ライフサイエンスコーパス: placenta

1 f the trophoblast, the tissue that forms the placenta.

2 phy of the fetal blood vessel network in the placenta.

3 otect endothelial function in the mother and placenta.

4 rivileged sites such as the testes, eye, and placenta.

5 2-specific antibodies transferred across the placenta.

6 y of additional effects on the mother and/or placenta.

7 soluble CORIN in preeclampsia originate from placenta.

8 stasis modulator (CALHM) family in the human placenta.

9 cells at the materno-fetal interface of the placenta.

10 y increased FPN in the liver, but not in the placenta.

11 lso detected endogenously in mouse and human placenta.

12 (CTB) progenitors of a first-trimester human placenta.

13 sult from direct actions on the fetus and/or placenta.

14 fter accounting for iron retained within the placenta.

15 ng biotin transporter activity in the murine placenta.

16 t trophoblast populations in first trimester placenta.

17 ta, and between a neonate and its associated placenta.

18 l type-specific signatures discovered in the placenta.

19 y useful early epigenetic markers for ASD in placenta.

20 constrictor effects of taurocholate in human placenta.

21 s ordinarily expressed at high levels in the placenta.

22 odies are not transferred equally across the placenta.

23 rmation of the maternofetal interface of the placenta.

24 uting to pathogenesis, and seeding the human placenta.

25 species (ROS) and impaired formation of the placenta.

26 lity of the offspring via alterations in the placenta.

27 vered by single-cell genomics studies of the placenta.

28 cells to chondroitin sulfate A (CSA) in the placenta.

29 having equivalent microbial loads within the placenta.

30 independent of effects on the mother and/or placenta.

31 the most highly polyploid cell types of the placenta.

32 equate iron availability for transfer across placenta.

33 delivery, and chemical diffusion through the placenta.

34 0 in the myometrium; and Il1b and Il6 in the placenta.

35 omorphologic analysis was performed for each placenta.

36 nsferred to the fetus or retained within the placenta.

37 k of vertical transmission of IAV across the placenta.

38 additional effects on the mother and/or the placenta.

39 with a reduced number of T(reg) cells in the placenta.

40 s containing the cytotoxic drug to cross the placenta.

41 ependent of effects on the mother and/or the placenta.

42 r complement deposition has been observed on placentas.

43 rther increased in villitis vs. non-villitis placentas.

44 vels in either normotensive or pre-eclamptic placentas.

45 unctional and/or labyrinthine zones in E12.5 placentas.

46 imprinted and maternally expressed in mouse placentas.

47 reased percent of methylation in miscarriage placentas.

48 influence of male traits on the evolution of placentas.

49 icantly higher in term human IUGR vs. normal placentas.

50 tivity was increased in BPA- and BPS-exposed placentas.

51 resulting in increased permeability of human placentas.

52 vels in either normotensive or pre-eclamptic placentas.

53 nstable in placental homogenates from normal placentas.

54 the outer trophectoderm layer that forms the placenta(1).

55 ed from human blastocysts or first-trimester placentas(7).

56 Background Prenatal identification of placenta accreta spectrum (PAS) disorder is essential fo

57 Overly deep invasion, the hallmark of placenta accreta spectrum (PAS), increases the risk of p

58 add to the growing body of evidence that the placenta acts as a peripheral clock, which may provide a

59 in maternal serum than in the fetal liver or placenta after lipid-adjustment (p < 0.001).

60 Placenta, amniotic fluid, and fetal tissues were ZIKV RN

61 e, 2% of recovered tracer was present in the placenta and 6% was found in the newborn.

62 ence for functional interactions between the placenta and brain in pregnant mice.

63 expressed by gestational tissues (e.g., the placenta and chorioamniotic membranes) during normal pre

64 maternal iron restriction and anemia, lower placenta and embryo weight, embryo anemia, and increased

65 y pregnant uterus, containing the primordial placenta and embryo.

