ライフサイエンスコーパス: pleckstrin

1 l with the PKC (protein kinase C) substrate, pleckstrin.

2 ignaling pathway compensates for the loss of pleckstrin.

3 ired actin assembly present in cells lacking pleckstrin.

4 Pleckstrin accounts for 1% of the total protein in these

5 (fibrillin 3 [FBN3], myosin IXA [MYO9A], and pleckstrin and Sec7 domain containing 3 [PSD3]) were ide

6 retion, phosphorylation of the PKC substrate pleckstrin, and Ca(2+) mobilization were unaffected in J

7 Overexpressed pleckstrin can affect polyphosphoinositide second messen

8 biquitination of the Dishevelled, Egl-10 and Pleckstrin (DEP) domain of the Wnt pathway protein Dishe

9 onformational changes in the dishevelled/Egl/pleckstrin (DEP) domain, a conserved structural motif th

10 which requires its dishevelled, Egl-10, and pleckstrin (DEP) domain, acts by promoting LIN-17 phosph

11 nslocation requires the Dishevelled, Egl-10, Pleckstrin (DEP) domain, but the molecular entity that s

12 n Gbeta5 and N-terminal Dishevelled, EGL-10, Pleckstrin/DEP Helical Extension (DEP/DHEY) domains are

13 ng these, the first dishevelled, Egl-10, and pleckstrin domain (DEP1) remains to be structurally char

14 This identified FERM, Rho/ArhGEF, and Pleckstrin domain protein 1 (Farp1) as strongly reduced

15 he protein Farp1 [FERM, RhoGEF (ARHGEF), and pleckstrin domain protein 1], a Rac1 activator previousl

16 ositol polyphosphate-5-phosphatase (INPP5D), pleckstrin domain-containing A3 (PHLDA3), sulfatase 2 (S

17 ation domains, but not the disheveled-Egl-10-pleckstrin domain.

18 of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain.

19 Platelets lacking pleckstrin exhibit a marked defect in exocytosis of delt

20 e mice containing a null mutation within the pleckstrin gene.

21 Expression of Dbl homology-pleckstrin homology (DH-PH) region of ITSN-2L (DH-PH(ITS

22 x) and catalytic Dbl homology and C-terminal pleckstrin homology (DH-PHc) domain.

23 the small GTPases through their Dbl homology/pleckstrin homology (DH.PH) domains.

24 ly showed that a BAR domain in tandem with a Pleckstrin Homology (PH domain) underlies the assembly o

25 PS interacts with specific residues in the pleckstrin homology (PH) and regulatory (RD) domains of

26 ng to a premature stop codon and loss of the pleckstrin homology (PH) and Src homology 2 (SH2) domain

27 pha-syntrophin lacking portions of the first pleckstrin homology (PH) domain (DeltaPH1a or DeltaPH1b)

28 Recombinant ORP4L and a variant without a pleckstrin homology (PH) domain (ORP4S) bind 25-hydroxyc

29 h Src homology 3 domain, ankyrin repeat, and pleckstrin homology (PH) domain 1 (ASAP1) is a multidoma

30 ciation of 5-HT6 receptor with neurofibromin Pleckstrin Homology (PH) domain also inhibits receptor c

31 The Dok7 structure consists of a Pleckstrin Homology (PH) domain and a Phosphotyrosine Bi

32 s leukocyte function, we have focused on its pleckstrin homology (PH) domain and find that deletion o

33 However, we also showed that the PLCepsilon pleckstrin homology (PH) domain and first two EF hands (

34 molecular interaction between its N-terminal pleckstrin homology (PH) domain and kinase domain, which

35 Pleckstrin homology (PH) domain and leucine-rich repeat

36 , a Ser473-specific Akt phosphatase, through pleckstrin homology (PH) domain binding.

