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1 th very limited brain exposure (1/190 of the plasma level).
2 with IgG(4)-RD and correlate with galectin-3 plasma levels.
3 e, low-fat diet reduced FGF21 expression and plasma levels.
4 that CT exhibits a long-term effect on miRNA plasma levels.
5 xpression on neutrophils and myeloperoxidase plasma levels.
6 ents cured with increasing quartiles of ASOX plasma levels.
7 red a strong correlation between FX and PTX2 plasma levels.
8 001), T3t/T4t (P = .001), and TSH (p = .001) plasma levels.
9 Tissue expression of miR-181a-5p reflected plasma levels.
10 and their expression correlated with CXCL10 plasma levels.
11 novel genetic loci regulating FVIII and VWF plasma levels, 10 of which we validated functionally.
12 600-IL-1Ra displayed markedly extended blood plasma levels 3 days post-administration, whereas anakin
15 y in the human brain, and that both psilocin plasma levels and 5-HT2AR occupancy are closely associat
17 We suggest an association between high ASOX plasma levels and increased antiparasitic efficacy in pa
18 penumbra, higher tumor necrosis factor alpha plasma levels and lower peripheral blood mononuclear cel
22 deduced fractional excretion using reported plasma levels and urinary and plasma creatinine estimate
23 Setting intraclot zymogen concentrations to plasma levels (and neglecting cofactor rate limitations)
25 y shows that low amyloid-beta42 and high NfL plasma levels are each independently and in combination
29 into a clinical setting, we show that AnxA1 plasma levels are reduced in human and murine stroke and
30 ypeptide 1 (CYP7B1) and results in increased plasma levels, as well as fecal excretion, of bile acids
32 L shedding from T cells and increased sCD62L plasma levels at CML diagnosis on molecular response to
33 MA delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutan
34 I-deficient mice, 5-OHTrp(72) apoA-I reached plasma levels comparable with those of native apoA-I yet
38 igher CHADS(2) scores, and higher dabigatran plasma levels despite more frequent use of lower-dose da
39 ients and unaffected carriers showed that FH plasma levels determined by the nonmutated chromosome mo
40 DNA sequences and therapeutic antiretroviral plasma levels did not support HIV replication as the cau
42 mine and HVA+DOPAC/dopamine) changed with E2 plasma levels, except for high PAH/low PFAS and low PAH/
43 nical and clinical reports of increased CCL2 plasma levels following in vivo administration of CCR2 a
46 -negative disease mechanisms affecting C1INH plasma levels in HAE type I patients, and may pave the w
50 d (CSF) levels of FGLs correlated with blood plasma levels in rats and non-human primates, and CSF-to
53 nalyses of biomarkers revealed that mean NfL plasma levels increased 3.4 times faster in participants
54 variant had significantly elevated TGF-beta1 plasma levels (median, 23 376.49 vs 18 476.52 pg/mL; P =
55 uced pulmonary inflammation and elevation of plasma level of interferon-beta and -gamma and interleuk
57 a potent inhibitor of OATP2B1, decreased the plasma level of the OATP2B1 substrate fexofenadine, sugg
58 with variable viral loads and measuring the plasma levels of >600 soluble proteins, our data highlig
59 y subjects using colon delivery capsules and plasma levels of (13) C-SCFAs (13) C-glucose, (13) C-cho
60 tyl)benzoic acid, 12, provided 5-fold higher plasma levels of 1 compared to oral administration of 1
63 8; 95% CI, 1.56-3.85; P < 0.001), and higher plasma levels of 16-alpha-hydroxyestradiol (OR per 1-ln
66 t a pharmacokinetic-adjusted dose (targeting plasma levels of 200 or 500 ng/ml), or placebo for 16 we
67 rols had no significant differences in their plasma levels of 38 inflammatory cytokines/chemokines me
68 KD), we assessed the association of baseline plasma levels of 4 inflammatory markers (interleukin-6 (
69 re, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink(R)
70 malnutrition with therapeutic foods reduced plasma levels of a biomarker of osteoclastic activity wi
71 ID patients displayed significantly elevated plasma levels of a marker of neutrophil activation neutr
77 We tested the association of rs72613567 with plasma levels of alanine transaminase (ALT) and clinical
81 o inhibit neutrophil degranulation decreased plasma levels of alpha-defs, caused a phenotypic reversi
83 nfr1(-/-)/Mdr2(-/-) mice displayed increased plasma levels of ALT, ALP, and bilirubin as well as a si
86 ApoC-III inhibition by volanesorsen reduced plasma levels of apoC-II, apoC-III, triacylglycerols, an
88 Transplantation trial, we determined whether plasma levels of B-type natriuretic peptide (BNP) and ca
90 fection and is usually assessed by measuring plasma levels of bacterial lipopolysaccharide (LPS).
