ライフサイエンスコーパス: poise

1 In the double-blind phase of POISE, 217 patients with primary biliary cholangitis wit

2 bstrate through a two-point binding mode and poises a coordinated diisopropylzinc moiety for alkyl gr

3 Here, we found that DDR signaling poises a series of epigenetic events, resulting in activ

4 e of both mycobacterial physiology and redox poise, an axis that is dispensable for survival under no

5 ch 'stripe' domains are associated with both poised and active chromatin landscapes and transcription

6 l pathways and were selectively enriched for poised and bivalent enhancer marks.

7 ory state is encoded epigenetically, through poising and transcriptional memory.

8 straints follow from heuristic thermodynamic poise approximations that take anticipated cellular meta

9 respiration helps control the stromal redox poise as a crucial part of high-light acclimation in C.

10 fruit fly, Drosophila melanogaster, is well poised as a system in which to explore these questions.

11 Secondary DNA structures are uniquely poised as therapeutic targets due to their molecular swi

12 , maximum current was reached for electrodes poised at -0.3V, closely followed by -0.25V and -0.1V to

13 eference electrode, biocathode potential was poised at -0.8 V (versus SHE) using a potentiostat, with

14 -body phenomena, and are often thought to be poised at a crossover between localized and itinerant re

15 f a specific nature, namely, if dynamics are poised at a so-called critical state characterized by a

16 ion factors to the transcriptional apparatus poised at promoters.

17 AMPhi) are innate immune cells strategically poised at the interface between lungs, respiratory patho

18 ssue-resident memory T cells (TRM cells) are poised at the portals of infection and provide long-term

19 c state of Nme1Cas9, the active site is seen poised at the scissile phosphodiester linkage of the tar

20 Assay simulates a scenario in which a mouse, poised at the threshold of its burrow, evaluates whether

21 l of the redox couple and eventually becomes poised at this value.

22 Pol II also maintains low poising at inactive promoters after major ZGA until the

23 arginine, suggesting starved T cells remain poised awaiting nutrients.

24 Finally, we show that IFNgamma signals poise B cells to differentiate by increasing their respo

25 The EABs poised below current plateau potential (<=-0.3V) exhibit

26 Together, our results reveal that poised BRC-defined microenvironments establish a feed-fo

27 ZRS at early embryonic stages maintaining a poised, but inactive state broadly across the distal lim

28 The electrode surface will become poised by the addition of a well-behaved redox pair, suc

29 entation and validation of the thermodynamic poise calculation itself.

30 nd focal allele-specific hypermethylation in poised chromatin.

31 exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neut

32 equent leukemic evolution of these "leukemia-poised" clones remain incompletely understood.

33 ws may indeed originate from neural networks poised close to a critical state.

34 arise because cellular plasma membranes are poised close to a miscibility transition under growth co

35 ve these signature loci in an epigenetically poised configuration.

36 ors for the maintenance of transcriptionally poised developmental genes.

37 T) cells, and gammadelta T cells, maintain a poised effector state has been unclear.

38 This unusual poise enables gradual post-translational regulation of t

39 bilization appears to disrupt the delicately poised energy balance governing thin filament regulation

40 n in the Drosophila embryo, we find that the poised enhancer signature is specifically generated duri

41 The poised enhancer signature, involving H3K4me1 and low lev

42 We discuss the possibility that the poised enhancer state is more generally the result of re

43 ermediate step before future activation, the poised enhancer state may be a mark for spatial regulati

44 -/-) CD8(+) T cells were unable to activate "poised" enhancer elements compared with wild-type CD8(+)

45 ng factors by increasing chromatin access at poised enhancers and chromosome architectural elements.

46 onents Med1 and Smc1a at newly activated and poised enhancers in ESC-derived epiblast-like cells.

47 Some sites of hypomethylation occur at weak/poised enhancers marked with H3K4 monomethylation in hem

48 Stem cells use poised enhancers of developmental regulators to maintain

49 otch transcriptional effector RBPJ activated poised enhancers to rapidly induce LXRalpha and other Ku

50 rted into nuclei, where they associated with poised enhancers with DNA-bound TEAD4 and H3K4me1.

