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1 -induced thrombocytopenia (HIT) is caused by platelet-activating anti-platelet factor 4 (PF4)/heparin
4 prothrombotic adverse drug effect induced by platelet-activating antibodies against multimolecular co
5 eparin reexposure can be safely performed if platelet-activating antibodies are no longer detectable
6 thrombocytopenia (HIT) can be appropriate if platelet-activating antibodies are no longer detectable.
7 a novel, unexpected, PS backbone-dependent, platelet-activating effect of nucleotide-based drug cand
8 mechanisms may contribute to the unexpected platelet-activating effects of pharmaceutical integrin a
13 alyzes the hydrolytic inactivation of plasma platelet activating factor (PAF) and is also known as PA
15 as well as resveratrol and quercetin, on the platelet activating factor (PAF) biosynthetic enzymes, a
16 plexed with the physiological ligand GM2 and platelet activating factor (PAF) have shown binding at t
19 th BN52021, WEB-2170, and WEB-2086 (specific platelet activating factor (PAF) receptor antagonists),
20 Both LPS and BLP stimulated the synthesis of platelet activating factor (PAF), a potent lipid mediato
21 rved that tumor necrosis factor (TNF)-alpha, platelet activating factor (PAF), and lipopolysaccharide
22 rmyl-methionyl-leucyl-phenylalanine (fMLP)), platelet activating factor (PAF), leukotriene B4 (LTB(4)
23 mbination with uridine 5'-diphosphate (UDP), platelet activating factor (PAF), or lysophosphatidic ac
24 incubated in H2O2 (70 micromol/L, 2 hours), platelet activating factor (PAF), prostaglandin E2 (PGE2
25 ion and chemoattraction, Mig potently blocks platelet activating factor (PAF)- and leukotriene B4 (LT
31 with the HDL-associated enzymes paraoxonase, platelet activating factor acetylhydrolase (PAF), and gl
32 nts, the most potent effect was observed for platelet activating factor acetylhydrolase alpha (Paf-AH
33 mesangial cell line induced upregulation of platelet activating factor and the fibrotic marker TGF-b
34 d to surrogate PMNs respond to activation by platelet activating factor by initiating translation and
35 regation was blocked using a monoclonal anti-platelet activating factor receptor (PafR) antibody and
37 ine, an H1R antagonist, blocked EAE, and the platelet activating factor receptor antagonist CV6209 re
38 creased adherence mediated by binding to the platelet activating factor receptor on epithelial cells.
40 D synthase, histamine receptor type 1 (H1R), platelet activating factor receptor, Ig Fc epsilon recep
41 rotein is rapidly synthesized in response to platelet activating factor under the control of a specia
43 ith N-formyl-methionyl-leucyl-phenylalanine, platelet activating factor, and leukotriene B4 was phosp
44 d immunoglobulins (IgG, IgA), cytokines with platelet activating factor, calcium ionophore, or phorbo
46 ogen synthase kinase 3beta inhibitor, blocks platelet activating factor-induced activation of glycoge
55 low density lipoprotein and comigrates with platelet-activating factor (PAF) acetylhydrolase on KBr
57 the PAFAH1B2 and PAFAH1B3 subunits of type I platelet-activating factor (PAF) acetylhydrolase, a phos
59 idized glycerophosphocholines (Ox-GPCs) with platelet-activating factor (PAF) activity produced non-e
61 er short-chained phospholipids--inflammatory platelet-activating factor (PAF) and apoptotic oxidative
62 genesis and photoimmune suppression, such as platelet-activating factor (PAF) and serotonin (5-HT) re
64 perties of the yoghurts PL fractions against platelet-activating factor (PAF) and thrombin-induced pl
69 r wild-type control as experimental animals, platelet-activating factor (PAF) at 10(-7) m as the test
71 at cigarette smoking leads to an increase in platelet-activating factor (PAF) content and PAF recepto
72 ured spleen and liver cytokine responses and platelet-activating factor (PAF) content in mice given C
73 -2) regulate surfactant protein-A (SP-A) and platelet-activating factor (PAF) expression, which incre
74 ittle, if any, role in neutrophil priming by platelet-activating factor (PAF) for OpZ-dependent respo
77 t studies have implicated the lipid mediator platelet-activating factor (PAF) in UVB-mediated systemi
78 models of LE that the phospholipid mediator platelet-activating factor (PAF) increases in LE and tha
97 tors of inflammation are not identified, but platelet-activating factor (PAF) is implicated as a pote
99 Because the lipid mediator of inflammation, platelet-activating factor (PAF) is released by UV-irrad
100 Animal models show that the receptor for platelet-activating factor (PAF) is responsible for many
105 ry potential of the proinflammatory mediator platelet-activating factor (PAF) on the subcellular dist
106 urvival after anaphylaxis, administration of platelet-activating factor (PAF) or histamine, and expos
107 th Kindlin-2 siRNA showed enhanced basal and platelet-activating factor (PAF) or lipopolysaccharide-s
108 esulted from inhibitory signals generated by platelet-activating factor (PAF) or oxidized LDL that ac
112 regation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibi
113 tor and that antagonists of 5-HT(2A) and the platelet-activating factor (PAF) receptor can block cis-
114 f intracellular Leishmania, we surmised that platelet-activating factor (PAF) receptor had a signific
116 Corneal stromal myofibroblasts express the platelet-activating factor (PAF) receptor, but its role
122 ne suppression are the binding of UV-induced platelet-activating factor (PAF) to its receptor and the
123 and the proinflammatory glycerophospholipid platelet-activating factor (PAF) were markedly reduced i
124 cell types with respect to the metabolism of platelet-activating factor (PAF), a biologically active
125 s by exploiting molecular mimicry to degrade platelet-activating factor (PAF), a host-derived inflamm
128 Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid
130 ated endocytosis (CME), we hypothesized that platelet-activating factor (PAF), an effective chemoattr
131 in corneal epithelial cells stimulated with platelet-activating factor (PAF), and interferes with th
132 UVB radiation generates the lipid mediator, platelet-activating factor (PAF), as well as oxidized ph
133 nergistic signaling induced by serotonin and platelet-activating factor (PAF), but not histamine.
