ライフサイエンスコーパス: pivotal

1 lose's structure-mechanics relationships are pivotal.

2 d modulate responses in and between cells is pivotal.

3 ed that 1((I)) reacts with CO(2) to form the pivotal 1((I))-CO intermediate at the 1((II/I)) redox po

4 biofabrication landscape and driven numerous pivotal advancements in tissue engineering and regenerat

5 ownregulating caveolin 1 (CAV1) that plays a pivotal and versatile role in multiple cancer-associated

6 gression, pharmacological disruption of this pivotal axis could serve as the basis for new therapeuti

7 her from the Jurassic Solnhofen has played a pivotal but controversial role in our evolutionary under

8 Autophagy, self-eating, is a pivotal catabolic mechanism that ensures homeostasis and

9 has not yet been performed to delineate the pivotal character of this unusual B cell population.

10 These data suggest that Oplr16 may act as a pivotal chromatin factor to control stem cell fate by mo

11 A second confirmatory pivotal clinical trial is underway to confirm the effica

12 Among pivotal clinical trials linked to contemporary FDA-appro

13 ite the exclusion of bicuspid anatomy in all pivotal clinical trials.

14 quantum dot (QD) synthesis, and they provide pivotal clues in understanding QD growth mechanisms.

15 Dimethylsulfoniopropionate (DMSP) is a pivotal compound in marine biogeochemical cycles and a k

16 proof-of-concept (i.e., Phase II trials) and pivotal, confirmatory (Phase III trials) testing.

17 there has been mounting evidence suggesting pivotal contributions of environmental factors and lifes

18 Interleukin (IL)-4 and IL-13 are both pivotal cytokines involved in the generation of allergic

19 signal transduction pathway, are emerging as pivotal determinants of malignancy in lung cancer.

20 It has been hypothesized that these pivotal dual traits for adaptation to both desiccation a

21 t proliferation, migration, and survival are pivotal during this process.

22 ation in patients with depression, providing pivotal early data for future treatment studies.

23 ly of phosphodiesterase 6 (PDE6), which is a pivotal effector enzyme for phototransduction and vision

24 ional, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16

25 This lncRNA was proven a pivotal element of the epithelial-to-mesenchymal transit

26 Therefore, IFN constitutes a pivotal element within the neuroinflammatory network of

27 o serves as a succinct primer on some of the pivotal epidemiological analyses (and their communicatio

28 ike have long believed that stressors play a pivotal etiologic role in risk, maintenance, and/or rela

29 c valve (AV) stenosis were excluded from the pivotal evaluations of transcatheter AV replacement (TAV

30 nts in HIV-1-infected humanized mice and one pivotal experiment in simian-human immunodeficiency viru

31 T(H)2 cells were thought to be a pivotal factor for initiation of the autoimmune blisteri

32 Epigenetic plasticity is a pivotal factor that drives metastasis.

33 ombinant acid ceramidase ameliorates the two pivotal features of cystic fibrosis lung disease, inflam

34 Pyranylation and glycosylation are pivotal for accessing a myriad of natural products, phar

35 of stimuli occurring in a specific order is pivotal for adipocyte state loss which underlies adipocy

36 tem (T7SS) exports several proteins that are pivotal for bacterial virulence.

37 x nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen inf

38 As CD8 T cell cytotoxicity is pivotal for controlling viral infections and eliminating

39 tical distal proteins of the SPL assembly is pivotal for fast and accurate directing of the compositi

40 mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies.

41 se of Ca(2+) through TRPML1 is thought to be pivotal for maintenance of intravesicular acidic pH as w

42 Sleep is pivotal for memory consolidation.

43 red deep ultraviolet (UV) photodetectors are pivotal for next-generation electronic skins to enrich h

44 lium and the surrounding microenvironment is pivotal for pancreas formation and differentiation as we

45 unication and provision of information seems pivotal for post-intensive care syndrome-family treatmen

46 Cooperation is pivotal for society to flourish.

47 bunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implica

48 hat Myc induction of amino acid transport is pivotal for subsequent bioenergetic and biosynthetic pro

49 beta(2) Integrin activation is pivotal for T cell recruitment and correlates with futur

50 the type and position of the substituent are pivotal for the design of Cy7-based applications.