51 5hmC was enriched within poised enhancers, and depleted within active enhancers,

52 ge enrichments biased toward both active and poised enhancers.

53 where spatial proximity of RNA and DNA could poise for the creation of fusion transcripts.

54 ange the nucleotide sequence of that RNA, is poised for a major expansion in scientific interest and

55 biological systems, and researchers are now poised for a precision-focused transformation in the way

56 t has an unrestricted activation loop and is poised for access to membranes.

57 velope acts as a reservoir, maintaining COP1 poised for action.

58 ell type specification genes, which are then poised for activation by external signal inputs.

59 FOXA1(-) TNBC tended to be SFK_pY527(-) (SFK poised for activation).

60 mplex with Isc10 and Smk1 during MII that is poised for activation.

61 until, at its most advanced position, it is poised for another Heinrich event.

62 base-pair and engaging the second base-pair poised for breaking.

63 The field appears poised for breakthroughs, including the exciting prospec

64 ive site in the quaternary Pol mu complex is poised for catalysis and nucleotide incoporation proceed

65 tructure not only visualizes the active site poised for catalysis of APOBEC3A, but pinpoints the resi

66 with a pri-miRNA docked in the active site, poised for cleavage.

67 vage and polyadenylation specificity factor, poised for cleavage.

68 es, with particular emphasis on technologies poised for clinical translation.

69 tions of androgen-independent cells that are poised for clonal selection after androgen-deprivation t

70 ional sites at onset of inflammation are not poised for cytotoxic function.

71 All complexes are well poised for dCTP insertion.

72 The phosphotransfer center is asymmetric, poised for dissociative nucleophilic substitution.

73 achieve a closed DNA polymerase active site poised for efficient nucleotide incorporation and illust

74 s (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity.

75 chromatin common among the GSCs tested were poised for expression of immune-related genes, including

76 in the naive state, indicating that they are poised for expression prior to the initiation of pluripo

77 or molecules with demethylated promoters and poised for expression.

78 reported to mark inactive enhancers that are poised for future activation.

79 rminants converge to render aged CD8(+) T(M) poised for greater recall responses.

80 , hair-follicle stem cells (HFSCs), normally poised for hair generation, are recruited to the site of

81 rally expanded RORgammat+ gammadelta T cells poised for IL-17 production were resistant to C. diffici

82 sue resident memory CD8(+) T cells (Trm) are poised for immediate reactivation at sites of pathogen e

83 itioned adjacent to the open DNA entry gate, poised for insertion, at the Mcm2-Mcm5 interface.

84 ation of the active gamma-secretase complex, poised for intramembrane proteolysis, by cryo-electron m

85 rocess affords alkylated benzenesulfonamides poised for medicinal chemistry applications and traceles

86 heterochromatin and euchromatin are globally poised for mutual antagonism, the mechanisms underlying

87 al structure of CD53 in an open conformation poised for partner interaction.

88 ficient high-temperature superconductors are poised for power transmission and magnetic imaging appli

89 ogy over the past years, the field now seems poised for practical application.

90 enhancer elements in healthy fibroblasts and poised for rapid activation in response to DNA damage.

91 hetic signaling is relatively new, but it is poised for rapid advancement.

92 e introduce a class of recyclable thermosets poised for rapid deployment.

93 orm a weakly populated excited state that is poised for rapid product release.

94 l reserve of NF-kappaB in peripheral T cells poised for responding to agonistic antigen-driven T cell

95 ents in cancers that would otherwise be less poised for response to immunotherapy, including cancers

96 ate cancer that are androgen independent and poised for selection as dominant clones after androgen d

97 The resulting ion-pair is poised for spontaneous electron transfer to O(2).

98 genome accessibility and renders adipocytes poised for thermogenic activation remains elusive.

99 pressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3.

100 phaHb, coordinate to the heme iron, which is poised for transfer into the heme-binding pocket of IsdB

101 egion of SspH1, promoting an E3 conformation poised for transthiolation.

