ライフサイエンスコーパス: pivot

1 tion during the transport cycle use G93 as a pivot.

2 l-ordered linker and C-terminus serving as a pivot.

3 y, i.e., they used the ankle as the point of pivot.

4 ut any rotation around the second sigma(C-N) pivot.

5 nonracemizing rotation around the sigma(C-C) pivot.

6 tly impact ErbB2 activity by disrupting this pivoting.

7 enhancing the effects of KT diffusion and MT pivoting.

8 in various directions, KT diffusion, and MT pivoting.

9 st acknowledging the temporary nature of the pivot?

10 odrug, demonstrated efficacy in the phase II PIVOT-02 trial.

11 IVO were comparable between PIVOT IO 001 and PIVOT-02.

12 open-label, phase III randomized controlled PIVOT-09 trial investigated the efficacy and safety of B

13 Of the 587 patients in PIVOT, 557 had full NC results and were included.

14 Of 176 participants enrolled in PIVOT, 88 were macula-off RRDs.

15 possibility that N-TIMP-1 might dynamically pivot a few degrees or more in the arc toward the MT1-MM

16 avascular Venous Oxygen saturation, and T2* (PIVOT), a recently developed MRI technique, was used to

17 a pendant pentyloxy group and the ability to pivot about a strong hydrogen-bonding network.

18 interdomain/cAMP-binding and D/D domains to pivot about each other.

19 OHCs moved antiphasic to the outer row; OHCs pivoted about the RL; and Hensen's cells followed the mo

20 atively rigid hydrogen-bonded unit, possibly pivoting about a central position near residue Val87.

21 ly toward the nucleotidyltransferase domain, pivoting about a short linker region.

22 e "flipped" within the transporter cavity by pivoting about Lys-436 leading to net transport from the

23 s, filaments can be seen passing through and pivoting about single points on the motility surface.

24 to sample different cojoint orientations by pivoting about the SL3,4 helical axis.

25 ltage-sensing arginines in their S4 segments pivot across the lipid bilayer as voltage sensor paddles

26 e between the mode of oscillation of a rigid pivoted airfoil in a flow and a hinged-free elastic plat

27 To examine linkage between the core pivot and DNA binding domains, the L148F substitution wa

28 d rotation of the two lobes around a central pivot and opening of a "lid" region that facilitates sub

29 h the alpha-helical transmembrane domain can pivot and rotate relative to the rigid beta-sheet bindin

30 tunnel, the use of electrostatic highways or pivoting and by conformational changes.

31 to signaling that exploits differential heme pivoting and heme bending.

32 possible activation pathways, which involve pivoting and rotational motions of the helices, respecti

33 nter of the platform, can undergo remarkable pivoting and tilting motions that appear buffered by N-g

34 to methyl-substituted triptycenes acting as pivots and encapsulating frames.

35 We make a distinction between such pivots and templates and discuss the biological implicat

36 y demanding tasks to a search for landmarks, pivots, and hubs.

37 -like nucleotide-binding domains of Galphai1 pivot apart to occupy multiple resolved states with disp

38 tional rearrangements: a winged-helix domain pivots approximately 90 degrees to close onto duplex DNA

39 and the amino acids involved in creating the pivot are not conserved.

40 iffer, with only minor exceptions equivalent pivots are seen in comparisons of Escherichia coli struc

41 Small rigid helices upstream of these 'pivots' are aligned, thereby decoupling their motion fro

42 agents (e.g. top connectors and stereocilia pivots) are responsible for approximately 9% of the over

43 Its cell-autonomous circadian oscillations pivot around a well characterised transcriptional/transl

44 orces two core subunits in Arp2/3 complex to pivot around one another, shifting half of the complex i

45 Further, pulled kinetochore-fibers pivot around poles but not chromosomes, retaining their

46 We speculate that E proteins could pivot around the fusion loop-pocket junction, allowing v

47 These recommendations pivot around transparency in academic-industry partnersh

48 mutating a critical residue proposed to be a pivot around which the two lobes of NCT rotate.

49 Existing works are more pivoted around entity-relation extraction using bidirect

50 The oligomeric interface pivoted around residue T585 as a joint that links and st

51 ia deflect by bending along their length and pivoting around an effective hinge located below the bas

52 tition responds principally as a rigid plate pivoting around its insertion along the spiral lamina.

