ライフサイエンスコーパス: pleckstrin homology domain

1 minal tail region, which contains a putative pleckstrin homology domain.

2 ed region in the upper lobe that resembles a pleckstrin homology domain.

3 itment of Itk to the plasma membrane via its pleckstrin homology domain.

4 , which is dependent on the integrity of its pleckstrin homology domain.

5 domain containing a RhoA binding site, and a pleckstrin homology domain.

6 ed plasma membrane interaction sites for the pleckstrin homology domain.

7 conformation of the beta3/beta4 loop of the pleckstrin homology domain.

8 nt Akt and Akt deltaPH, a mutant lacking the pleckstrin homology domain.

9 hyrin interactions and an intact collybistin pleckstrin homology domain.

10 ugh a physical association requiring the AKT pleckstrin homology domain.

11 yrosine kinase, which contains an N-terminal pleckstrin homology domain.

12 tide repeat (TPR) region capped by a cryptic pleckstrin homology domain.

13 m exons, with a deduced peptide containing a pleckstrin homology domain.

14 th the catalytic domain of Akt but lacks the pleckstrin homology domain.

15 n-like repeats, a Dbl homology domain, and a pleckstrin homology domain.

16 All TCL1 isoforms bind to the Akt pleckstrin homology domain.

17 es, several putative SH3-binding sites and a pleckstrin homology domain.

18 by a mechanism that requires its N-terminal pleckstrin homology domain.

19 common a catalytic Dbl homology and adjacent pleckstrin homology domain.

20 interact with the DH domain but not with the pleckstrin homology domain.

21 EF contains a Dbl homology (DH) domain and a pleckstrin homology domain.

22 4.1-ezrin-radixin-moesin (FERM) domain and a pleckstrin homology domain.

23 sine 373 in the N-terminal part of Kindlin-3 pleckstrin homology domain.

24 radixin, moesin (FERM) domain bisected by a pleckstrin-homology domain.

25 of the characteristics of those observed in pleckstrin homology domains.

26 he majority of plant PLDs by having phox and pleckstrin homology domains.

27 m distinct lipid-binding preferences of ROCK pleckstrin homology domains.

28 GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains.

29 GTPase dynamin-2 at its GTPase, middle, and pleckstrin homology domains.

30 d a complex with p115 RhoGEF involving their pleckstrin homology domains.

31 n1A/B bind directly to ROCK2 through its PH (Pleckstrin Homology) domain.

32 hate (PIP(3)) through interaction with their pleckstrin-homology domains.

33 AK and contains multiple domains including a pleckstrin homology domain, a rhoGTPase-activating prote

34 Itk has an N-terminal pleckstrin homology domain, a Tec Homology domain with a

35 tional protein binding modules including two pleckstrin homology domains, a leucine zipper motif and

36 exchange factor domains each with associated pleckstrin homology domains, a serine/threonine kinase d

37 We show that adaptor protein containing a pleckstrin-homology domain, a phosphotyrosine-binding do

38 Single mutations in the putative pleckstrin homology domain abolish binding of the tail d

39 A pleckstrin homology domain adjacent to the catalytic Dbl

40 different from that of other CDPKs; it has a pleckstrin homology domain adjacent to the kinase domain

41 SAP3 was biochemically similar to ASAP1: the pleckstrin homology domain affected function of the cata

42 rin-phosphoinositide recognition through its pleckstrin homology domain all result in failure to buil

43 ell membrane through interactions with their pleckstrin homology domains, allowing PDK1 to activate A

44 eptor, while its nuclear export requires its pleckstrin homology domain and a competent Crm1-dependen

45 its amino-terminal end, lack of an apparent pleckstrin homology domain and a highly charged linker r

46 ed that the N-terminal region containing the pleckstrin homology domain and a linker region distingui

47 The DIP13 alpha protein has a pleckstrin homology domain and a phosphotyrosine binding

48 s, the N-terminal portion of dIRS contains a pleckstrin homology domain and a phosphotyrosine binding

