ライフサイエンスコーパス: pocket

1 embrane access channel and substrate binding pocket.

2 rbocyclic rings accessing the ribose-binding pocket.

3 formation and exhibits a deep ligand-binding pocket.

4 n a U-shaped conformation within its binding pocket.

5 membrane to enable access of drugs into its pocket.

6 rate-bound CntA help to define the substrate pocket.

7 mall molecules that bind to the TEAD central pocket.

8 d causes steric hindrance in the HIF binding pocket.

9 water molecules reached and left the binding pocket.

10 d phosphorylation near the eIF3d cap-binding pocket.

11 raction within the deep transmembrane domain pocket.

12 ine and tyrosine residues within the binding pocket.

13 targeted via their hydrophobic, orthosteric pocket.

14 he stem region or to the sialic acid-binding pocket.

15 ineates a largely hydrophilic client protein pocket.

16 tricted by R295(7.40) in the agonist-binding pocket.

17 t lead to the deformation of the GDP-binding pocket.

18 point to these compounds binding in the ATP pocket.

19 a previously undescribed allosteric binding pocket.

20 that can be targeted in the region of the L2 pocket.

21 vation through occupation of the specificity pocket.

22 drogen-bonding interactions in a hydrophobic pocket.

23 and 3D shape complementarity for the binding pocket.

24 trol the accessibility of the anti-apoptotic pocket.

25 y lead (12) revealed a potential new binding pocket.

26 cating the volume of the preQ(1)-recognition pocket.

27 domain stabilizing the S1 substrate-binding pocket.

28 71, Tyr-87, and Phe-89 at the center of this pocket.

29 by a shallow epitope lacking defined binding pockets.

30 lity (BBBP), and the targeting of allosteric pockets.

31 cted to lead to the formation of small Fermi pockets.

32 ing because they lack small-molecule binding pockets.

33 that encircle the portal to their non-polar pockets.

34 use and the number of teeth with periodontal pockets.

35 ets and the presence of deepened periodontal pockets.

36 lenge owing to the largely identical binding pockets.

37 sional channel connected to three peripheral pockets.

38 come by targeting unique residues or binding pockets.

39 % for nucleotide- and 91.3% for heme-binding pockets.

40 contacts with 2 distinct negatively charged pockets.

41 , the L2 loop, or somewhere in between these pockets.

42 es that have dipeptides bound in the A and F pockets.

43 s are component parts of the peptide-binding pocket 7 (P7) of the HLA-DR heterodimer, suggesting that

44 nserved residues V44, A45, R242, and E243 in pocket A of LiSIR2rp1.

45 ersible bond with Cys 215 in the ATP-binding pocket, a residue that is not present in human CLK1, the

46 that the KoH body has a much deeper binding pocket, allowing MBG to be held 4 angstrom further down

47 A similar pocket also appears to be present in the highly pathogen

48 lecules confined within hydrophobic reaction pockets alters the energetics of adsorption and catalysi

49 One of these is the flagellar pocket, an invagination of the cell membrane around the

50 cluster is adjacent to the SAR1 GTP-binding pocket and alters the kinetics of GTP exchange.

51 1-yl exit vector pointing into the transient pocket and displacing a conserved water network.

52 to participate in covering the NADH-binding pocket and establishing the water channels that connect

53 RJW100 adopts multiple configurations in the pocket and fails to make an interaction critical for act

54 methylbenzimidazole tail splayed into a side pocket and its corrin ring buried.

55 DR3beta loop anchored proximal to the MR1 A'-pocket and mediated direct contact with the 5-OP-RU anti

56 maintains indirect interactions with the ATP-pocket and mediates a critical salt bridge with a glutam

57 V2G10, by contrast, sits atop the enzymatic pocket and occludes substrate accessibility.

58 by inhibitors that occupy an "alkyl-induced" pocket and possess bicyclic hinge-binding motifs capable

59 tranexamic acid conjugates targeting the S1 pocket and primed sites, substrate-analogue linear homop

60 pyridyl ethers directed into the hydrophobic pocket and small carbocyclic rings accessing the ribose-

61 ontains an intramembrane cholesterol-binding pocket and that interaction with cholesterol may regulat

62 interaction, a lipid-mediated NADPH-binding pocket and the electron transfer path.

63 ntrols communication between the ATP-binding pocket and the helical gate.