102 viously identified for other cell types, non-poised genes are B cell state specific.

103 om individual species act downstream of core poised genes during development in a species-specific fa

104 We found that while Pol II poised genes generally overlap functionally among differ

105 s induce lineage-appropriate developmentally poised genes poorly while lineage-inappropriate genes, i

106 pore as an organizing scaffold for inducible poised genes.

107 ity is in large part DNA-encoded and that it poises genes for future context-specific activation in r

108 Our data poise H3K23me3 as an additional chromatin modification i

109 er loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enha

110 sis, induces immunomodulatory functions, and poises HSCs for myeloid cell production.

111 currents were related to the conformational poise imposed on the pump.

112 A Helix-X segment is poised in an open conformational state; the heme a farne

113 We find that core genes poised in germ cells from multiple amniote species are a

114 issue-resident macrophages are metabolically poised in situ to protect and exploit their tissue-niche

115 ere, we demonstrate that the Mn4O5Ca complex poised in the S0 state contains an exchangeable hydroxo

116 to a stimulus of small amplitude when it is poised in the weakly chaotic regime.

117 tissue development, whereas genes that gain poising in germ cells from individual species act downst

118 velopmental genes supports their epigenetic "poising" in hSSCs for future/embryonic expression, while

119 odynamic constraints, and that thermodynamic poise information is actionable during network reconcili

120 Thus, the ER redox poise is tuned by reciprocal control of glutathione impo

121 mposes a transcriptional state on the tumor, poising it to respond to the aberrant accumulation of do

122 Collectively, these data suggest an RNA-poise model, where spatial proximity of RNA and DNA coul

123 elopment of vaccination strategies that will poise most human subjects to respond to pandemic influen

124 de clearance of stalled ribosomes from mRNA, poising mRNA for degradation and rendering stalled ribos

125 d only on the droplet surface, while systems poised near the boiling point permitted enzyme penetrati

126 lization, and which occurred only in systems poised near the boiling point.

127 in chains characteristic of a gel phase, yet poised near the sol phase, a solution of independent chr

128 Our data indicate that the GerA receptor is poised on a knife's edge during spore development.

129 riant acid/base residues, Glu499 and Tyr578, poised on each side of the target uronic acid residue, t

130 h recognizes the guanine base) and lid-loop (poised over the nucleotide phosphates) that accompany nu

131 n the absence of zinc-which are predicted to poise p53 on the cusp of folding/unfolding in the cell,

132 t metabolic profiles that may differentially poise platelets for activation.

133 uggests that quiescence represents states of poised potential and active restraint, as stem cells "id

134 of some residual H3K27me3, compared to less-poised promoters.

135 stages when hormone responsive enhancers are poised, revealing critical epigenetic roles involved in

136 romoters characterized by low expression and poised RNA-polymerase.

137 esting B cell and shifted from non-poised to poised state after B cell activation.

138 changes indicating that NtcA can reside in a poised state controlled by other factors.

139 ate that the erm enhancer is maintained in a poised state in neural stem cells by the histone deacety

140 erm immature INP enhancer in an inactive but poised state in neuroblasts.

141 development where H3K27me3 loss released the poised state of apparently bivalent promoters, whereas d

142 Together, our data shed new light on the poised state of ITC, in which innateness is defined by a

143 and the third corresponds to establishing a poised state of latent regulator priming through an unkn

144 We suggest that the indicated poised state of NtcA enables a more differentiated respo

145 Thus, the poised state that allows rapid meiotic reentry in mouse

146 In mESCs, the proteins bind to active and poised TBP-bound promoters along with promoters of polyc

147 ments and spontaneous inter-subunit rotation poise the newly-made protein and RF2 to dissociate in pr

148 The model revealed that a weak coupling can poise the system of unstable oscillators closer to the b

149 a MoFe protein variant, beta-188(Cys), which poises the P cluster in the oxidized P(+) state, demonst

150 We propose that poising the fast-activating enhancers of master regulato

151 gulator's deeply conserved function, thereby poising the regulator to jump-start formation of the new

152 riming mechanism at developmental promoters, poising them for future lineage-specific activation.

