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1 ble, 18.4 h oral t(1/2), and 0.19 L/(h x kg) plasma clearance).
2    Primary outcome was measured GFR (iohexol plasma clearance).
3 adrenaline concentrations because of reduced plasma clearance.
4 acterized by high brain penetrance and rapid plasma clearance.
5 ral dosing, but exposure was limited by high plasma clearance.
6 docytosis of circulating LDL, increasing its plasma clearance.
7 properties but has poor solubility and rapid plasma clearance.
8  lipoproteins accumulate because of impaired plasma clearance.
9 GC 945 to KB tumor-bearing mice showed rapid plasma clearance (0.021 L/h) and tissue distribution.
10 iltration rateiohexol measured using iohexol plasma clearance: 19 2 vs 16 2 mL/min/1.73 m2; p = 0.13
11  half-life of disposition 69.7 +/- 39.7 hrs, plasma clearance 2.39 +/- 1.32 mL/hr/kg, and volume of d
12 f BPS, in comparison with BPA, and its lower plasma clearance (3.5 times lower), the oral BPS systemi
13 he liver was the major organ responsible for plasma clearance, accounting for >60% of the peptide upt
14 e drug-to-antibody ratio (DAR); however, ADC plasma clearance also increases with DAR, reducing expos
15 ient) were 10.8% and 0.88, respectively, for plasma clearance and 15.3% and 0.77, respectively, for f
16                               RSHZ19 had low plasma clearance and a half-life of approximately 23 day
17  higher plasma free fraction, and (c) faster plasma clearance and brain uptake kinetics, enabling mea
18 the C15 and C18 analogues displaying delayed plasma clearance and enhanced tumor uptake and retention
19 A, which in experimental models has a slower plasma clearance and greater fibrin specificity and is 8
20 receptor-related protein function, decreased plasma clearance and hepatic uptake of (131)I-apoB-48 LD
21                                       Slower plasma clearance and increased drug exposure over time o
22 ptor class B (SR-BI) failed to normalize the plasma clearance and liver uptake of [(3)H]CE from LCAT-
23 roperties in the rat and dog with respect to plasma clearance and oral bioavailability and is a poten
24                                 Although the plasma clearance and the rate of renal excretion of the
25                             To determine the plasma clearance and tissue distribution in mice of the
26 f eliminating the MR on MR- and MPR-mediated plasma clearance and tissue distribution of infused phos
27                                              Plasma clearance and volume of distribution for both cag
28 bind the replaced glycoprotein, increase its plasma clearance, and inhibit its activity, preventing s
29 umor model simulating the interstitial flow, plasma clearance, and transport of the drug within the t
30 nts were half-life, time to C(max) [t(max)], plasma clearance, and volume of distribution of cagrilin
31                  Exceptional potency and low plasma clearance are required to meet dose size requirem
32  of them has a good correlation with UV/P or plasma clearance at this level of renal function.
33 ts provided excellent renal images, with the plasma clearance averaging 228 mL/min for (99m)Tc(CO)(3)
34 duced cocaine burden in tissues, accelerated plasma clearance by 20-fold, and prevented cocaine-induc
35 rformed to quantify manganese and gadolinium plasma clearance by using inductively coupled plasma mas
36 mple at 45 min was found to be 23, using the plasma clearance calculated from a multi-sample clearanc
37 51)Cr-ethylenediaminetetraacetic acid (EDTA) plasma clearance counting but is time-consuming and requ
38   (99m)Tc-Diethylenetriaminepentaacetic acid plasma clearance curves from 79 subjects were analyzed.
39  We evaluated this approach for interpreting plasma clearance curves with the goal of reducing curve-
40 by applying a three-compartment model to the plasma clearance data of intravenously injected [(14)C]i
41                    Dose-dependent changes in plasma clearance did not occur.
42 ts show that these three compounds exhibit a plasma clearance equivalent to iothalamate (a commonly c
43   Results indicated that drug lipophilicity, plasma clearance, faster target dissociation, and, in pa
44                    We estimated methotrexate plasma clearance for 1279 patients with ALL treated with
45 n cultured cells and dramatically slowed its plasma clearance from a t(1/2) of <10 min to 18 h.
46                                         Mean plasma clearance, half-life, and steady-state volume of
47                                         Mean plasma clearance in humans was 9 +/- 3 mL/min/kg, and th
48         But unlike FH, FHL-1 exhibits a fast plasma clearance in mice, occurs sparsely in human plasm
49 ng polyacrylamide gel electrophoresis and by plasma clearance in mice.