64 P) molecules remodels both the ISRIB-binding pocket and the pockets that would engage eIF2alpha durin

65 of teeth with deepened (>=4 mm) periodontal pockets and the presence of deepened periodontal pockets

66 t enhances affinity to the substrate-binding pocket, and fine-tuning of the chemical composition of t

67 ing defects (i.e., cavities including voids, pockets, and pores) are prevalent in membrane-integral e

68 ructure-level analysis showed ligand binding pocket architectures differences in size, shape and elec

69 The electrostatic properties across the S1 pocket are further attenuated by charged Glu192 at the r

70 of Emc4 and the hydrophilicity of the client pocket are required for EMC function.

71 Pockets are represented by pharmacophore-annotated point

72 isations in logarithmic (mainly in flagellar pocket area and endosomes) and late stationary phase (mi

73 BigDyn modulates ASIC1a, identify the acidic pocket as the binding site for BigDyn, and thus highligh

74 nteractions of the ligand with a hydrophobic pocket at the interface of the second extracellular loop

75 ne compound (NITD-434) induced an allosteric pocket at the junction of the fingers and palm subdomain

76 N-terminus inserting into the ligand binding pocket at the transmembrane bundle of the receptor, whic

77 onoiNet also computes significance scores of pocket atoms, called BionoiScores, to provide meaningful

78 the morphology and function of the flagellar pockets between different trypanosomatids, with their li

79 T with one compound revealed peptide binding pocket binding.

80 ovalently target the cysteine in the central pocket, block the interaction with coactivator yes-assoc

81 As a dust grain dissolves, the pockets burst and emit acoustic signals that are detecte

82 is substitution disrupts cGMP binding to the pocket, but it also unexpectedly causes PKG1 to have hig

83 In Japan, a 30% copayment (out of pocket) by the user and a 70% contribution by Japan's un

84 at compound 5 did not reach highly conserved pocket C and established interactions with the semiconse

85 active site, including the interaction with pocket C, a region not commonly exploited by previously

86 nges in the 220-loop of the receptor-binding pocket caused similar interactions with human receptor a

87 distinctive interactions within the binding pocket, causing unique allosteric effects in the enzyme.

88 -band Fermi surface, consisting of both hole pockets centred at (pai, 0) and electron pockets centred

89 ole pockets centred at (pai, 0) and electron pockets centred at (pai/2, pai/2).

90 cal attachment level (CAL) gain (>=3 mm) and pocket closure (post-surgery probing depth [PD] <= 4 mm)

91 x-month residual PD was 3.7 +/- 1.1 mm, with pocket closure recorded in 79.6% of patients.

92 when either clinically relevant CAL gain and pocket closure were not achieved.

93 ically relevant CAL gain was associated with pocket closure, and failing when either clinically relev

94 Binding of the inhibitor to this pocket collapsed the MKP5 active site and was predicted

95 mic face is a structure called the flagellar pocket collar (FPC), which is essential for FP biogenesi

96 s the existence of an optimal ligand-binding pocket conformation for capsaicin-mediated TRPV1 activat

97 nse variants localized to an electronegative pocket considered critical for back-to-back binding of d

98 ng to a partial collapse of the conserved S1 pocket, consistent with the first and controversial crys

99 aled unrestricted nonprime substrate binding pockets, consistent with the broad substrate specificity

100 Epa family members are lectins with binding pockets containing several conserved and variable struct

101 , a conserved residue in the AAG active-site pocket, contributes to discrimination against eG.

102 Out-of-pocket cost per problem-based visit rose by $9.4 (31.5%)

103 The fact that potential patient out-of-pocket costs might influence decision making has rarely

104 hresholds of patient income levels or out-of-pocket costs that predict risk of financial toxicity are

105 drugs among patients with the highest out-of-pocket costs, without detectable increases in health-pla

106 l/valsartan that explicitly addresses out-of-pocket costs.

107 containing active sites or molecule-binding pockets could interact with short, structured RNA molecu

108 kers direct the capping group toward shallow pockets defined by the L1 loop, the L2 loop, or somewher

109 an synthesis, affinity assays, sugar binding pocket deletions, site-directed mutagenesis, and constru

110 h higher percentage of interproximal probing pocket depth (P = .004).

111 Pocket depth (PD) and clinical attachment level (CAL) fo

112 he mean CAL was 9.56 +/- 1.93 mm with a mean pocket depth (PD) of 8.41 +/- 1.42 mm.