91 e cardiomyocyte death and fibrosis and lower plasma levels of biomarkers of cardiac damage (high-sens
93 et of patients with PAH had markedly reduced plasma levels of BMP9 and BMP10 in the absence of GDF2 m
96 sed the risk of breast cancer with regard to plasma levels of c-peptide, gastric inhibitory polypepti
99 dy, we evaluated the association of baseline plasma levels of C-terminal FGF23 with time to first hos
100 d markedly higher and enduring post-baseline plasma levels of C1-INH functional activity and C1-INH a
102 Our data showed a significant increase in plasma levels of CCL18 in HIV-1-infected individuals com
103 This study shows associations of higher plasma levels of Cer-16 and SM-16 with increased risk of
105 f lanadelumab was assessed by measurement of plasma levels of cleaved high-molecular-weight kininogen
110 During the first week of life the elevated plasma levels of CRP predicted the risk of BPD (OR 3.4,
111 e, and a decrease in recipient postoperative plasma levels of CXCL10 (C-X-C motif chemokine 10), inte
114 n and left ventricular function, and reduced plasma levels of cytokines (interleukin 6, granulocyte c
115 Secondary endpoints included alveolar and plasma levels of cytokines and soluble form of the recep
116 s (1.5 g/kg on day 1 and 1 g/kg on day 3) on plasma levels of cytokines in biobanked samples from 78
117 iocirculatory function, portal pressure, and plasma levels of cytokines, collecting data from 18 pati
119 = 2.04; 95% CI, 1.16-3.57; P = 0.01), lower plasma levels of dehydroepiandrosterone-sulfate (OR per
120 holipid form may provide a means to increase plasma levels of DHA-lysoPC, thereby decreasing the risk
122 renal clearance might lead to subtherapeutic plasma levels of drugs with predominant renal clearance.
123 the association of genetic variants with the plasma levels of each of the 156 Framingham Cardiovascul
126 All hemodialysis patients showed higher plasma levels of endothelial-derived EV than healthy sub
129 nitial release burst, generated steady-state plasma levels of Exenatide, but with PT320 producing con
130 y with the demonstration that an increase in plasma levels of FABP4 is inhibited by chloroquine treat
131 associations between this haplotype and the plasma levels of factors such as TGF-b, S100B, sRAGE and
132 ers have hypertriglyceridaemia and increased plasma levels of fatty acids, which are taken up and sto
136 with increased liver expression and elevated plasma levels of fibroblast growth factor 21 (FGF21), a
138 KD), we assessed the association of baseline plasma levels of four inflammatory markers (interleukin-
139 is a highly regulated process that maintains plasma levels of free fatty acids to supply energy to ce
140 people living with HIV (PLWH) have increased plasma levels of fungal polysaccharide (1->3)-beta-D-Glu
141 functional human FVIII, leading to increased plasma levels of FVIII and restoration of blood clotting
143 atients showed significantly greater fasting plasma levels of glucose and insulin and HOMA-IR, and po
147 erent compared with adults; at the same time plasma levels of haemostatic proteins vary considerably
153 g human B-1 cells positively associates with plasma levels of IgM antibodies specific for malondialde
154 , Tnfa, and Crp expression in WBCs, elevated plasma levels of IL-1beta, IL-6, and IL-8, increased IL-
155 e unaltered by 11beta-HSD1 deficiency though plasma levels of IL-4, IL-6 and TNF-alpha were slightly
157 sion of T-cell activation markers and higher plasma levels of IL-6 than did healthy ANA+ European Ame
159 easuring changes in immune cell frequencies, plasma levels of immune mediators, and differentially ex
162 ted in a significant decrease of retinal and plasma levels of inflammatory cytokines and adhesion fac
164 risingly, systemic DPP4 inhibition increases plasma levels of inflammatory markers in regular chow-fe
172 lyx damage during I/R is evidenced by rising plasma levels of its principal constituents, heparan sul
175 g peripheral artery tonometry (EndoPAT), and plasma levels of l-arginine, arginase-1, and asymmetric
176 rocytes in peripheral blood smear, increased plasma levels of lactate dehydrogenase activity, blood u
178 ibited distinct patterns of association with plasma levels of lipids and liver enzymes, respectively.