153 nRH neurons during positive feedback further poise these cells for increased response to higher frequ

154 during apoptosis, implying that dying cells poise to recover, even while under apoptotic stress.

155 le facets of FSHD research, the field is now poised to accelerate the process of therapeutic discover

156 ur findings indicate that hypoxic niches are poised to accumulate CSCs in a molecular process driven

157 Policymakers are poised to act and 1 proposal entails reorganizing the cu

158 ly the basolateral and CeM amygdalar nuclei, poised to activate CeM for autonomic arousal.

159 This constellation of residues is poised to activate the substrate by Schiff base formatio

160 entiation of most lineages, transitions from poised to active or inactive states, and shifts in nucle

161 es in the past few years and ongoing work is poised to add even more.

162 ht and electron microscopy (CLEM) is ideally poised to address such problems.

163 The design of sequences which are poised to adopt two very different conformations sets th

164 imaging ((129)Xe MRI) in pediatric asthma is poised to advance our understanding of disease mechanism

165 e sequencing and gene-based therapies appear poised to advance the management of rare lipoprotein dis

166 KEAP1 is thus poised to affect MCM2-7 dynamics or function rather than

167 cy and a more favorable toxicity profile are poised to alter the landscape of RET-dependent cancers.

168 l death signalling pathways; these cells are poised to apoptose when survival pathways are inhibited.

169 chaperone showed how well the carboxylate is poised to attack the phosphoramidate, helping to explain

170 of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and

171 al cholinergic interneurons and therefore is poised to be a positive regulator of cholinergic activit

172 iated herpesvirus (KSHV) latent episomes are poised to be activated by the KSHV replication and trans

173 molybdenum disulfide (MoS(2)) nanosheets are poised to be at the core of low-voltage electronic devic

174 cycle just before division, where it is then poised to be precisely localized at new growth poles in

175 While polygenic risk scores (PRSs) are poised to be translated into clinical practice through p

176 oth the new drug and the antibodies that are poised to be used against HIV.

177 xpression of their targets and are therefore poised to become a main pillar of cellular cancer immuno

178 rimental demonstration provided here, PLM is poised to become a powerful technique for revealing the

179 is 'natural sampler DNA' (nsDNA) approach is poised to become a powerful, affordable, universal tool

180 underlying genetic forms of hearing loss is poised to become a reality.

181 T3SEs and improved performance, Bastion3 is poised to become a widely used, state-of-the-art toolkit

182 eable technological scenarios where they are poised to become front runners.

183 The landscape approach is thus poised to become one of the most influential methods for

184 ntibodies, molecularly targeted exosomes are poised to become the next generation of smartly engineer

185 We are now poised to begin developing self-disseminating vaccines t

186 melanoma is a dermatologic area particularly poised to benefit from such innovation.

187 Patients with CKD are uniquely poised to benefit from these integrative, multi-omics ap

188 ctions also target the striatum, oxytocin is poised to bias the balance of DA tone through multiple s

189 on each side of the dimerisation interface, poised to bind a pair of Rheb molecules at a similar sep

190 We observed that this residue is poised to bind substrate in the active structure and dis

191 organized into three substrate-binding lobes poised to bind their respective nucleosomal epitopes.

192 a specific dimerization mode of RET that is poised to bring the two kinase domains into close proxim

193 etic engineering, and cell manufacturing are poised to broaden T-cell-based therapies and foster new

194 ease 2019 pandemic, PICU physicians are well poised to care for adult patients in a surge capacity, a

195 ectron microscopy structures of these RNases poised to cleave their pre-rRNA substrates within the B.

196 fatty acid metabolism and therefore uniquely poised to communicate the intracellular energy status of

197 a(2+) ions, forming a heterotetramer that is poised to compete with microbial pathogens for essential

198 of subsets of tissue fibroblasts which seem poised to contribute to the angiogenic response.

199 link the Piezo repeats to the pore, and are poised to control gating allosterically.

