ライフサイエンスコーパス: planar polarity

1 n a pattern that correlates with the axis of planar polarity.

2 ristle morphogenesis, cuticle synthesis, and planar polarity.

3 are both necessary and sufficient to orient planar polarity.

4 ns may be more a consequence than a cause of planar polarity.

5 a primordium reorients a neuromast's axis of planar polarity.

6 cadherin that controls both cell growth and planar polarity.

7 ity is regulated during the establishment of planar polarity.

8 cells plays a key role in the development of planar polarity.

9 g photoreceptor differentiation, survival or planar polarity.

10 a second, unidentified signal that mediates planar polarity.

11 nd Sple is critical for the specification of planar polarity.

12 mi functions downstream of Fz in controlling planar polarity.

13 f individual cells to establish and maintain planar polarity.

14 e proteins required for self-organization of planar polarity.

15 ith no significant influence on cell fate or planar polarity.

16 d low dissociation rates, resulting in MyoII planar polarity.

17 ens junctions and is required for Rho-kinase planar polarity.

18 hich contain hair cell receptors of opposing planar polarity.

19 n the Misshapen kinase disrupt follicle cell planar polarity.

20 mechanisms of gradient function can generate planar polarity.

21 7 morphants did not support a global loss of planar polarity.

22 nction of the ciliopathy protein Rpgrip1l in planar polarity.

23 of the most prominent examples of epithelial planar polarity.

24 tion, kinocilium positioning, and basal body planar polarity, accompanied by defects in the organizat

25 atial patterns of gene expression coordinate planar polarity across a multicellular population throug

26 tissue level, all hair cells display uniform planar polarity across the epithelium.

27 late novel mutations in frizzled that affect planar polarity activity and have identified a group of

28 membranes by Frizzled was required only for planar polarity activity, implying that qualitatively di

29 r lesions, we find a subset that affect only planar polarity activity.

30 tissue stress promotes proximal-distal (PD) planar polarity alignment.

31 enetic process that depends on follicle cell planar polarity and BM remodeling.

32 estingly, although some of these affect both planar polarity and canonical activity, as previously re

33 t Frizzled-Dishevelled interactions underlie planar polarity and canonical Wnt signaling.

34 onal guidance factors, that is implicated in planar polarity and control of cell movements.

35 gradient of X, the vector of which specifies planar polarity and depends on two cadherin proteins, Da

36 zled and the roles of Drosophila Frizzled in planar polarity and dorsal enclosure.

37 Canoe loss subtly enhances AJ planar polarity and dramatically increases planar polari

38 rates, and clearly define specific roles for planar polarity and for the novel planar cell polarity g

39 ead, our findings strongly suggest that Pins planar polarity and force generated from mesoderm invagi

40 We re-examined the role of Rho1 in wing planar polarity and found that it had multiple functions

41 t/G-protein/PI3K pathway that coordinates HC planar polarity and intercellular PCP signaling.

42 protein, amplifies Rho-kinase and myosin II planar polarity and junctional localization downstream o

43 at Dvls are continuously required for E cell planar polarity and may prevent hydrocephalus.

44 veal that both phosphovariants reduce myosin planar polarity and mechanical anisotropy, altering the

45 e, we investigate interactions between Ft-Ds planar polarity and mechanical forces in the developing

46 However, the functional relationship between planar polarity and migration in this tissue is unknown.

47 that Tartan and Ten-m are necessary for the planar polarity and organization of compartment boundary

48 e lethality and disrupt the establishment of planar polarity and photoreceptor specification in eye i

49 terior axis and act in combination to direct planar polarity and polarized cell rearrangements during

50 t fj interacts genetically with ft and ds in planar polarity and proximodistal patterning.

51 locking mesoderm invagination disrupted Pins planar polarity and spindle orientation.

52 rosophila wing a favored system for studying planar polarity and the coordination of cellular and tis

53 known about the mechanisms guiding ependymal planar polarity and whether this organization is acquire

54 To test further the link between planar polarity and Wnt signaling we misexpressed Wg in

55 for cochlear duct coiling and elongation, HC planar polarity, and asymmetric localization of core PCP

56 ing specifying cell fate, orienting cell and planar polarity, and directing cell migration.

57 nisms for the intracellular specification of planar polarity, and further review evidence for models

58 s, yet the mechanisms by which they regulate planar polarity are poorly understood.

59 in developmental biology is how pattern and planar polarity are transmitted in epithelial structures

60 The patterning mechanisms that underlie planar polarity are well characterised in Drosophila, wh

61 e investigated whether signaling involved in planar polarity at the apical surface can influence posi

62 n is reduced and this leads to disruption of planar polarity at the tissue level.