135 Leu-Phe (fMLP), adenosine diphosphate (ADP), platelet-activating factor (PAF), interleukin-8 (IL-8),
136 shown that the lipid inflammatory mediator, platelet-activating factor (PAF), synthesized by activat
137 mbrane inhibits hyperpermeability induced by platelet-activating factor (PAF), VEGF in ECV-CD8eNOSGFP
138 e calcium entry (SOCE) following the initial platelet-activating factor (PAF)-induced release of Ca(2
152 gulation of expression of the plasma form of platelet-activating factor acetylhydrolase (PAF AH) in t
155 or was inactivated by alkaline hydrolysis or platelet-activating factor acetylhydrolase (PAF-AH) trea
156 the possibility that the activity represents platelet-activating factor acetylhydrolase (PAF-AH), an
158 t that the cytoplasmic PLA(2) enzyme complex platelet-activating factor acetylhydrolase (PAFAH) Ib, w
159 fective milk containing diminished levels of platelet-activating factor acetylhydrolase (PAFAH).
161 roteins such as alpha-N-catenin (CTNNA2) and platelet-activating factor acetylhydrolase 1b regulatory
163 eration by ectopic expression of PL-specific platelet-activating factor acetylhydrolase 2 (PAFAH2) ma
164 lycopene), and antioxidant enzyme activity (platelet-activating factor acetylhydrolase [PAF-AH] and
165 A recent report demonstrates that plasma platelet-activating factor acetylhydrolase activity incr
166 om allergy, such as suggesting that baseline platelet-activating factor acetylhydrolase activity leve
169 lesterolemic human plasma with a recombinant platelet-activating factor acetylhydrolase completely ab
170 izygous mutations in the human gene encoding platelet-activating factor acetylhydrolase IB subunit al
171 imal study, transfection of tumor cells with platelet-activating factor acetylhydrolase inhibited tum
172 nt controversy over whether paraoxonase 1 or platelet-activating factor acetylhydrolase is responsibl
173 rpose of this study was to determine whether platelet-activating factor acetylhydrolase Sse and strep
174 creened by enzymatic assays for SpeB and the platelet-activating factor acetylhydrolase Sse, and a ne
175 coding complement component receptor 2/CD21, platelet-activating factor acetylhydrolase, and oxidized
176 tions in the relative levels of paraoxonase, platelet-activating factor acetylhydrolase, ceruloplasmi
177 lation and elongation protein zeta-1 (FEZ1), platelet-activating factor acetylhydrolase, isoform Ib,
178 e inconclusive in determining whether plasma platelet-activating factor acetylhydrolase, or lipoprote
179 nzymes, BChE and a new extracellular form of platelet-activating factor acetylhydrolase, PAFAH1b2.
180 ated phospholipase A2 (Lp-PLA2), also called platelet-activating factor acetylhydrolase, plays in ath
185 In hippocampal slices exposed to a stable platelet-activating factor analogue, tetanic stimulation
187 on anaphylaxis suggest an important role for platelet-activating factor and its relationship to the n
188 flammatory mediators (tumor necrosis factor, platelet-activating factor and prostaglandins), studies
189 locked by a combination of antihistamine and platelet-activating factor antagonist (but neither alone
190 Tsujimura et al. report that the release of platelet-activating factor by basophils stimulated with
192 surfactant phospholipids and biosynthesis of platelet-activating factor in noninflammatory remodeling
195 ceptor antagonists, or overexpression of the platelet-activating factor metabolizing enzyme acetylhyd
196 depletion by the G protein-coupled agonists platelet-activating factor or fMLP, but abolished agonis
197 tional state, and subsequent activation with platelet-activating factor or formyl-methionyl-leucyl-ph
199 ormally sensitive to substance P, but not to platelet-activating factor or serotonin, suggesting that
200 Under the same experimental conditions, platelet-activating factor primed neutrophils for supero
201 factor, the ability of alpha-toxin to induce platelet-activating factor production was assessed, and
202 eir ability to generate oxidized lipids with platelet-activating factor receptor (PAF-R) agonist acti
204 er of melanoma metastasis, via activation of platelet-activating factor receptor (PAFR) and cAMP-resp
205 dditional recognition system mediated by the platelet-activating factor receptor (PAFr) and directed
206 e hypothesis that influenza up-regulates the platelet-activating factor receptor (PAFr) and thereby p
210 hibitors identified a prominent role for the platelet-activating factor receptor (PAFr) in hypoxia-as
213 f synaptic activity in a manner dependent on platelet-activating factor receptor (PAFR) signaling.