53 orientation near chromosomes while allowing pivoting around poles.

54 showed that MT gliding along cell edges and pivoting around the centrosome regulate MT rearrangement

55 rally been accepted that the head rotates by pivoting around the neck helix (h28) of 16S rRNA, its so

56 Our present study pivots around four apparently unrelated cancer types amo

57 he two states reveals that the finger domain pivots around the [4Fe-4S] cluster-containing tip of the

58 oximal rhynchokinesis in which the upper jaw pivots around the nasal-frontal (N-F) hinge.

59 d in the post-cleavage furrow; then one cell pivots around the other, resulting in stacking into a co

60 rotein-coding genes and many non-coding RNAs pivots around the regulated activity of RNA polymerase I

61 The canonical model for SCN timekeeping pivots around transcriptional/translational feedback loo

62 domain interface, allowing Fabs and Cmu2 to pivot as a unit both in-plane and out-of-plane.

63 ected by a sensory stimulus, the stereocilia pivot as a unit, producing a shearing displacement betwe

64 ion process, we observed domain rotation and pivoting as well as a translation and simultaneous rolli

65 reatest in individuals closest to the center pivot, as a result of a higher pathogen dose.

66 rds the east and opens anticlockwise about a pivot at its eastern end.

67 ional to height, indicating that stereocilia pivot at their basal insertion points.

68 h transients on fibers in rigor do not cause pivoting at Gly699 or reverse the power stroke.

69 Pivoting at Gly699 rotates probes at SH1 suggesting that

70 A different structure, generated by pivoting at Gly699, better resembles the native rigor co

71 e anchorage throughout the spindle obstructs pivoting at poles.

72 Movement originates from pivoting at stacked non-canonical base pairs in a Family

73 aided by a model of energy transduction that pivots at Gly699 to change probe-binding cleft conformat

74 domain is ejected from the complex and VPS15 pivots at the base of the V.

75 astral microtubules emanating from the pole pivoting away from the cortex.

76 uppies because they evade capture by rapidly pivoting away from the predator once it has committed to

77 tilts (around its phosphate group and N1 as pivots) away from the catalytic lysine 145 and the prote

78 We also argue that the field needs to pivot back to basics, as understanding the entirety of t

79 id-free closed apo conformation, revealing a pivoting beta-sheet mechanism that functions to open and

80 mple visual interface, which allows users to pivot between gene-centric and cancer type views.

81 prechordal plate appears as a mesendodermal pivot between the notochord and the ventral foregut midl

82 The loop pivots between different conformational states about a h

83 ies and challenges, yet the understanding of pivots between research areas and their outcomes remains

84 ractions between substituents vicinal to the pivot bond.

85 t is modelled as a mass connected to a fixed pivot by means of radial and tangential elastic elements

86 Our results suggest that passive thermal pivoting can bring microtubules from side-by-side poles

87 he138, appear to work in conjunction with FY-pivot canonical residues to facilitate alternative confo

88 tnerships, and research expertise to quickly pivot clinical trial sites to conduct COVID-19 vaccine t

89 etinal Detachment Outcomes Randomized Trial (PIVOT) conducted between August 2012 and May 2017 at St

90 and width of surrounding tidal flats have a pivoting control on marsh erosion.

91 B cell-NK/NKT cell cross-talk is a critical pivot controlling survival of infection with virulent F.

92 ertiary retina practice with primary RRD met PIVOT criteria and were eligible for PnR.

93 ent rate at 12 months among patients meeting PIVOT criteria undergoing PnR.

94 iewed and the proportion of patients meeting PIVOT criteria was determined.

95 Patients that met PIVOT criteria who underwent PnR with a follow-up >3 mon

96 achment rate with PnR in patients fulfilling PIVOT criteria, with similar results to those encountere

97 ts were identified, of which 577 (52.9%) met PIVOT criteria.

98 The classical QR factorization with pivoting, developed as a fast numerical solution to eige

99 reactions via C-C and C-N bond formation to pivot donor and acceptor at the NDI core.