49 Ect2 membrane association requires a pleckstrin homology domain and a polybasic cluster that

50 ctly associates with Pak1 via its N-terminal pleckstrin homology domain and also phosphorylates Pak1

51 ys show that both a conserved surface on the pleckstrin homology domain and an intact TPR region are

52 ctly inhibits Akt through binding to the Akt pleckstrin homology domain and blocking Akt membrane tra

53 I 3-kinase by KL promotes binding of the Dok pleckstrin homology domain and Dok-1 recruitment to the

54 e kinases, is characterized by an N-terminal pleckstrin homology domain and has been shown to be a do

55 Mechanistically, AMOTL2 binds to AKT pleckstrin homology domain and interrupts AKT's membrane

56 embrane Ig association requires a functional pleckstrin homology domain and is controlled by the C te

57 Pleckstrin homology domain and leucine rich repeat prote

58 In this study, we identified pleckstrin homology domain and leucine-rich repeat prote

59 in the linker region between the N-terminal pleckstrin homology domain and the catalytic kinase doma

60 products control an interaction between the pleckstrin homology domain and the Dbl homology domain,

61 r the role of amisyn in exocytosis: Both the pleckstrin homology domain and the SNARE motif are neede

62 Two of these isoforms lack an intact pleckstrin homology domain and yet appear to have signif

63 Utilizing pleckstrin homology domains and a PtdIns phosphatase to

64 affinities between the Vav Dbl homology and pleckstrin homology domains and permits Rac binding.

65 contain an N-terminal dimerization region, a pleckstrin homology domain, and a C-terminal Src homolog

66 K, has three cysteine-rich domains (CRDs), a pleckstrin homology domain, and a kinase domain.

67 e signaling domains, a GTPase-like domain, a pleckstrin homology domain, and an ArfGAP domain, and ex

68 tructurally similar to PLCdelta1, it lacks a pleckstrin homology domain, and it remains unclear how P

69 ab1 possess an intact Met-binding motif, the pleckstrin homology domain, and the binding sites for ph

70 also forms intramolecular contacts with the pleckstrin homology domain, and these contacts must also

71 data currently restricted to the GTPase and pleckstrin homology domains, and the dynamin-related hum

72 tains tandem DAG binding (C1) modules, a PH (pleckstrin homology) domain, and a Ser/Thr protein kinas

73 in a RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and various proline-rich mo

74 es PIP3 binding to basic residues in the Akt pleckstrin homology domain, aPKCs lack this domain.

75 106, we identified two regions on its double-pleckstrin homology domain architecture that mediated hi

76 Pleckstrin homology domains are modular domains that dir

77 Pleckstrin homology domains are structurally conserved f

78 DEP (for Disheveled, EGL-10, Pleckstrin) homology domains are present in numerous sig

79 n2 chimeras, we identified the lipid-binding pleckstrin homology domain as being responsible for the

80 ctional specificity is determined by the Akt pleckstrin homology domain as chimeric Akt1, where Akt1

81 ransferase pulldown analyses identified Akt1 pleckstrin homology domain as the interactive domain.

82 tic domain for its GEF activity, whereas the pleckstrin homology domain assists in the PX-mediated ac

83 vity for the ARF GTP-binding proteins, and a pleckstrin homology domain at the C terminus.

84 vity and localization of mTORC2 via the Sin1 pleckstrin homology domain at the plasma membrane is PI3

85 The non-pleckstrin homology domain beta-spectrin (beta2SP) (the

86 ones and reports that Pob3 and Rtt106 double pleckstrin homology domains bind histones H3-H4, we also

87 Furthermore, we show that the pleckstrin homology domain binds the catalytic domain of

88 (1) Removal of the pleckstrin homology domain blocked polarized spectrin as

89 e we have measured the diffusive behavior of pleckstrin homology domains bound to phosphoinositide ph

90 latory region promotes ASK1 activity via its pleckstrin homology domain but also facilitates ASK1 aut

91 the N terminus a Phox homology domain and a pleckstrin homology domain, but not the C2 domain.

