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1 oxy group, led to the oxatetracyclic core of platensimycin.
2 to develop a concise asymmetric synthesis of platensimycin.
3 and biologically related but different from platensimycin.
4 lay a key role in the biological activity of platensimycin.
5 used in the synthesis of the antibiotic (-)-platensimycin.
9 logical evaluation of two distinct series of platensimycin analogues with varying degrees of complexi
12 ydroxyl group in the unified biosynthesis of platensimycin and platencin, two highly functionalized d
15 yntheses of platensimycin and its congeners, platensimycins B(1) and B(3), platensic acid, methyl pla
20 Platencin, though structurally similar to platensimycin, has been found to operate through a sligh
22 while the substituted benzoic acid domain of platensimycin is a highly conserved structural motif wit
26 ings refine our present understanding of the platensimycin pharmacophore and establish certain struct
33 inhibitors of mammalian fatty acid synthase, platensimycin specifically inhibits fatty acid synthesis
34 95 and 3.91 microg/ml, respectively, whereas platensimycin targets only FabF (IC50 = 0.13 microg/ml)