ライフサイエンスコーパス: poised

1 of G4 sequence motifs upstream of TSS of non-poised active genes suggests a potential role of quadrup

2 ch 'stripe' domains are associated with both poised and active chromatin landscapes and transcription

3 l pathways and were selectively enriched for poised and bivalent enhancer marks.

4 fruit fly, Drosophila melanogaster, is well poised as a system in which to explore these questions.

5 Secondary DNA structures are uniquely poised as therapeutic targets due to their molecular swi

6 , maximum current was reached for electrodes poised at -0.3V, closely followed by -0.25V and -0.1V to

7 eference electrode, biocathode potential was poised at -0.8 V (versus SHE) using a potentiostat, with

8 -body phenomena, and are often thought to be poised at a crossover between localized and itinerant re

9 f a specific nature, namely, if dynamics are poised at a so-called critical state characterized by a

10 en reduction region and the ring voltage was poised at a value at which superoxide oxidation ensued y

11 ion factors to the transcriptional apparatus poised at promoters.

12 AMPhi) are innate immune cells strategically poised at the interface between lungs, respiratory patho

13 ssue-resident memory T cells (TRM cells) are poised at the portals of infection and provide long-term

14 c state of Nme1Cas9, the active site is seen poised at the scissile phosphodiester linkage of the tar

15 Assay simulates a scenario in which a mouse, poised at the threshold of its burrow, evaluates whether

16 l of the redox couple and eventually becomes poised at this value.

17 arginine, suggesting starved T cells remain poised awaiting nutrients.

18 The EABs poised below current plateau potential (<=-0.3V) exhibit

19 Together, our results reveal that poised BRC-defined microenvironments establish a feed-fo

20 ZRS at early embryonic stages maintaining a poised, but inactive state broadly across the distal lim

21 The electrode surface will become poised by the addition of a well-behaved redox pair, suc

22 nd focal allele-specific hypermethylation in poised chromatin.

23 equent leukemic evolution of these "leukemia-poised" clones remain incompletely understood.

24 ws may indeed originate from neural networks poised close to a critical state.

25 arise because cellular plasma membranes are poised close to a miscibility transition under growth co

26 ve these signature loci in an epigenetically poised configuration.

27 ors for the maintenance of transcriptionally poised developmental genes.

28 T) cells, and gammadelta T cells, maintain a poised effector state has been unclear.

29 bilization appears to disrupt the delicately poised energy balance governing thin filament regulation

30 n in the Drosophila embryo, we find that the poised enhancer signature is specifically generated duri

31 The poised enhancer signature, involving H3K4me1 and low lev

32 We discuss the possibility that the poised enhancer state is more generally the result of re

33 ermediate step before future activation, the poised enhancer state may be a mark for spatial regulati

34 -/-) CD8(+) T cells were unable to activate "poised" enhancer elements compared with wild-type CD8(+)

35 ng factors by increasing chromatin access at poised enhancers and chromosome architectural elements.

36 onents Med1 and Smc1a at newly activated and poised enhancers in ESC-derived epiblast-like cells.

37 Some sites of hypomethylation occur at weak/poised enhancers marked with H3K4 monomethylation in hem

38 Stem cells use poised enhancers of developmental regulators to maintain

39 otch transcriptional effector RBPJ activated poised enhancers to rapidly induce LXRalpha and other Ku

40 rted into nuclei, where they associated with poised enhancers with DNA-bound TEAD4 and H3K4me1.

41 5hmC was enriched within poised enhancers, and depleted within active enhancers,

42 hich is normally observed in developmentally poised enhancers.

43 ge enrichments biased toward both active and poised enhancers.

44 ange the nucleotide sequence of that RNA, is poised for a major expansion in scientific interest and

45 biological systems, and researchers are now poised for a precision-focused transformation in the way

46 t has an unrestricted activation loop and is poised for access to membranes.

47 velope acts as a reservoir, maintaining COP1 poised for action.

48 ell type specification genes, which are then poised for activation by external signal inputs.