92 Akt identified two cysteine residues in the pleckstrin homology domain (C60 and C77) to be reversibl

93 Using Rac1, the Dbl homology-pleckstrin homology domain catalyzed the in vitro exchan

94 We utilized green fluorescent protein-pleckstrin homology domain chimeras (termed FLAREs for f

95 e exchange factor (rhoGEF) domain and tandem pleckstrin homology domain, consistent with a role in rh

96 PLEKHA7 (pleckstrin homology domain containing family A member 7)

97 Herein, we show that Pleckstrin homology domain containing protein family mem

98 Pleckstrin homology domain-containing A7 (PLEKHA7) is a

99 ylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein wh

100 on of a phosphotyrosine binding domain and a pleckstrin homology domain-containing adaptor protein, A

101 SH2-B, an Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein, b

102 Gab2, a newly identified pleckstrin homology domain-containing docking protein, i

103 These two lipid messengers bind to pleckstrin homology domain-containing effectors that reg

104 B) and SifA- and kinesin-interacting protein/pleckstrin homology domain-containing family M member 2

105 anoparticles (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family O member 1

106 TEN in macrophage leads to activation of the pleckstrin homology domain-containing guanine-nucleotide

107 elective phosphoinositide sequestration with pleckstrin homology domain-containing phospholipase Cdel

108 Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-e

109 the ArfGAP with coiled-coil, Ank repeat, and pleckstrin homology domain-containing protein ACAP2 as a

110 We show that Pleckstrin homology domain-containing protein family mem

111 In the wild-type neutrophils, the pleckstrin homology domain-containing protein kinase B (

112 the kinetics of membrane localization of the pleckstrin homology domain-containing proteins CRAC, Akt

113 This pool of PI-4P specifically recruits pleckstrin homology domain-containing proteins involved

114 PIP3 recruits pleckstrin homology domain-containing proteins to the me

115 engineered proteins containing one to three pleckstrin homology domains coupled by flexible linkers.

116 er formation and transcription activity in a pleckstrin homology domain-dependent manner.

117 alized at cell periphery in fibroblasts in a pleckstrin homology domain-dependent manner.

118 ve Src homology 3 (SH3) domains, the Dbl and pleckstrin homology domains (DH and PH domains, respecti

119 nal tags and the membrane-trapped EYFP(N)-PH pleckstrin homology domains did not change on depolariza

120 rst, the inositide-binding pocket of the Itk pleckstrin homology domain directs the constitutive asso

121 conserved three-nucleotide microexon in the pleckstrin homology domain, display differential affinit

122 Removal of the pleckstrin homology domain dramatically reduced the in v

123 IQGAP1 C-terminal domain and the cytohesin-3 pleckstrin homology domain, each tagged with enhanced gr

124 All of the genes encode a pleckstrin homology domain, except OSBPL2.

125 The first of these, a centrally located pleckstrin homology domain, exhibited three properties:

126 oned on top of a long helical stalk with the pleckstrin homology domain flexibly attached on its oppo

127 s that the Exo84 Ral-binding domain adopts a pleckstrin homology domain fold, and that RalA interacts

128 s have similar N-terminal regions containing pleckstrin homology domains followed by coiled-coils and

129 escent protein (GFP) fusion construct of the pleckstrin homology domain from Bruton's tyrosine kinase

130 alized by expressing a fusion protein of the pleckstrin homology domain from PLCdelta and green fluor

131 omology (DH) domain from one monomer and the Pleckstrin homology domain from the other, activated Cdc

132 classes of polypeptide sequences, including pleckstrin homology domains, FYVE domains, and short lin

133 opy and green fluorescent protein-tagged Akt pleckstrin homology domain (GFP-AktPH) as a molecular se

134 sistent with these findings, studies using a pleckstrin homology domain-green fluorescent protein (PH

135 in inhibited TRPV1, a PI(3,4,5)P(3)-specific pleckstrin homology domain had no effect.

