) have cells that express either calbindi

133 m concentration, 0.33 ug . g(-1) +/- 0.04 in piriform cortex, 0.24 ug . g(-1) +/- 0.04 in dentate gyr

134 We did not observe these effects in anterior piriform cortex, amygdala or orbitofrontal cortex, indic

135 t of local field potential activity in human piriform cortex, amygdala, and hippocampus.

136 c suppression of responses from the amygdalo-piriform cortex, an associative temporal cortical struct

137 The three-layered piriform cortex, an integral part of the olfactory syste

138 related with fMRI activity in midbrain, OFC, piriform cortex, and amygdala.

139 ygdala, cingulate cortex, hippocampus (CA1), piriform cortex, and BNST were lower in OVX+E2 females c

140 e associative network originating within the piriform cortex, and can be reshaped by passive odour ex

141 l (2-OG), enhanced encoding of food odors in piriform cortex, and shifted food choices toward energy-

142 eurons within hippocampus, central amygdala, piriform cortex, and striatum, brain regions associated

143 d with within-category pattern separation in piriform cortex, and the magnitude of this drug-induced

144 ry areas, the anterior olfactory nucleus and piriform cortex, and the olfactory associated orbital an

145 of the forebrain, including medial amygdala, piriform cortex, and ventrolateral septum, showed low c-

146 gions, such as the hippocampus, thalamus, or piriform cortex, but not in the cerebellum beginning at

147 s have unique and redundant functions in the piriform cortex, controlling the timing of differentiati

148 e laminin immunoreactivity is present in the piriform cortex, corpus callosum (myelinated tracts) amy

149 In piriform cortex, CRF1 binding increased in females and d

150 glutamatergic pacemaker circuits within the piriform cortex, each of which can initiate waves of act

151 ted olfactory epithelium and OB, but not the piriform cortex, express similar, sustained circadian rh

152 e ipsilateral and contralateral OB, AON, and piriform cortex, few studies have examined this circuitr

153 hat extend, largely undiminished, across the piriform cortex, forming a large excitatory network that

154 distributed ensembles of neurons within the piriform cortex, forming cortical representations of odo

155 icited cross-adapting responses in posterior piriform cortex, in accord with the pattern observed in

156 In the piriform cortex, individual odorants activate a unique e

157 s including the olfactory nuclei, neocortex, piriform cortex, induseum griseum, hippocampus, thalamus

158 ammed spatial relationships may not exist in piriform cortex, making flexible random associations the

159 tive cell numbers were high in, for example, piriform cortex, paraventricular nucleus, supraoptic nuc

160 a while responses immediately downstream, in piriform cortex, remain robust.

161 Neurons in piriform cortex, responsive to a given odorant, are not

162 cus on the hippocampus, somatosensory, paleo/piriform cortex, striatum, and various amygdala nuclei.

163 ositive, we showed that in the motor cortex, piriform cortex, striatum, CA1 region of the hippocampus

164 , known to abolish gamma oscillations in the piriform cortex, strongly reduced vStr gamma power and t

165 However, in piriform cortex, the activity of target neurons increase

166 The AC is composed of axons from the piriform cortex, the anterior olfactory nucleus and the

167 riched for oxytocin receptors, including the piriform cortex, the left auditory cortex, and CA2 of th

168 ing channelrhodopsin at multiple loci in the piriform cortex, when paired with reward or shock, elici

169 ory receptors to olfactory bulb, and then to piriform cortex, where ensembles of activated neurons fo

170 tern does not appear to be maintained in the piriform cortex, where stimuli appear to be coded in a d

171 nt mice presented a reduced thickness of the piriform cortex, which affected projection neurons in la

172 enerated in the forebrain, especially in the piriform cortex, which is the main target of the olfacto

173 Such topography has not been observed in the piriform cortex, whose responses to odorants are sparsel

174 ity of the olfactory cortex, principally the piriform cortex, will be described in the context of how

175 ical loop between the olfactory bulb and the piriform cortex, with cortex explaining incoming activit

176 or stimulation enhanced theta power in human piriform cortex, with robust effects at the level of sin

177 t but not the associational afferents of the piriform cortex.

178 ives rich glutamatergic projections from the piriform cortex.

179 odel of cholinergic modulation in the OB and piriform cortex.

180 olfactory tract (lot) guidepost cells in the piriform cortex.

181 maker circuits in the septal nucleus and the piriform cortex.

182 b and in the pyramidal cells of the anterior piriform cortex.

183 ns, and later to layer II/III neurons of the piriform cortex.

184 olinergic modulation of the OB inputs to the piriform cortex.