49 FOXA1(-) TNBC tended to be SFK_pY527(-) (SFK poised for activation).

50 mplex with Isc10 and Smk1 during MII that is poised for activation.

51 until, at its most advanced position, it is poised for another Heinrich event.

52 base-pair and engaging the second base-pair poised for breaking.

53 The field appears poised for breakthroughs, including the exciting prospec

54 ive site in the quaternary Pol mu complex is poised for catalysis and nucleotide incoporation proceed

55 tructure not only visualizes the active site poised for catalysis of APOBEC3A, but pinpoints the resi

56 with a pri-miRNA docked in the active site, poised for cleavage.

57 vage and polyadenylation specificity factor, poised for cleavage.

58 es, with particular emphasis on technologies poised for clinical translation.

59 tions of androgen-independent cells that are poised for clonal selection after androgen-deprivation t

60 ional sites at onset of inflammation are not poised for cytotoxic function.

61 All complexes are well poised for dCTP insertion.

62 The phosphotransfer center is asymmetric, poised for dissociative nucleophilic substitution.

63 achieve a closed DNA polymerase active site poised for efficient nucleotide incorporation and illust

64 s (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity.

65 chromatin common among the GSCs tested were poised for expression of immune-related genes, including

66 in the naive state, indicating that they are poised for expression prior to the initiation of pluripo

67 or molecules with demethylated promoters and poised for expression.

68 reported to mark inactive enhancers that are poised for future activation.

69 rminants converge to render aged CD8(+) T(M) poised for greater recall responses.

70 , hair-follicle stem cells (HFSCs), normally poised for hair generation, are recruited to the site of

71 rally expanded RORgammat+ gammadelta T cells poised for IL-17 production were resistant to C. diffici

72 functional Ag-specific CD8 T cells that are poised for immediate protection; however, this is at the

73 sue resident memory CD8(+) T cells (Trm) are poised for immediate reactivation at sites of pathogen e

74 itioned adjacent to the open DNA entry gate, poised for insertion, at the Mcm2-Mcm5 interface.

75 ation of the active gamma-secretase complex, poised for intramembrane proteolysis, by cryo-electron m

76 rocess affords alkylated benzenesulfonamides poised for medicinal chemistry applications and traceles

77 heterochromatin and euchromatin are globally poised for mutual antagonism, the mechanisms underlying

78 al structure of CD53 in an open conformation poised for partner interaction.

79 ficient high-temperature superconductors are poised for power transmission and magnetic imaging appli

80 ogy over the past years, the field now seems poised for practical application.

81 enhancer elements in healthy fibroblasts and poised for rapid activation in response to DNA damage.

82 hetic signaling is relatively new, but it is poised for rapid advancement.

83 e introduce a class of recyclable thermosets poised for rapid deployment.

84 orm a weakly populated excited state that is poised for rapid product release.

85 l reserve of NF-kappaB in peripheral T cells poised for responding to agonistic antigen-driven T cell

86 ents in cancers that would otherwise be less poised for response to immunotherapy, including cancers

87 ate cancer that are androgen independent and poised for selection as dominant clones after androgen d

88 The resulting ion-pair is poised for spontaneous electron transfer to O(2).

89 genome accessibility and renders adipocytes poised for thermogenic activation remains elusive.

90 pressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3.

91 phaHb, coordinate to the heme iron, which is poised for transfer into the heme-binding pocket of IsdB

92 egion of SspH1, promoting an E3 conformation poised for transthiolation.

93 viously identified for other cell types, non-poised genes are B cell state specific.

94 om individual species act downstream of core poised genes during development in a species-specific fa

95 We found that while Pol II poised genes generally overlap functionally among differ

96 s induce lineage-appropriate developmentally poised genes poorly while lineage-inappropriate genes, i

97 pore as an organizing scaffold for inducible poised genes.

