ライフサイエンスコーパス: point to

1 chlorate salts that depress water's freezing point to ~-60 degrees C, our approach provides a unique

2 5.1 percentage point (95% CI, 3.0 percentage points to 7.2 percentage points; P < .001).

3 Our results point to a "limited change/induced fit" mechanism in whi

4 ronment relative to the native CODH cofactor point to a biochemical CO oxidation mechanism that requi

5 Taken together, our data point to a central role for EBV in mediating the tumour

6 Structural data point to a common dimerization and activation path for T

7 Our results point to a critical importance of the cationic N-termina

8 These results point to a critical role for hypothalamic TNFR1 signalin

9 nchanged in the face of oxidative stress and point to a critical role of obesity in T2DM cardiomyopat

10 The intersections between CAA and AD point to a crucial role for improving vascular function

11 Our recent findings point to a dedifferentiation mechanism by which reprogra

12 The experiments with SUR1-KO beta-cells point to a direct effect of AG on beta-cells and not, as

13 Together, our results point to a family of functional human microproteins that

14 Our results point to a general principle of interplay between phasic

15 surements from the partial 'toothed' dentary point to a giant body size for the species, although the

16 as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system i

17 ssion among older adults, systematic reviews point to a lack of longitudinal investigations, and the

18 structural covariance study of OCD to date, point to a less segregated organization of structural co

19 G4s as important cis-regulatory elements and point to a link between disruption of UTR pG4 and diseas

20 quinone metabolism, but more recent findings point to a more toxifying function of NQO2, particularly

21 how obesity worsens cancer outcomes and may point to a new metabolic approach to treating some cance

22 These data point to a novel "thiol-blocked" [(PDT)Mo(V)O(S(Cys))(th

23 In sum, our findings point to a novel mechanism of action for this successful

24 Taken together, these results point to a pathogenic role of monocytes in patients with

25 s of carboxylic acids bound by the catalyst, point to a plausible resting state of the catalyst-subst

26 These limited examples point to a poor understanding of cage catalysis in gener

27 Recent isotopic and paleomagnetic data point to a possible connection between carbonaceous chon

28 e context of model construction, the results point to a potentially significant gap between high-dime

29 opic potential of incretins in human T2D and point to a potentially unifying model for T2D progressio

30 These findings point to a promising direction for achieving low-bandgap

31 operties, including photoconductivity, would point to a revision of the traditional concept of struct

32 These data point to a role for alternative polyadenylation of LDLR

33 These data point to a role for mSWI/SNF complexes in therapy-relate

34 and following specific childhood events, and point to a role for the early-life environment in shapin

35 Our data point to a role for TOP2A as a structural chromosome mai

36 class II TCP genes in Aristolochia fimbriata point to a role of CYC and CIN genes in maintaining diff

37 The current findings point to a scale-dependent manifestation of membrane pro

38 s a universal function of these proteins and point to a second mechanism by which MvaT and MvaU may c

39 ritized de novo mutations in autism probands point to a small set of well-known ASD genes, the disrup

40 Recent studies pointed to a crucial role for apolipoproteins in the pat

41 s, which supports previous studies that have pointed to a link between early anesthesia exposure and

42 Although the proteomic analysis pointed to a loss of function for the D252H mutant prote

43 Previous work by Cory's group pointed to a synergistic interaction of MYC and MNT in n

44 ear the intracellular end of the S6 helices, pointing to a conserved cytoplasmic gate and suggesting

45 not an integral component of the ICL repair, pointing to a different mechanism of fork protection at

46 the membrane only in recently divided cells, pointing to a feedback mechanism between the cell cycle,

47 genesis and alters Sonic Hedgehog signaling, pointing to a key role in cytoskeleton-cilia interdepend

48 cal relationships between hosts and viruses, pointing to a need to reconsider current approaches aime

49 lncRNA that mediates cancer immune evasion, pointing to a new target for immune potentiation.

