ライフサイエンスコーパス: pleiotropic

1 ly neutral (2.83%) than are antagonistically pleiotropic(6) (0.04%), and transcripts that display low

2 innate and adaptive immunity, but its highly pleiotropic actions have diminished its prospects for us

3 The pleiotropic actions of interleukin-2 (IL-2) are essentia

4 The pleiotropic actions of N/OFQ may limit the development o

5 e strength of Notch signaling contributes to pleiotropic actions of Notch; however, we do not yet hav

6 Given that both TRPV4 and PI3Kgamma have pleiotropic actions, targeting the interaction between t

7 nger proteins (KZFPs) control the timely and pleiotropic activation of TE-derived transcriptional cis

8 to many cellular functions and diseases - a pleiotropic actor at both the genetic and the molecular

9 nvironment where they evolved - yet globally pleiotropic - affecting additional phenotypes that may r

10 ex- and environment-specific or antagonistic pleiotropic allelic effects.

11 iconius wing-patterning genes are strikingly pleiotropic among wing pattern traits.

12 Pleiotropic analysis successfully identified more than 1

13 ted pathways, PI3K/AKT and RAS/ERK, are also pleiotropic and affect multiple fetal processes from pro

14 The pleiotropic and complex gibberellin (GA) response relies

15 rolling a quantitative trait are more likely pleiotropic and functionally correlated, thus providing

16 owever, the effects of MYC up-regulation are pleiotropic and inconsistent with a poorly proliferative

17 A majority of hcASD genes are pleiotropic, and affect proliferation/differentiation an

18 and dipyridamole, many of which also possess pleiotropic anti-inflammatory or antiviral effects.

19 our study indicates that LRIG1 represents a pleiotropic AR-regulated feedback tumor suppressor that

20 alth Initiative and identified an additional pleiotropic association with vitamin B12 levels.

21 ell as alcohol use, with 150 loci evidencing pleiotropic association.

22 transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of

23 ority of blood pressure-associated SNPs show pleiotropic associations.

24 xhibits negative autoregulation and controls pleiotropic attributes of T(FH) differentiation and func

25 Bardet-Biedl syndrome (BBS) is a pleiotropic autosomal recessive ciliopathy affecting mul

26 Fcgamma receptors (FcgammaRs), which confer pleiotropic biological activities.

27 cally active metabolite of vitamin A, exerts pleiotropic biological effects, including the activation

28 was accompanied with enhanced regulation of pleiotropic biological effects.

29 This Perspective discusses the pleiotropic biology of GM-CSF and the scientific merits

30 eless, WT also occurs in the context of more pleiotropic cancer predispositions, such as DICER1, Li-F

31 Lack of both YciB and DcrB results in pleiotropic cell defects including increased levels of l

32 gnated FGF19, FGF21, and FGF23 mediate their pleiotropic cellular effects by binding to and activatin

33 Prohibitin 1 (PHB1) serves pleiotropic cellular functions with dynamic subcellular

34 y interactions with FGFRs that control their pleiotropic cellular responses.

35 ng various tissues and cells, indicating the pleiotropic cellular roles of CCM2 through their multipl

36 Bardet-Biedl syndrome (BBS) is a pleiotropic ciliopathy caused by dysfunction of primary

37 We conclude that this pleiotropic colour polymorphism is most probably maintai

38 encephalomyopathies randomly associated with pleiotropic complex I defects.

39 n important tool for studying the underlying pleiotropic connections among human diseases and traits.

40 one stage of development, indicating limited pleiotropic consequences for most mutations that contrib

41 allelic inactivating variants in SCUBE3 have pleiotropic consequences on development and cause a prev

42 Both aPKCs have pleiotropic context-dependent functions that can transla

43 They are typically pleiotropic, controlling development, cell growth, survi

44 cumulate during evolution incur a variety of pleiotropic costs and benefits with different probabilit

45 Results further indicate that estimates of pleiotropic costs from GWA analyses explain, in part, pa

46 ble, because resistance alleles with minimal pleiotropic costs may evade artificial selection and be

47 IL-2 is a pleiotropic cytokine and a key survival factor for Tregs

48 observed that intestinal neurons produce the pleiotropic cytokine IL-18.