98 We examined the poised (H3K4me3/H3K27me3 bivalent) epigenetic state in m

99 er loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enha

100 A Helix-X segment is poised in an open conformational state; the heme a farne

101 We find that core genes poised in germ cells from multiple amniote species are a

102 issue-resident macrophages are metabolically poised in situ to protect and exploit their tissue-niche

103 ral agencies, and industry, such that we are poised in the ensuing years to positively address the un

104 ere, we demonstrate that the Mn4O5Ca complex poised in the S0 state contains an exchangeable hydroxo

105 to a stimulus of small amplitude when it is poised in the weakly chaotic regime.

106 d only on the droplet surface, while systems poised near the boiling point permitted enzyme penetrati

107 lization, and which occurred only in systems poised near the boiling point.

108 in chains characteristic of a gel phase, yet poised near the sol phase, a solution of independent chr

109 trols the initial stages of transition from 'poised', non-transcribed rDNA chromatin into its active

110 Our data indicate that the GerA receptor is poised on a knife's edge during spore development.

111 riant acid/base residues, Glu499 and Tyr578, poised on each side of the target uronic acid residue, t

112 Two poised one-electron transfer systems (potassium ferricya

113 Bivalent (poised or paused) chromatin comprises activating and rep

114 h recognizes the guanine base) and lid-loop (poised over the nucleotide phosphates) that accompany nu

115 uggests that quiescence represents states of poised potential and active restraint, as stem cells "id

116 lso show marked enrichment for enhancers and poised promoters across multiple cell types.

117 of some residual H3K27me3, compared to less-poised promoters.

118 stages when hormone responsive enhancers are poised, revealing critical epigenetic roles involved in

119 ctor, Zelda, is responsible for establishing poised RNA polymerase at Dorsal target genes before Dors

120 omatin structure and promoter recruitment of poised RNA polymerase II preinitiation complex (RNAPII P

121 romoters characterized by low expression and poised RNA-polymerase.

122 or, during memory, Cdk8(+) Mediator recruits poised RNAPII PIC lacking the Kin28 CTD kinase.

123 esting B cell and shifted from non-poised to poised state after B cell activation.

124 changes indicating that NtcA can reside in a poised state controlled by other factors.

125 ate that the erm enhancer is maintained in a poised state in neural stem cells by the histone deacety

126 erm immature INP enhancer in an inactive but poised state in neuroblasts.

127 development where H3K27me3 loss released the poised state of apparently bivalent promoters, whereas d

128 Together, our data shed new light on the poised state of ITC, in which innateness is defined by a

129 and the third corresponds to establishing a poised state of latent regulator priming through an unkn

130 We suggest that the indicated poised state of NtcA enables a more differentiated respo

131 Thus, the poised state that allows rapid meiotic reentry in mouse

132 Bcl2l11 promoter to maintain this gene in a poised state.

133 In mESCs, the proteins bind to active and poised TBP-bound promoters along with promoters of polyc

134 le facets of FSHD research, the field is now poised to accelerate the process of therapeutic discover

135 ur findings indicate that hypoxic niches are poised to accumulate CSCs in a molecular process driven

136 Policymakers are poised to act and 1 proposal entails reorganizing the cu

137 ly the basolateral and CeM amygdalar nuclei, poised to activate CeM for autonomic arousal.

138 This constellation of residues is poised to activate the substrate by Schiff base formatio

139 entiation of most lineages, transitions from poised to active or inactive states, and shifts in nucle

140 es in the past few years and ongoing work is poised to add even more.

141 ht and electron microscopy (CLEM) is ideally poised to address such problems.

142 The design of sequences which are poised to adopt two very different conformations sets th

143 imaging ((129)Xe MRI) in pediatric asthma is poised to advance our understanding of disease mechanism

144 e sequencing and gene-based therapies appear poised to advance the management of rare lipoprotein dis

145 When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon traum

146 KEAP1 is thus poised to affect MCM2-7 dynamics or function rather than

147 cy and a more favorable toxicity profile are poised to alter the landscape of RET-dependent cancers.

148 l death signalling pathways; these cells are poised to apoptose when survival pathways are inhibited.