50 hibition rescued the miR-211(-/-) phenotype, pointing to a new therapeutic target to counteract retin

51 enes BCL2 and MYC in malignant lymphoma thus pointing to a possible new mechanism for their dysregula

52 in both anesthetized as well as awake mice, pointing to a potential mechanism by which the olfactory

53 loops substantially decreases search times, pointing to a potential physical mechanism for regulatin

54 rom the much shallower thorax of H. sapiens, pointing to a recent evolutionary origin of fully modern

55 tion in a hormone-rich environment, possibly pointing to a role in ER + BC, especially in older cases

56 d branching were reduced in AP-4-HSP neurons pointing to a role of AP-4-mediated protein trafficking

57 , Cr, Hg, Ni and Pb) varied from 0.9 to 1.4, pointing to a similar distribution between the two muscl

58 ates extending as far as +/-2 helical turns, pointing to a substantial degree of cooperativity in SAH

59 hic range of more than 50 million years(14), pointing to a substantial invasion of aquatic environmen

60 of HNF4alpha during hepatocyte development, pointing to a target in the treatment of liver disease i

61 and coordination between stimulus and wings, pointing to a tight coupling between head and wing movem

62 Thus, the present investigation points to a breakdown in host-bacterial mutualism in per

63 Emerging evidence points to a central role of mitochondria in psychiatric

64 In particular, increasing evidence points to a double-edged role of the immune system in st

65 Much evidence points to a dramatic thinning of East Asian lithosphere

66 It points to a genetic underpinning to clinically predicted

67 This points to a greater evolutionary potential of the epigen

68 s of both periodontal and periapical lesions points to a high receptor activator of NF-kappaB ligand/

69 involvement of effector T cell subsets thus points to a key role of T cells in MS disease initiation

70 It also points to a mechanism by which changes in flowering phen

71 The proof of concept herein points to a mechanistic basis for possible applications

72 s capsids may be under-appreciated, and also points to a nontraditional strategy for assembly inhibit

73 This insight points to a pharmacological approach that could be used

74 lacental function, their regulation of STC-1 points to a potentially important role in the maintenanc

75 llion years of Antarctic geological deposits points to a prolonged survival of giant-sized pelagornit

76 red with a spectrum of permeabilities, which points to a promising target for treating transport diso

77 pic exuberance displayed in this battlefield points to a reciprocal selective pressure suggesting a c

78 , substantial evidence from patients with MS points to a role for CD8+ T cells in disease pathogenesi

79 It points to a thriving population less than 5000 years bef

80 Together, our data points to a two-step mode of J-domain action, a recognit

81 ds was carried out, the combination of which points to a WF enhancement mechanism which is based on d

82 Recent neuroimaging findings point to abnormalities in the thalamus of patients with

83 Participants pointed to about one letter per second, rarely made spel

84 Children frequently require PELD exception points to achieve appropriate priority ranking.

85 ilure to develop immune memory to infection, pointing to actionable targets for immunotherapy.

86 Recent studies also point to activity-independent size fluctuations, possibl

87 Our findings point to adaptation to climate change in agriculture and

88 of genes for sphingolipid catabolic enzymes, pointing to additional mechanisms for maintaining sphing

89 metal protrusion to be metal-dependent, but point to an equivalent octahedral-coordinated M(4+) carb

90 Taken together, these findings point to an increased availability of reducing equivalen

91 Observational studies point to an inverse correlation between low-density lipo

92 Our results point to an oxidative stress tolerance network that is i

93 hyla and the non-monophyly of monoderm ones, pointing to an early origin of two-membraned cells and t

94 The data are pointing to an important role of the NOD-like receptor f

95 compared to PD1 pathway blockade alone(6,7), pointing to an incomplete understanding of the role of I

96 e population are affected by water scarcity, pointing to an urgent need for improving freshwater quan

97 in LVEF from a baseline of >= 10 percentage points to an absolute value of < 50% following osimertin

98 Genetic and biochemical evidence points to an association between mitochondrial dysfuncti

99 or surgery in general, a variety of evidence points to an association between perioperative opioid ex

100 Our time-calibrated tree points to an origin and early diversification of green s

101 Early evidence pointed to angiotensin-converting enzyme 2 (ACE2) as SAR

102 These findings point to antagonistic allostery in ISRIB action on eIF2B

103 ucture of the chromophore system through the point-to-axial chirality transmission mechanism.