200 that control their function; fibroblasts are poised to coordinate fibrogenesis in tissue injury, neop

201 With this knowledge, we are poised to design the next generation of complex biologic

202 In this configuration, ORC is poised to direct the recruitment of the second hexamer i

203 oaches with emerging molecular tools will be poised to elucidate the functional importance of endophy

204 New techniques are now poised to enable the measurement of cell-generated mecha

205 plexes with multiple divergent trityl groups poised to engage in embraces.

206 their location, these aromatase neurons are poised to engage nociceptive circuits, whether it is thr

207 caused widespread changes in gene expression poised to enhance vascular inflammation, thrombosis, lea

208 the US Food and Drug Administration and are poised to enter the practice of medicine for leukemia an

209 at the mitochondrial pyruvate carrier MPC is poised to exert ultrasensitive control on the balance be

210 ytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and diffe

211 contact a carboxylate oxygen of caC and are poised to facilitate acid-catalyzed caC excision.

212 llectively referred to as soft photonics-are poised to form the platform for tunable optical devices

213 nk represents a new branch on a tree that is poised to grow rapidly and offer new kinds of insights o

214 mportant generalization of the HMM, which is poised to have a deep impact across the field of biophys

215 or the interpretation of these data, and are poised to have a substantial effect on diagnosis, manage

216 Terahertz (THz) radiation is poised to have an essential role in many imaging applica

217 ake the choices they do, then we may be more poised to help them manage their medications, influence

218 Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medi

219 he-art deep learning for object detection is poised to improve the accuracy and efficiency of biologi

220 ms, artificial intelligence (AI) methods are poised to improve the precision of diagnostic and therap

221 The field of congenital heart surgery is poised to incorporate new innovations such as bioenginee

222 reasing in intensity and size and, thus, are poised to increase in importance as disturbance agents.

223 Fertilizer use is poised to increase in the tropics, where widespread food

224 this complex acts as a latent Z-type ligand poised to increase the Lewis acidity of the gold center,

225 Prior to S phase, multiple origins are poised to initiate replication by recruitment of the pre

226 The insights presented herein are poised to inspire the design of other catalyst-controlle

227 mmensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infection

228 ever, the mechanisms by which T cells remain poised to kill cancer cells despite expressing high leve

229 ls has completed clinical development and is poised to make an impact on clinical practice.

230 Today, glycobiology is poised to make major new contributions to cell biology a

231 analysis reveals that B. phytofirmans PRF is poised to metabolize thiosulfate to sulfite in a sulfur

232 Acots in the mitochondrial matrix are poised to mitigate beta-oxidation overload and maintain

233 explain how a strong pOFC pathway, which is poised to moderate activity of CeM, through IM, can be u

234 site of intense immune cell activity that is poised to mount an effective response against a pathogen

235 macrophages of the islets of Langerhans are poised to mount an immune response even at steady state,

236 anges gamma-tubulins into a helical geometry poised to nucleate microtubules.

237 the plasma membrane in resting cells that is poised to orchestrate assembly of key signaling componen

238 Gastroenterologists are uniquely poised to participate in the multidisciplinary managemen

239 Thus, it is well poised to play a broad and integrative role in visual pe

240 for further improvement, HASEL actuators are poised to play an important role in a paradigm shift tha

241 g protein (GPBP), a BM protein, was uniquely poised to play diverse roles in this transition owing to

242 (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating t

243 essed in resting B cell and shifted from non-poised to poised state after B cell activation.