113 Clinical assessments, including pocket depth (PD), clinical attachment level (CAL), and

114 nts associated with >= 6 mm residual probing pocket depth (PPD) were included and randomly assigned t

115 Pre- and post-therapy clinical (probing pocket depth [PPD], clinical attachment level [CAL], gin

116 imilar when stratified on baseline levels of pocket depth, gingival bleeding, ACH, and smoking status

117 Peri-implantitis patients with implant pocket depths (IPD) of 5-8 mm underwent subgingival impl

118 Furthermore, clinical parameters (Probing Pocket Depths, Bleeding On Probing, Plaque Index) and ma

119 whether alcohol use predicts the periodontal pocket development over an 11-year follow-up period.

120 e activity, and mutating Dnmt5's ATP-binding pocket disproportionately reduces ATPase stimulation by

121 bic residues in the [4Fe-4S] cluster binding pocket, distinct from previously characterized canonical

122 folded at high temperatures and exhibit more pocket diversity than naturally occurring NTF2-like prot

123 Efficient methods to treat persistent pockets during periodontal maintenance therapy (PMT) req

124 ibiotic activity by restraining drug-binding pocket dynamics, rather than preventing antibiotic bindi

125 and occupies the orthosteric ligand-binding pocket enabled by a conformational change that doubles t

126 [as percentage of GDP], private, and out-of-pocket expenditure on health [both as percentage of curr

127 Finally, out-of-pocket expenses for indirect health-care costs were a ke

128 gation of short peptides which offer binding pockets exposed with arrays of imidazoles and lysines.

129 Reduced occupancy of a particle-stabilising pocket factor in the complexed virus and the presence of

130 ishes stronger binding interactions with the pocket, favoring menaquinone for charge transport in T.

131 ed of 12 HSP27 dimers with a phosphorylation pocket flanked by serine residues between their N-termin

132 cleotidyltransferase domain, detailing a new pocket for anti-viral therapy development.

133 The receptor also features a side pocket for ligand binding.

134 highlights the high importance of the P2/P3 pockets for the binding of nonpeptide ligands.

135 be targeted, in addition to RNA cap and SAM pockets, for antiviral development.

136 ory disease that can lead to the periodontal pocket formation and tooth loss.

137 ealed a conserved horseshoe-like hydrophobic pocket formed by an unusually long loop.

138 ll SCs, independent of the CIV isoform, in a pocket formed by Cox1, Cox3, Cox12, and Cox13, away from

139 om one Ig1 domain inserts into a hydrophobic pocket from the opposing Ig1 domain producing an interac

140 be due to the emergence of a new hydrophobic pocket generated by the insertion of the six amino acid

141 e and a lysine residue in the ligand binding pocket (GluN2D-Met763/Lys766, GluN2C-Met736/Lys739) are

142 based on the percentage of teeth/person with pockets >=4 mm deep.

143 Here, we report efforts to exploit a cryptic pocket (H95/Y96/Q99) we identified in KRAS(G12C) to iden

144 The binding pocket has been observed in initiator caspases of other

145 ), providing two pincer-type {N(3) } binding pockets, has been reported to readily eliminate H(2) and

146 the structural disorder and lack of binding pockets have made design of small molecules for transcri

147 he substrate-binding pocket to a new pocket, pocket III.

148 ocket, supporting the suggested role of this pocket in DNA packaging for the Dependoparvovirus The st

149 ) substitution within the first cGMP-binding pocket in PKG1.

150 ta3Arg-309) helices located at the base of a pocket in the beta(+)-alpha(-) subunit interface that ex

151 We confirmed that the interacting pocket in the DNAJA1-mutp53(R175H) complex was crucial f

152 (R175H) proteins, identified the interacting pocket in the DNAJA1-mutp53(R175H) complex, and found on

153 suitability of the agonist-bound orthosteric pocket in the MT receptor structures for the structure-b

154 conserved tryptophan (W571) from its typical pocket in these Env mutants renders the Env insensitive

155 d an unpredicted non-peptide agonist-binding pocket in which reorganization of extracellular loop 3 a

156 ces between shallow and residual periodontal pockets in patients with periodontitis (Stages III and I

157 tion of solvent-exposed non-polar tracts and pockets in proteins.