179 dividual gallstone loci were associated with plasma levels of lipids, lipoproteins, and liver enzymes
180 videnced by global ADC decrease and elevated plasma levels of lipocalin-2 and microRNA-150, was assoc
181 LA-DR+CD8+ (activated) T-cell frequency, and plasma levels of lipopolysaccharide (LPS), LPS binding p
182 contemporary general population study, high plasma levels of lipoprotein(a) were associated with inc
183 Finally, Ss+ was also associated with higher plasma levels of matrix metalloproteinases ([MMP]-1, -2,
184 oavailability approaches 100% with sustained plasma levels of memantine over seven days and profiles
185 INF individuals exhibit significantly higher plasma levels of microbial translocation markers (LPS, s
189 -specific T-cell responses and directly with plasma levels of molecules involved in Wnt/beta-catenin
193 mouse models, with increases in brain and/or plasma levels of neurotoxic TNFalpha and several other p
196 two cohorts and tested the effects of OC on plasma levels of oxytocin, adrenocorticotropic hormone (
197 he Stellarex DCB in comparison with PTA, and plasma levels of paclitaxel fall to low levels within 1
198 ther basophil activation in whole blood, and plasma levels of peanut-specific immunoglobulins, are us
199 d systemic inflammation, including increased plasma levels of pentraxin-2 and activated antigen-prese
202 ue of the JCI, Mani and colleagues show that plasma levels of plasma liver-enriched antimicrobial pep
205 oms, including IR, by markedly elevating the plasma levels of pro-inflammatory cytokines, including I
207 n and puncture-induced sepsis, decreases the plasma levels of proinflammatory cytokines and organ inj
211 prospectively examined associations between plasma levels of purine metabolites with T2D risk and th
216 prothrombinase and a further ~3-4-fold when plasma levels of S195A prothrombin were present (k(a) ((
220 dvanced magnetic resonance imaging (MRI) and plasma levels of select proteins were examined here in a
221 SCA individuals had significantly increased plasma levels of serotonin (5-HT), and serotonin molecul
226 d regression model analysis demonstrate that plasma levels of soluble interleukin-27 (IL-27) are sign
227 nsion of the CD8 T cell compartment and with plasma levels of soluble mediators of antiviral immunity
231 no significant effect of SVR was observed in plasma levels of sRANKL (P=0.205), OPG (P=0.249), and sR
232 ome (ICU treatment) was associated with high plasma levels of sTIM-3 and myeloperoxidase, suggesting
236 biota from young and older mice and measured plasma levels of the adverse gut-derived metabolite trim
237 associated with gut dysbiosis and increased plasma levels of the adverse gut-derived metabolite trim
238 of the trial was to assess whether extending plasma levels of the alpha7-nicotinic acetylcholine rece
240 ID was found to be associated with increased plasma levels of the B-cell-attracting chemokine CXCL13.
243 This was associated with a reduction in plasma levels of the clinical biomarker of cardiac injur
246 p = 0.02) upon the second challenge, whereas plasma levels of the key antiinflammatory cytokine inter
248 ted and HIV plus dengue-coinfected patients, plasma levels of the platelet-derived chemokines RANTES/
249 a novel positive association between VAT and plasma levels of the potential pharmacological agent pip
252 ocytes (31.7% vs 24.7%, P = .01), and higher plasma levels of the soluble CD163 scavenger receptor (0
253 d monocytes, accompanied by locally elevated plasma levels of the T-cell chemoattractant CXCL-11.
255 itol is of medical interest because elevated plasma levels of this polyol are predictive for visceral
257 irectly transported, the Oat3KO had elevated plasma levels of TMAO, which is associated with cardiova
260 nt significantly reduced the heart recipient plasma levels of troponin T by 34% (14 900 +/- 12 100 ng
261 study, we observed a significant increase of plasma levels of TRX80 in old subjects compared with hea
262 y day 360 in abstinent AH patients; however, plasma levels of tumor necrosis factor alpha, IL-8, IL-1
263 alicylic acid treatment resulted in enhanced plasma levels of tumor necrosis factor-alpha (+53%; p =
268 , which have been previously associated with plasma levels of VWF and FVIII, were associated with the
271 ied to test the causal role of FVIII and VWF plasma levels on the risk of arterial and venous thrombo
272 ent with therapeutically relevant isradipine plasma levels, or Cav1.3 LTCC deficiency in 6-OHDA-treat
275 endothelial (HMEC-1) cell assay, reduced FH plasma levels produced by the nonmutated chromosome corr
277 a dose which recapitulates stressor-induced plasma levels, reproduced stress-potentiated cocaine-pri
279 d zeaxanthin dietary supplementation despite plasma levels showing continuous exposure to lutein and
280 ly 21-day circulating IgG half-life and high plasma levels; similarly, FcRn recycles albumin and is t
281 availability, and achieving circulating free plasma levels that provided near maximal CGRP receptor c
282 y a central role in maintaining high albumin plasma levels through a cellular recycling pathway.
283 newly-developed proguanylin assay, we found plasma levels to be raised in humans after total gastrec
288 s were carried out on hairless rats, and DHE plasma levels were determined by liquid chromatography-t
290 erimental findings, baseline myeloperoxidase plasma levels were independently associated with a histo
292 d transforming growth factor beta (TGF-beta) plasma levels were measured in 22 pediatric patients wit
295 um correlated highly (p<0.0001 for all), but plasma levels were only 76.9% of paired serum concentrat
297 Moreover, MCAM was effective at times when plasma levels were very low, suggesting that pharmacodyn
298 tic plaques and is reflected by increased C5 plasma levels, which have promising value as a novel cir
299 The relationships between increasing ASOX plasma levels with the proportion of cysts resolved and