136 A putative pleckstrin homology domain has been identified in the my

137 phosphate-dependent Rac exchanger 1 (P-Rex1) pleckstrin homology domain has effects consistent with P

138 verlays with phospholipid binding in related pleckstrin homology domains, however, suggests that ISPs

139 n addition to the PX domain, a region in the pleckstrin homology domain (Ile-306-Ala-310) aids in the

140 In place of the pleckstrin homology domain in dynamin, however, Drp1 con

141 ientation of the Dbl-homology domain and the pleckstrin-homology domain in the same Dbl family protei

142 Although a PI(4,5)P(2)-specific pleckstrin homology domain inhibited TRPV1, a PI(3,4,5)P

143 together with an N-terminal F0 domain and a pleckstrin homology domain inserted in the F2 domain.

144 ein signaling) homology, protein kinase, and pleckstrin homology domains-integrate their respective a

145 Here, we show that pleckstrin homology domain interacting protein (PHIP), a

146 Here we assessed the prognostic impact of pleckstrin homology domain-interacting protein (PHIP) co

147 Here, we show that the activation of Pleckstrin homology domain-interacting protein (PHIP), p

148 in kinase, Src homology 2 and 3, RhoGEF, and pleckstrin homology domains involved in cell signaling.

149 proximal to mitochondria, and the C-terminal pleckstrin homology domain is associated with the plasma

150 ion by APC/Ag, and we found that whereas the pleckstrin homology domain is required for plasma membra

151 phosphorylation of PKD at Tyr463 in the PH (pleckstrin homology) domain is mediated by the Src-Abl p

152 at in vivo Itk exists as a monomer, with the pleckstrin homology domain less than 80 A from the C ter

153 (PP1) or the hydrophobic motif phosphatase, pleckstrin homology domain leucine-rich repeat protein p

154 The pleckstrin homology domain leucine-rich repeat protein p

155 Here we show that the pleckstrin homology domain leucine-rich repeat protein p

156 The recent discovery of the PHLPP (pleckstrin homology domain leucine-rich repeat protein p

157 s, promotes dephosphorylation of Akt through pleckstrin homology domain leucine-rich repeats protein

158 ) exchanger regulatory factor 1 (NHERF1) and pleckstrin-homology domain leucine-rich repeat protein p

159 examined the phospholipid binding profile of pleckstrin homology domain localizing mutations.

160 tol 4,5-bisphosphate [PtdIns(4,5)P(2)] via a pleckstrin homology domain located in the myo1c tail, wh

161 The central pleckstrin homology domain may mediate transient CAPS in

162 we have characterized a surprisingly direct pleckstrin homology domain-mediated mechanism through wh

163 We also further examined pleckstrin homology domain-mediated PKD regulation to de

164 t on a conserved FYVE domain, its C-terminal pleckstrin homology domain mediates recruitment to membr

165 ing demonstrated that the N-terminal Kalirin pleckstrin homology domain mediates the interaction with

166 These behaviors require a pleckstrin homology-domain membrane tether and a WD40 cl

167 Gab3 contains an amino-terminal pleckstrin homology domain, multiple potential sites for

168 All mutations increased kinase activity, and pleckstrin homology domain mutants exhibited enhanced ph

169 , a conserved self-association domain, and a pleckstrin homology domain near its COOH terminus.

170 ec7 domain with an approximately 100-residue pleckstrin homology domain near the C terminus.

171 Our results show that FAK binds the pleckstrin homology domain of AGAP2, and the binding is

172 ompetitor nor substrate mimetic, it binds to pleckstrin homology domain of Akt and blocks Akt membran

173 ether lipid analogues (PIAs) that target the pleckstrin homology domain of Akt and selectively induce

174 the C2A domain of JFC1 colocalized with the pleckstrin homology domain of Akt in vivo, and both the

175 gged fluorescent fusion protein encoding the pleckstrin homology domain of Akt, indicating that 3-pho

176 induces TRB3, which, through binding to the pleckstrin homology domain of Akt, prevents its plasma m

177 se in phosphorylation was independent of the Pleckstrin homology domain of Akt.