50                                              Plasma clearances in BALB/c mice are similar among the f
51                                              Plasma clearance (in liters per hour) and free fraction
52 based formulas with a gold standard (iohexol plasma clearance) in 193 renal transplant recipients usi
53 ; measurements of (14)C-ACPC and (67)Ga-DTPA plasma clearance (K(1)), (14)C-ACPC transport ( partial
54 hods of measuring whole-skeleton (99m)Tc-MDP plasma clearance (K(bone)) in 12 osteoporotic postmenopa
55                                      Iohexol plasma clearance measurement as gold standard.
56 n volunteers followed by sequential imaging, plasma clearance measurements and timed urine collection
57                  Each study included a UV/P, plasma clearance method (three-sample) and single-sample
58  GFR measured by nonradiolabeled iothalamate plasma clearance (mGFR) in 72 subjects with cirrhosis.
59 using the slope-intercept method for iohexol plasma clearance (mGFR) in population cohorts from Malaw
60                                            A plasma clearance model was selected over urine clearance
61 s for mGFR determination using 1-compartment plasma clearance models and iohexol as the exogenous fil
62                   The mGFR was determined by plasma clearance of (51)Cr-EDTA.
63 uterium-labeled steroid hormones as tracers; plasma clearance of 100 mg of hydrocortisone; levels of
64 ce, capture ELISA measurements revealed fast plasma clearance of 11C7-scFv8D3 concomitantly with brai
65 se complexes (alpha 2M*) also diminished the plasma clearance of 125I-factor Xa in a dose-dependent f
66 ng activity displayed dramatically prolonged plasma clearance of 125I-factor Xa.
67                       TNK-TPA demonstrated a plasma clearance of 151 +/- 55 mL/min and a half-life of
68                          In normal rats, the plasma clearance of 18F-PFH was 4.11+/-1.09 mL/min/100 g
69                                          The plasma clearance of 18F-PFH was determined using a singl
70                                 Finally, the plasma clearance of 2d, 2h, and 2j remained unchanged up
71 4 years' follow-up we estimated GFR from the plasma clearance of 51Cr-labelled edetic acid (EDTA), an
72 nomolar affinity to TSLP (K(D) = 13 nM), low plasma clearance of 6.4 mL/min/kg, and an effective half
73              Compared with labeled antibody, plasma clearance of 99mTc was faster with labeled EPI-HN
74                     CETP normalized both the plasma clearance of [(3)H]cholesteryl esters ([(3)H]CE)
75 s (OATPs) mediate the liver uptake and hence plasma clearance of a broad range of drugs.
76 apoA-II transgenic mice exhibited a delay in plasma clearance of a glucose bolus.
77              Recently, a study validated the plasma clearance of a new exogenous filtration marker, r
78                                              Plasma clearance of active TPA was faster than clearance
79 ound to alpha2M or alpha2M-MA did not affect plasma clearance of alpha2M/alpha2M-MA.
80 urement of glomerular filtration rate by the plasma clearance of an IV single dose of iohexol and est
81 en together, these data showed that impaired plasma clearance of apoE2-containing, triglyceride-rich
82 in the liver responsible for the binding and plasma clearance of apolipoprotein E-containing lipoprot
83  explained between-individual variability in plasma clearance of bedaquiline, its M2 metabolite, and
84 r both before and after I/R and improved the plasma clearance of bile acid and biliary outputs of bil
85        Genetically eliminating the MR slowed plasma clearance of both P- and NP-GUS and enhanced the
86 ignificant correlations between CrCl and the plasma clearance of both total topotecan [Spearman's cor
87        Recent studies have demonstrated that plasma clearance of cortisol is markedly reduced during
88 d by urinary clearance of inulin (n=488) and plasma clearance of Cr-EDTA (n=337).
89                                The impact of plasma clearance of dexamethasone and anti-asparaginase
90 imum observed plasma concentration and total plasma clearance of ET-743 (mean +/- standard deviation)
91 ethods for GFR measurement using urinary and plasma clearance of exogenous filtration markers and foc
92            Pharmacokinetic evaluation of the plasma clearance of GBCA is required for all new agents
93                                              Plasma clearance of HDL particles and HDL-associated cho
94                                 Although the plasma clearance of HDL-CE was not significantly altered
95                             Importantly, the plasma clearance of hFVIII was significantly decreased i
96 synthesized VLDL normally but showed reduced plasma clearance of human VLDL and a corresponding reduc
97 addition, coinjection of free OX26 saturated plasma clearance of immunoliposomes.
98 ocus on urinary clearance of iothalamate and plasma clearance of iohexol compared with inulin clearan
99 dults referred for measured GFR (mGFR) using plasma clearance of iohexol in Stockholm, Sweden, who ha
100                                              Plasma clearance of iohexol is a pivotal metric to quant
101 filtration rate (determined by measuring the plasma clearance of iohexol) between the baseline value
102 change from baseline in GFR, measured by the plasma clearance of iohexol.
