ライフサイエンスコーパス: plasmalemmal

1 Mucosal epithelial cells thus express a plasmalemmal 5-HT transporter identical to that of serot

2 The dendritic plasmalemmal 5HT3A labeling was prominent within and nea

3 data demonstrate no major role for impaired plasmalemmal action potential conduction in the excitati

4 action-induced muscle injury causes impaired plasmalemmal action potential conduction, which could ex

5 MEND is blocked by siRNA knockdown of the plasmalemmal acyl transferase, DHHC5.

6 idually mediate the formation of functional, plasmalemmal alpha4betadelta GABARs.

7 ied by a respective decrease and increase in plasmalemmal and cytoplamic NK3R densities in AVP-labele

8 s moderately expressing p-mTOR (Ser 2448) in plasmalemmal and cytoplasmic compartments.

9 ere immunogold-silver labeled to examine the plasmalemmal and cytoplasmic distribution of these recep

10 nal profiles M2R immunogold was localized to plasmalemmal and cytoplasmic regions and showed a simila

11 t ER-alpha immunoreactivity (IR) was seen in plasmalemmal and cytoplasmic regions of spine heads, wit

12 (betagamma) subunits, stably associates with plasmalemmal and cytosolic caveolin.

13 ic chain of ion transport proteins including plasmalemmal and mitochondrial Na(+) /Ca(2+) exchangers,

14 disorders of acid-base transporters involve plasmalemmal and organellar transporters of H(+), HCO3(-

15 gold labeling for NBAT was distributed along plasmalemmal and vacuolar membranes within somata, dendr

16 Plasmalemmal and vesicular gamma-aminobutyric acid (GABA

17 ophins retain functional domains and mediate plasmalemmal assembly of the dystrophin-associated glyco

18 Plasmalemmal ATP sensitive potassium (K(ATP)) channels a

19 encoding the Kir6.2 and SUR1 subunits of the plasmalemmal ATP-sensitive K+ (KATP) channel.

20 GABA, which is subsequently released through plasmalemmal Best1 channels to control neuronal excitabi

21 e of the thymocytes undergoing apoptosis had plasmalemmal bound galectin-9.

22 ntracytoplasmic vesicles, in contrast to the plasmalemmal budding of HIV-1 typically seen with infect

23 microdomain that develops rapidly near open plasmalemmal Ca(2+) channels like voltage-gated L-type (

24 global Ca(2+) transients, with no change in plasmalemmal Ca(2+) current.

25 t was found to be able to substitute for the plasmalemmal Ca(2+) exchange function, thus rendering th

26 ble from those in the absence of Ca(2+) when plasmalemmal Ca(2+) extrusion was suppressed.

27 ca2 knockout (KO) is compensated by enhanced plasmalemmal Ca(2+) fluxes.

28 rved that, in primary mesothelial cells, the plasmalemmal Ca(2+) influx played a pivotal role.

29 solic Ca(2+) in hASMC through stimulation of plasmalemmal Ca(2+) influx, but excluded store-operated

30 NFAT1 is stimulated by sub-plasmalemmal Ca(2+) microdomains, whereas NFAT4 addition

31 In the absence of store depletion, plasmalemmal Ca(2+) permeability in resting muscle is ve

32 uggest that an important fraction of resting plasmalemmal Ca(2+) permeability is mediated by the Orai

33 ce of store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2+) release-activated Ca(2+) (CRAC) chan

34 igger store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2+)-selective Orai1 channels.

35 ng1 interfered with downstream IP3-dependent plasmalemmal Ca2+ entry without affecting the release of

36 selective for NCX: L-type Ca2+ currents and plasmalemmal Ca2+ pumps were not affected.

37 n inhibitory effect on Ca2+ extrusion by the plasmalemmal Ca2+-ATPase.

38 es of Ca2+ from the SR (sparks), stimulating plasmalemmal Ca2+-sensitive K+ (BK) channels, determines

39 ve terminals by exposure to veratridine or a plasmalemmal [Ca2+]o receptor agonist (Gd3+).