66 rrection, the signals were averaged over the placenta and fetal brain and converted to the change in

67 ternal hyperoxia on blood oxygenation of the placenta and fetal brain were examined by using blood ox

68 by all vaccines, breakthrough seeding of the placenta and fetal head was observed in a small subset o

69 g Listeria monocytogenes colonization of the placenta and fetus and that this protection is due to bo

70 tion affected innate immune cells within the placenta and fetus and whether these cells influenced vi

71 rnal homeostatic mechanisms that protect the placenta and fetus from maternal iron excess.

72 n status affects the delivery of iron to the placenta and fetus.

73 likely suppresses critical blood flow to the placenta and fetus.

74 k of PTB and causes epigenetic change in the placenta and fetus; therefore, we utilized these patient

75 his study were to examine PFAS levels in the placenta and identify sociodemographic risk factors in a

76 el to examine the effects of imatinib on the placenta and implantation after long-term imatinib expos

77 or other atypical chemokine receptors in the placenta and indicate that defects in such receptors may

78 he ability of Zika virus (ZIKV) to cross the placenta and infect the fetus is a key mechanism by whic

79 e animals, C. burnetii shows tropism for the placenta and is associated with late-term abortion, at w

80 ~1300-fold higher than LIN28A in human term placenta and is the predominant paralog expressed in pri

81 position and transcriptional activity of the placenta and its compartments during physiologic and pat

82 potential mediators of crosstalk between the placenta and maternal brain and fetal brain, respectivel

83 Unlike insulin, such drugs cross the placenta and may thus have independent effects on fetal

84 weight, placenta histoarchitecture, and the placenta and metrial gland transcriptome were observed b

85 e associated with T-cell infiltration of the placenta and placental pathological abnormalities.

86 the transcription of viral RNA in the human placenta and predisposes the mother to pre-eclampsia.

87 its metabolites were transported across the placenta and reached the brain of offspring.

88 How the virus crosses the placenta and the role of the immune response in this pro

89 on, the 'utero-placental pump', by which the placenta and underlying uterine wall contract independen

90 Placentas and lung tissue were collected at birth for mo

91 xidative stress are features of preeclamptic placentas and preeclampsia with FGR.

92 ed AMPK activation in the uterine artery and placenta, and AICAR increased AMPK activation in these t

93 accumulation of natural T(reg) cells in the placenta, and an increase in the number of miscarriages.

94 ic pair, between portions of a monochorionic placenta, and between a neonate and its associated place

95 involvement of FeNOs in both mouse and human placenta, and call for their further study as a critical

96 he largest sample of matched maternal serum, placenta, and fetal liver tissues during mid-gestation a

97 Chorioamnionitis, inflammation of the placenta, and fetal membranes (FMs) are commonly observe

98 ne glands impact development of the decidua, placenta, and fetus.

99 ill present, transcriptionally active in the placenta, and fusogenic.

100 roughout gestation, concomitant with smaller placentas, and altered placental structure at midgestati

101 stable in placental homogenates from normal placentas, and that NO, nitrite and nitrosothiols react

102 reech presentation; placenta previa/abruptio placenta/ante-partum haemorrhage; multiple birth; pre-de

103 Leaving aside placenta previa/abuptio placenta/ante-partum hemorrhage, further significant fac

104 ical significance): placenta previa/abruptio placenta/ antepartum hemorrage; non-reassuring fetal sta

105 GLL1 as a member of a unique group of cancer-placenta antigens (CPA) that may constitute immunotherap

106 lf-life; however, adverse effects toward the placenta appear to have compound-specific signatures.

107 the only effective treatments for a retained placenta are the surgical procedures of manual removal o

108 s, currently a large proportion of delivered placentas are discarded without inspection.

109 r agonists (Tpo-RAs), which likely cross the placenta, are not recommended during pregnancy.

110 placenta units, with a specific focus on the placenta as a hypothesized target.

111 ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic me

112 ression levels of LIGHT were increased in HM placentas as compared with controls, and LIGHT and sFlt-

113 The placenta, as a mediator of the maternal and fetal system

114 n of the vasculature structure in the entire placenta, as well as detecting placental defects in path

115 comes, with a subset sacrificed at E19.5 for placenta assessment via immunohistochemistry and qPCR.