100 point as the IRT and NDVI sensors (from the pivot, downward at a 45 angle).

101 Pyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens due to

102 distal residues flexible, through a beta-Man pivot, ensuring anchored projection from the protein she

103 ains around the wedge helix, which acts as a pivot, facilitates nucleolytic cleavage.

104 animals can successfully employ short range 'pivot' feeding effectively on evasive prey.

105 y (copepods) using a technique known as the 'pivot' feeding, which involves rapid movement to overcom

106 d isolated yeast spindle poles, we show that pivoting flexibility can be modified by mutating a micro

107 rcome this geometric bias, but the intrinsic pivoting flexibility of the microtubule-pole interface h

108 ngstrom across the ribosome that connect the pivot for head swiveling with the axis of intersubunit r

109 ral communities: the outer-head contains the pivot for head swiveling, and an inner-head community is

110 their mid- and long-term strategic plans to pivot for long-term success while managing the COVID-19

111 opposite end of the substrate, serving as a pivot for the actions of F53 and H110.

112 ered a beta5 motif that acts as a structural pivot for the kinase domain in MET and other TAM family

113 hat each foot can act as a temporarily fixed pivot for the other.

114 rients actin filaments using the contacts as pivots, forming bundles that then generate lateral tensi

115 Of the 21 pivots found, six are observed in the large subunit rRNA

116 uitinase (DUB), thereby offering a strategic pivot from conventional approaches to target tumor suppr

117 litude distribution, could differentiate the pivot from surrounding peripheral regions and thereby as

118 Many immunologists quickly pivoted from their existing research to focus on coronav

119 to successfully address disparities requires pivoting from outdated race-based practices to a race-co

120 h pluripotency progression and morphogenesis pivots from WNT to MEK signals.

121 Larger pivots further exhibit weak engagement with established

122 ghly connected rare-earth (RE) MOFs, where a pivot group is placed in the center of a linker similar

123 By tuning the composition of pivot groups and steric hindrances of the substituents o

124 We call these 'FY-pivot' GTPases after their most distinguishing feature,

125 ther, a number of LacI mutations in the core pivot have been identified recently by their altered beh

126 ing of the catalytic cleft since R463 on the pivot helix is pushed into contact distance with the bet

127 enzyme-binding site lies directly under the "pivot helix" of the NAD(+) binding domain.

128 er, ADP, NAD(+), and NADH all bind under the pivot helix, but a second GTP molecule does not.

129 DP interact with R459 (R463 in huGDH) on the pivot helix.

130 exception of the truncated side chain on the pivot helix.

131 s more disordered the further it is from the pivot helix.

132 served at the second coenzyme site under the pivot helix.

133 Herein, we introduce molecular pivot-hinge installation as a linker desymmetrization st

134 a variety of nanoscale mechanisms, including pivots, hinges, crank sliders and rotary systems(14-17),

135 ity to directly explore the role of the core pivot in repressor function.

136 arrowed-down base of stereocilia, where they pivot in response to sound and gravity.

137 a hair bundle, a cluster of microvilli that pivot in response to sound vibrations, causing the openi

138 Here, we identify FOXO4 as a pivot in senescent cell viability.

139 bons 3 and 3' was isolated and its role as a pivot in the anthocyanins-type multistate of chemical re

140 This interaction acts as a pivot in the conformational search associated with foldi

141 nar cell polarity signaling enables cells to pivot in the direction of limb elongation via this N-cad

142 to migrate against the flow direction while pivoting in a zig-zag motion.

143 lexibilities, we establish the importance of pivoting in vivo for timely pole separation.

144 minal peptide of hCCS are consistent with a "pivot, insert, and release" mechanism that is similar to

145 hereas in the subunit that binds GS-Hna, R15 pivots into the active site, which breaks its interactio

146 ter BEMPEG plus NIVO were comparable between PIVOT IO 001 and PIVOT-02.

147 The PIVOT IO 001 study did not meet its primary end points o

148 osure of pathogens aerosolized during center pivot irrigation of diluted dairy wastewaters.