49 In this study, we examined the role of the pleiotropic cytokine IL-6 in acute infection with pneumo

50 The pleiotropic cytokine IL-6 plays an integral role not onl

51 It is a pleiotropic cytokine involved in allergic reactions, par

52 IL-21 is a pleiotropic cytokine produced predominantly by CD4+ T ce

53 e regarding the functional diversity of this pleiotropic cytokine remains.

54 Interleukin-6 (IL-6) is a pleiotropic cytokine that has been shown to be produced

55 Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chroni

56 IL-6 is a major pleiotropic cytokine which critically links innate and a

57 TNFalpha is a pleiotropic cytokine which fuels tumor cell growth, inva

58 phage migration inhibitory factor (MIF) is a pleiotropic cytokine with critical and supporting roles

59 ribe the nonclassic roles attributed to this pleiotropic cytokine, including how IL-10 regulates basi

60 IL-15, a pleiotropic cytokine, stimulates generation of NK, NK-T,

61 how pathological phase transitions relate to pleiotropic defects in cellular functions and the accrua

62 -ahead of lesion onset, and is paralleled by pleiotropic defects in terminal differentiation.

63 on of miR159 in tobacco and rice resulted in pleiotropic defects including stunted growth, implying f

64 onserved H3.3-deposition factor, have severe pleiotropic defects that manifest predominantly at adult

65 n is inhibited, which results in detrimental pleiotropic defects, questioning the purpose of the miR1

66 enotypically reminiscent of atprmt3, showing pleiotropic developmental defects and aberrant pre-rRNA

67 derepression of their interacting genes and pleiotropic developmental phenotypes, including embryoni

68 In pleiotropic diseases, multiple organ systems are affecte

69 ondria, is associated with aging, and causes pleiotropic diseases.

70 Here, we report a pleiotropic disorder with a unique constellation of neur

71 Sensitivity tests for pleiotropic distortion were mostly inconsistent with gla

72 The floR mutation is highly pleiotropic, down-regulating production of gas vesicles,

73 set of drug efflux transporters that confer pleiotropic drug resistance (PDR).

74 Pleiotropic drug resistance arises by the enhanced extru

75 tudies have raised the possibility of such a pleiotropic effect for the epsilon4 allele in short-term

76 on involving a suppressor mutation and for a pleiotropic effect of H on plant growth that might const

77 Our results suggest a pleiotropic effect of JQ1 on pathways that have shown to

78 .116346115C > A (rs144636307) in RGS3 showed pleiotropic effect on left ventricular mass index, left

79 that functions extracellularly and exhibits pleiotropic effect on multiple intracellular signaling p

80 on early root growth through a developmental pleiotropic effect.

81 n analysis does not indicate that there is a pleiotropic effect.

82 ease allergens, the activation of additional pleiotropic effectors with strong disease linkage.

83 mplex with FGFR and FGF23 and that sKlotho's pleiotropic effects all depend on FGF23.

84 Large-scale simulation experiments without pleiotropic effects also corroborated these results.

85 he compound as an RXR agonist explaining the pleiotropic effects and report its systematic structure-

86 e stochastic accumulation of mutations whose pleiotropic effects are unpredictable.

87 CAD, but it's shown as a risk factor due to pleiotropic effects associated with LDL-c and HDL-c SNPs

88 The results show ORMDL3 has pleiotropic effects during cellular inflammation, consis

89 ferred to as class II substitutions, exhibit pleiotropic effects during virus replication.

90 ZmMADS69 shows pleiotropic effects for multiple traits of agronomic imp

91 ify Hsc70-4 as a SCA3 enhancer, and indicate pleiotropic effects from HSP70 chaperones, which are gen

92 Our findings establish FAT1 as a gene with pleiotropic effects in human, in that frameshift mutatio

93 Disruption of members of this family causes pleiotropic effects in many organisms by unknown mechani

94 GA has shown pleiotropic effects in vitro, including: antitumor effec

95 The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of growth

96 nd sensitivity analysis to address potential pleiotropic effects led to no substantive change in esti

97 s result in cilia dysfunction, often causing pleiotropic effects observed in a group of human disease

98 with in vivo CRISPR screens, we show how the pleiotropic effects of autophagy control cancer-cell-int

99 Pleiotropic effects of CcfM on magnetosome chain organiz

100 ranslation in Drosophila We propose that the pleiotropic effects of dbf loss-of-function mutants are

101 We observe pleiotropic effects of expression predictors for a numbe

102 lution bypassing constraints associated with pleiotropic effects of genes.