63 mispositioned along both the apicobasal and planar polarity axes of mutant hair cells, and hair bund

64 red for positioning the basal body along the planar polarity axis.

65 as been implicated in receptor recycling and planar polarity but not in apical/basal polarity.

66 that Rho-kinase plays an instructive role in planar polarity by targeting Baz/Par-3 and myosin II to

67 Two aspects of planar polarity can be analyzed quantitatively at cellul

68 onstrate that effects of Fj on wing size and planar polarity can be explained by Fj phosphorylating t

69 Cilia are at the core of planar polarity cellular events in many systems.

70 ts are regulated by two pathways: the 'core' planar polarity complex and the Fat/Dachsous system.

71 on, cell fate determination, cell migration, planar polarity, convergent extension, and immunity.

72 t this pathway is normally overridden by the planar polarity cue provided by adherens junctions.

73 been shown that four-jointed is involved in planar polarity decisions in the eye as well as proximal

74 Planar polarity decisions in the wing of Drosophila invo

75 However, the cell shape and planar polarity defects in fat mutants are not suppresse

76 border of clones and that there is rescue of planar polarity defects on the equatorial border of thes

77 n and microtubule organization, resulting in planar polarity defects without overt effects on the cor

78 rodegeneration, segmentation, patterning and planar polarity defects.

79 Quantification of planar polarity deficits through postnatal development d

80 e propose that apical domain changes reflect planar polarity-dependent mechanical forces operating du

81 Planar polarity describes the coordinated polarisation o

82 By analyzing mutants lacking the planar-polarity determinant Vangl2, we ascertained that

83 loping wing and show that it is required for planar polarity determination in both the wing and the a

84 Planar polarity development in the Drosophila wing is un

85 onal information through the production of a planar polarity diffusible signal, and later in R3 fate

86 changes in cell shape, cell interactions and planar polarity during convergent extension in the Droso

87 hway is also central to the establishment of planar polarity during Drosophila eye development.

88 Planar polarity effector (PPE) genes such as inturned (i

89 enes) functioning as a group upstream of the Planar Polarity Effector (PPE) genes which in turn funct

90 dule, which we term CPLANE (ciliogenesis and planar polarity effector), and an extensive associated p

91 Inturned (INTU), a cilia and planar polarity effector, performs prominent ciliogenic

92 The Ciliogenesis and PLANar polarity Effectors (CPLANE) protein complex is es

93 jointed expression gradient is important for planar polarity establishment and that local inversions

94 Planar polarity establishment in epithelia requires inte

95 nctions downstream of Frizzled in specifying planar polarity, Flamingo-dependent dendritic outgrowth

96 hway has been shown to be a key regulator of planar polarity for hairs on the wing, ommatidia in the

97 es have been a model system for the study of planar polarity for many years and a number of genes req

98 ng of the Drosophila wing, a "core" group of planar polarity genes has been identified which acts dow

99 decision is directed by the activity of the planar polarity genes, and, in particular, higher activi

100 rborization, highlighting the importance of "planar polarity" genes for defining the shape of a neuro

101 lear co-repressor that is also essential for planar polarity; however, it is not known what genes Atr

102 ntrol of the Frizzled pathway that generates planar polarity in a number of cell types.

103 pected plasticity that maintains coordinated planar polarity in actively moving populations through t

104 Planar polarity in animals is conferred by Wnt signaling

105 d help to determine left-right asymmetry and planar polarity in development.

106 at operates in the mechanisms that establish planar polarity in Drosophila epithelia, any clear evide

107 fj) is required for proximodistal growth and planar polarity in Drosophila tissues.

108 , could pattern hair, bristle and ommatidial planar polarity in Drosophila, and that additional tissu

109 PCP proteins maintain planar polarity in many epithelial tissues and have been

110 l expansion, division plane orientation, and planar polarity in plants.

111 ucts, interfaces that can cause reversals of planar polarity in the clone and wild-type cells outside

112 In both the midline and node, the defect in planar polarity in the double mutants arises because PCP

113 pe, junctional localization and cytoskeletal planar polarity in the Drosophila embryo are regulated b

114 We find that planar polarity in the Drosophila embryo is established

115 ases/JNK cascades are not major effectors of planar polarity in the Drosophila eye.

116 arval blood cell development, wing venation, planar polarity in the eye, and formation of other adult

117 d Atrophin act twice in the determination of planar polarity in the eye: first in setting up position

118 have shown that many proteins that regulate planar polarity in the fly eye are organized into discre

119 of developing outer hair cells gives rise to planar polarity in the mammalian cochlea.

120 actions with Prickle and PTK7, and disrupted planar polarity in the neuroectoderm.