116 erentiation models, and in single cells from placentas at different stages of pregnancy.

117 Why then should placentas be less reliable organs than hearts or kidneys

118 se 2 gene (Acer2) is highly expressed in the placenta between embryonic day (E) 9.5 and E12.5.

119 safe and adequate blood supply and a villous placenta-blood interface from which nutrients and oxygen

120 These chemicals cross the placenta, but no studies have examined their association

121 fter a child is born, the examination of the placenta by a pathologist for abnormalities, such as inf

122 Thus, invasion of the placenta by intracellular parasites puts the maternal im

123 e cell types of a representative hemochorial placenta by performing single nuclei RNA sequencing (snR

124 edly more inert bisphenol S (BPS) affect the placenta, C57BL6J mouse dams were fed 200 mug/kg body we

125 pregnancy, proinflammatory responses in the placenta can cause severe fetal complications, including

126 As an immune-privileged organ, the placenta can tolerate the introduction of antigens witho

127 lation significantly differs between the two placenta cohorts, with most CpG sites showing increased

128 IgE crossed the placenta, dependent on the fetal neonatal Fc receptor (F

129 nderlying the immunoregulatory activities of placenta-derived human amnion epithelial cells (hAEC).

130 During infection of placenta-derived JEG-3 cells, C. burnetii showed sensiti

131 including "in utero embryonic development," "placenta development," and "regulation of transcription.

132 une cells facilitate embryo implantation and placenta development.

133 acrophage and neutrophil infiltration in the placenta did not differ between healthy and complicated

134 It remains unclear how a small but normal placenta differs from the small FGR placenta in terms of

135 C cistron microRNA, in first trimester human placentas displayed strong expression in villous trophob

136 domization analyses revealed five loci where placenta DNA methylation may causally influence maternal

137 adverse pregnancy outcome and that the human placenta does not have a microbiome, but it does represe

138 II(hi) phenotype that normally occurs in the placenta during high-burden infections.

139 t transport and endocrine zones of the mouse placenta during normal pregnancy and maternal inhalation

140 e 19 (C19MC) is exclusively expressed in the placenta, embryonic stem cells and certain cancers howev

141 sports IgG across barriers, for example, the placenta, enhancing fetal humoral immunity to levels sim

142 ferroptosis signaling in the human and mouse placenta, established a role for PLA2G6 in attenuating t

143 advances an adaptive explanation for why the placenta evolves by arguing that an increased degree of

144 Theory proposes that the placenta evolves in response to high performance-demandi

145 agic but not non-hemorrhagic Acer2-deficient placentas exhibit an expansion of parietal trophoblast g

146 ed that 70% of samples with HHV-6 RNA in the placenta exhibited inherited, chromosomally integrated H

147 n treatment increased PL expression in human placenta explants and JEG3 trophoblast cells.

148 were significantly induced in ZIKV-infected placenta explants.

149 At delivery, we collected samples from placenta (fetal side) and measured DNA methylation using

150 quantified endogenous NOx in human and mouse placenta following determination of the stability of exo

151 In total, 1,107 women with retained placenta following vaginal delivery were recruited.

152 d placental abruption.METHODSWe analyzed the placenta for the presence of severe acute respiratory sy

153 enhance the delivery of therapeutics to the placenta for the treatment of diseases of pregnancy.

154 ntributes to trophoblast differentiation and placenta formation.

155 ression of the shared gene signatures in the placenta from an independent study of preeclampsia cases

156 wever, many alterations are also observed in placenta from uncomplicated pregnancies.