103 nsitivity analyses support an inference that pleiotropic effects of genetic variants on urate and met

104 ns of this study include potential bias from pleiotropic effects of genetic variants, and lack of gen

105 ate dogs and other animals and (2) potential pleiotropic effects of genetic variation affecting dog o

106 also termed mat-c, mutants to determine the pleiotropic effects of HvCEN on developmental timing and

107 CRBN is responsible for the pleiotropic effects of IMiDs, yet its function in angiog

108 gle-trait association, potentially revealing pleiotropic effects of individual genes.

109 iation studies, autoimmune-related and other pleiotropic effects of lung function-associated variants

110 ile acid metabolism, antibiotic use, and the pleiotropic effects of microbially produced metabolites.

111 The widespread pleiotropic effects of most mutations may constrain the

112 genetic diversity together with the positive pleiotropic effects of mutations have allowed TSWV to ra

113 he observed yield increase is accompanied by pleiotropic effects of Ppd-H1 resulting in shorter life

114 influenced the rate, genetic mechanisms, and pleiotropic effects of resistance to ciprofloxacin in Ac

115 al contexts of plant life while avoiding the pleiotropic effects of system-wide losses of gene functi

116 Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haem

117 s of this study relate to possible bias from pleiotropic effects of the considered genetic variants a

118 eceptor-specific signaling outcomes from the pleiotropic effects of the ligands.

119 lts reveal a mechanism by which A20 mediates pleiotropic effects of TNFalpha playing role in aggressi

120 analysis in the UK Biobank demonstrates the pleiotropic effects of TSH-associated variants and a pol

121 Our findings highlight the pleiotropic effects of TSH-associated variants on thyroi

122 r each of these 12 genes to assess potential pleiotropic effects on 700 complex traits and diseases.

123 aggregation, changes in gene expression, and pleiotropic effects on cell phenotype.

124 ntify and characterize genetic variants with pleiotropic effects on cytokines.

125 These pleiotropic effects on different T cell populations duri

126 e-specific deleterious effects, antagonistic pleiotropic effects on early and late-age fitness compon

127 h TULP4 presenting as a strong candidate for pleiotropic effects on eBMD and gene expression in osteo

128 This variant has pleiotropic effects on eye, hair, and skin pigmentation.

129 Integrin-specific hydrogels have diverse pleiotropic effects on hMSC reparative activities, modul

130 d SNPs in the promoter of MFAP2 that exhibit pleiotropic effects on human disease traits.

131 Aberrantly expressed lncRNAs in HCC exert pleiotropic effects on miRNAs, mRNAs, and proteins.

132 ve of the dietary trait-associated loci have pleiotropic effects on multiple human complex diseases a

133 ndirect selection on mutations through their pleiotropic effects on multiple phenotypes.

134 nomic risk for neuropsychiatric disorder has pleiotropic effects on multiple processes and neural cir

135 is highlights how the same mutation can have pleiotropic effects on one functional state of a protein

136 eptiles and indicating that these loci exert pleiotropic effects on other aspects of physiology.

137 genes Ppd-H1, Sdw1, Vrn-H1 and Vrn-H3 exert pleiotropic effects on plant development and grain yield

138 ation and specialized metabolism, leading to pleiotropic effects on plant growth and development.

139 d wheat produced an awnletted phenotype with pleiotropic effects on plant height and fertility.

140 chizophrenia in health care settings and has pleiotropic effects on related psychiatric disorders as

141 identify a historical substitution that has pleiotropic effects on S100A9 proinflammatory activity a

142 These pleiotropic effects on the ability of the pathogen to in

143 the rigidity of the outer membrane to exert pleiotropic effects on the functionality of gram-negativ

144 e while having only limited and inconsistent pleiotropic effects on the leaf microbiome in maize.

145 at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related

146 and CD, we identified genetic variants with pleiotropic effects on two clinically distinct immune-me

147 We further observe that variants with pleiotropic effects preferentially act in common progeni

148 Further, pleiotropic effects resulted in greater plasmid persiste

149 Limitations of this study include a risk of pleiotropic effects that may affect causal inference, an

150 ed as a post-translational modification with pleiotropic effects that span from regulation of transcr

151 and NRP1 demonstrated that VEGF mediates its pleiotropic effects through distinct receptors on each m

152 with cardiovascular disease, indicating for pleiotropic effects with health implications.