40 Inhibition of plasmalemmal calcium channels diminished the magnitude a

41 store-operated calcium entry (SOCE) through plasmalemmal calcium channels that open in response to s

42 ne adenylyl cyclases synthesize a restricted plasmalemmal cAMP pool that is intensely endothelial bar

43 contrast to the barrier-enhancing actions of plasmalemmal cAMP, the ExoY cytosolic cAMP pool induced

44 Plasmalemmal Cav2.3 protein was higher than in dopaminer

45 number of distinct noncoated pits resembling plasmalemmal caveolae also accumulated in anti-dynamin a

46 ll surface signal-transducing domains termed plasmalemmal caveolae and interacts with caveolin, an in

47 proaches revealed that MARCKS is targeted to plasmalemmal caveolae and undergoes subcellular transloc

48 Plasmalemmal caveolae are membrane microdomains that are

49 herichia coli, was specifically localized to plasmalemmal caveolae in BMMCs.

50 ve previously shown that eNOS is targeted to plasmalemmal caveolae in endothelial cells.

51 ynthase (eNOS) interacts reversibly with the plasmalemmal caveolae structural protein, caveolin-1.

52 cells, eNOS has been shown to be targeted to plasmalemmal caveolae, a process that is dependent on my

53 for eNOS palmitoylation and localization to plasmalemmal caveolae, and suggest further that sequence

54 Caveolin-1, a principal component of plasmalemmal caveolae, has been reported as a potentiall

55 (cav-1), the principle structural protein of plasmalemmal caveolae, regulates inflammatory signaling

56 sible subcellular targeting of the enzyme to plasmalemmal caveolae.

57 mice lack caveolin-1 protein expression and plasmalemmal caveolae.

58 ogical evidence that dynamin associates with plasmalemmal caveolae.

59 e efficient subcellular targeting of eNOS to plasmalemmal caveolae.

60 ducing domains in the plasma membrane termed plasmalemmal caveolae.

61 re of enzyme docking to caveolin proteins in plasmalemmal caveolae.

62 ion of Ca2+-dependent signal transduction in plasmalemmal caveolae.

63 caveolin-1 are associated within endothelial plasmalemmal caveolae.

64 d signal-transducing membrane domains termed plasmalemmal caveolae.

65 Thus, acylation targets eNOS to plasmalemmal caveolae.

66 hatidylinositol 4,5-bisphosphate (PIP(2)) in plasmalemmal caveolae.

67 de synthase (eNOS) promotes its targeting to plasmalemmal caveolae; agonist-promoted depalmitoylation

68 well as abundant glial processes also showed plasmalemmal CB1R and were mainly without muOR immunorea

69 studies illustrate that DTBI evokes evolving plasmalemmal changes that highlight mechanical and poten

70 rmacological agents to determine the role of plasmalemmal channels in Ca(2)(+) homeostasis.

71 shown to form nonselective, high-conductance plasmalemmal channels permeable to ATP, thereby offering

72 inct pathways that include diffusion through plasmalemmal channels, translocation by multiple transpo

73 Depletion of plasmalemmal cholesterol influences the distribution of

74 xtracellular matrix (ECM) glycoproteins, and plasmalemmal Cl(-) transporters - could help the identif

75 these pathways and substances was to repair plasmalemmal damage in eukaryotic cells.

76 of vesicles have been observed at regions of plasmalemmal damage in many cell types.

77 is induced by Ca2+ inflow resulting from the plasmalemmal damage.

78 l DAT gold particles (per square micron) and plasmalemmal DAT gold particles (per micron) than those

79 tified as cholinergic targets, 35% contained plasmalemmal DAT, and 65% were without detectable DAT im

80 ssion of the alpha4 subunit is necessary for plasmalemmal delta subunit localization at pubertal onse

81 ugh there was already a reduction in the NR1 plasmalemmal density at this time point.

82 ignificant (1) decrease in the extrasynaptic plasmalemmal density of obligatory GluN1-NMDA subunits i

83 PKG (protein kinase G)-dependent increase in plasmalemmal density of the insulin-independent glucose

84 The plasmalemmal dihydropyridine receptor (DHPR) is the volt

85 in injury (DTBI) is associated with neuronal plasmalemmal disruption, leading to either necrosis or r

86 To assess plasmalemmal disruption, rats (n = 21) received intracer

87 o, but independent of, neurons demonstrating plasmalemmal disruption.

88 to identify injury-induced neuronal somatic plasmalemmal disruption.

89 Ca(2+) influx through plasmalemmal disruptions activates calpain, vesicle accu

90 ll sizes and (2) a shift from cytoplasmic to plasmalemmal distribution of GluN1 in large dendrites re

91 As suggested by their restricted plasmalemmal distribution, the high ouabain-affinity Na+

92 ne apparatus, whereas MOR showed a prominent plasmalemmal distribution.

93 ny neuronal profiles showed endomembrane and plasmalemmal distributions of one or both receptors.