104 Our results point to axoplasmic Ca(2+) concentrations as a determina

105 iew, we summarize new lines of evidence that point to both platelet and endothelial dysfunction as es

106 IL-1R as a regulator of host homeostasis and point to cachexia as a cost of long-term reliance on IL-

107 Our study points to CeA(GA) as a potential powerful therapeutic ta

108 composition of arterial tissue, specifically pointing to cell, not collagen, content as the dominant

109 Ample evidence points to central role of NF-kappaB in such pathologic r

110 Our models pointed to China and India, countries with the highest p

111 Genetic studies have pointed to class II TCP genes as major regulators of cel

112 The results point to CN changes that are more common in high-ploidy

113 ential, SIB-specific FC signature, which may point to compensatory neurofunctional mechanisms in pers

114 ency reconstructions for the Peruvian coast, point to complexities introduced by apparent contradicti

115 e the rat HPF flatmap was used as a starting point to construct an analogous flatmap for the mouse, w

116 of the food carbonylome seems to be the key point to control HAA formation in foods.

117 Increasing evidence points to critical roles for the urothelium in the devel

118 usly until ~2000 when it reached its highest point to date of 75%; it was slightly lower at 73% in 20

119 y receptor binding and Fc effector activity, pointing to deficient humoral development rather than di

120 asing studies on visual function in ASD have pointed to detail-oriented perception, which has been hy

121 These fragments represent a starting point to develop ALAS2 inhibitors as substrate reduction

122 Our findings point to different cardiovascular risk profiles in mothe

123 Metchnikoff's seminal lectures as a starting point to discuss the tremendous variety of cell biology

124 of age-at-onset in Huntington's disease (HD) point to distinct modes of potential disease modificatio

125 Our study may point to distinct stages of progression of COVID-19 lung

126 g multidomain chromatin binding proteins and point to divergent evolution of their regulation.

127 These results point to dual functions of histidine-43 in structurally

128 sion of the model was derived by assigning 1 point to each risk factor: the transplantation for Aclf-

129 Our findings point to early adolescence as a phase of rapid change in

130 ses associated with protection were seen and point to effects of the microbiome on vaccine-induced im

131 ure in vivo and in vitro, using relevant end points to elucidate potential mechanisms of oral arsenic

132 structural water associated with myofibrils) pointed to evident protein aggregation and loss of funct

133 Altogether, our findings point to evolutionary pathways where newly-acquired gene

134 cell biology and TLR function as a starting point to explore the mechanistic and evolutionary aspect

135 cted visual acuity was similar at every time point to eyes that were not receiving extra DME treatmen

136 best predict exogenous sugar use by ants all point to factors constraining sugar production: net abov

137 without first mutating into derived B types, pointing to founder effects or immunological or environm

138 The presence of hyperorality points to FTLD rather than non-FTLD pathology (p < 0.001

139 Emerging data point to functional heterogeneity of fibroblasts.

140 Emerging literature indeed points to functional heterogeneity even within anatomica

141 ll receptor genes, this KLRA allele fixation points to fundamental and potentially differential funct

142 ndings may represent an encouraging starting point to further expand this chemical class, adding a ne

143 Our studies point to HF as the main plasma product contributing to N

144 The results point to higher admission rates for ATAAD during months

145 by AMP/ATP levels independently of AMPK, and point to hypoxia/energy depletion as potential modifiers

146 extract core regulatory modules at each time point, to identify key regulators driving changes of the

147 defined, pathogen-specific antibodies often point to immunological mechanisms of protection.