51 he development of salt-tolerant genotypes is pivotal for the effective utilization of salinized land

52 ial cells lining the conducting airways) are pivotal for the efficacy of intranasally administered fl

53 this class of NW bursting neurons should be pivotal for the encoding and transmission of stimulus in

54 ified the cell-adhesion molecule ELFN2 to be pivotal for the functional wiring of cones with the ON t

55 r findings highlight new mechanisms that are pivotal for the maintenance of immature gametocytes in t

56 nucleotide and ribonucleotide levels that is pivotal for the parasite.

57 Subduction zones are pivotal for the recycling of Earth's outer layer into it

58 ative RNA-based strategy to interfere with a pivotal function of the tumor-related lncRNA HOTAIR, com

59 We previously demonstrated the pivotal functions of the D(1) receptor dDA1 in aversive

60 s >=65 years of age in the HiR (US CoreValve Pivotal High Risk) and SURTAVI trials (Surgical or Trans

61 ings suggest the importance of butyrate as a pivotal HM compound able to protect against FA.

62 /benefit ratio and that are reputed to be of pivotal importance to health.

63 ermediates in the biosynthesis pathway is of pivotal importance.

64 e immunosuppressive adenosine, are therefore pivotal in acute inflammation.

65 acquire a proreparative phenotype, which is pivotal in controlling inflammation and fibrosis.

66 The N38(HA1) glycan thus is pivotal in directing antibody responses by controlling a

67 Podocytes are pivotal in establishing the selective permeability of th

68 he bulky octahydronapthalene substituent was pivotal in fashioning the challenging concave-substitute

69 act of adaptive behavioural responses may be pivotal in making meaningful ecological inferences about

70 ial for the oscillator function but are also pivotal in mediating light inputs to the oscillator.

71 COVID-19 patients or preclinical models are pivotal in providing novel insights into coronavirus-hos

72 SIRT1, a NAD(+)-dependent deacetylase, is pivotal in regulating hepatic gene expression and has em

73 tion of developmental signals themselves, is pivotal in setting developmental responses in both plant

74 also generated new knowledge, which could be pivotal in the design of novel devices.

75 rom lineages outside of Insecta will provide pivotal information to resolve this conundrum.

76 r results underscore immune homeostasis as a pivotal interventional target against clock-related diso

77 ganized to perform their functions remains a pivotal issue in biological and chemical science.

78 The MEKK1 protein is a pivotal kinase activator of responses to cellular stress

79 n humans and nonhuman primates, suggesting a pivotal link between sensorimotor control and temporal p

80 These data demonstrate a pivotal mechanism in the immunometabolic regulation of m

81 of GlyRs containing the alpha3 subunit is a pivotal mechanism of pain hypersensitivity.

82 e D1 receptors in the dentate gyrus act as a pivotal mediator of antidepressant actions in mice.

83 The tool can identify pivotal miRNAs or mRNAs that contribute to the complexit

84 Steroid hormones are pivotal modulators of pathophysiological processes in ma

85 e long-term findings and final analysis of a pivotal multicenter trial of ibrutinib monotherapy in pr

86 Pivotal mutations conferring loss-of-glycosylation, and

87 These efforts have provided pivotal new insights into the diverse molecular mechanis

88 The pivotal one involves a resolution, through the quinine-

89 This pivotal open-label, phase 2, single-arm trial was done a

90 However, a large pivotal outcome trial found that the ESA darbepoetin alf

91 f ExsD and the ExsA beta barrel constitute a pivotal part of the ExsD-ExsA interface.

92 that the liver-heart inflammatory axis has a pivotal pathophysiological role in the development of he

93 ped (68)Ga-PSMA-11 by conducting a bicentric pivotal phase 3 clinical trial for PET imaging for prost

94 Further investigation in a pivotal phase 3 trial is underway.

95 A pivotal phase II and a confirmatory phase III study are

96 stige, and social learning, pride provides a pivotal piece of the puzzle.

97 eceptor antagonist (IL-1Ra) has emerged as a pivotal player in the defense against periodontitis.