94 These specialized plasmalemmal domains are enriched in G protein-coupled r

95 old within the active zone, cytoplasmic, and plasmalemmal domains of axon terminals, and subjacent to

96 ins, and within postsynaptic subsynaptic and plasmalemmal domains, accompanied high synapse density.

97 particles within presynaptic cytoplasmic and plasmalemmal domains, and within postsynaptic subsynapti

98 (METH) both rapidly (within hours) decrease plasmalemmal dopamine (DA) uptake and cause long-term de

99 of antipeptide antisera against M5R and the plasmalemmal dopamine transporter (DAT) in single sectio

100 ically released dopamine is regulated by the plasmalemmal dopamine transporter (DAT), an integral mem

101 minals differ in levels of expression of the plasmalemmal dopamine transporter (DAT).

102 al tail domain (ITD), is required to inhibit plasmalemmal expression of BK channels.

103 fferent method for the isolation of PVs from plasmalemmal fragments obtained by a silica-coating proc

104 We show that ET-1, which activates plasmalemmal G protein-coupled receptors and InsP3 produ

105 Postnatal expression of the plasmalemmal GABA transporter-1 (GAT-1), GAT-3, and the

106 f chronic unpredictable stress increased the plasmalemmal glial-glutamate transporter 2 (EAAT2) and i

107 PF cells express a plasmalemmal heptahelical receptor (CaR) that binds Ca2+

108 he plasmalemma to repair small (1-30 microm) plasmalemmal holes or a complete transection of the plas

109 Plasmalemmal immunogold particles representing alpha(1)1

110 n surface area of intracellular cisterns and plasmalemmal infoldings.

111 the plasma membrane and reseal laser-induced plasmalemmal injuries and that are small enough to be in

112 caused immediate, scattered neuronal somatic plasmalemmal injury to all of the extracellular HMWTs us

113 both A-type potassium channel synthesis and plasmalemmal insertion of vesicles bearing these potassi

114 ll surface proteins located primarily in the plasmalemmal invaginations called caveolae.

115 Many of these long plasmalemmal invaginations had clathrin-coated pits alon

116 ndocytosis and induced the formation of long plasmalemmal invaginations with attached clathrin-coated

117 eolin-1 (Cav-1) is the structural protein of plasmalemmal invaginations, termed caveolae, which funct

118 Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs via

119 f guidance cue receptors leads to opening of plasmalemmal ion channels remains largely unknown.

120 that overexpress specific calcium permeable plasmalemmal ion channels with available selective pharm

121 e flagella, a process that probably involves plasmalemmal ion channels.

122 ling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish trans

123 recognize membrane proteins localized to the plasmalemmal junction between migrating neurons and adja

124 In addition, sub-plasmalemmal ('junctional') components of the ER (jER) a

125 We showed that gephyrin stabilizes plasmalemmal KCC2 and promotes its clustering in hippoca

126 We show that gephyrin controls plasmalemmal KCC2 clustering and that loss of gephyrin c

127 s paralleled by a decrease in both total and plasmalemmal KCC2 protein.

128 ting showed that BFA blocked the increase in plasmalemmal KCNMB1 levels achieved via CLR enrichment.

129 ns of Ca(2+) ("Ca(2+) sparks") that activate plasmalemmal large-conductance Ca(2+)-activated K(+) (BK

130 tained both dextrans, demonstrating enduring plasmalemmal leakage, with many demonstrating necrosis.

131 From these and other data, we propose that plasmalemmal lesions in most eukaryotic cells (including

132 le alpha4 knockout (KO) mice were tested for plasmalemmal levels of the delta subunit within dendriti

133 The decline in plasmalemmal localization is manifested as decreased res

134 Increased plasmalemmal localization of alpha4betadelta GABA(A) rec

135 At pubertal onset, plasmalemmal localization of the delta subunit is reduce

136 and C2E domains are dispensable for correct plasmalemmal localization.

137 but showed a more prominent, size-dependent plasmalemmal location in nondopaminergic dendrites.

138 owed diffuse staining around a predominantly plasmalemmal location.

139 activity in striatal vesicle subcellular and plasmalemmal membrane fractions, respectively.

140 Plasmalemmal membrane labeling for MOR1 was more frequen

141 Metabolism of anionic phospholipids in plasmalemmal membrane may be a novel and general mechani

142 rter antagonist, reversed alterations in the plasmalemmal membrane potential (V(m)) and pH.

143 site, Abeta concentrates APP molecules into plasmalemmal membrane protein clusters.