37 ls that this region harbours a non-canonical pleckstrin homology (PH) domain connected to a 16-leucin

38 in binding activity and/or the COOH-terminal pleckstrin homology (PH) domain for their assembly compe

39 A crystal structure defines a pleckstrin homology (PH) domain in REC114 and its direct

40 MAPK signaling and requires interaction of a pleckstrin homology (PH) domain in Ste5 with phosphatidy

41 These ArfGEFs carry a pleckstrin homology (PH) domain in tandem with their cat

42 osphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including a

43 TrioC in its basal state and found that the pleckstrin homology (PH) domain interacts with the Dbl h

44 ,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the act

45 The pleckstrin homology (PH) domain is one of the most wides

46 The pleckstrin homology (PH) domain is well known for its ph

47 mbrane docking mechanism of a representative pleckstrin homology (PH) domain isolated from the genera

48 e recruitment of the Akt phosphatase PHLPP1 (pleckstrin homology (PH) domain leucine-rich repeat prot

49 The pleckstrin homology (PH) domain located in the N-termina

50 to discover novel compounds that bind to the pleckstrin homology (PH) domain of AKT, thereby inhibiti

51 Bem4p interacted with the pleckstrin homology (PH) domain of Cdc24p, which functio

52 brane-inserting variable loop 1 (VL1) of the pleckstrin homology (PH) domain of dynamin-1 and demonst

53 Moreover, we identified the pleckstrin homology (PH) domain of G protein-coupled rec

54 In the present study, we aim to target the pleckstrin homology (PH) domain of GAB1 for cancer treat

55 The pleckstrin homology (PH) domain of human Fapp1, which bi

56 The pleckstrin homology (PH) domain of Lbc is located at the

57 work has shown that binding of PIP(3) to the pleckstrin homology (PH) domain of P-Rex1 is required fo

58 The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN

59 hosphatidylinositol 3,4-bisphosphate, to the pleckstrin homology (PH) domain of PDK1 is known to be e

60 RH domain, activated RhoA also binds to the pleckstrin homology (PH) domain of PDZRhoGEF.

61 other PI(4,5)P2-binding proteins such as the pleckstrin homology (PH) domain of phospholipase Cdelta1

62 The N-terminal pleckstrin homology (PH) domain of PLCbeta2 mediates bot

63 The pleckstrin homology (PH) domain of the general receptor

64 inositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protei

65 ARAP3 by analyzing neutrophils from an ARAP3 pleckstrin homology (PH) domain point mutation knock-in

66 is modulated by the orientation of dynamin's pleckstrin homology (PH) domain relative to the underlyi

67 CERT's N-terminal pleckstrin homology (PH) domain targets it to the Golgi

68 Dynamins 1, 2, and 3 contain a pleckstrin homology (PH) domain that binds phosphoinosit

69 and in vitro can phosphorylate Rok near the pleckstrin homology (PH) domain that mediates membrane a

70 the kindlin FERM domain contains an inserted pleckstrin homology (PH) domain that recognizes membrane

71 recruited to the plasma membrane through its pleckstrin homology (PH) domain that recognizes phosphat

72 ecruited to the Golgi through binding of its pleckstrin homology (PH) domain to phosphatidylinositol

73 itions, an intramolecular interaction of the pleckstrin homology (PH) domain with the von Willebrand

74 The kindlin FERM domain is interrupted by a pleckstrin homology (PH) domain within its F2 subdomain.

75 This interaction involves a tripartite pleckstrin homology (PH) domain within Rgc2 and a partia

76 Brag2 contains a pleckstrin homology (PH) domain, and its nucleotide exch

77 daptor protein, phosphotyrosine interaction, pleckstrin homology (PH) domain, and leucine zipper-cont

78 proteins, one with and the other without the pleckstrin homology (PH) domain, as substrates for mTORC

79 a PtdIns(3,4,5)P(3)-binding protein, the AKT-pleckstrin homology (PH) domain, at the leading edge; he

80 ssociation with adaptor protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding

81 y-associated human SH2B1 variants lie in the Pleckstrin homology (PH) domain, suggesting that the PH

82 mma and the Alexa Fluor 594-labeled PLC-beta pleckstrin homology (PH) domain, we demonstrate that the

83 GD1 contains a phosphoinositide (PI) binding pleckstrin homology (PH) domain, we focused on genetic i

84 Here, we report that mutations in the pleckstrin homology (PH) domain-containing protein AtPH1

85 Drosophila melted encodes a pleckstrin homology (PH) domain-containing protein that

86 We report a conserved armadillo and pleckstrin homology (PH) domain-containing protein, term

87 in Dictyostelium discoideum, including five pleckstrin homology (PH) domain-containing proteins.