153 analysis, these genetic loci also exhibited pleiotropic effects with myopia, neurodegenerative disea

154 treating cancer, but these drugs often have pleiotropic effects, and identifying patients who will b

155 E and StBMI1-1-antisense (AS) lines produced pleiotropic effects, including altered leaf architecture

156 effect testing in the presence of horizontal pleiotropic effects, is reasonably robust under various

157 This is largely due to their minimal pleiotropic effects, limiting their impact to one partic

158 The antibody used has pleiotropic effects, so we set out to gain insight into

159 demonstrates that the loss of PpiB leads to pleiotropic effects, supporting the role of PpiB in main

160 n genes underlying these disorders uncovered pleiotropic effects, with a single gene affecting multip

161 ceptibility loci and to detect and interpret pleiotropic effects.

162 rafficking they may underlie statin specific pleiotropic effects.

163 Many of them show strong pleiotropic effects.

164 ngs, indicating either off-target effects or pleiotropic effects.

165 ion to detect polymorphisms with potentially pleiotropic effects.

166 We identified five variants with potentially pleiotropic effects.

167 Butyrate is a microbial metabolite with pleiotropic effects.

168 omeres is poorly understood because ROS have pleiotropic effects.

169 s for correlated and uncorrelated horizontal pleiotropic effects.

170 as in humans, alleles governing growth have pleiotropic effects.

171 rs; compared with tissue-specific enhancers, pleiotropic enhancers show stronger depletion of archaic

172 Q-Q and fold enrichment plots showed a high pleiotropic enrichment of SNPs associated with two trait

173 Interferons (IFNs) comprise a pleiotropic family of signaling molecules that are often

174 Such pleiotropic fitness effects determine the evolutionary f

175 We found that evolution led to diverse pleiotropic fitness gains and losses, driven by multiple

176 ar activities; however, the mechanism of the pleiotropic function is unknown.

177 ines GWAS follow-up studies and highlights a pleiotropic function of MX2 in melanoma susceptibility.

178 Leptin is an adipocyte-derived hormone with pleiotropic functions affecting appetite and mood.

179 Due to its pleiotropic functions as a ubiquitin binding protein, de

180 vity will provide important insight into its pleiotropic functions as well as the management of patie

181 (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development.

182 ies found orexin to be expressed and perform pleiotropic functions in multiple tissues in mammals.

183 this study demonstrates that C5aR2 possesses pleiotropic functions in primary human macrophages, high

184 r G protein-coupled receptor 56 (GPR56)) has pleiotropic functions in the development of multiple org

185 Here, we review the pleiotropic functions in tumor and immune cells of enhan

186 RP1 is an abundant nuclear protein with many pleiotropic functions involved in epigenetic and transcr

187 The pleiotropic functions of DJ-1 include reactive oxygen sp

188 In this perspective, the pleiotropic functions of iRhom2 are discussed with respe

189 A deeper knowledge of the pleiotropic functions of MC mediators, as well as the mo

190 overing molecular mechanisms modulating CTCF pleiotropic functions throughout the genome.

191 IL-9 is a cytokine with pleiotropic functions, and it has been suggested that it

192 P62/SQSTM1 and OPTN proteins have pleiotropic functions, including regulation of innate im

193 31) chain family of cytokines, which exhibit pleiotropic functions, including the regulation of myelo

194 ral control are lacking for unraveling these pleiotropic functions.

195 or an outlier SNP (rs550057) from the highly pleiotropic gene ABO.

196 We discuss how functional diversification of pleiotropic genes in the regulation of different traits

197 d by the evolution of different functions of pleiotropic genes in their regulation of different trait

198 d exhibit polygenic inheritance underlain by pleiotropic genes.

199 whether these associations are explained by pleiotropic genetic variants or shared comorbidities is

200 duction, but the mechanisms underlying these pleiotropic growth effects remain unclear.