148 Taken together, our data point to immunothrombotic dysregulation as a key marker

149 Epidemiological evidence points to important health benefits of immediate ART ini

150 Growing evidence points to indigenous peoples and local communities (IPLC

151 ent sensory modalities, body parts, and time points to inform behavioral choice, but the relevant sen

152 ent PA fingerprint in aqueous plant extracts pointed to invasive Senecio inaequidens as the main sour

153 s-of-function experiments with CYR61 in vivo point to it being a key chemokine controlling liver fibr

154 ively, this beneficial role of selenomelanin points to it as a sixth variety of yet to be discovered

155 nistic basis of EMC's multifunctionality and point to its role in differentially regulating the bioge

156 In sum, our data point to KIF14 as a critical node connecting cell cycle

157 We also point to knowledge gaps and research opportunities, emph

158 contrast with a PRS for CAD, the lipid PRSs point to known and directly modifiable risk factors prov

159 (eg, in the laboratory or hospital) settings point to large disparities, even in the same parameters

160 fixation patterns suggest that participants pointed to letters they selected themselves, not letters

161 Some have learned to communicate by pointing to letters of the alphabet.

162 uced amplitude of BLA-GC synaptic responses, pointing to long-term depression (LTD) as a mechanism fo

163 Moderate quality evidence points to lower baseline vision and poorer response to t

164 rbated production of cytokines, mainly IL-6, points to macrophages as key to understand differential

165 These results point to malleability in the coding features of multiple

166 idual observed multidecadal variability, and points to model deficiency in simulating multidecadal va

167 t 0, 2, 4, 8, and 12-week (termination) time points to monitor PV cross-sectional area at each PV abl

168 phy varied considerably between individuals, pointing to more pronounced inter-individual differences

169 Taken together, our results point to multiple facets of sleep neurophysiology that t

170 These data point to N-MADD-4B processing and cell-surface proteogly

171 Emerging evidence points to NAAA-regulated PEA signaling at PPAR-alpha as

172 -trimethoxyphenyl)pyrazin-2-amine, APA), and pointed to NAT2 loss being a therapeutically exploitable

173 Our work points to novel roles for FST, PEPD, and PDGFC in adipos

174 whereas decreased essential amino acids may point to nutritional deficiencies in AMD.

175 n morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brai

176 man capabilities are produced together could point to opportunities to help jointly reduce the wide d

177 progression of type 1 diabetes mellitus and points to opportunities to use therapies that revitalize

178 users and so could theoretically cue them to point to particular letters.

179 ation peaks (FDR [false discovery rate], 5%) pointed to pathways altered in heart failure.

180 In addition, emerging data point to perturbations in the gut microbiome as a key re

181 target defective RyR2 channels in humans and pointing to phenytoin as a more human-safe alternative t

182 lation and rotation using 3D reconstruction, point to point mirroring and merging of the 3D created v

183 A point-to-point change in the COD trace in 1 direction th

184 ate within 2% dose difference to be 95.4% in point-to-point dose comparisons.

185 r organization, visually apparent as intense point-to-point interactions in Hi-C maps.

186 The conventional wisdom suggests that "point-to-point" ion diffusion at the interface determine

187 Thus, our data point to potential adverse neurobehavioral consequences

188 Our findings point to potential drastic and rapid consequences of cli

189 While in vitro studies point to potential mechanisms that could support such bu

190 expression of the CLEC2D receptor, which may point to potential novel roles of EBNA3A in T cell and N

191 c risk factors in psychiatric disorders that point to potential shared biological mechanisms-synaptic

192 ggestive of immunotherapy resistance is low, pointing to potential utility of immunotherapy for PSCC.

193 research is needed, our preliminary findings point to potentially different exposure attributes that

194 ol mechanisms, we identify dependencies that point to potentially new mechanisms.