185 ompared to juvenile rats in both the OFC and piriform cortex.

186 rom several areas, including S1, SR, FM, and piriform cortex.

187 bilateral reversible lesions of the anterior piriform cortex.

188 i.e., the hippocampus, substantia nigra, and piriform cortex.

189 ive input times than neurons in the anterior piriform cortex.

190 (mitral/tufted [MT] cells) projecting to the piriform cortex.

191 undant axo-axonic synapses across the entire piriform cortex.

192 operties of these synapses across the entire piriform cortex.

193 in putative centrifugal cells and posterior piriform cortex.

194 al migration and homologous to the mammalian piriform cortex.

195 on of odors more similar to that seen in the piriform cortex.

196 y bulbs and higher brain regions such as the piriform cortex.

197 he lateral olfactory tract and the posterior piriform cortex.

198 al glutamatergic neurons within normal adult piriform cortex.

199 iate into pyramidal glutamatergic neurons in piriform cortex.

200 n local field potentials within the anterior piriform cortex.

201 integration and analogous to the vertebrate piriform cortex.

202 ctions with both the olfactory bulb (OB) and piriform cortex.

203 temporal cortices, with no changes noted in piriform cortex.

204 ugh phase resetting of delta oscillations in piriform cortex.

205 alogous to the representation of odorants in piriform cortex.

206 istributed ensembles of neurons in the mouse piriform cortex.

207 t power gradient originating in the adjacent piriform cortex.

208 sentations of odor identity and intensity in piriform cortex.

209 ctively expressed in different layers of the piriform cortex.

210 presentations of odor objects are encoded in piriform cortex.

211 principal excitatory neuron in the anterior piriform cortex.

212 tral/tufted (MT) cells carrying OB output to piriform cortex.

213 patial order in the bulb is discarded in the piriform cortex; axons from individual glomeruli project

214 essing center for olfactory information, the piriform cortex?

215 and polysynaptically) to primary olfactory (piriform) cortex (PC)-connections that might be hypothes

216 from single neurons in posterior olfactory (piriform) cortex (pPC) of awake rats while presenting ba

217 nctional coupling between OFC and olfactory (piriform) cortex and between vmPFC and amygdala revealed

218 or representations in the primary olfactory (piriform) cortex depend on excitatory sensory afferents

219 The olfactory (piriform) cortex has long been hypothesized to encode od

220 The olfactory (piriform) cortex is thought to generate odour percepts a

221 sensory paleocortex, the primary olfactory (piriform) cortex of mice.

222 orsal (MD) thalamus links primary olfactory (piriform) cortex to olfactory neocortical projection sit

223 ity in the mouse primary olfactory (anterior piriform) cortex.

224 distributed in the rodent primary olfactory (piriform) cortex.

225 or representations in rat primary olfactory (piriform) cortex.

226 mble activity patterns in primary olfactory (piriform) cortex.

227 d are highly expressed in primary olfactory (piriform) cortex.

228 training to test for functional asymmetry in piriform cortical activity during learning.

229 The results demonstrate that piriform cortical activity during slow-wave state is sha

230 The results suggest that piriform cortical activity during slow-wave states is sh

231 c and GABAergic neuronal subtypes within the piriform cortical circuits.

232 This piriform cortical ensemble activity predicts olfactory p

233 en overlapping mixtures resulted in impaired piriform cortical ensemble pattern separation (enhanced

234 havioral discrimination ability and enhanced piriform cortical ensemble pattern separation.

235 e results demonstrate transient asymmetry in piriform cortical function during odour discrimination l

236 Single-unit activity of piriform cortical layer II/III neurons was recorded simu

237 LEC reversible lesions enhanced ipsilateral piriform cortical local field potential oscillations dur

238 Proximal synapses arise from piriform cortical neurons and facilitate with paired-pul

239 While lot cells and other piriform cortical neurons share a pallial origin, the fa

240 oked excitatory synaptic transmission in rat piriform cortical neurons.

241 t input from olfactory bulb mitral cells and piriform cortical pyramidal cells and is the gateway for

242 ns of the ipsilateral LEC increased anterior piriform cortical single-unit spontaneous activity.

243 single missing component, whereas olfactory (piriform) cortical neural ensembles perform pattern comp

244 y (coherence) between the bilateral anterior piriform cortices is learning- and context-dependent.

245 onal cortical areas (insular, cingulate, and piriform cortices) and hippocampus proper.