157 Placentas from 134 pregnant women were examined after de

158 re, we performed whole methylome analyses of placentas from a prospective study MARBLES (Markers of A

159 E19.5 placentas from Delta9-THC-exposed pregnancies exhibited

160 Importantly, analysis in euploid placentas from first trimester pregnancy loss reveals th

161 Volume fraction of T-cells increased in placentas from pregnancies complicated by pre-eclampsia

162 In human placentas from pregnancies with mild iron deficiency, TF

163 investigated genome-wide DNA methylation in placentas from term IVF, preterm IVF, term control (unas

164 re increased in fetal growth restriction vs. placentas from women with normal pregnancies, particular

165 ntal villous tissue are increased in FGR vs. placentas from women with normal pregnancies, particular

166 Placentas from women with type 1 (n = 13), type 2 (n = 6

167 In this study, we examined preterm and term placentas, from unassisted conceptions and those conceiv

168 biomarkers fms-related tyrosine kinase 1 and placenta growth factor, and glomerular atrophy; urinary

169 capitulates the unique features of the human placenta has been challenging.

170 te the existence of a cross talk between the placenta (hCG) and the decidua (CXCL10) in the control o

171 case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidit

172 Sex-dependent differences in fetal weight, placenta histoarchitecture, and the placenta and metrial

173 to be upregulated in singleton preeclamptic placentas; however, this appears to be a female infant s

174 We identified 12 known placenta imprinted genes, including KCNQ1 Mendelian rand

175 ulation of mitochondrial biogenesis in human placenta in a fetal sex-dependent manner, including decr

176 independent of effects on the mother and the placenta in adverse development.

177 iation in the anatomy and development of the placenta in different species, meaning that animal model

178 lopment, although their transport across the placenta in IUGR pregnancies is poorly understood.

179 The importance of the placenta in supporting mammalian development has long be

180 t normal placenta differs from the small FGR placenta in terms of ability to transfer nutrients to th

181 e of antiangiogenic proteins released by the placenta in the development of pre-eclampsia and review

182 new insights into the function of the human placenta in utero.

183 low net flow and high net oxygenation in the placenta in vivo, which are consistent with efficient de

184 scordance between dichorionic twins, between placentas in a dichorionic pair, between portions of a m

185 etween the trophoblast organoids and in vivo placentas in their transcriptomes and ability to produce

186 cy, the Zika flavivirus (ZIKV) infects human placentas, inducing defects in the developing fetus.

187 In the placenta, inductive perforin-2 expression in decidual ma

188 horing villous explants from first-trimester placentas infected with ZIKV ex vivo.

189 tiated in a highly regular pattern along the placenta inside the gynoecia of flowering plants.

190 e 341 proteins significantly secreted by the placenta into the fetal circulation.

191 proteins were significantly secreted by the placenta into the maternal circulation, including placen

192 The placenta is a complex life-history trait that is ubiquit

193 circulating factors of fetal origin from the placenta is a hallmark of pre-eclampsia.

194 Placenta is a naturally senescent tissue; we demonstrate

195 al and pathological studies suggest that the placenta is central to the pathogenesis of this syndrome

196 A fully functional placenta is critical for a successful pregnancy.

197 The human placenta is essential for successful reproduction.

198 The transport of substances across the placenta is essential for the development of the fetus.

199 We conclude that bacterial infection of the placenta is not a common cause of adverse pregnancy outc

200 Our findings also suggest that FPN in the placenta is not actively regulated by fetal liver HAMP u

201 The placenta is susceptible to activation of the unfolded pr

202 The placenta is the interface between mother and fetus in al

203 f Hyaenidae among carnivorans.IMPORTANCE The placenta is the most diverse organ among mammals, due in

204 ltration of maternal CD8(+) T cells into the placenta, is hypothesized to be secondary to either a ti

205 no difference between study arms in terms of placenta malaria after adjusting for birth season, parit

206 man placental tissue to evaluate whether the placenta may be influenced by seasonal cues.