98 Neutrophils are pivotal players in immune defence which includes a proce

99 the PD pathologies by upregulating these two pivotal players, in addition to escalating delta-secreta

100 A pivotal problem in NGS based small RNA analysis is ident

101 this endogenous factor causes emphysema; its pivotal protective function is suggested by its ability

102 Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all

103 Graded transcription factors are pivotal regulators of embryonic patterning, but whether

104 Foxp3+ regulatory T (T reg) cells are pivotal regulators of immune tolerance, with T cell rece

105 Taken together, our results indicate a pivotal regulatory role for the SphK1/S1P axis in mainta

106 integrity of the immune system represents a pivotal risk factor and prognostic biomarker for Merkel

107 essed acetyl-lysine reader proteins, plays a pivotal role as a coactivator of enhancer signaling acro

108 kappaB kinase 2 (IKK2) is well known for its pivotal role as a mediator of the canonical NF-kappaB pa

109 Retinoid X receptor (RXR) plays a pivotal role as a transcriptional regulator and serves a

110 he Drosophila melanogaster model to reveal a pivotal role for basement membrane composition in the fo

111 Our results suggest a pivotal role for complement activation in BD-induced ren

112 Here we demonstrate a pivotal role for E2F1, a cell cycle regulatory transcrip

113 Mechanistically, we show a pivotal role for ESRRB in regulating the activity of ESC

114 Our results reveal a pivotal role for ETO2 in erythropoiesis and globin gene

115 These findings indicate a pivotal role for LDH in modulating cytokine-mediated T c

116 ngle-neuron recordings in monkeys suggests a pivotal role for the prefrontal cortex in the representa

117 Our data suggest a pivotal role for the VP in computing teaching signals th

118 ance of forests in the carbon cycle, and the pivotal role for wood decay, accurate ecosystem projecti

119 Nanoconfined water plays a pivotal role in a vast number of fields ranging from bio

120 ctive and efficient electrocatalysts plays a pivotal role in advancing the development of electrochem

121 thene in addition to dioxane, unraveling its pivotal role in aerobic biostimulation that utilizes pro

122 Basophils play a pivotal role in allergic inflammation.

123 Gene-environment interactions have a pivotal role in ASD pathogenesis.

124 Oceanic oxygen minimum zones (OMZs) play a pivotal role in biogeochemical cycles due to extensive m

125 ynamics of mitochondria in live cells play a pivotal role in biological events such as cell metabolis

126 Lipids play a pivotal role in biological processes and lipid analysis

127 The HLA system plays a pivotal role in both clinical applications and immunolog

128 pomethylation of promoters of lncRNAs play a pivotal role in cancer progression, suggesting the impor

129 RNA-protein interactions play a pivotal role in cell homeostasis and disease, but curren

130 Solvation plays a pivotal role in chemistry and biology.

131 Despite VKOR's pivotal role in coagulation, its structure and active si

132 parasites on ecosystem engineers given their pivotal role in communities.

133 ough the immune response is likely to play a pivotal role in controlling Kaposi sarcoma (KS)-associat

134 Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral bl

135 es with the host innate immune system play a pivotal role in determining virus host range and virulen

136 ndicate that D(1)R - H(3)R heteromers play a pivotal role in dopamine signaling and represent novel t

137 hat genome-wide enhancer remodeling played a pivotal role in driving therapeutic resistance via compe

138 primordial pathways of metabolism, playing a pivotal role in energy metabolism and biosynthesis.

139 Electrostatic interactions play a pivotal role in enzymatic catalysis and are increasingly

140 The hippocampus is likely to play pivotal role in generating these effects: it undergoes s

141 In plants, RNA interference (RNAi) plays a pivotal role in growth and development, and responses to

142 Despite its pivotal role in homeostasis, regeneration and cancer, li

143 ngs suggest that TEMRA CD8(+) T cells play a pivotal role in humoral and cellular rejection and revea

144 Although NF-kappaB is known to play a pivotal role in lung cancer, contributing to tumor growt

145 ajor degradation pathways, autophagy plays a pivotal role in maintaining effective turnover of protei

146 se model, the data reveals that TET2 plays a pivotal role in mammary gland development and luminal li

147 /or protein level, have been shown to play a pivotal role in many biological contexts.

148 Reactive oxygen species (ROS) play a pivotal role in many cellular processes and can be eithe

149 ) is a key enzyme of coronaviruses and has a pivotal role in mediating viral replication and transcri

150 C (PKC), and AMPA receptor genes that play a pivotal role in memory function, were down-regulated in

151 ein homolog (PfRh) family of proteins play a pivotal role in merozoite invasion and hence are importa

152 Among the core histones, H3 variants play a pivotal role in modulating nucleosome structure and func

153 he endocochlear potential, thereby playing a pivotal role in normal hearing.