121 morphogenesis depends on an unusual form of planar polarity in the organ's outer epithelial layer, t

122 Here, we demonstrate abnormal planar polarity in the Xenopus neuroectoderm depleted of

123 PCA method performs robustly in quantifying planar polarity independently of variation in cell geome

124 w the localization of PCP proteins transmits planar polarity information across the developing sensor

125 tation is a morphogenetic behavior that uses planar polarity information in the ECM to control tissue

126 Planar polarity is a fundamental property of epithelia i

127 Planar polarity is a global, tissue-level phenomenon tha

128 Planar polarity is a well-studied phenomenon resulting i

129 Planar polarity is a widespread phenomenon found in many

130 Although it is known that tissue planar polarity is controlled by non-canonical Wnt/plana

131 This planar polarity is critical for motile cilia function bu

132 factor.We re-examine our working model that planar polarity is determined by the cells reading the g

133 In invertebrates and vertebrates, planar polarity is established and maintained by the lar

134 Planar polarity is evident in the coordinated orientatio

135 Development of this planar polarity is necessary for normal hearing as stere

136 These studies demonstrate that planar polarity is rapidly established in a spatiotempor

137 Planar polarity is required for the posterior positionin

138 on of cells in the plane of a tissue, termed planar polarity, is a characteristic feature of epitheli

139 lar resolution shows that the acquisition of planar polarity leads to asymmetric pulsatile Myosin II

140 ell migration and suggest that follicle cell planar polarity may be an emergent property of individua

141 in two near-orthogonal coordinated biases in planar polarity: mediolateral and proximodistal.

142 to each other and to a previously identified planar polarity mutation.

143 the latter group mapping separately from the planar polarity mutations.

144 The distinctive planar polarity of auditory hair cells is evident in the

145 quired non-cell-autonomously to organize the planar polarity of basal actin in follicle cells, possib

146 truct allows for simple visualization of the planar polarity of basal bodies that underlies polarized

147 c intracellular distributions and coordinate planar polarity of cell populations.

148 The DEP domain of dishevelleds mediates planar polarity of cells within a sheet through regulati

149 ct in a positive feedback loop to direct the planar polarity of cilia.

150 The planar polarity of endogenous Vangl2 in the neuroectoder

151 zes to ciliary basal bodies and controls the planar polarity of ependymal cells through regulating th

152 factory cilia and participates in specifying planar polarity of ependymal cilia.

153 r results demonstrate that Lis1 mediates the planar polarity of hair cells through regulation of micr

154 In the auditory sensory epithelium, planar polarity of individual hair cells is defined by t

155 d respiratory cilia were largely normal, the planar polarity of mutant ependymal cilia was disrupted,

156 ed by clones of fringe cells can reverse the planar polarity of photoreceptor clusters, indicating th

157 lium to control cochlear duct elongation and planar polarity of resident sensory hair cells (HCs), in

158 ven-transmembrane cadherin [5], controls the planar polarity of sensory bristles and the orientation

159 inner ear, at least two systems regulate the planar polarity of sensory hair bundles.

160 J planar polarity and dramatically increases planar polarity of the apical polarity proteins Bazooka/

161 stles that point posteriorly, indicating the planar polarity of the cells.

162 distance, the type of cuticle formed and the planar polarity of the cells.

163 major role in determining the global axis of planar polarity of the developing skin.

164 riented hairs and bristles that indicate the planar polarity of the epidermal cells.

165 of distally pointing hairs that reveals the planar polarity of the wing.

166 e normal apical-basal polarity, but lose the planar polarity of their basal actin stress fibers, a ph

167 terior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and p

168 is not known what genes Atrophin controls in planar polarity, or how Atrophin activity is regulated d

169 urry functions independently of the frizzled planar polarity pathway and that it probably functions i

170 that, during collective cell migration, the planar polarity pathway can mediate communication betwee

171 reveal a general mechanism by which the core planar polarity pathway can promote polarised cell rearr

172 The core planar polarity pathway consists of six proteins that fo

173 The core planar polarity pathway coordinates epithelial cell pola

174 The planar polarity pathway coordinates the polarity of non-

175 ts in basal metazoans suggests that the core planar polarity pathway evolved shortly after, but not n

176 g hypothesis that a vertebrate analog of the planar polarity pathway governs convergent extension mov

177 We report a novel role for the core planar polarity pathway in promoting cell intercalation

178 nstream of Fz/Dsh to mediate a branch of the planar polarity pathway involved in ommatidial rotation

179 The Frizzled (Fz)-dependent core planar polarity pathway is a major regulator of polarise

180 The conserved core planar polarity pathway is essential for coordinating po

181 We find that the planar polarity pathway promotes this invasive migration

182 from both the canonical Wnt pathway and the planar polarity pathway.

183 -distal (P-D) axis by the Dachsous-Fat-Dachs planar polarity pathway.

184 hways of which the best characterized is the planar polarity pathway.