244 These novel strategies are not only poised to prevent progressive tissue scarring, but also

245 ditionally, CCR6-expressing resident T cells poised to produce IFN-gamma and IL-17 were enriched in e

246 TPH cells appear to be uniquely poised to promote B-cell responses and antibody producti

247 shape changes, but if they go awry, they are poised to promote disease states such as cancer cell met

248 C1 protomers are placed close to each other, poised to promote the active dimer of the intracellular

249 raphy-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules underlyi

250 Large-scale genome sequencing is poised to provide a substantial increase in the rate of

251 tead are a broadly reactive layer of T cells poised to quickly develop into regulatory or effector ce

252 t exposes its ligand-binding site, but it is poised to rapidly assemble into intracellular signal-gen

253 These memory CD8 T cells remain poised to rapidly elaborate effector functions upon re-e

254 Macrophages stand poised to rapidly produce large amounts of inflammatory

255 Optical atomic clocks are poised to redefine the Systeme International (SI) second

256 chromatin compaction states and may be more poised to redifferentiate into contractile fibroblasts i

257 Membrane-based separation is poised to reduce the operation cost of propylene/propane

258 area required a community of arbovirologists poised to refocus their research efforts and rapidly cha

259 re of KCCs including an extracellular domain poised to regulate transport activity through an outer g

260 roplet microfluidic screening processors are poised to replace robotic automation by miniaturizing bi

261 sickness), orally dosed fexinidazole stands poised to replace the current treatment regimen for Tryp

262 mproved understanding of brain disorders are poised to reshape how DBS is viewed and delivered to pat

263 romatin architecture allowing genes that are poised to respond rapidly to developmental cues to be pr

264 erprint of their effector history and remain poised to respond rapidly upon re-exposure to the pathog

265 We demonstrate that the MHB region is poised to respond to calcium transients that occur in th

266 LC), a diverse class of lymphocytes that are poised to respond to environmental insults including vir

267 nd an inflamed microenvironment and thus are poised to respond to immune checkpoint inhibitors (ICIs)

268 ns, which specify polarity in the zygote, be poised to respond to the centrosome.

269 In summary, hepatic ILC2s are poised to respond to the release of IL-33 upon liver tis

270 e-resolved RNA structure probing with TMO is poised to reveal a wide range of dynamic RNA folding pro

271 South Africa is poised to scale up PrEP services for transgender women.

272 The VA is poised to share and extend best practices to other healt

273 ring, changes in the maternal microbiota are poised to significantly affect the newborn.

274 equatorial gap increases in an ADP football poised to split into half-footballs.

275 Single-cell microfluidic devices are poised to substantially impact the hematology field by p

276 ogical challenges that their communities are poised to tackle in the near future.

277 d maternal-child health researchers who were poised to tackle this new public health challenge; and (

278 euroscience of brain-wide neural circuits is poised to take off.

279 our homes, hospitals, and schools, they are poised to take on increasingly social roles.

280 indicating that the genetic loci are already poised to transcribe these novel RNAs.

281 Connected vehicles are poised to transform the field of environmental sensing b

282 Synthetic biology is now poised to transform the potential of plant biotechnology

283 interface with partner disciplines that are poised to transform the practice of drug discovery and d

284 anxiety, the ventral hippocampus is uniquely poised to translate the experience of stress into altere

285 icate that not only is resting alphaIIbbeta3 poised to undergo a conformational change that exposes i

286 en bond donor catalyzed cascade reaction are poised to undergo a McMurry coupling to form previously

287 l reasons, biological mixtures are naturally poised to undergo a small number of demixing phase trans

288 unsaturated morpholine derivatives that are poised to undergo further functionalization for the prep

289 at a significant fraction of the proteome is poised to undergo phase separation under physiological c

290 hich has accumulated four [e(-)/H(+)] and is poised to undergo reductive elimination of H(2) coupled

291 f inhibitory principal neurons that are well poised to use GABAergic and NPY signaling to regulate th

292 olymeric capsules, the developed strategy is poised to usher the development of the next generation o

293 d ENaC, altering the cyst phenotype from one poised toward fluid secretion toward one more favorable

294 , acetaldehyde, and ethanol but seemed to be poised toward the production of ethanol from acetaldehyd

295 7me3 at developmental promoters represents a poised transcriptional state.

296 open-label extension of the pivotal phase 3 POISE trial.

297 rized by a type 17 program associated with a poised type 2 state.

298 nctionalized anilines and aldehydes suitably poised with Micheal acceptor.

299 l implantable microphone technology has been poised with physiologic issues such as sound distortion

300 stone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.