154 y in fronto-parietal brain areas that play a pivotal role in oculomotor control, such as the lateral

155 Astrocytic TIMP-1 was demonstrated to play a pivotal role in OSM-mediated remyelination.

156 Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remo

157 iological cargo, including RNA, that plays a pivotal role in physiological and pathological processes

158 Phytoalexins play a pivotal role in plant-pathogen interactions.

159 individual reproductive strategies, played a pivotal role in population dynamics, leading to the form

160 CPC plays a pivotal role in preventing chromosome misalignment.

161 of their cognate tRNAs and therefore play a pivotal role in protein synthesis.

162 mine D1 receptor-expressing neurons exerts a pivotal role in psychostimulant-induced neuronal gene re

163 d messenger in endothelial cells and plays a pivotal role in regulating a number of physiologic proce

164 a long non-coding RNA (lncRNA) that plays a pivotal role in regulating myeloid cell development via

165 subunit (SSU) mRNA entry channel and plays a pivotal role in ribosome loading onto the mRNA.

166 Acetylcholine in the striatum plays a pivotal role in such adaptation, and its release has bee

167 tor alpha (RORalpha) phosphorylation plays a pivotal role in sulfotransferase 1E1 gene regulation wit

168 Regulatory T (Treg) cells play a pivotal role in suppressing auto-reactive T cells and ma

169 sh, chemically unaltered bedrock and plays a pivotal role in sustaining life.

170 The high-density corneal innervation plays a pivotal role in sustaining the integrity of the ocular s

171 Metabolomics plays a pivotal role in systems biology, and NMR is a central to

172 oft membrane matter (lipids and water) has a pivotal role in the catalytic G-protein cycle.

173 ructure of sea connections, highlighting its pivotal role in the development of maritime trade.

174 Dysregulation of this protein plays a pivotal role in the development of various solid and hae

175 MRI, particularly brain MRI, has a pivotal role in the early diagnosis of CNS complications

176 two blended polymer components, that plays a pivotal role in the electrical nature of the resulting m

177 pike-ACE2 interface, which may have played a pivotal role in the emergence of SARS-CoV-2 in humans.

178 Multimodality imaging plays a pivotal role in the evaluation and management of infecti

179 Neuronal cadherin (NCAD) plays a pivotal role in the formation of synapses and dendritic

180 findings also demonstrate that RUNX3 plays a pivotal role in the inhibition of apoptosis found in the

181 TNF-alpha plays a pivotal role in the LPS-upregulated astrocyte activation

182 Its protein product plays a pivotal role in the maintenance of genome integrity.

183 In summary, YAP plays a pivotal role in the maintenance of the human placental t

184 lated cytokine expression by T cells plays a pivotal role in the pathogenesis of autoimmune diseases.

185 Inflammation has a pivotal role in the pathogenesis of CVD.

186 The complement system plays a pivotal role in the pathogenesis of ischemia-reperfusion

187 n I and metabolized by ACE 2 (ACE2), plays a pivotal role in the pathogenesis of lung injury.

188 ctor (HIF) signaling plays a fundamental and pivotal role in the pathogenesis of PH.

189 the development of Mtb vaccines could play a pivotal role in the prevention and control of this devas

190 Cardiac imaging has a pivotal role in the prevention, diagnosis and treatment

191 receptor accessory protein 2 (MRAP2) plays a pivotal role in the regulation of several G protein-coup

192 ations demonstrate that these neurons play a pivotal role in the regulation of thirst stimulated by N

193 Voltage-gated Ca(2+) channels play a pivotal role in this process as they are the major condu

194 that potentiates receptor activity, plays a pivotal role in this process.