246 ntal cortex than in motor, somatosensory, or piriform cortices, greater in superficial than in deep l

247 olfactory tubercle, and frontal and temporal piriform cortices, suggesting dissociable whole-brain ne

248 C projections to both the olfactory bulb and piriform cortices.

249 rtex and ipsilaterally in the entorhinal and piriform cortices.

250 ant responses in the cortex reveals that the piriform discards spatial segregation as well as chemoto

251 These data imply that the piriform does not use spatial order to map odorant ident

252 t chemogenetic silencing of these Fos-tagged piriform ensembles selectively interferes with odor fear

253 there was increased c-fos expression in the piriform-entorhinal cortex and hypothalamus, and a modes

254 experiments reveal that these layer-specific piriform genes mark different subclasses of neurons, whi

255 unctional assessment of the AON afferents to piriform in male and female C57Bl/6J mice.

256 ity was detected in cortical areas including piriform, insular, cingulate and somatomotor cortices, t

257 d memories, and odour information encoded in piriform is routed to target brain areas involved in mul

258 representation of odor in olfactory cortex (piriform) is distributive and unstructured and can only

259 t early blood-brain barrier pathology in the piriform network is a sensitive and specific predictor (

260 tion of odor representations in the anterior piriform network suggests that odor objects are widely d

261 er of synapses between a bulb glomerulus and piriform neuron is invariant at one.

262 r experiments identify specific ensembles of piriform neurons as critical components of an olfactory

263 In the absence of applied odors, piriform neurons exhibit spontaneous firing at mean rate

264 Activation of a small subpopulation of piriform neurons expressing channelrhodopsin at multiple

265 demonstrate that different subpopulations of piriform neurons expressing ChR2 can be discriminated an

266 e AON could powerfully enhance activation of piriform neurons in response to odor.SIGNIFICANCE STATEM

267 as well as excitation, the responsiveness of piriform neurons is at least twofold less sparse than cu

268 First, the number of piriform neurons n and bulb glomeruli g scale as n~g(3/2

269 Piriform neurons receive convergent excitatory inputs fr

270 Furthermore, chemogenetic reactivation of piriform neurons that were Fos tagged during olfactory f

271 e that AON inputs can significantly activate piriform neurons, as they are coupled to NMDAR currents

272 m a subpopulation of concentration-invariant piriform neurons.

273 namic changes such as those observed here in piriform odor encoding are at the heart of perceptual le

274 Moreover, piriform odor representations exhibit attractor dynamics

275 The AON may enhance the piriform odor response, encouraging further study to det

276 t taste-odor convergence occurs in posterior piriform olfactory cortex and calls for a reformulation

277 ng synchronizes electrical activity in human piriform (olfactory) cortex, as well as in limbic-relate

278 t odor category codes within the perirhinal, piriform, orbitofrontal, and insular cortices suggests t

279 antly, classification analysis revealed that piriform oscillatory activity conveys olfactory-specific

280 However, it remains unknown if piriform outputs are spatially organized, and if distinc

281 ur category, identity and value are coded in piriform (PC), orbitofrontal (OFC) and ventromedial pref

282 ings indicate that aversive learning induces piriform plasticity with corresponding gains in odor ena

283 nverging evidence that recurrently-connected piriform populations stabilize sensory representations i

284 rong temporal summation of AON inputs within piriform pyramidal neurons, and suggest that the AON cou

285 ssess their potential to activate or inhibit piriform pyramidal neurons.

286 forms glutamatergic excitatory synapses onto piriform pyramidal neurons; and while these inputs are n

287 and while these inputs are not as strong as piriform recurrent collaterals, they are less constraine

288 served cortical volume in the entorhinal and piriform regions compared with T2(+/+)PS mice.

289 e cell degeneration in the retrosplenial and piriform regions.

290 However, piriform response patterns change substantially over a 1

291 medial prefrontal (mPFC), agranular insular, piriform, retrosplenial, and parahippocampal cortices.

292 erion performance, Arc ensembles in anterior piriform showed enhanced stability for the rewarded odor

293 Moreover, AON-to-piriform synapses contain a substantial NMDAR-mediated c

294 ls emphasizing the importance of distributed piriform templates for the perceptual reconstruction of

295 monstrate that oxytocin directly impacts the piriform, the olfactory sensory cortex, to mediate socia

296 Moreover, direct projections from piriform to OFC can be entrained to elicit learned olfac

297 , only one minor cortical area, the amygdalo-piriform transition area (AmPir), contained neurons upst

298 In piriform, we observed that odor responses were largely u

299 rk of associative or intracortical inputs to piriform, which may enhance or constrain the cortical od

300 ndividual glomeruli project diffusely to the piriform without apparent spatial preference.