178 nase domain interacted specifically with the pleckstrin homology domain of BchC1.

179 Btk kinase activity and sequences within the pleckstrin homology domain of Btk.

180 In vitro, the pleckstrin homology domain of Cb binds phosphoinositides

181 fuse B-cell lymphoma homology domain and the pleckstrin homology domain of Cb.

182 inding in its active, GTP-bound state to the pleckstrin homology domain of Cb.

183 t manner and confirmed that the Dbl homology-pleckstrin homology domain of CeRhoGEF was capable of Rh

184 cteristics, are comparable with those of the pleckstrin homology domain of cytohesin-3 (general recep

185 hat the Rac1 docking site resides within the pleckstrin homology domain of Dbs.

186 he membrane-binding and curvature-generating pleckstrin homology domain of Dyn1 plays an important ro

187 The pleckstrin homology domain of dynamin is essential for t

188 d when either anti-dynamin antibodies or the pleckstrin homology domain of dynamin-1 was loaded into

189 re and can be also found associated with the pleckstrin homology domain of dynamin.

190 Gab2 recruitment requires the pleckstrin homology domain of Gab2 and is sensitive to t

191 tidylinositol 4,5-bisphosphate, binds to the pleckstrin homology domain of GEP100.

192 The pleckstrin homology domain of GRP1 binds phosphatidylino

193 ther PTEN, a PI(3,4,5)P3 phosphatase, or the pleckstrin homology domain of Grp1, which sequesters PI(

194 n with sequence similarity to the C-terminal pleckstrin homology domain of human pleckstrin.

195 -regulated phosphorylation at Ser(24) in the pleckstrin homology domain of IRS-1 by mPLK/IRAK represe

196 K-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain

197 iched microdomains (DIGs) via binding of the pleckstrin homology domain of Itk to the PI 3-K product

198 we identify a stable interaction between the pleckstrin homology domain of Kal7 and the juxtamembrane

199 The interaction of TrkA with the pleckstrin homology domain of Kalirin may be one example

200 Moreover, deletion of the pleckstrin homology domain of kindlin-1 also failed to r

201 This interaction involves the pleckstrin homology domain of kindlin-3 and blades 5-7 o

202 ear the COOH terminus is dispensable and the pleckstrin homology domain of Lnk contributes to, but is

203 A COOH-terminal pleckstrin homology domain of Mid2p was required for its

204 t, and mutational analysis revealed that the pleckstrin homology domain of P-Rex1 is required.

205 demonstrate that expression of the isolated pleckstrin homology domain of p120 GAP specifically inhi

206 Herein, we show that the pleckstrin homology domain of p63RhoGEF is not involved

207 2-O-Bn-InsP5 interacts specifically with the pleckstrin homology domain of PDK1 and impairs formation

208 The pleckstrin homology domain of PdkA is sufficient to loca

209 5)P(2) at a slower rate (2.0 s(-1)) than the pleckstrin homology domain of phospholipase C-delta (13

210 introduced a R40D point mutation within the pleckstrin homology domain of phospholipase C-delta(1),

211 eins/domains, such as the PI(4,5)P2-specific pleckstrin homology domain of phospholipase Cdelta1 (PHP

212 The association is mediated through the pleckstrin homology domain of PKD and the C-terminal dom

213 o the cell membrane via its interaction with pleckstrin homology domain of PLC-gamma1.

214 rnover by following the translocation of the pleckstrin homology domain of PLCdelta1 fused to green f

215 In contrast to the pleckstrin homology domain of PLCdelta1 it does not have

216 ,5-trisphosphate (Ins(1,4,5)P(3)), using the pleckstrin homology domain of PLCdelta1 tagged to eGFP (

217 isphosphate in single SHSY5Y cells using the pleckstrin homology domain of PLCdelta1 tagged with gree

218 ation in living cells and compared it to the pleckstrin homology domain of PLCdelta1.