149 r station-attached unintrusively to a center pivot irrigation system for detecting cotton water stres

150 The pivot is critical to rotors postulated to maintain atria

151 Each pivot is typically in direct physical contact with at le

152 n the middle of transmembrane helix 6, which pivots its intracellular half outward to accommodate the

153 An ethynyl unit as spacer and pivot joint provides almost free azimuthal rotation of t

154 We identified inter-ring pivot joints that articulate during ring closure.

155 ds, with the hydrophobic core serving as the pivot, leads to exposure of hydrophobic sites for target

156 Z- and PIWI-containing lobes, as well as the pivot-like conformational changes associated with comple

157 We observe pivot-like domain movements within the Ago scaffold on p

158 ical tissue architecture is established by a pivot-like process between sister cells.

159 arbomedics, Bicarbon, Standard, Regent, Open Pivot, Masters, or Advantage valve models.

160 sted that potassium channels are gated via a pivoted mechanism of the pore-lining helix.

161 ter, and (ii) as a modulator to restrict the pivot motion at the S4-S5 linker and at a critical hinge

162 around their long axis, and undergo an acute pivoting movement to reorient perpendicular to the oocyt

163 mophore to its all-trans form, that involves pivoting movements of kinked helices, which, while maint

164 As a group, the behaviors of the core pivot mutants are consistent with the allosteric structu

165 horter length scale cannot robustly restrict pivoting near chromosomes, while anchorage throughout th

166 rogenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adip

167 ggests a conformational change that involves pivoting of a transmembrane, four-helix bundle (M1, M2,

168 w the requirement for a distinct ~30 degrees pivoting of aa-tRNA about the anticodon stem within the

169 Pivoting of helix M is accompanied by counterclockwise r

170 By measuring the pivoting of microtubules around isolated yeast spindle p

171 Pivoting of microtubules around spindle poles might help

172 olarity through PI3K-dependent branching and pivoting of protrusions.

173 to the other by a mechanism of electrostatic pivoting of the CoA moiety, mediated by a set of conserv

174 e transporter family, show that the downward pivoting of the Core domains relative to the Gate domain

175 Pivoting of the prybar induced by force demolishes an in

176 esidue and its neighbour (Im9 Tyr55) are the pivots of a 19 degrees rigid-body rotation that relates

177 me signaling molecules, which thereby become pivots of angiogenic balance.

178 bout which the kinase and regulatory domains pivot on conserved hinges to modulate transphosphorylati

179 advances in childhood cancer treatment will pivot on developing biology-driven new drug development

180 all thickening and its clinical implications pivot on different wall thickening mechanisms in various

181 applications of solar-driven water splitting pivot on significant advances that enable scalable produ

182 al reaction-implantation and decidualization-pivot on the time-sensitive loss of progesterone-resista

183 that included a bundle of interventions and pivoted on preoperative rectal screening for multidrug-r

184 The route pivoted on the construction of a late-stage protecting-g

185 Pivoting on a two-stage catalytic Michael addition/conde

186 tended CYPOR structures demonstrate that, by pivoting on the C terminus of the hinge, the FMN domain

187 Pivoting on the chemoselective iridium(I)-catalyzed redu

188 helix undergoes a lever-like swinging motion pivoting on the intrasubunit hinge, and the entire TM2 b

189 ghtly folded core containing the latch motif pivots on a more flexible hinge region to occlude the po

190 The antimicrobial use of silver compounds pivots on the 100-year-old application of silver nitrate

191 egion together with bound CaM forms a hinge, pivots on the conserved Arg(536), and regulates electron

192 Our method pivots on the deployment of a deep operator network (Dee

193 Auxin-regulated transcription pivots on the interaction between the AUXIN/INDOLE-3-ACE

194 Once implanted, embryo survival pivots on the transformation of the endometrium into an

195 ode II there appears to be a definite "point pivot" on the major-groove side of the two base-pairs th

196 pulations that were 1 to 10 km from a center pivot operation.

197 exerted torque during manipulation of freely pivoting or unstable objects.

198 only serve as proof-of-concept but will also pivot our understanding of how to manage/treat TB cases

199 hat V3 can move independently of V2, with V3 pivoting out from its "tucked" position in the trimer wh

200 The F-G-helix cassette pivots over the I-helix in direct response to the size o

201 orter during reentrant propagation (ie, with pivoting) parallel to fibers (10.6 +/- 4.2 mm) compared

202 red with plane wave propagation (ie, without pivoting) parallel to fibers (32.8 +/- 6.5 mm, P < .02),

203 d posteriorly throughout flexion in a medial pivot pattern.