144 ce between the endoplasmic reticulum and the plasmalemmal membrane was ruled out as a mechanism for t

145 Membrane/lipid rafts, plasmalemmal microdomains enriched in cholesterol, sphin

146 MLRs are plasmalemmal microdomains enriched in sphingolipids, cho

147 es to determine whether eNOS is localized to plasmalemmal microdomains implicated in signal transduct

148 Caveolae are plasmalemmal microdomains that are involved in vesicular

149 into sphingomyelin-rich and cholesterol-rich plasmalemmal microdomains, thereby acquiring resistance

150 ulum/polyribosomes, and accumulations of sub-plasmalemmal microfilaments containing spindle densities

151 e caused preferential Ca(2+) uptake into sub-plasmalemmal mitochondria.

152 The plasmalemmal monoamine transporters clear the extracellu

153 tibodies on distinct endocytic processes and plasmalemmal morphology were then assayed by fluorescenc

154 t newly enveloped VZV to late endosomes, and plasmalemmal MPRci are necessary for entry by cell-free

155 ac myocytes to eliminate any contribution of plasmalemmal Na(+) channels to the observed actions of t

156 gamma subunit is a specific component of the plasmalemmal Na(+),K(+)-ATPase.

157 was without effect, whereas the reverse mode plasmalemmal Na(+)/Ca(2+) exchange inhibitor KB R7943 re

158 presynaptic [Ca(2+)]i recovery, and blocking plasmalemmal Na(+)/Ca(2+) exchange produced only a small

159 mp, acting in proportion to their effects on plasmalemmal Na(+)/Ca(2+) exchange.

160 ncreases in cytosolic Ca(2+) mediated by the plasmalemmal Na(+)/Ca(2+) exchanger (NCX) operating in t

161 heart-enriched isoform, CHP3, regulates the plasmalemmal Na(+)/H(+) exchanger NHE1 isoform by enhanc

162 10-15% of PFC NE axons exhibit predominantly plasmalemmal NET and evident TH immunoreactivity.

163 However, the proportion of plasmalemmal NET nearly doubled from 29% in control anim

164 Plasmalemmal neurotransmitter transporters (NTTs) regula

165 es to induce Ca(2+) influx through expressed plasmalemmal nicotinic channels.

166 (2+) levels through STIM1-mediated gating of plasmalemmal Orai channels.

167 Immunoelectron microscopy revealed plasmalemmal OTR at enterocyte adherens junctions.

168 s and induced a significant increase in near plasmalemmal p47(phox) and a decrease in cytoplasmic p47

169 between young females and males in the near plasmalemmal p47(phox) on AVP dendrites seen in the pres

170 The plasmalemmal PA is synthesized by phosphorylation of dia

171 R) are functionally coupled to the overlying plasmalemmal (PL) microdomains in PL-jER units named 'PL

172 uclear region moving 3 times faster than the plasmalemmal pool, suggesting that protein-lipid or prot

173 Furthermore, the plasmalemmal presence of CD36 and intracellular lipid le

174 th insulin, we measured GLUT4 translocation, plasmalemmal presence of the fatty acid transporter CD36

175 t up to 20 spines shared a recycling pool of plasmalemmal proteins rather than maintaining independen

176 induces phosphorylation of endothelial cell plasmalemmal proteins residing in caveolae as detected b

177 membrane protein VAMP/synaptobrevin and the plasmalemmal proteins syntaxin and SNAP-25.

178 ar endosomal and lysosomal membranes to form plasmalemmal pseudopods.

179 st that endogenous calpain activity promotes plasmalemmal repair by vesicles or other membranes which

180 Plasmalemmal repair is necessary for survival of damaged

181 formation of a dye barrier (seal) to assess plasmalemmal repair, we now report that B104 hippocampal

182 To reveal plasmalemmal resealing or enduring disruption, rats were

183 sporter (DAT) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the term

184 gic neurons that have a limited capacity for plasmalemmal reuptake of dopamine, a characteristic of t

185 he 5-HT levels reflect vesicular release and plasmalemmal reuptake through the serotonin transporter

186 specific multiprotein complexes at discrete plasmalemmal, sarcoplasmic reticular and myofilament sit

187 The frequency and rate of plasmalemmal sealing are decreased by a small molecule i

188 undant parallel pathways of Ca(2+)-dependent plasmalemmal sealing of injured neurons mediated in part

189 ractions, proteins, and pathways involved in plasmalemmal sealing should suggest novel neuroprotectiv

190 endent, PKA-independent, pathway involved in plasmalemmal sealing.