195 Endothelial Tie2 signaling plays a pivotal role in vascular barrier maintenance at baseline

196 alently due to the atherothrombosis, where a pivotal role is played by platelet activation, it would

197 The pivotal role of calcitonin gene-related peptide (CGRP) i

198 Our findings suggest a pivotal role of caspase 3 signaling in mediating spine i

199 dict the risk of asthma - which suggests the pivotal role of cell-cell junction in the pathological c

200 lusion, we provide a mechanistic basis for a pivotal role of complement and NETs in COVID-19 immunoth

201 erefore provide an updated discussion of the pivotal role of coronary computed tomography angiography

202 Despite the pivotal role of fungi in plant adaptation, it remains un

203 We discuss the growing evidence of the pivotal role of horizontal virus transfer from invertebr

204 We showed the pivotal role of ionization centers in the formation of s

205 se with high meibum delivery, indicating the pivotal role of meibum secretion in ocular surface healt

206 d spectroscopic techniques, and discovered a pivotal role of P450-P450 interactions and of multiple-l

207 Our findings demonstrate the pivotal role of PERK in tumor-MDSC functionality and unv

208 Our results suggest a pivotal role of plant ontogeny in driving not only the e

209 Our study identifies a pivotal role of S. epidermidis in healthy maturation of

210 These experiments provide evidence for a pivotal role of the C5a/C5aR1 axis in propagating renal

211 Prnp180Q/196Q and WT mice, underscoring the pivotal role of the GPI-anchor in driving the aggregate

212 This study underlines the pivotal role of the Nrf2 regulatory network in the conte

213 Our results underpin the pivotal role of the physicomechanical properties of LCGs

214 Considering the pivotal role of the twilight zone is therefore essential

215 Here we characterized the pivotal role of the versatile cytokine macrophage migrat

216 sac and the primate embryo and highlight the pivotal role of the yolk sac as a multifunctional hub fo

217 New investigations have demonstrated the pivotal role of these molecules in modulating white and

218 Our findings demonstrate a unique and pivotal role of TPR in gene expression through TREX-2- a

219 omplex with the inhibitor, demonstrating the pivotal role of Y203 through a pai-pai stacking interact

220 ag)) and entropy arguments, we report on the pivotal role played by the mutual interactions in the re

221 Despite this pivotal role, standardization of preclinical PET/CT prot

222 in, an evolutionary conserved protein, plays pivotal roles during lipid droplet (LD) biogenesis and i

223 (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intesti

224 the innate and adaptive immune systems, with pivotal roles for pro-inflammatory cytokines such as tum

225 mTORC1, suggesting that AcCoA and EP300 play pivotal roles in cell anabolism and catabolism.

226 Distal enhancers play pivotal roles in development and disease yet remain one

227 Nuclear size plays pivotal roles in gene expression, embryo development, an

228 Cutaneous somatosensory modalities play pivotal roles in generating a wide range of sensorimotor

229 broblast growth factor (FGF) signaling plays pivotal roles in generating and maintaining NPCs during

230 tify age-associated B cells as a subset with pivotal roles in immunological health, disease, and agin

231 These results indicate that Npr1 has pivotal roles in inhibiting renal fibrosis and hypertrop

232 bHLH-family transcription factors that play pivotal roles in modulating plant growth and development

233 s-which are abundant in polar soils and have pivotal roles in nutrient cycling-typically being close

234 They are known to play pivotal roles in regulating gene expression, especially

235 the nuclear hormone receptor family, playing pivotal roles in regulating glucose and lipid metabolism

236 ta indicate that T cell-specific miRNAs play pivotal roles in regulating lifespan through their influ

237 ls, used at both short and long ranges, play pivotal roles in regulating the behavior of conspecifics

238 (3)Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns

239 d on myeloid cells 2 (TREM2) signaling plays pivotal roles in regulating these functions and loss of

240 Golgi organization 1 (TANGO1) proteins play pivotal roles in the secretory pathway.

241 family of PX domain-containing proteins with pivotal roles in trafficking and signaling.

242 ion between proteins and nucleic acids plays pivotal roles in various biological processes such as tr

243 sociated glycans of pathogenic bacteria, has pivotal roles in virulence.

244 Our findings demonstrate the pivotal roles of local cardiac myocyte metabolism and K(

245 expression, providing new insights into the pivotal roles of PIFs as signal integrators in regulatin

246 ristic for a given subgroup play subtle, but pivotal, roles in guaranteeing that the correct interfac

247 erformed to verify the expression pattern of pivotal S. spontaneum MADS-box genes and suggested that

248 ioned to play instrumental roles in numerous pivotal scientific studies without the need for event re

249 SPYRAL Pivotal showed the superiority of catheter-based renal d

250 ne phosphatase SHP2 controls the activity of pivotal signaling pathways, including MAPK, JAK-STAT, an

251 Despite the pivotal significance of this enzymatic transformation, a

252 the glandular trichomes of N. tabacum are of pivotal significance to be undertaken.