103 erious disorder caused by very low or absent plasma clearance of LDL, substantially raised LDL choles
104 PS, whereas SR-BI-null mice showed decreased plasma clearance of LPS into the liver and hepatocytes c
105                                   We suggest plasma clearance of nonradioactive markers be more widel
106 f stimulus-secretion coupling and a model of plasma clearance of oxytocin was tested.
107                                          The plasma clearance of PEG-rHDL was estimated after injecti
108                   The successful decrease in plasma clearance of rhDAO by mutations of the heparin-bi
109 ions as a liver receptor responsible for the plasma clearance of SECs.
110                         GFR, measured as the plasma clearance of the endogenous marker iohexol, to co
111                                              Plasma clearance of the major radiolabeled metabolite ([
112                                Mean systemic plasma clearance of total topotecan was significantly re
113               There was no difference in the plasma clearances of (99m)Tc(CO)(3)(NTA) and (131)I-OIH,
114               There was no difference in the plasma clearances of (99m)Tc(CO)3(NTA) and (131)I-OIH (1
115 ntrast to the situation observed in baboons, plasma clearances of both compounds were similar in huma
116                                          The plasma clearances of Na(2)[(99m)Tc(CO)(3)(NTA)] and (131
117  area under the curve (0-last) and decreased plasma clearance over compound I and efavirenz, the stan
118 and desialylated pFn (aFn) displayed a rapid plasma clearance (P < .001) with greater than 50% of bot
119 ution of ADC, independent of payload dose or plasma clearance, plays a major role in ADC efficacy.Sig
120                                   Pemetrexed plasma clearance positively correlated with GFR (r2 = 0.
121 amine sulfoconjugated to the respective free plasma clearances (r2 = .30, p < .01, and r2 = 0.29, p <
122 the natural logarithm of the respective free plasma clearances (r2 = 0.58, p < .001, and r2 = 0.39, p
123 lus and the Thiele modulus are ratios of the plasma clearance rate and antibody catabolism, respectiv
124 On a time scale of minutes, we determine the plasma clearance rate in the wild-type mouse, using time
125 was metabolically stable and displayed a low plasma clearance rate.
126          The (99m)Tc-MAEC complex/(131)I-OIH plasma clearance ratio in humans ranged from 45% (anti-(
127         Some hydroxamic acids display a high plasma clearance resulting in poor in vivo activity, tho
128                                A total of 12 plasma clearance studies for AA and urea, consisting of
129 ion within a tumor including dose, affinity, plasma clearance, target expression, internalization, pe
130                     AF-L displayed a quicker plasma clearance than CL, and 25.4%, 2.7%, and 1.2% of t
131                                              Plasma clearance, the molecular composition of radioacti
132 es were about 21.1 and 3.4 times slower than plasma clearance times for nalmefene and naloxone, respe
133 analysis) were used to evaluate the fluoride plasma clearance to bone mineral (K(i)).
134                                          The plasma clearance, total volume of distribution, and term
135 ts, which was commensurate with the observed plasma clearance values upon intravenous administration.
136  result in a 2-5-fold increase in calculated plasma clearance values when the excipient interferes wi
137 netic experiments, four trioxolanes had high plasma clearance values, suggesting a potential metaboli
138 curve increased linearly with dose, and mean plasma clearance was 1.86 mL/kg/min (range, 1.21 to 2.41
139  controls -(5.3 +/- 1.7) x 10(-3) s(-1), and plasma clearance was 2.6-fold higher in BCC than control
140                                              Plasma clearance was 29 +/- 1 L/h, and plasma free fract
141          The mean +/- standard deviation IRN plasma clearance was 374 +/- 148 mL/min/m2, with median
142                      The median flavopiridol plasma clearance was 8.0 L/h/m2 (range, 2.6 to 17.1 L/h/
143                          The mean total body plasma clearance was 95.7 +/- 30.8 m/min and the harmoni
144                                              Plasma clearance was estimated with nonlinear mixed-effe
145                                              Plasma clearance was FHBG > FHPG >> FIAU.
146 ter iv ddI administration, only the maternal plasma clearance was found to be significantly increased
147 ined in a biexponential manner, and systemic plasma clearance was high relative to liver blood flow.
148 elation of the single-sample method with the plasma clearance was higher than with UV/P.
149                                  Carboplatin plasma clearance was linearly related to GFR (r = 0.85,
150 osed mice; however, in the pre-dosed animals plasma clearance was more rapid and tissue clearance app
151                                              Plasma clearance was rapid, with liver and kidneys repre
152                                              Plasma clearances were determined from 10 blood samples
153                                              Plasma clearances were determined from 8 blood samples o
154        The 90Y/111In-DOTA-biotin had a rapid plasma clearance, which was biphasic with <10% residual
155 examethasone drug conjugate exhibited a fast plasma clearance, with a half-life of approximately 5-8

 
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