191 local ablation, adult ECs survive through a plasmalemmal self-repair response, while neonatal ECs ar

192 ate and palmitate and is targeted thereby to plasmalemmal signal-transducing domains termed caveolae.

193 calization of neurotrophin receptor (NTR) to plasmalemmal signaling microdomains, termed membrane/lip

194 rge dendrites, but was more often located at plasmalemmal sites in small dendrites, the majority of w

195 2- selectively produced by mitochondria near plasmalemmal sites of Ca2+ entry acts as a modulator to

196 these dendrites the MOR1 was at nonsynaptic plasmalemmal sites.

197 Phospholemman regulates the plasmalemmal sodium pump in excitable tissues.

198 lls per group, *, p < 0.01), and reduced the plasmalemmal staining of hERG.

199 lls per group; *, p < 0.01), and reduced the plasmalemmal staining of hERG.

200 tients with multiple sclerosis yielded faint plasmalemmal staining on both KIR4.1-expressing and non-

201 In T cells, RyRs co-localize with the plasmalemmal store-operated Ca(2+) channels of the Orai

202 t activates extracellular Ca2+ entry via the plasmalemmal store-operated channel transient receptor p

203 nolabeling on endomembranes just beneath the plasmalemmal surface (+42.1 +/- 11.3%; p < 0.05) in non-

204 ion with the negatively charged, cytoplasmic plasmalemmal surface and with CaVbeta, even in the absen

205 o controls had a reduced percentage of their plasmalemmal surface apposed to unmyelinated axon profil

206 DOR-immunoreactivity was associated with the plasmalemmal surface at or near the postsynaptic density

207 er than 5.5-fold (p < .0001) by altering its plasmalemmal surface expression; WNK3 did not affect ROM

208 eactivity was most often associated with the plasmalemmal surface near asymmetric synapses.

209 p75NTR-IR was most often associated with the plasmalemmal surface near postsynaptic densities; in den

210 concurrent increase in the percentage of the plasmalemmal surface occupied by active zones and the si

211 dy state distribution of GAT-3 at the apical plasmalemmal surface requires a protein-protein interact

212 these structures and was not limited to the plasmalemmal surface.

213 cles, and was less consistently found on the plasmalemmal surface.

214 f unmyelinated axons (from 15 to 35%) to the plasmalemmal surface; and (b) located primarily in the c

215 YNMLCFGIY1015 possible participation in Slo1 plasmalemmal targeting and demonstrate its role as a mai

216 in the amount, subcellular localization, or plasmalemmal targeting of DAT within individual dopamine

217 transport rate, cell surface stability, and plasmalemmal trafficking of KCC2 are rapidly and reversi

218 sites required for the vasopressin-mediated plasmalemmal translocation and activation of NKCC2 in vi

219 All clinically approved drugs targeting the plasmalemmal transporters for dopamine, norepinephrine,

220 pain, leading to disruption of E-C coupling, plasmalemmal transverse tubule degeneration, abnormal Ca

221 ytosis demonstrated that UCD38B bypasses the plasmalemmal uPAS complex and directly acts intracellula

222 In glial plasmalemmal vesicle (GPV) preparations from treated rat

223 binding protein G(i), and thereby activates plasmalemmal vesicle formation and the directed migratio

224 d SOD with antibodies (Ab/SOD, size 10nm) to plasmalemmal vesicle-associated protein (Plvap) that is

225 et endothelial cell adhesion molecule 1, and plasmalemmal vesicle-associated protein).

226 We have demonstrated that the plasmalemmal vesicles (caveolae) of the continuous micro

227 Plasmalemmal vesicles (PVs) or caveolae are plasma membr

228 The vast majority of plasmalemmal vesicles carrying albumin also immunostaine

229 ecting a small fraction of the population of plasmalemmal vesicles of vascular endothelia are describ

230 ated muscle requires proper communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ re

231 d by alkaline incubation involves opening of plasmalemmal voltage-dependent Ca channels and Ca(2+) en

232 le having no effect on the regulation of the plasmalemmal voltage-gated Ca(2+) channel, Ca(v)1.2.

233 plasma membrane and to repair laser-induced plasmalemmal wounds in dysferlin-deficient human myoblas

234 levels, resealing kinetics of laser-induced plasmalemmal wounds, myotube formation, and cellular via

235 3, members of the Zip (Zrt/Irt-like protein) plasmalemmal Zn transporter family, are predominantly ex