88 enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain-containing scaffold prot

89 osphate [PI(3,4)P2] and consequently recruit pleckstrin homology (PH) domain-containing signaling pro

90 Vav3 coactivates AR in a Vav3 pleckstrin homology (PH) domain-dependent but GEF-indepe

91 Intramolecular pleckstrin homology (PH) domain-kinase domain (KD) inter

92 sicle scission via membrane insertion of its pleckstrin homology (PH) domain.

93 tes Akt-Thr308 and Ser473 independent of the pleckstrin homology (PH) domain.

94 eletion causing early termination within the pleckstrin homology (PH) domain.

95 teracted via its PEST domain with Akt at the pleckstrin homology (PH) domain.

96 pyrimidine analogues targeting site-2 of the pleckstrin homology (PH) domain.

97 43 infection, we found that ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2), gamma-interf

98 ined ab initio and defines a new subclass of pleckstrin homology (PH) domains along with a new family

99 other processes by recruiting proteins with pleckstrin homology (PH) domains and possibly other doma

100 Pleckstrin homology (PH) domains are lipid-binding modul

101 Pleckstrin homology (PH) domains are protein domains tha

102 Pleckstrin homology (PH) domains have been identified on

103 that the C-terminal region comprising three pleckstrin homology (PH) domains interacts with the N-te

104 Pleckstrin homology (PH) domains mediate protein-membran

105 olism relies on selective recruitment of the pleckstrin homology (PH) domains of FAPP proteins to the

106 Here, we have found that the pleckstrin homology (PH) domains of PLCbeta2 and PLCbeta

107 c site on SOS, and the Dbl homology (DH) and Pleckstrin homology (PH) domains of SOS (the DH-PH unit)

108 with GDP-Ras and with the Dbl homology (DH)/pleckstrin homology (PH) domains of SOS, bringing GDP-Ra

109 ssociated regulators (Slm1 and Slm2) contain pleckstrin homology (PH) domains that exhibit specificit

110 Here, we demonstrate that binding of pleckstrin homology (PH) domains to phosphatidylinositol

111 ne (PM) through its Ras association (RA) and pleckstrin homology (PH) domains, both of which were req

112 EFA6R shares the catalytic Sec7, pleckstrin homology (PH), and coiled coil (CC) domains o

113 AGAP1 is composed of G-protein-like (GLD), pleckstrin homology (PH), Arf GAP, and ankyrin repeat do

114 or protein APPL1 (adaptor protein containing pleckstrin homology (PH), phosphotyrosine binding (PTB),

115 re of the complex of Rac2 bound to the split pleckstrin homology (spPH) domain of phospholipase C-gam

116 5 effector APPL1 (Adaptor Protein containing pleckstrin homology [PH] domain, PTB domain and Leucine

117 GTPase-activating protein [ArfGAP] with dual pleckstrin homology [PH] domains 1) has been suggested t

118 AIP1 via its pleckstrin homology and C2 domains binds to phosphatidyl

119 al cell spreading: it binds paxillin via the pleckstrin homology and F0 domains to activate Rac1, and

120 3BP2 is a pleckstrin homology and Src homology 2 domain-containing

121 Here, we examine the lipid-binding pleckstrin homology and Tec homology (PH-TH) module of B

122 The binding was mediated by the pleckstrin homology and the kinase domains of AKT and wa

123 ouse embryo fibroblasts showed that both the pleckstrin homology and the Pro/Arg-rich domains determi

124 In contrast, the N-terminal pleckstrin homology and/or coiled-coil domains of GRF1 a

125 subunit of FACT (Spt16-M) to reveal a double pleckstrin homology architecture.