204 The pivot penalty applies nearly universally across science

205 The pivot penalty generalizes across fields, career stage, p

206 urrounding the reactive cysteine SH1 and the pivot point about which the light chain-containing regio

207 uster of Phe residues at the fulcrum of this pivot point allows for dramatic repositioning of the cas

208 helices swing as a single rigid body about a pivot point at the N-terminal end of the F helix, allowi

209 Our findings identify CaMKII as a pivot point between mitochondrial defects and axon degen

210 arrangement is the formation of a molecular pivot point between the two domains as a result of diffe

211 ons, indicating that the V3 base serves as a pivot point during the transition between these two stat

212 e of electrostatic contacts that serves as a pivot point for a TRiC-PFD conformational cycle.

213 state, suggesting that His(232) serves as a pivot point for conformational changes.

214 erms of the role of this residue (G699) as a pivot point for motion of the lever arm.

215 Instead, the pandemic can be a pivot point for societal transformation to value longer

216 nding site, a proline-proline crossover is a pivot point for structural changes associated with trans

217 imately 30 degrees , and tilts sideways at a pivot point formed by a highly conserved hydrophobic reg

218 ated counterclockwise by 30 degrees around a pivot point in an alpha-helix of ARPC4 (Glu(1)-Asn(1)) t

219 testinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC).

220 etry-related histidine residues at a central pivot point in the dimer interface suggests a mechanism

221 The other pivot point is an intersubunit one at which all four TM2

222 We identified a hydrophobic pivot point located at the dimer-dimer assembly interfac

223 e motion of the TM2 segments that includes a pivot point near middle of the helix.

224 Lys42, Ile190, and Gly191 are located at the pivot point of intersubunit conformational changes that

225 ity of nominal scabrolide B as the purported pivot point of the biosynthesis of these polycyclic norc

226 120 degrees relative to the full RSC about a pivot point previously identified as a regulatory hub in

227 port enzyme-PCNA alignments and a kinked DNA pivot point that appear suitable to coordinate rotary ha

228 Rotation is found to occur around a fixed pivot point that is caused by the specific interaction o

229 results suggest that Ser-257 functions as a pivot point, allowing the nicotinamide of NADP(+) to sli

230 between the two domains of RSV CA creates a pivot point, which is central to controlling their relat

231 rmational diffusion time can be considered a pivot point.

232 d the surface and the consequent loss of the pivot point.

233 arget for signaling inputs, resides near the pivot point.

234 terminus of the D1-D2 linker functions as a pivoting point that allows the dynamic movement of the D

235 ion of the CcpA subdomains and relocation of pivot-point residue Thr61, which leads to juxtaposition

236 mber of rigid-body movements (twists) around pivot points (hinges) introduced in the reference protei

237 nal DHQS domains further reveals a series of pivot points about which these movements occur and illus

238 d, based on the selection of two appropriate pivot points along the RNA backbone, P and C4'.

239 n atomic description of the locations of the pivot points and the motional features of key structural

240 Pivot points are short, functionally important, and high

241 the metal surface but also for providing the pivot points needed for repetitive vertical rotation of

242 orrelate with areas of slowed conduction and pivot points of reentrant wavelets.

243 k in the "normal" myocardial zone and at the pivot points to the entrance to the CCP.

244 Two pivot points were found in the motions of the inner TM2

245 glycines flanking the beta strand may act as pivot points, facilitating the conformational changes of

246 it is transmitted to the other via conserved pivot points, where the E and F' helices from two partne

247 ed of four segments, joined by very flexible pivots positioned at alanine 5, 8, and 11.

248 The pivoting positions are typically associated with structu

249 The scientific community pivoted rapidly, providing unique and innovative means t

250 Abrupt changes in loading during wave-front pivoting, rather than membrane ionic properties or fiber

251 etinal Detachment Outcomes Randomized Trial (PIVOT) recruitment criteria.