158 l structures reveal two S-citalopram binding pockets in the central binding (S1) site and the extrace

159 compound F0045(S) confirmed that it binds to pockets in the HA stem similar to bnAbs FI6v3 and CR9114

160 uanidino-benzimidazoles to target the opened pocket, including a dihydro-imidazoquinazoline with a pr

161 Most SCS infections present as generator pocket infection.

162 sociated with the development of periodontal pockets (IRRs varied from 0.6 to 1.0).

163 covalently binds with FMN and Cu(II)-binding pocket is located at the interface of the NfoR dimer.

164 emokine N terminus with the receptor-binding pocket is the key driver of signaling, the signaling amp

165 h there being a minimally frustrated binding pocket leading to a funneled binding landscape.

166 of activators binds IRE1 in the kinase front pocket, leading to a distinct conformation of the activa

167 tructures have a lower number of hydrophobic pockets, leading to a lower capacity to entrap hydrophob

168 ding prevents local unfolding of the Hb heme pocket, leaving IsdH unable to wrest the heme from Hb.

169 The binding pocket lies between the two protein domains, whereas all

170 IF with three prediction challenges: protein pocket-ligand prediction, protein-protein interaction si

171 mine (5-HT) (i.e., serotonin) to the binding pocket located on the extracellular domain (ECD) and all

172 he inhibitor into a SULT1A3-specific binding pocket located outside the active site, and a side chain

173 observed in percentage of both healthy PPDs (pockets < 5 mm) and converted pockets (sites no longer r

174 er identify which factor (CAL gain, residual pocket) mainly contributed to determine a treatment fail

175 face with the empty, symmetry-mismatched IGL pocket maintained at the seam.

176 from that of Phe13 of Ape13, while the Phe13 pocket may be occupied by Pro32 of ELA.

177 ace, commercial insurance, and higher out-of-pocket medication costs (c-statistic 0.74).

178 Out-of-pocket medication costs for patients who have heart fail

179 patients' perspectives on discussing out-of-pocket medication costs with clinicians, 49 adults, aged

180 with glycine in the zebrafish MetRS-binding pocket (MetRS-L270G), we enabled the cell-type-specific

181 way for large-scale synthetic preparation of pocket-modified vancomycin analogues that directly addre

182 In addition, risperidone occupies a sub-pocket near the Na(+) binding site, whereas eticlopride

183 E transmembrane helices that form a binding pocket not previously characterized.

184 cover prevalent epistasis within the binding pocket of a human G protein-coupled receptor (GPCR) yiel

185 synuclein and glutamine 111 in the catalytic pocket of CypA.

186 n and binding at the putative ligand binding pocket of CypD.

187 row Drude peak from a high-mobility electron pocket of double Weyl quasiparticles, and the temperatur

188 nionic amino acids surrounding the catalytic pocket of DspB in PNAG substrate recognition and hydroly

189 s structural hot spots in the ligand binding pocket of Epa proteins is a main driver of their functio

190 In addition, Glu570 in the active pocket of hTRPV1 plays an important role in identifying

191 of a 3' terminal Uridine into the catalytic pocket of Nbr EXO indicates that 2'-O-methylation of the

192 ments were shown to bind in the palmitoleate pocket of Notum.

193 f the catalytic subunit Isw1 with the acidic pocket of nucleosomes and the accessory subunit Ioc3 wit

194 s FXIII was topically applied into the wound pocket of rats, eleven adhesive failures occurred betwee

195 top SNP encodes p.Met76Val in the P4 binding pocket of the HLA class II gene HLA-DPB1 (rs1042151A>G,

196 ction of selected compounds with the binding pocket of the NorA efflux pump.

197 rved interactions at the specificity binding pocket of trypsin and trypsin-like proteins from Serine-

198 thin the uridine diphosphate glucose binding pocket of yGsy2p.

199 es thus foreshadow the generation of binding pockets of advanced proteins and have the potential to c

200 tes within the ATP and D-cycloserine binding pockets of Ddl.

201 een the catalytic site and the sugar-binding pockets of domain V and contributing to a processive elo

202 The binding pockets of extant enzymes feature precise positioning of

203 n of interactions in the S1, S1beta, and S1' pockets of FXIa through a combination of structure-based

204 Bacteria-like morphology was identified in pockets of human fetal meconium at mid-gestation by scan

205 d structural features present in the binding pockets of methyllysine binding domains.