126 ns multiple domains, including an N-terminal pleckstrin homology coiled-coiled extension (PHn-CC-Ex)

127 Here, we show that Pleckstrin homology containing family member 5 (Plekhg5)

128 Akt identified two cysteine residues in the pleckstrin homology domain (C60 and C77) to be reversibl

129 n addition to the PX domain, a region in the pleckstrin homology domain (Ile-306-Ala-310) aids in the

130 hy values among the Akt isoforms in both the pleckstrin homology domain (P domain) and regulatory dom

131 mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinosito

132 mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinosito

133 FRET analyses detect large movements of the pleckstrin homology domain (PHD) from a 'closed' conform

134 4,5)P2 lipid sensor, phospholipase C delta 1 pleckstrin homology domain (PLC delta1-PH), is completel

135 Single mutations in the putative pleckstrin homology domain abolish binding of the tail d

136 different from that of other CDPKs; it has a pleckstrin homology domain adjacent to the kinase domain

137 rin-phosphoinositide recognition through its pleckstrin homology domain all result in failure to buil

138 Ect2 membrane association requires a pleckstrin homology domain and a polybasic cluster that

139 ys show that both a conserved surface on the pleckstrin homology domain and an intact TPR region are

140 ctly inhibits Akt through binding to the Akt pleckstrin homology domain and blocking Akt membrane tra

141 Mechanistically, AMOTL2 binds to AKT pleckstrin homology domain and interrupts AKT's membrane

142 Pleckstrin homology domain and leucine rich repeat prote

143 In this study, we identified pleckstrin homology domain and leucine-rich repeat prote

144 in the linker region between the N-terminal pleckstrin homology domain and the catalytic kinase doma

145 r the role of amisyn in exocytosis: Both the pleckstrin homology domain and the SNARE motif are neede

146 106, we identified two regions on its double-pleckstrin homology domain architecture that mediated hi

147 n2 chimeras, we identified the lipid-binding pleckstrin homology domain as being responsible for the

148 ransferase pulldown analyses identified Akt1 pleckstrin homology domain as the interactive domain.

149 tic domain for its GEF activity, whereas the pleckstrin homology domain assists in the PX-mediated ac

150 vity and localization of mTORC2 via the Sin1 pleckstrin homology domain at the plasma membrane is PI3

151 The non-pleckstrin homology domain beta-spectrin (beta2SP) (the

152 latory region promotes ASK1 activity via its pleckstrin homology domain but also facilitates ASK1 aut

153 PLEKHA7 (pleckstrin homology domain containing family A member 7)

154 Herein, we show that Pleckstrin homology domain containing protein family mem

155 oned on top of a long helical stalk with the pleckstrin homology domain flexibly attached on its oppo

156 A putative pleckstrin homology domain has been identified in the my

157 phosphate-dependent Rac exchanger 1 (P-Rex1) pleckstrin homology domain has effects consistent with P

158 In place of the pleckstrin homology domain in dynamin, however, Drp1 con

159 together with an N-terminal F0 domain and a pleckstrin homology domain inserted in the F2 domain.

160 Here, we show that pleckstrin homology domain interacting protein (PHIP), a

161 proximal to mitochondria, and the C-terminal pleckstrin homology domain is associated with the plasma

162 at in vivo Itk exists as a monomer, with the pleckstrin homology domain less than 80 A from the C ter

163 Here we show that the pleckstrin homology domain leucine-rich repeat protein p

164 The recent discovery of the PHLPP (pleckstrin homology domain leucine-rich repeat protein p

165 (PP1) or the hydrophobic motif phosphatase, pleckstrin homology domain leucine-rich repeat protein p

166 The pleckstrin homology domain leucine-rich repeat protein p

167 s, promotes dephosphorylation of Akt through pleckstrin homology domain leucine-rich repeats protein

168 examined the phospholipid binding profile of pleckstrin homology domain localizing mutations.