207 nce and oxidative stress in the preeclamptic placenta may be prevented by improving mitochondrial fun

208 tivation of non-canonical NF-kappaB in human placenta may play a critical role in processes of term o

209 that Caudal-type homeobox-2 (Cdx2) cells in placenta may represent a novel cell type for cardiac reg

210 The placenta mediates nutrient delivery to fetuses and its f

211 These data show that the placenta minimally expresses the canonical cell-entry me

212 the surgical procedures of manual removal of placenta (MROP) and uterine curettage, which are not uni

213 NPFF receptor 2 (NPFFR2) mRNA is highest in placenta, nothing is known about NPFF-NPFFR2 functions i

214 aired mitochondrial biogenesis in male human placenta of diabetic mothers.

215 ndance of IGF2 protein also decreased in the placenta of males only (-95%).

216 We found myeloid cells were elevated in the placenta of pregnant ZIKV-infected Rag1(-/-) mice treate

217 ouse PL genes were robustly decreased in the placentas of Adipoq (-/-) dams.

218 ETC protein expression is down-regulated in placentas of infants with intrauterine growth restrictio

219 g evidence of mitochondrial UPR (UPR(mt)) in placentas of PE < 34 wk patients.

220 nd adenosine A(2B) receptor (ADORA2B) in the placentas of PE mouse models induced by AT(1) -AA or LIG

221 antly improved in the context of a wild-type placenta or by genetically restricting cytokine signalin

222 ontributions of the challenge on the mother, placenta or offspring are difficult to disentangle.

223 e intrinsic to the maternal environment, the placenta or the interaction between the two.

224 n antibodies are delivered either across the placenta or through breast milk.

225 ce and low-grade inflammation in the mother, placenta, or fetus (or a combination of the 3) in pregna

226 membrane (AM) isolated from regions over the placenta (PAM) or cervix (CAM) and examined the effect o

227 The placenta participates in maternal insulin sensitivity ch

228 IVFs of 3 mm or greater were associated with placenta percreta (AUC, 0.81; 95% CI: 0.73, 0.89; P < .0

229 iameter of 3 mm or greater was predictive of placenta percreta and peripartum complications.

230 ability of IFV diameter to help predict PAS, placenta percreta, and peripartum complications and for

231 The placenta performs crucial physiological functions to ens

232 hat monocyte/macrophage myeloid cells in the placenta play a significant role in inhibiting ZIKV VTx

233 clampsia (aOR: 1.5; 95% CI: 1.3 to 1.7), and placenta previa (aOR: 1.5; 95% CI: 1.2 to 1.8).

234 scending order of statistical significance): placenta previa/abruptio placenta/ antepartum hemorrage;

235 tistical significance): breech presentation; placenta previa/abruptio placenta/ante-partum haemorrhag

236 Leaving aside placenta previa/abuptio placenta/ante-partum hemorrhage,

237 emness of trophoblast progenitors within the placenta primordium.

238 eight ratio (IBR) < 5th centile] had lighter placentas, reduced initial rate uptake of (14)C-glutamin

239 ion of an HFD results in vascular changes in placenta reflected by alterations in expression of pivot

240 y of essential molecular transporters in the placenta, reflecting a transporter-mediated uptake, foll

241 The placenta releases large quantities of extracellular vesi

242 ines the spacing of ovule anlagen within the placenta remained unexplored.

243 nt and function, but their regulation in the placenta remains unclear.

244 he reporting limit in 99, 75, 55, and 49% of placentas, respectively.

245 These results suggest that the placenta responds to seasonal cues and add to the growin

246 to the systemic circulation, and thereby the placenta, resulting in local inflammation, placental dys

247 Histological examination of the placenta revealed a dense macrophage infiltrate, but no

248 .8) and with differential DNAm of 71 CpGs in placenta, robust to latent-factor adjustment reflecting

249 Signal dynamics reflected the placenta's perfusion pattern modulated by biotin transpo

250 reases in first trimester and is elevated in placenta samples from women with preeclampsia.

251 formed and mutations were determined for 365 placenta samples with complete exposure and covariate da

252 nd classification of DV lesions in digitized placenta slides, along with a method of coupling learned

253 Oral anti-hyperglycaemics cross the placenta, so effects on fetal anthropometry could result

254 results illustrate the permanent renewal of placenta-specific genes by retroviral capture and de fac

255 Histopathological features in placentas suggested that PFOA and GenX may exhibit diver

256 of the markers for specialized cell types in placenta, suggesting a role during TE differentiation.