185 naptic plasticity in the brain as well as in planar polarity pathways in the skin.

186 s is independent of canonical apicobasal and planar polarity pathways.

187 d by Fz receptors in Drosophila: the Wnt and planar polarity pathways.

188 , mechanical stress, neighbour topology, and planar polarity pathways.

189 During planar polarity patterning of the Drosophila wing, a "co

190 e requirements of each complex component for planar polarity patterning.

191 ependent refinement process that rescues the planar polarity phenotype within 10 d of birth.

192 g that an active refinement process corrects planar polarity phenotypes in Vangl2 knock-out (KO) mice

193 Here we describe the planar polarity phenotypes of loss-of-function and overe

194 ngl2 is deleted from the inner ear, yielding planar polarity phenotypes similar to Vangl2 KOs at late

195 Recent work has established that the planar polarity (PP) proteins become localized to either

196 e control of gene expression, cell adhesion, planar polarity, proliferation and apoptosis.

197 the stability on cell junctions of the core planar polarity protein Frizzled (Fz).

198 ng [4-6], as a key component regulating core planar polarity protein localization in Drosophila.

199 richome positioning is dependent on the core planar polarity proteins adopting asymmetric subcellular

200 The asymmetric localisation of core planar polarity proteins at apicolateral junctions is re

201 We propose a model where the core planar polarity proteins Celsr1 and Frizzled-6 (Fz6) com

202 In the absence of strabismus activity, the planar polarity proteins Dishevelled and Prickle are mis

203 We find that the planar polarity proteins Frizzled, Dishevelled, Flamingo

204 mingo to mediate apicolateral recruitment of planar polarity proteins including Dishevelled and Prick

205 Core planar polarity proteins localise asymmetrically to oppo

206 The core planar polarity proteins localize asymmetrically to the

207 The core planar polarity proteins play important roles in coordin

208 Unlike planar polarity proteins such as Frizzled or Inturned, M

209 through asymmetric localisation of the core planar polarity proteins to opposite cell membranes, whe

210 n governed by the asymmetric distribution of planar polarity proteins within cells.

211 Hence, we developed a novel planar polarity quantification method based on Principal

212 However, previous planar polarity quantification methods can be affected b

213 of regulation of Rho GTPase activity by the planar polarity receptor Frizzled, which itself becomes

214 Concurrently, multiple cell intrinsic planar polarity (referred to as iPCP) modules mediate pl

215 that are not corrected during the period of planar polarity refinement.

216 This planar polarity requires the transmembrane receptor Friz

217 nase and myosin II achieve reduced levels of planar polarity, resulting in decreased junctional tensi

218 of bidirectional feedback interactions among planar polarity, shape, and stresses; our model thus rep

219 nstead, the Frizzled (Fz) protein mediates a planar polarity signal that controls the anteroposterior

220 ceptor that acts through a GTPase pathway in planar polarity signaling and as a receptor for Wingless

221 ical protrusion formation of nascent HCs and planar polarity signaling are both important for the Roc

222 ly Drosophila melanogaster for canonical and planar polarity signaling have concluded that there is m

223 Drosophila egg, including an unconventional planar polarity signaling pathway, a distinctive type of

224 Activation of both canonical and planar polarity signaling requires interaction between F

225 d with several other molecules with roles in planar polarity signaling, including Dishevelled and Fri

226 membrane adhesion, receptor trafficking, and planar polarity signaling.

227 e protein kinase PAR-1 is also essential for planar polarity signaling.

228 the Dsh DEP domain that specifically disrupt planar polarity signaling.

229 Disruption of planar polarity signalling causes abnormalities in actin

230 hrough a pathway similar to that involved in planar polarity signalling in Drosophila.

231 n streak formation we have inhibited the Wnt planar-polarity signalling pathway by expression of a do

232 ctions, MyoII enrichment on these junctions (planar polarity) stabilizes them.

233 A common feature of animal planar polarity systems is the formation of molecular br

234 eraction with Mwh Rho1 has functions in wing planar polarity that are parallel to and upstream of fz.

235 n the eye have non-autonomous disruptions in planar polarity that are restricted to the polar border

236 Although nascent hair bundles have correct planar polarity, the polarity of their responses to mech

237 Two pathways regulate planar polarity: the core proteins and the Fat-Dachsous-

238 iprotein complexes in processes ranging from planar polarity to adhesion to oriented cell division to

239 LR asymmetry, studies of mutations affecting planar polarity, together with exciting new data in cell

240 fish floor plate the function of Rpgrip1l in planar polarity was mediated by dishevelled stabilizatio

241 portance to the normal control of growth and planar polarity, we have only a limited understanding of

242 the how these genes work together to produce planar polarity, yet fundamental questions remain unansw