201 a) of cAMP-dependent protein kinase (PKA), a pleiotropic holoenzyme that regulates numerous fundament

202 Growth hormone (GH), a pleiotropic hormone secreted by the pituitary gland, reg

203 Collectively, these data characterize the pleiotropic hormone-independent mechanisms underlying ac

204 ganogenesis and when dysfunctional result in pleiotropic human genetic disorders called ciliopathies,

205 A) and angiopoietin 2 (Ang2/ANGPT2), induces pleiotropic immune mechanisms that facilitate tumor reje

206 s l-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects.

207 major disease categories, and illustrate the pleiotropic impact of CNVs in human disease.

208 ern computer and mobile web browsers, making pleiotropic information readily available to a broad ran

209 to quickly explore complex high-dimensional pleiotropic information.

210 that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs.

211 Phosphatidic acid (PA) is a pleiotropic lipid second messenger whose modes of action

212 ing novel) were identified, 25 of which were pleiotropic loci (13 variants being novel) for both trai

213 atistic-based framework to map and interpret pleiotropic loci in a joint analysis of multiple disease

214 Identifying and interpreting pleiotropic loci is essential to understanding the share

215 A common approach to mapping pleiotropic loci is to meta-analyze GWAS summary statist

216 not observe consistent effect directions of pleiotropic loci on the traits.

217 to cardiovascular disease and identified 13 pleiotropic loci, which showed four different patterns o

218 ositive or negative genetic correlations; 25 pleiotropic loci; and 100 independent pleiotropic varian

219 We propose PLEIO (Pleiotropic Locus Exploration and Interpretation using O

220 y cilia defects result in a group of related pleiotropic malformation syndromes known as ciliopathies

221 Our results also show how coding change in a pleiotropic master regulator could have small, quantitat

222 port the location of this TAM as well as the pleiotropic mechanism of action of anti-MARCO antibody t

223 Consistent with a pleiotropic mechanism of action, RMC-4550 in combination

224 Interleukin-1 beta (IL-1beta) is a pleiotropic mediator of inflammation and is produced in

225 ciation analysis based on subsets (ASSET), a pleiotropic meta-analytic technique, allowed jointly ass

226 The pleiotropic metabolic effect of loss-of-function mutatio

227 Yet, as inherently pleiotropic molecules, microRNAs have been difficult to

228 Dhx15 deficiency leads to pleiotropic morphological phenotypes in homozygous mutan

229 Owing to the rather pleiotropic nature of Ca(2+) transporters and other Ca(2

230 Due to their pleiotropic nature, the reader will be specifically dire

231 Therefore, these results point to a pleiotropic network of cholinergic signals that direct c

232 id researchers in constructing and digesting pleiotropic networks, we present PleioNet, a web-based v

233 Vasoactive intestinal peptide (VIP) is a pleiotropic neuropeptide synthetized in trophoblasts at

234 of literature substantiating the beneficial pleiotropic neurovascular effects of chronic statin trea

235 In contrast to pleiotropic null mutants, only pollen numbers are signif

236 It is unclear how the pleiotropic outcomes of evolution are shaped by the intr

237 constitutive activation of SKN-1 results in pleiotropic outcomes, including a redistribution of soma

238 The pleiotropic PAR1 agonist, 3K3A-APC, reduces neurological

239 The apelin receptor system is a pleiotropic pathway with a potential for therapeutic tar

240 gation of several causal relationships, many pleiotropic pathways are uncovered with already establis

241 Adjustment for pleiotropic pathways reduces the heterogeneity across th

242 Gruber Syndrome type 3 (MKS3) resulting in a pleiotropic phenotype with hydrocephalus and renal cysti

243 rized this state and found that it underlies pleiotropic phenotypes and has a common rewiring of gene

244 ions or reductions can lead to cell death or pleiotropic phenotypes or may have no apparent visible e

245 unction approaches are impeded by the severe pleiotropic phenotypes resulting from these losses.

246 Loss of Hfq typically results in pleiotropic phenotypes, and, in the major human pathogen

247 deed, the yeast exposed to the host takes on pleiotropic phenotypes, enabling the generation of popul

248 t steps in LPS O-antigen synthesis can cause pleiotropic phenotypes.

249 ction in F-type cells, consistent with their pleiotropic phenotypic changes.

250 Stress has pleiotropic physiologic effects, but the neural circuits

251 acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy h

252 (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions.