219 that generate the specific PI ligand for the pleckstrin homology domain of SFC/VAN3, phosphatidylinos

220 A single point mutation in the pleckstrin homology domain of SKAP55 (R131M) blocks the

221 t of ADAP to LFA-1 integrin complexes by the pleckstrin homology domain of SKAP55, and this recruitme

222 the E17K-transforming point mutation in the pleckstrin homology domain of the Akt1 oncoprotein.

223 5)P3)-mediated membrane translocation of the pleckstrin homology domain of the kinase Akt and thus au

224 Unlike the human and murine orthologs, the pleckstrin homology domain of zebrafish Sptb is not remo

225 s where the isolated Dbl homology (DH) or DH/pleckstrin homology domains of LARG functioned as a stro

226 Utilizing the pleckstrin homology domains of PKC-delta and Btk protein

227 of GFP fused to the PtdIns(3,4,5)P3-binding pleckstrin-homology domain of Akt (GFP-PH-Akt), a fusion

228 ional motifs, i.e., the Dbl-homolgy (DH) and Pleckstrin-homology domains of Dbl, Cdc42, and the PBD d

229 -anchoring patches when it was attached to a pleckstrin homology domain or a CAAX motif.

230 Overexpression of the pleckstrin homology domain or a mutant Gab2 molecule lac

231 by fusion with tandem phospholipase C-delta1 pleckstrin homology domains or by co-expression with wil

232 do not require Net1A catalytic activity, its pleckstrin homology domain, or its regulatory C terminus

233 hy values among the Akt isoforms in both the pleckstrin homology domain (P domain) and regulatory dom

234 green fluorescent protein (GFP) fused to the pleckstrin homology domain (PH) of PKB (GFP-PHPKB) indic

235 gomerization was localized to the N-terminal pleckstrin homology domain (PH1) or adjacent sequences;

236 acent to and overlapping with the N-terminal pleckstrin homology domain (PH1).

237 mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinosito

238 mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinosito

239 FRET analyses detect large movements of the pleckstrin homology domain (PHD) from a 'closed' conform

240 sphatidylinositol-4,5-bisphosphate using the pleckstrin-homology domain (PHD) and engage in rapid mem

241 on encompassing the N-terminal to C-terminal pleckstrin homology domains (PHn-PHc), are auto-inhibite

242 s recruitment of Itk to the membrane via its pleckstrin homology domain, phosphorylation of Itk by th

243 requires recruitment to the membrane via its pleckstrin homology domain, phosphorylation of Itk by th

244 r protein, APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding (PTB

245 5 effector APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding doma

246 4,5)P2 lipid sensor, phospholipase C delta 1 pleckstrin homology domain (PLC delta1-PH), is completel

247 LCdelta) (enhanced green fluorescent protein-pleckstrin homology domain-PLCdelta) directly demonstrat

248 ment in Golgi PI-4P that was detected with a pleckstrin homology domain probe.

249 acterized the lipid-binding specificity of a pleckstrin homology domain protein.

250 ing regions, which lie between the motor and pleckstrin homology domains, reduced the instantaneous v

251 n homology domain (residues 224-417) and the pleckstrin homology domain (residues 711-808).

252 tivating protein (ARF GAP) with a PI-binding pleckstrin homology domain, result in discontinuous vein

253 cleotide exchange factors containing Dbl and Pleckstrin homology domains resulting in membrane insert

254 T) in TGEF2 impaired inhibition by the TGEF2 pleckstrin-homology domain, resulting in dramatically in

255 taining the GEF (Sec7) and membrane-binding (pleckstrin homology) domains, revealing that it has a co

256 rized by having four structural modules: PH (pleckstrin homology) domain, SH3 (Src homology 3) domain

257 Binding of a GFP-tagged pleckstrin homology domain specific for phosphatidylinos

258 LARG possesses a tandem Dbl homology and pleckstrin homology domain structure and, consequently,

259 and is inhibited by SifA binding to the SKIP pleckstrin homology domain, suggesting that SifA may be