252 compared with muscle actin in the barbed end pivot region and areas in subdomains 1 and 2 and for F-a

253 were a peptide on top of subdomain 2 and the pivot region between subdomains 1 and 3 with muscle acti

254 dicate the structural importance of the core pivot region that connects the N- and C-subdomains flank

255 at an interface between two subdomains that pivot relative to one another, as revealed by comparison

256 oning of actomyosin contractility and steric pivots required for amoeboid motility of T cells in tiss

257 d that NCT with the mutation of the proposed pivot rescues gamma-secretase activity inNCT-deficient c

258 Choice tasks were selected using a pivoted segmented experimental design to improve task re

259 The Lachman test, pivot shift test and KT-3000 were used to objectively ev

260 We reasoned that wavefronts circling the pivot should broaden the amplitude distribution of bipol

261 in and binds in part to TnC; the core domain pivots significantly; the N-lobe of TnC binds specifical

262 ding stereocilia together is >1000 times the pivot stiffness of stereocilia and that these links can

263 We found that the presence of a sorting pivot, such as the nest wall or an attraction force towa

264 This anchoring site may act as a pivot that amplifies transverse movements of the ErbB2 T

265 while the interlocked structure serves as a pivot that maintains the directionality and selectivity

266 , late in protraction, the intrinsic muscles pivot the vibrissae farther forward.

267 0) to factor Xa in different orientations by pivoting the C-terminal kringle-2/protease domain pair o

268 ithout the steps of stitching image columns, pivoting the light-sheet and sectioning the heart mechan

269 s accomplished by planting the head and then pivoting the trunk.

270 er into the dimeric structures and provide a pivot to allow the monomer-monomer interfaces to change

271 ew markets are limited and by 13-38% under a pivot to Asia strategy.

272 velopmentally essential proto-oncogene, as a pivot to decipher cellular mechanisms in bridging TGFbet

273 esults into health care, and are prepared to pivot to emergency research when needed.

274 opalladium intermediates is revealed to be a pivot to the success of electrooxidative catalysis.

275 As research pivots to a more ecosystem and global change perspective

276 that helix-7 acts as a molecular wedge that pivots to enforce rapid making and breaking of miRNA:tar

277 ng and promoter-less in-vitro transcription (PIVoT) to show that UpxY recognizes a paused RNA polymer

278 the S4-S5 linkers dilate the central pore by pivoting together around a hinge at the base of the pore

279 declines, the focus of malaria management is pivoting toward low-density, subclinical infections and

280 t investment in UHC, especially as countries pivot towards non-communicable disease and injury care.

281 to broader health systems, and donors should pivot towards strategic support, including technical ass

282 In addition, both TARP-y8 and CNIH2 pivot towards the pore exit upon activation, extending t

283 immunodeficiency virus (HIV)-1 infection has pivoted towards long-acting antiretrovirals (LA-ARVs).

284 The criteria of the PIVOT trial can be applied to real-world scenarios in th

285 PIVOT trial participants who had undergone either pneuma

286 e excluded as these had been enrolled in the PIVOT trial, and another 40/482 (8.3%) were excluded due

287 similar results to those encountered in the PIVOT trial.

288 oup) or ongoing triple ART (OT group) in the PIVOT trial.

289 nous Retinal Detachment Outcomes Randomized (PIVOT) trial criteria who were randomly assigned to unde

290 Pivot, twisting, or valgus forces were reported mechanis

291 6.5 mm, P < .02), indicating that wave-front pivoting was primarily responsible for shortening of lam

292 om increased current load experienced by the pivoting wave front.

293 The micro-reentry pivot waves were anchored to the longitudinal block regi

294 y, particularly using the knee as a point of pivot, whereas patients with PD adopted an ankle strateg

295 tilise water in the formation of a molecular pivot which is essential in allowing relative movement o

296 op of Dll4/Notch utilizes Nrp1 levels as the pivot, which in turn establishes differential responsive

297 This temporary pivot will necessitate distance teaching and learning ac

298 henylalanine or tyrosine that functions as a pivot within this network.

299 negatively associated with distance from the pivot zone in simulated spiral waves, rats, and sheep.

300 n bipole was consistently colocated with the pivot zone.