206 The binding pockets of odorant binding proteins from Anopheles gambi

207 ng is crucial in the greater Atlanta area as pockets of poverty and old housing put some children at

208 co-determined by synergy between the binding pockets of the MHC molecule.

209 ng may allow identification and targeting of pockets of transmission.

210 mental surveillance reveals importations and pockets of unimmunized children that dictate intensive t

211 ture, an "intrinsic ligand," and hydrophobic pockets off a pore cavity that is surprisingly small.

212 A pocket on Nef previously identified as crucial for recru

213 six residues of P11 inserted into a shallow pocket on Stx2A1 and interacted with Arg-172, Arg-176, a

214 eric substrate-binding site in a hydrophobic pocket on the enzyme surface.

215 reveals that carbamazepine binds at a novel pocket on the FZD8 CRD.

216 small molecules ICCB-19 and Apt-1 bind to a pocket on the N-terminal TRAF2-binding domain of TRADD (

217 2 and has been assumed to fit snuggly into a pocket on the PD-1 surface.

218 ted within a fibrin matrix into subcutaneous pockets on the dorsal flanks of SCID mice.

219 oethanol (TFE) for the generation of PVP/TFE pockets on the surface of a PCL jet.

220 It becomes accessible upon pocket opening for selective covalent attachment of elec

221 [7%] patients), implantable pulse generator pocket pain (five [4%]), and muscle spasm or cramp (thre

222 Pocket PATH and usual care groups' nonadherence rates we

223 In multivariable analysis, the Pocket PATH group showed lower risk of nonadherence to l

224 Maryland - passed legislation to cap out-of-pocket payments for specialty drugs at $150 per prescrip

225 Out-of-pocket payments per 30 tablets were lower among Medicaid

226 Individuals who incurred out-of-pocket payments that were more than 10% of their annual

227 urance, 2.6% (95% CI, 2.6%-2.6%); and out-of-pocket payments, 1.1% (95% CI, 1.0%-1.1%).

228 nce, and 9.2% (95% CI, 8.3%-10.4%) by out-of-pocket payments.

229 ance, and 9.4% (95% CI, 9.4%-9.4%) by out-of-pocket payments.

230 eriodontitis (PPD = 5 to 8 mm) in at least 2 pockets per contralateral quadrants within the same arch

231 past two decades, but residual transmission pockets persist across the Amazon Basin, where Plasmodiu

232 catastrophic expenditures, defined as out-of-pocket plus premium spending exceeding 19.5% of family i

233 xtends the substrate-binding pocket to a new pocket, pocket III.

234 ors (missing teeth, percentage of sites with pocket probing depth >=6 mm, and mean pocket probing dep

235 s with pocket probing depth >=6 mm, and mean pocket probing depth) had an area under the curve (AUC)

236 Periodontal parameters, including pocket probing depth, bleeding on probing, and clinical

237 nt with the formation of a substrate-binding pocket providing access to the catalytic site.

238 We developed and applied a binding-pocket redesign strategy, guided by machine learning, to

239 ues (R141A/R397A) within the (E)FtsN-binding pocket reduced the activation of PBP1b by FtsN but not b

240 Finally, the position of each pocket relative to the active site also appeared to be i

241 M originally residing in the N(2) S(2) (4-) pocket, replaced by protonation at the amido nitrogens,

242 healthy PPDs (pockets < 5 mm) and converted pockets (sites no longer requiring surgical treatment);

243 We propose that sugar-binding pockets spatially closer to the catalytic domain play a

244 The primary outcome was the change in out-of-pocket spending among specialty-drug users who were in t

245 forms must place emphasis on reducing out-of-pocket spending for patients with multimorbidity to prov

246 timated the median annual per patient out-of-pocket spending on PrEP was approximately US$72.

247 We evaluated 3 main outcomes: (1) out-of-pocket spending, (2) premium contributions, and (3) like

248 o $406; P = .001) increase in patient out-of-pocket spending, but no significant changes in total hea

249 e gelling solvent situated in the "molecular pocket" stitches the gelators through weak H-bonding int

250 umber of de novo proteins supporting diverse pocket structures.