169 tol 4,5-bisphosphate [PtdIns(4,5)P(2)] via a pleckstrin homology domain located in the myo1c tail, wh

170 All mutations increased kinase activity, and pleckstrin homology domain mutants exhibited enhanced ph

171 Our results show that FAK binds the pleckstrin homology domain of AGAP2, and the binding is

172 ompetitor nor substrate mimetic, it binds to pleckstrin homology domain of Akt and blocks Akt membran

173 nase domain interacted specifically with the pleckstrin homology domain of BchC1.

174 In vitro, the pleckstrin homology domain of Cb binds phosphoinositides

175 fuse B-cell lymphoma homology domain and the pleckstrin homology domain of Cb.

176 inding in its active, GTP-bound state to the pleckstrin homology domain of Cb.

177 cteristics, are comparable with those of the pleckstrin homology domain of cytohesin-3 (general recep

178 he membrane-binding and curvature-generating pleckstrin homology domain of Dyn1 plays an important ro

179 The pleckstrin homology domain of dynamin is essential for t

180 tidylinositol 4,5-bisphosphate, binds to the pleckstrin homology domain of GEP100.

181 K-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain

182 we identify a stable interaction between the pleckstrin homology domain of Kal7 and the juxtamembrane

183 Moreover, deletion of the pleckstrin homology domain of kindlin-1 also failed to r

184 This interaction involves the pleckstrin homology domain of kindlin-3 and blades 5-7 o

185 t, and mutational analysis revealed that the pleckstrin homology domain of P-Rex1 is required.

186 Herein, we show that the pleckstrin homology domain of p63RhoGEF is not involved

187 2-O-Bn-InsP5 interacts specifically with the pleckstrin homology domain of PDK1 and impairs formation

188 The pleckstrin homology domain of PdkA is sufficient to loca

189 5)P(2) at a slower rate (2.0 s(-1)) than the pleckstrin homology domain of phospholipase C-delta (13

190 eins/domains, such as the PI(4,5)P2-specific pleckstrin homology domain of phospholipase Cdelta1 (PHP

191 that generate the specific PI ligand for the pleckstrin homology domain of SFC/VAN3, phosphatidylinos

192 A single point mutation in the pleckstrin homology domain of SKAP55 (R131M) blocks the

193 t of ADAP to LFA-1 integrin complexes by the pleckstrin homology domain of SKAP55, and this recruitme

194 the E17K-transforming point mutation in the pleckstrin homology domain of the Akt1 oncoprotein.

195 5)P3)-mediated membrane translocation of the pleckstrin homology domain of the kinase Akt and thus au

196 -anchoring patches when it was attached to a pleckstrin homology domain or a CAAX motif.

197 ment in Golgi PI-4P that was detected with a pleckstrin homology domain probe.

198 acterized the lipid-binding specificity of a pleckstrin homology domain protein.

199 Furthermore, amisyn contains an N-terminal pleckstrin homology domain that mediates its transient a

200 formationally "opens" CB2SH3+ and allows the pleckstrin homology domain to properly bind lipids depen

201 hemoattractant-elicited translocation of the pleckstrin homology domain to the membrane and substanti

202 er than the interaction of the adhesion of a pleckstrin homology domain with phosphatidylinositol 4,5

203 Itk has an N-terminal pleckstrin homology domain, a Tec Homology domain with a

204 e signaling domains, a GTPase-like domain, a pleckstrin homology domain, and an ArfGAP domain, and ex

205 tructurally similar to PLCdelta1, it lacks a pleckstrin homology domain, and it remains unclear how P

206 es PIP3 binding to basic residues in the Akt pleckstrin homology domain, aPKCs lack this domain.