195 These findings point to previously unknown heterogeneity within the bon

196 These data point to profound epigenetic effects of Stattic that are

197 lates SARS-CoV-2 infection outcome, the data point to putative transcriptional genetic markers of sus

198 Our finding points to putative allostatic changes that affect the fu

199 These findings point to Rap1 as a critical mediator of stress-driven ne

200 ogical dynamics in the vicinity of a tipping point to reinforce the desired state and how social mech

201 These results point to remapping impairment in the hippocampus, possib

202 Together, our results point to reorganization in the contralesional hemisphere

203 een undermined, offer specific examples, and point to resources that document the enormity of the cur

204 l media devoid of any organic carbon source, pointing to S. elongatus-E. coli K-12 as the most active

205 link fertility to nutritive environment and point to Sax signaling as the nutrient-sensitive branch

206 sequencing, and lineage tracing experiments point to selection of relatively low-affinity MBCs as a

207 ors, and protein structure function analysis points to several immune pathways, including complement

208 unchanged along the interior-edge gradient, pointing to severe biotic homogenisation at all strata.

209 y impact risk of a RD, whereas the last four point to shared aetiologies with macular condition, myop

210 -19 infection that are also enriched in IBD, pointing to shared molecular networks between COVID-19 a

211 Importantly, these studies are the first to point to simple C3 aliphatic side-chain modification of

212 This study point to soft bread as a safe and efficient source of me

213 ponses associated with the longevity effect, pointed to specific amino acids enriched in the CR condi

214 aved rapidly into Fab and smaller fragments, pointing to specific regions where additional stability

215 relevant to understanding human anxiety, and points to specific molecules within this circuit that co

216 ategy has the potential to ease supply choke points to substantially expand COVID-19 testing and scre

217 able for use as an intermediate clinical end point to substitute for OS to accelerate phase III (neo)

218 ristic of Cas9-independent off-targeting and point to TC motifs as activity hotspots of the cytidine

219 The current findings from BaYaka fathers point to testosterone as a psychobiological correlate of

220 Cys208 as key regulators of MGL function and point to the BTZ scaffold as a useful starting point for

221 Our results also point to the caution that must be exercised in using the

222 Our findings point to the co-limitation of alpine plant community bio

223 ion strata would confirm a supernova origin, point to the core-collapse explosion of a massive star,

224 Our results point to the crucial role of excitatory higher-order pat

225 Mechanistic studies point to the crucial role of the photocatalyst-base inte

226 F2-associated spinal and cranial meningiomas point to the differences in timing of tumor initiation a

227 sessing drug effect on cardiac contractility point to the fundamental translational value of the curr

228 Together, this could point to the GPi as a potentially effective target for b

229 Our results point to the importance of reward rather than punishment

230 ng preclinical neuropathic pain efficacy and point to the MNK inhibitor tomivosertib (eFT508) as an i

231 These findings point to the need for caution in avoiding excessive use

232 of residents and environmental contamination point to the need for prioritizing IC interventions to c

233 Our results point to the need for targeted field and experimental st

234 All these observations point to the need of additional efforts to uncover evolu

235 Relatedly, our results point to the need to better align project- and national-

236 r molecule-centered cheminformatics analyses point to the need to dramatically increase the diversity

237 ng OA and BrC in daytime wildfire plumes and point to the need to understand how processing of nightt

238 These results point to the possibility of controlling the polarization

239 These findings point to the possibility of therapeutics that target isl

240 Moreover, these results point to the possibility that feelings of chronic social

241 These results point to the potential contribution of single-gene CNVs

242 Results also point to the potential influence of variables not direct

243 alone and in concert with genetic risk, and point to the potential role of epigenetics in mediating

244 fy ABCB5 as a GBM chemoresistance marker and point to the potential utility of targeting ABCB5 to imp

245 organelle autophagies, and provide an entry point to the relatively unexplored process of degrading

246 s and human-level theories of action control point to the role of highly integrated, conjunctive repr

247 Kinetic studies point to the second protonation event as being rate-dete

248 Recent studies in various types of cancer point to the significance of epigenetic aging in tumorig

249 Altogether, these findings point to the significant role of postnatal social experi

250 They were then asked to point to the targets after a delay and a change in persp

251 n the natural control of HIV-1 infection and point to the use of DR3 agonists in HIV-1 vaccine regime