251 We also reveal that a drug-binding pocket substitution discovered within a multidrug resist

252 the previously described nucleotide-binding pocket, supporting the suggested role of this pocket in

253 oups of some compounds occupy a water-filled pocket surrounding an nNOS-specific aspartate residue (a

254 he amino acid side chains lining the binding pockets switch in a coordinated fashion between a peptid

255 together with Thr-35 of WW1, form a binding pocket that accommodates a polyproline stretch within th

256 large, membrane-accessible substrate-binding pocket that alternately faced the ER lumen and cytosol a

257 the presence of a secondary sulfate-binding pocket that could be exploited in the design of future i

258 tional change in residues of the FMN-binding pocket that display peptide-bond flipping upon NAD(+) bi

259 modes of binding in the (DHQD)(2)PHAL chiral pocket that explain the system's remarkable control over

260 resting position and inserted into an acidic pocket that is about 5 angstrom away.

261 We identify an amino-acid-binding pocket that is formed by transmembrane helices 1, 6, and

262 We also characterize a calcium-binding pocket that is highly conserved across TRP channel subty

263 esulted in a water accessible ligand-binding pocket that lacked sodium ions.

264 but they also highlighted a common backside pocket that the UbVs used for enhanced affinity and spec

265 structural features of the substrate-binding pocket that underlie the divergent evolution of substrat

266 ted and drugged with antibodies, they harbor pockets that are only accessible to small molecules and

267 models both the ISRIB-binding pocket and the pockets that would engage eIF2alpha during active nucleo

268 an interconnected surface frame containing 'pockets' that house highly water-repellent and mechanica

269 with the inhibitor Lys(32) in the trypsin S1 pocket, the inhibitor C-terminal residue Ser(33) cleavag

270 small molecule occupancy of protein binding pockets, thus creating the potential to modulate human b

271 ng surface and extends the substrate-binding pocket to a new pocket, pocket III.

272 er, D(2)R(spi) exhibited an extended binding pocket to accommodate spiperone's phenyl ring, which pro

273 triterpenoid glycosides within a new binding pocket to characterize the structure-activity relationsh

274 nating access of a central substrate binding pocket to either side of the membrane.

275 allows ligands in the extracellular binding pocket to favor either of the two intracellular conforma

276 Ivermectin directly binds this pocket to inhibit MAPKAP2-mediated HSP27 phosphorylation

277 f key residues connecting the ligand-binding pocket to the G(s)-coupling site, and a specific interac

278 y couple the dynamics of the quinone binding pocket to the site of NADH reduction.

279 t packing in and the shape of the peripheral pockets, to afford large changes in the global pore geom

280 targets used, the wider range of target and pocket types, and the diversity of therapeutic areas exp

281 ite and contributes to substrate specificity pockets underpopulated in other HP2Ps.

282 transduction between the ATP and RNA binding pockets using molecular dynamics simulations and enzymat

283 ic residues in two consecutive sugar-binding pockets (variant DSR-OKDelta1-Y1162A-F1228A) induced qua

284 by a conformational change that doubles the pocket volume.

285 rogen bonding interaction with Thr599 in the pocket was achieved with a tertiary amide moiety, confir

286 ing site 20 angstrom away from the catalytic pocket was identified, and its potential participation i

287 n in silico screen of the MR1 ligand-binding pocket, we identify one ligand, 3-([2,6-dioxo-1,2,3,6-te

288 osed paralimbal, curved self-sealing scleral pockets were made 3 mm away from the limbus along with a

289 ar conformation to the P4-P6 peptide binding pockets, whereas clozapine N-oxide, which did not activa

290 Z complex reveals a hydrophobic FtsZ-binding pocket, which defines the SepF homodimer as the function

291 n summary, in the environment of periodontal pockets, which are bathed in gingival crevicular fluid c

292 ble within the ostensibly identical cavitand pockets-which differ only in the presence and/or positio

293 defines the size and shape of the catalytic pocket, while the pai-methyl-l-histidine (Pmh) moiety tr

294 e in fusogenic activity via a Ca(2+) binding pocket with conserved glutamic acid (E) and aspartic aci

295 he backbone as well as forms the SAM-binding pocket with its three distinctive loops, affect the bind

296 a significantly higher number of periodontal pockets with >=4 mm (P < 0.001).

297 Criticality is known to occur in "hot" Fermi pockets with a high density of states close to the Fermi

298 ng as a deep, sterically limited hydrophobic pocket, with the outward pointing piperidine moiety bein

299 spase-1 L2 and L2' loops bound a hydrophobic pocket within the GSDMD C-terminal domain distal to its

300 o both the "selectivity" and "alkyl-induced" pockets within the adenosine triphosphate (ATP) binding