207 e exchange factor (rhoGEF) domain and tandem pleckstrin homology domain, consistent with a role in rh

208 conserved three-nucleotide microexon in the pleckstrin homology domain, display differential affinit

209 IQGAP1 C-terminal domain and the cytohesin-3 pleckstrin homology domain, each tagged with enhanced gr

210 do not require Net1A catalytic activity, its pleckstrin homology domain, or its regulatory C terminus

211 s recruitment of Itk to the membrane via its pleckstrin homology domain, phosphorylation of Itk by th

212 requires recruitment to the membrane via its pleckstrin homology domain, phosphorylation of Itk by th

213 5 effector APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding doma

214 tivating protein (ARF GAP) with a PI-binding pleckstrin homology domain, result in discontinuous vein

215 and is inhibited by SifA binding to the SKIP pleckstrin homology domain, suggesting that SifA may be

216 Along with an N-terminal pleckstrin homology domain, the central domain affects n

217 Fragments of CynA lacking the pleckstrin homology domain, which are normally found in

218 pholipids due to a lack of the lipid-binding pleckstrin homology domain, which is used for lipid-medi

219 hat PfCDPK7 interacts with PI(4,5)P2 via its pleckstrin homology domain, which may guide its subcellu

220 PHLDB1 contains a pleckstrin homology domain, which we show binds phosphat

221 Pleckstrin homology domain-containing A7 (PLEKHA7) is a

222 B) and SifA- and kinesin-interacting protein/pleckstrin homology domain-containing family M member 2

223 anoparticles (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family O member 1

224 TEN in macrophage leads to activation of the pleckstrin homology domain-containing guanine-nucleotide

225 elective phosphoinositide sequestration with pleckstrin homology domain-containing phospholipase Cdel

226 Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-e

227 the ArfGAP with coiled-coil, Ank repeat, and pleckstrin homology domain-containing protein ACAP2 as a

228 We show that Pleckstrin homology domain-containing protein family mem

229 This pool of PI-4P specifically recruits pleckstrin homology domain-containing proteins involved

230 PIP3 recruits pleckstrin homology domain-containing proteins to the me

231 Here we assessed the prognostic impact of pleckstrin homology domain-interacting protein (PHIP) co

232 Here, we show that the activation of Pleckstrin homology domain-interacting protein (PHIP), p

233 formation by eps8 siRNA or overexpression of pleckstrin homology domain-truncated Eps8 (i.e. 261-p97(

234 interact with the DH domain but not with the pleckstrin homology domain.

235 EF contains a Dbl homology (DH) domain and a pleckstrin homology domain.

236 4.1-ezrin-radixin-moesin (FERM) domain and a pleckstrin homology domain.

237 sine 373 in the N-terminal part of Kindlin-3 pleckstrin homology domain.

238 minal tail region, which contains a putative pleckstrin homology domain.

239 tide repeat (TPR) region capped by a cryptic pleckstrin homology domain.

240 on encompassing the N-terminal to C-terminal pleckstrin homology domains (PHn-PHc), are auto-inhibite

241 ones and reports that Pob3 and Rtt106 double pleckstrin homology domains bind histones H3-H4, we also

242 engineered proteins containing one to three pleckstrin homology domains coupled by flexible linkers.

243 by fusion with tandem phospholipase C-delta1 pleckstrin homology domains or by co-expression with wil

244 ition to the canonical Dbl homology (DH) and pleckstrin homology domains that carry out the guanine n

245 a membrane (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-

246 ell membrane through interactions with their pleckstrin homology domains, allowing PDK1 to activate A

247 verlays with phospholipid binding in related pleckstrin homology domains, however, suggests that ISPs

248 ing regions, which lie between the motor and pleckstrin homology domains, reduced the instantaneous v

249 d a complex with p115 RhoGEF involving their pleckstrin homology domains.

250 GTPase dynamin-2 at its GTPase, middle, and pleckstrin homology domains.

251 of the characteristics of those observed in pleckstrin homology domains.

252 ral analysis revealed that both ISPs adopt a pleckstrin homology fold often associated with phospholi

253 surface properties that are present in other pleckstrin homology fold-based interaction modules.

254 Consistent with our finding that the double pleckstrin homology structure is common to these three h

255 f SHARPIN, which adopts the highly conserved pleckstrin homology superfold that is often used as a sc

256 e GST is glutathione S-transferase and PH is pleckstrin homology) and in vivo.

257 ture, but instead requires a neighboring PH (Pleckstrin Homology) domain to achieve these functions.

258 n1A/B bind directly to ROCK2 through its PH (Pleckstrin Homology) domain.