257 ge, the prevalence of detectable PFAS in the placenta suggests a need to biomonitor for exposure to P

258 Systemic signalling from the endocrine placenta targets the maternal endothelium and multiple o

259 tissues, including reproductive tissues and placenta, than the FP isolate.IMPORTANCE Zika virus rema

260 rome results in an inefficient and senescent placenta that impairs embryonic development.

261 to isolate trophoblast cells from the human placenta that proliferate in vitro.

262 ously unknown proteins secreted by the human placenta that regulate maternal physiology and fetal dev

263 ll density within the junctional zone of the placenta that was not present in SD tissues.

264 olate trophoblast from first-trimester human placentas that can be grown long term in a three-dimensi

265 on, with a focus on the defining cell of the placenta - the trophoblast.

266 In male placenta, the levels of H3K27 acetylation and PGC-1alpha

267 on of asexual "blood-stage" parasites in the placenta, the major virulence mechanism.

268 ion of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmissio

269 patterns at various developmental stages in placenta tissue.

270 ge are prevented by prenatal exposure of the placenta to a mitochondrially-targeted antioxidant.

271 we analyzed perforin-2 activity in the mouse placenta to determine whether perforin-2 plays a similar

272 Given the critical role of the placenta to transfer oxygen and nutrients from mother, t

273 l placental development and a failure of the placenta to transport sufficient nutrients to match feta

274 ltimately, the approach will allow many more placentas to be screened in a more standardized manner,

275 Sangkhae et al. used mouse models and human placentas to explore maternal, placental, and fetal resp

276 vergent mechanisms of toxicity in the embryo-placenta unit, whereas PFOA- and GenX-exposed livers sha

277 luate exposure effects on the dam and embryo-placenta unit.

278 in pregnant mice and their developing embryo-placenta units, with a specific focus on the placenta as

279 lity to improve the delivery of drugs to the placenta upon administration to the mother may offer new

280 in cells of mesometrium, decidua of embryos, placenta, uterus, ovary, and brain of foetuses by immuno

281 Placenta, venous and arterial cord blood were collected

282 sampled uterine vein was ipsilateral to the placenta was 54.8 (IQR 37.1-88.4) pg/mL (n = 11) and 23.

283 a novel ligand placensin expressed in human placenta was found based on the paralogous relationship

284 us of the mother; gestational age <29 weeks; placentas weighing <500 g; stillbirth; premature rupture

285 very LoS 3-5 days; maternal age 35-39 years; placenta weight 1,000-1,500 g; birthweight < 2,000 g; ma

286 thology, higher placental weights and embryo-placenta weight ratios, and greater incidence of placent

287 Placentas were homogenized, and syncytiotrophoblast micr

288 ed dams, whereas 2/3 PR isolate-infected dam placentas were ZIKV RNA positive.

289 Although the STC-1 gene is expressed by the placenta what regulates its secretion and from which cel

290 hallenge has been the syncytial cells of the placenta, which have made dissociation and independent e

291 lso indicates rapid venous drainage from the placenta, which is important because this outflow has be

292 traits are only gained in lineages that lack placentas; while there is little or no influence of male

293 Such computer-assisted examination of human placentas will enable real-time adjustment to infant and

294 The transcriptome of the placenta with a female fetus was considerably more alter

295 last organoids closely resembles the villous placenta with a layer of cytotrophoblast (VCT) that diff

296 fetus was considerably more altered than the placenta with a male fetus in FOXA2 cKO dams.

297 of the conjugated fluorescence probe in the placenta with a total accumulation of 2.8% of the initia

298 CD122+Macs develop in the uterus and placenta with kinetics that mirror IFN activity at the m

299 y and Plasmodium falciparum infection in the placenta with PE is underexplored.

300 stational age (AGA), FGR babies have smaller placentas with reduced activity of amino acid transporte