253 es access to both natural products through a pivotal spirolactam intermediate (3), which can be acces

254 ic steatohepatitis (NASH) is considered as a pivotal stage in nonalcoholic fatty liver disease (NAFLD

255 he developing brain.SIGNIFICANCE STATEMENT A pivotal step for establishing appropriate excitatory-inh

256 Our previous studies discovered that a pivotal step in the disease process is the activation of

257 uction of tissue factor (TF) on monocytes, a pivotal step in the initiation, localization, and propag

258 Pivotal study design differences between experimental st

259 d security has been globally recognized as a pivotal sustainability challenge in the UN Sustainable D

260 Fluorescent barcoding is a pivotal technique for the investigation of the microscal

261 that considering environmental variables is pivotal to assess the fitness consequences of parental s

262 g N-methyl-D-aspartate receptors (NMDARs) is pivotal to brain development and function.

263 The chloroplast has recently emerged as pivotal to co-ordinating plant defence responses and as

264 We discovered that PEBP1 is pivotal to driving dynamic interactions with both profer

265 abit formation has been recently proposed as pivotal to eating disorders.

266 ntrol of hepatic glucose production (HGP) is pivotal to maintain systemic glucose homeostasis.

267 eractions within the conserved motif LXXXXD, pivotal to the binding specificity of BH3 domains of pro

268 a (TGFbeta), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibro

269 novel system, we establish CD11c(+) cells as pivotal to the establishment of acute antiviral CD8 T ce

270 This group appears pivotal to the subsequent evolutionary history of forest

271 The proteasome is pivotal to the timely removal of abnormal proteins but i

272 causes of inherited skin disorders has been pivotal to the understanding of epidermal differentiatio

273 NA sequencing pinpointed immune cell subsets pivotal to these responses, implicating CD14(+) monocyte

274 olution of individual regulatory elements is pivotal to understand the tempo and mode of gene express

275 g neuronal activity during human seizures is pivotal to understanding mechanisms of seizure onset and

276 sing neuronal involvement in ictal events is pivotal to understanding seizure dynamics and in definin

277 sregulation of STAT3, a transcription factor pivotal to various cellular processes including Th17 cel

278 suggests a dysfunctional immune synapse as a pivotal tolerogenic mechanism.

279 For decades, it has been a pivotal tool in elucidating the unique polar auxin trans

280 epertoire of oxidized cysteine residues, are pivotal towards a better understanding of the protein re

281 Here we show that C/EBPbeta acts as a pivotal transcription factor for APOE and mediates its m

282 rmore, in the absence of four SPA genes, the pivotal transcription factor PIF4 fails to accumulate, i

283 s that impacts the estrogen receptor (ER), a pivotal transcriptional regulator in health and disease.

284 The results of this pivotal trial highlight the benefits of disease-specific

285 for acute pain were supported by at least 1 pivotal trial; the pivotal trials (n = 19) had a median

286 e IV Iron Therapy in Haemodialysis Patients (PIVOTAL) trial randomized 2141 patients undergoing maint

287 pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the efficacy of re

288 e supported by at least 1 pivotal trial; the pivotal trials (n = 19) had a median duration of 1 day (

289 ion of new approvals supported by at least 2 pivotal trials decreased from 80.6% in 1995-1997 to 52.8

290 e higher than the rates reported in previous pivotal trials done in advanced melanoma with measurable

291 d protocol in this study were similar to the pivotal trials of aflibercept for CMO secondary to CRVO,

292 Pivotal trials of beta-blockers (BB) and angiotensin con

293 18, the FDA approved opioids on the basis of pivotal trials of short or intermediate duration, often

294 her CVD events were consistently reported in pivotal trials supporting contemporary anticancer drugs

295 FrEF by making indirect comparisons of three pivotal trials, EMPHASIS-HF (n=2737), PARADIGM-HF (n=839

296 nalysis combines evidence from the pilot and Pivotal trials.

297 ore comorbidities than those enrolled in the pivotal trials; however, major in-hospital adverse event

298 including the number, size, and duration of pivotal trials; trial control groups; the use of enriche

299 The type III secretion system (T3SS) is a pivotal virulence mechanism of many Gram-negative bacter

300 le to modulate the methylation status of the pivotal VSMC gene myosin heavy chain 11 (Myh11).