260 alian cells, Ccpg1 binds to the Dbl homology/pleckstrin homology domain tandem motif of Dbs and inhib

261 the association is through multiple domains (pleckstrin homology domain, TEC homology domain, and SH2

262 trate adaptor protein with an amino-terminal pleckstrin homology domain that is structurally similar

263 Furthermore, amisyn contains an N-terminal pleckstrin homology domain that mediates its transient a

264 binding module, may functionally replace the pleckstrin homology domain that typically follows a Dbl

265 pically possess tandem Dbl homology (DH) and pleckstrin homology domains that act in concert to catal

266 Overexpression of pleckstrin homology domains that bind phosphatidylinosit

267 ition to the canonical Dbl homology (DH) and pleckstrin homology domains that carry out the guanine n

268 Along with an N-terminal pleckstrin homology domain, the central domain affects n

269 formationally "opens" CB2SH3+ and allows the pleckstrin homology domain to properly bind lipids depen

270 kinase substrate promotes the binding of the pleckstrin homology domain to the Dbl homology domain an

271 hemoattractant-elicited translocation of the pleckstrin homology domain to the membrane and substanti

272 ide regulating TRPV1, we applied recombinant pleckstrin homology domains to inside-out excised patche

273 Using GFP-tagged pleckstrin homology domains to monitor PtdIns(3,4,5)P(3)

274 nables its Dbl (diffuse B-cell lymphoma) and pleckstrin homology domains to work together (in trans)

275 ture, but instead requires a neighboring PH (Pleckstrin Homology) domain to achieve these functions.

276 EFs, XPLN contains a tandem Dbl homology and pleckstrin homology domain topography, but lacks homolog

277 formation by eps8 siRNA or overexpression of pleckstrin homology domain-truncated Eps8 (i.e. 261-p97(

278 PI 3-kinase-dependent manner through the Vav pleckstrin homology domain upon M-CSF stimulation.

279 on located between the kinase domain and the pleckstrin homology domain using two-dimensional phospho

280 In addition, the membrane-associating pleckstrin homology domain was found to associate with t

281 As found for other ASAP family Arf GAPs, the pleckstrin homology domain was necessary for activity.

282 een membranes and cytosol; either the RGS or pleckstrin homology domain was sufficient for this parti

283 egion of phospholipase D containing the phox/pleckstrin homology domains was found to interact with G

284 a protein containing one PDZ domain and two pleckstrin homology domains, was isolated in this screen

285 First, using the isolated pleckstrin homology domain, we found that ceramide speci

286 inase, Akt and Cit-Akt-PH, a fluorescent Akt pleckstrin homology domain which binds PI(3,4,5)P(3).

287 Fragments of CynA lacking the pleckstrin homology domain, which are normally found in

288 GRK3, Drosophila GPRK1 includes a C-terminal pleckstrin homology domain, which binds to phosphoinosit

289 We show that SKIP's pleckstrin homology domain, which directly binds SifA, a

290 Second, using a construct lacking this pleckstrin homology domain, which does not require trans

291 on involved JIP1 protein binding to the Akt1 pleckstrin homology domain, which in turn promoted the p

292 pholipids due to a lack of the lipid-binding pleckstrin homology domain, which is used for lipid-medi

293 hat PfCDPK7 interacts with PI(4,5)P2 via its pleckstrin homology domain, which may guide its subcellu

294 coexpression of phospholipase C (PLC) delta-Pleckstrin homology domain, which sequesters the membran

295 PHLDB1 contains a pleckstrin homology domain, which we show binds phosphat

296 er than the interaction of the adhesion of a pleckstrin homology domain with phosphatidylinositol 4,5

297 idylinositol 3,4,5-trisphosphate through the pleckstrin homology domain with subsequent ARF6 activati

298 a membrane (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-

299 Clg contains Dbl/pleckstrin homology domains with substantial sequence ho

300 hey have unique N termini, both have similar pleckstrin homology domains within the N terminus region