214 polymeric immunoglobulin receptor (pIgR) and platelet-activating factor receptor (PAFr) to attach and
215 iciency in interleukin 1alpha (IL-1alpha) or platelet-activating factor receptor (PAFR), an important
216 of A. baumannii binds to A549 cells through platelet-activating factor receptor (PAFR), resulting in
221 experiments revealed that L5 signals through platelet-activating factor receptor and lectin-like oxid
222 s demonstrate the differential expression of platelet-activating factor receptor and TLR-4 in uterine
223 nti-eotaxin and anti-RANTES mAbs, but not by platelet-activating factor receptor antagonists (CV6209,
226 tion was assessed, and whether the epidermal platelet-activating factor receptor could augment toxin-
227 ctive effect resulted in part from decreased platelet-activating factor receptor expression on endoth
228 antibody or therapeutic agents that modulate platelet-activating factor receptor expression, may conf
229 stry studies demonstrate the presence of the platelet-activating factor receptor in both endometrial
230 nally, retroviral-mediated expression of the platelet-activating factor receptor into the platelet-ac
232 milar involvement for an unrelated GPCR (the platelet-activating factor receptor), indicating that it
233 Bacterial lipoteichoic acid activates the platelet-activating factor receptor, which is G protein-
234 rom the international phase III trial of the platelet-activating factor receptor-antagonist Lexipafan
235 platelet-activating factor receptor into the platelet-activating factor receptor-negative epithelial
236 ent studies used model systems consisting of platelet-activating factor receptor-positive and -negati
240 hil, macrophage, and neutrophil secretion of platelet-activating factor subsequent to FcgammaR stimul
241 of PMN cationic entry after thapsigargin or platelet-activating factor suggested that SOCE occurs th
243 as prior exposure to a p38-activating agent (platelet-activating factor) diminished the TNFalpha-indu
244 some of these peptides (eg, endothelin-1 and platelet-activating factor) has decreased mortality and
245 nt chemicals (bradykinin, capsaicin, low pH, platelet-activating factor), whereas Adelta-fibres are r
247 toxic injury via activation of receptors for platelet-activating factor, a proinflammatory signaling
248 tic oxidatively truncated phospholipids, and platelet-activating factor, a remarkably potent and plei
249 ory cellular metabolite up-regulated by Tat, platelet-activating factor, also induced oxidative stres
251 ory G protein-coupled chemoattractants fMLP, platelet-activating factor, and IL-8 elicit unique patte
252 ipids, including sphingosine, sphingomyelin, platelet-activating factor, and lysophosphatidylcholine.
254 production induced by TNF-alpha, GM-CSF, and platelet-activating factor, and this loss of pyk2 activi
255 e mediated by the autocrine activity, not of platelet-activating factor, but rather of endogenous CCR
256 arturition signals, surfactant protein A and platelet-activating factor, by the developing mouse feta
257 irway eosinophils to chemoattractants (FMLP, platelet-activating factor, CCL11, CCL5, CXCL8) with res
259 duction of prostaglandins, leukotrienes, and platelet-activating factor, is present in EAE lesions.
260 merous chemoattractants, such as chemokines, platelet-activating factor, or FMLP, through a process k
262 mediators, including TNF-alpha, GM-CSF, and platelet-activating factor, overcomes the adhesion-media
263 -alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor, PAF) and the generation of 2
264 phils were treated with fMLP with or without platelet-activating factor, PMA alone, or tumor necrosis
265 ity, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular perm
266 lus for the synthesis for the lipid mediator platelet-activating factor, the ability of alpha-toxin t
268 ructurally diverse neutrophil-priming agents platelet-activating factor, TNF-alpha, and the substance
269 5-hydroxytryptamine), platelet factor 4, and platelet-activating factor, which specifically stimulate
270 lpha-toxin resulted in significant levels of platelet-activating factor, which were approximately 50%
271 l, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated
272 via CD14-, NF-kappaB-, and p44/42-dependent, platelet-activating factor-independent activation of the
275 ependent manner, LXs significantly inhibited platelet-activating factor-induced increases in leukocyt
277 TWEAK-blocking antibody prevented histamine/platelet-activating factor-induced vascular subcutaneous
278 gosine blocks thapsigargin-, ionomycin-, and platelet-activating factor-mediated SOCE despite normal
289 uding vascular endothelial growth factor and platelet-activating factor; by contrast, endothelial cel
297 tin-like receptor 2 (CLEC-2) is an essential platelet-activating receptor in hemostasis and thrombosi
298 C-type lectin-like receptor 2 are essential platelet activating receptors in hemostasis and thrombo-
299 omponents that specifically target different platelet-activating receptors such as the collagen-bindi