253 Aging is a pleiotropic process affecting many aspects of mammalian

254 IL-33 is a cytokine with pleiotropic properties and effects on Treg function and

255 Osteopontin (OPN) is a pleiotropic protein and is abundantly present in milk.

256 ciated athanogene 3 (BAG3), a stress-induced pleiotropic protein that is involved in protein quality

257 ibitor of metalloproteinases-1 (TIMP-1) is a pleiotropic protein, promoting both tumor-suppressive an

258 multiple environments could be explained by pleiotropic QTL or multiple tightly linked QTL.

259 test how a composite trait is determined by pleiotropic QTLs for its component traits or jointly by

260 Missense variants demonstrated a pleiotropic range of detrimental effects upon protein mo

261 Here, we define a new pleiotropic regulator found in screens of GV mutants.

262 peron repressor, RbsR, was also defined as a pleiotropic regulator of flotation and virulence factor

263 together, our findings suggest that hHB is a pleiotropic regulator of RIG-I/MDA5-mediated antiviral r

264 Here, we identified human HB (hHB) as a pleiotropic regulator of the replication of RNA viruses

265 ights the importance of RsmS, as a conserved pleiotropic regulator of virulence and antibiotic biosyn

266 ression of gafA is in turn controlled by the pleiotropic regulator protein CtrA and the quorum-sensin

267 teomics analysis, we showed AgtR is a highly pleiotropic regulator that influences up to 252 genes re

268 regulator that operates through subordinate pleiotropic regulators including Rap, RpoS, RsmA, PigU,

269 ining to biological mechanisms inferred from pleiotropic relationships.

270 ummer dormant QTL regions in male map showed pleiotropic responses and epistatic interactions with ot

271 ecular mechanisms underlying this surprising pleiotropic result, consideration for applied phage biol

272 that the therapeutic effects of apigenin are pleiotropic, resulting in decreased oxidative stress, ac

273 that gathers increasing attention due to its pleiotropic role as a pathogen and emerging vector for h

274 3 alternative sigma factor F (SigF) plays a pleiotropic role in Synechocystis sp. PCC 6803 physiolog

275 amma coactivator 1-alpha (PGC1alpha) plays a pleiotropic role in the control of cancer cell metabolis

276 Overall, our study uncovers the pleiotropic role of otoferlin in the hair cell synaptic

277 ated with severe side effects because of its pleiotropic role.

278 Pleiotropic roles are proposed for brain extracellular v

279 udied member of the HMGB protein family, has pleiotropic roles in cells including an association with

280 rcellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeo

281 Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeost

282 That said, S1P plays pleiotropic roles in the immune response, and it will be

283 This work sheds light on the pleiotropic roles of DeltaNp63 in cancer and unveils cri

284 ribonucleases provided evidence of important pleiotropic roles of the enzymes in mycobacterial RNA me

285 It is unclear how the pleiotropic second messenger Ca(2+) drives excitation-co

286 o acid and substrate specificity of the host pleiotropic serine/threonine kinase GSK3.

287 These results position MKK6 as a new pleiotropic signal transducer that promotes both pro-apo

288 assay that jointly measures activity of five pleiotropic signaling kinases: Akt, IkappaB kinase (IKK)

289 mechanism in which temporal regulation of a pleiotropic signaling protein underlies cortical circuit

290 We also identified a pleiotropic site necessary for DNA accessibility of a sh

291 The fact that all these pleiotropic SNPs have opposite allelic effects in SSc an

292 ses as a result of their shared, potentially pleiotropic SNPs.

293 ally mediated flow-induced activation of the pleiotropic transcription factor nuclear factor-kappaB a

294 a promising avenue in PDAC treatment due to pleiotropic tumor-inhibitory effects.

295 DICER1 syndrome is an autosomal-dominant, pleiotropic tumor-predisposition disorder caused by path

296 Sensitivity analyses excluding pleiotropic variants provided consistent associations.

297 Pleiotropic variants within these loci showed opposite a

298 ses that are more robust to the inclusion of pleiotropic variants, including MR-Egger, weighted media

299 ns; 25 pleiotropic loci; and 100 independent pleiotropic variants, many of which are regulatory eleme

300 Mutualisms can be promoted by pleiotropic win-win mutations which directly benefit sel