252 These data point to the VP as a critical player in obesity and sugg

253 ess state associated with torsional loading, pointed to the ability of the reversible thermoelastic t

254 Research in the past decade has pointed to the broad benefits of trained immunity for ho

255 Proponents have pointed to the existence of New World crops, such as the

256 FTIR analyses pointed to the formation of metal carboxylates, an indic

257 sal membrane-specific proteoglycan, Col18a1, pointing to the basement membrane as part of the stem ce

258 lley phonons - phonons with momentum vectors pointing to the corners of the hexagonal Brillouin zone

259 modulated by the strategy switching signal, pointing to the importance of PFo in behavioral flexibil

260 th a hydrophobic positively charged peptide, pointing to the involvement of different receptors or ac

261 identified idiosyncrasies in truth resources pointing to the need for new methods to construct genomi

262 ising array of complex sociocognitive skills pointing to the possibility that the domestication proce

263 hat great apes can successfully adjust their pointing to the spatial configuration of the referent en

264 More importantly, our finding points to the "Food Security Paradox", food insecurity i

265 nvolved in light-driven enzyme catalysis and points to the competing factors of enzyme catalysis and

266 Our analysis points to the different operation regimes associated FFE

267 This points to the importance of multiple, maintained, new, a

268 Overall, our model points to the importance of taking into account receptor

269 The prevailing explanation points to the interplay between predisposing genes and e

270 Our work points to the involvement of the hippocampal system in t

271 This points to the need for efficient methods to accurately q

272 he water column of the Canadian Arctic Ocean points to the need for international regulatory mechanis

273 Our work points to the need to further investigate the presence a

274 more, careful evaluation of ice core records points to the occurrence of several closely spaced volca

275 from IDSs since their ancient occurrence and points to the possibility of a wide distribution of ILTP

276 This points to the potential importance of microbial dormancy

277 cent marine heat waves from around Australia points to the potential important role that respite or r

278 vitro targets underpinning neurodegeneration points to the potential interest of the selected seaweed

279 Thus, our study points to the potential of an alternative therapeutic st

280 This points to the remarkable chemical stability of paramagne

281 hiolitis-related hospitalization and 3 later points to the risk of recurrent wheezing by age 3 years.

282 Emerging evidence points to the role of the endocannabinoid system in long

283 Accumulating evidence points to the role of the Medial Temporal Lobe (MTL) and

284 n.SIGNIFICANCE STATEMENT Increasing evidence points to the role of the neocortex in encoding spatial

285 cognition are also linked with vitamin A and point to their possible treatment with vitamin A or RA.

286 iffer between exitrons and retained introns, pointing to their distinct regulation.

287 ng baking and released free quercetin, which points to their thermal instability.

288 ated most letters about half a second before pointing to them.

289 metry, and chemoinformatic analyses that all point to these compounds binding in the ATP pocket.

290 Recent advances point to these different regulatory pathways as organizi

291 Model for End-Stage Liver Disease exception points to these patients.

292 alysis with microbial co-occurrence networks points to these three expanding taxa as potential mediat

293 Although RCTs may provide a useful starting point to think about bias, they do not provide a gold st

294 creatic ductal adenocarcinoma, was observed, pointing to this class of molecules as a valuable templa

295 In addition, our model also points to two other factors that have been largely disre

296 The commentators' critiques and suggestions point to useful refinements and applications of the mode

297 entory of +14,900 petagrams of carbon (PgC), pointing to volcanic CO(2) emissions as the main carbon

298 Furthermore, the resulting mechanistic model points to ways in which sHSP chaperone activity may be i

299 Taken together, these data point to what we believe is a novel DAMP-mediated proces

300 and 160 genome-wide significant associations pointing to wnt/beta-catenin, TGF-beta and sonic hedgeho