259 taining the GEF (Sec7) and membrane-binding (pleckstrin homology) domains, revealing that it has a co

260 ic fluorescent reporter, PH-GFP (where PH is pleckstrin homology), detected an Ag-dependent enrichmen

261 lponin homology (CH) domain with the Acidic, pleckstrin homology, and DH domains.

262 ncover necessary contributions of the CDC25, Pleckstrin homology, and Ras-associating domains, but no

263 of functional domains, including N-terminal pleckstrin homology, coiled-coil, and calmodulin-binding

264 s best known for containing the 2 prototypic Pleckstrin homology, or PH, domains.

265 These behaviors require a pleckstrin homology-domain membrane tether and a WD40 cl

266 -mediated regulation required the N-terminal pleckstrin homology-GRAM domain and Cys413 within the ph

267 pollen tubes, SEC3a displayed amino-terminal Pleckstrin homology-like domain (SEC3a-N)-dependent suba

268 of conserved positive charges and a central pleckstrin homology-like domain are important for plasma

269 We report here the identification of pleckstrin homology-like domain family B member 1 (PHLDB

270 Pleckstrin Homology-Like Domain, Family A, member 1 (PHL

271 nd by mRNA expression of the p53 target gene pleckstrin homology-like domain, family A, member 3 ( PH

272 binding within a region predicted to adopt a pleckstrin homology-like fold in the N terminus of RME-8

273 Here, we report an important role for the pleckstrin homology-related domain family member, T-cell

274 independently of acetylation while a double pleckstrin-homology (PH) domain binds the K56-containing

275 Although the pleckstrin-homology (PH) domain is known to mediate phos

276 Introduction of the exogenous isolated pleckstrin-homology (PH) domain of p63RhoGEF (residues 3

277 hrin-coated vesicles and contains a putative pleckstrin-homology (PH) domain that has been shown to p

278 , including a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (

279 Dok7 comprises a pleckstrin-homology (PH) domain, a phosphotyrosine-bindi

280 el role for the adaptor protein containing a pleckstrin-homology (PH) domain, phosphotyrosine-binding

281 Additionally, we identify an acylated pleckstrin-homology (PH) domain-containing protein (APH)

282 a key signaling molecule, acts by recruiting pleckstrin-homology (PH) domain-containing proteins to c

283 rvations, we study the Dbl-homology (DH) and Pleckstrin-homology (PH) domains of Bcr-Abl p210, which

284 ignaling-like (RGSL), Dbl-homology (DH), and pleckstrin-homology (PH) domains.

285 to expose their catalytic Dbl-homology (DH)/pleckstrin-homology (PH) regions, which triggers downstr

286 sphatidylinositol-4,5-bisphosphate using the pleckstrin-homology domain (PHD) and engage in rapid mem

287 ) exchanger regulatory factor 1 (NHERF1) and pleckstrin-homology domain leucine-rich repeat protein p

288 We show that adaptor protein containing a pleckstrin-homology domain, a phosphotyrosine-binding do

289 T) in TGEF2 impaired inhibition by the TGEF2 pleckstrin-homology domain, resulting in dramatically in

290 radixin, moesin (FERM) domain bisected by a pleckstrin-homology domain.

291 hate (PIP(3)) through interaction with their pleckstrin-homology domains.

292 l characterization of Sac2 revealed a unique pleckstrin-like homology Sac2 domain conserved in all Sa

293 (Ubl) domain of parkin binds directly to the pleckstrin-like receptor for ubiquitin (Pru) domain with

294 hRpn13 contains an N-terminal pleckstrin-like receptor for ubiquitin domain that binds

295 which, like ubiquitin, binds the N-terminal pleckstrin-like receptor of ubiquitin (PRU) domain of RP

296 the proteasome by binding of its N-terminal pleckstrin-like receptor of ubiquitin (PRU) domain to C-

297 Pleckstrin-null platelets aggregate normally in response

298 Although pleckstrin-null platelets merged their granules in respo

299 These data show that pleckstrin regulates the fusion of granules to the cell

300 Pleckstrin, the platelet and leukocyte C kinase substrat