149 in which 5 binds to S2 with its C6-C11 group poised to attack C1 in GPP to form the moenocinyl sidech

150 chaperone showed how well the carboxylate is poised to attack the phosphoramidate, helping to explain

151 of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and

152 al cholinergic interneurons and therefore is poised to be a positive regulator of cholinergic activit

153 iated herpesvirus (KSHV) latent episomes are poised to be activated by the KSHV replication and trans

154 molybdenum disulfide (MoS(2)) nanosheets are poised to be at the core of low-voltage electronic devic

155 cycle just before division, where it is then poised to be precisely localized at new growth poles in

156 ic cul-de-sacs, many mountain streams appear poised to be redoubts for cold-water biodiversity this c

157 While polygenic risk scores (PRSs) are poised to be translated into clinical practice through p

158 oth the new drug and the antibodies that are poised to be used against HIV.

159 xpression of their targets and are therefore poised to become a main pillar of cellular cancer immuno

160 rimental demonstration provided here, PLM is poised to become a powerful technique for revealing the

161 is 'natural sampler DNA' (nsDNA) approach is poised to become a powerful, affordable, universal tool

162 underlying genetic forms of hearing loss is poised to become a reality.

163 T3SEs and improved performance, Bastion3 is poised to become a widely used, state-of-the-art toolkit

164 eable technological scenarios where they are poised to become front runners.

165 The landscape approach is thus poised to become one of the most influential methods for

166 ntibodies, molecularly targeted exosomes are poised to become the next generation of smartly engineer

167 We are now poised to begin developing self-disseminating vaccines t

168 melanoma is a dermatologic area particularly poised to benefit from such innovation.

169 Patients with CKD are uniquely poised to benefit from these integrative, multi-omics ap

170 ctions also target the striatum, oxytocin is poised to bias the balance of DA tone through multiple s

171 on each side of the dimerisation interface, poised to bind a pair of Rheb molecules at a similar sep

172 We observed that this residue is poised to bind substrate in the active structure and dis

173 organized into three substrate-binding lobes poised to bind their respective nucleosomal epitopes.

174 a specific dimerization mode of RET that is poised to bring the two kinase domains into close proxim

175 for the first time, the field seems uniquely poised to bring these new tools to effectively tackle EB

176 etic engineering, and cell manufacturing are poised to broaden T-cell-based therapies and foster new

177 ease 2019 pandemic, PICU physicians are well poised to care for adult patients in a surge capacity, a

178 ectron microscopy structures of these RNases poised to cleave their pre-rRNA substrates within the B.

179 fatty acid metabolism and therefore uniquely poised to communicate the intracellular energy status of

180 a(2+) ions, forming a heterotetramer that is poised to compete with microbial pathogens for essential

181 of subsets of tissue fibroblasts which seem poised to contribute to the angiogenic response.

182 link the Piezo repeats to the pore, and are poised to control gating allosterically.

183 that control their function; fibroblasts are poised to coordinate fibrogenesis in tissue injury, neop

184 With this knowledge, we are poised to design the next generation of complex biologic

185 els, located at the tops of stereocilia, are poised to detect tension induced by hair bundle deflecti

186 ity to differentiate into Th1 cells but were poised to differentiate better into induced nTreg cells,

187 In this configuration, ORC is poised to direct the recruitment of the second hexamer i

188 tes produced from methanol decomposition are poised to directly undergo hydroformylation upon migrati

189 oaches with emerging molecular tools will be poised to elucidate the functional importance of endophy

190 New techniques are now poised to enable the measurement of cell-generated mecha

191 plexes with multiple divergent trityl groups poised to engage in embraces.

192 their location, these aromatase neurons are poised to engage nociceptive circuits, whether it is thr

193 caused widespread changes in gene expression poised to enhance vascular inflammation, thrombosis, lea

194 the US Food and Drug Administration and are poised to enter the practice of medicine for leukemia an

195 at the mitochondrial pyruvate carrier MPC is poised to exert ultrasensitive control on the balance be

196 Developmental systems biology is poised to exploit large-scale data from two approaches:

197 ytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and diffe

198 contact a carboxylate oxygen of caC and are poised to facilitate acid-catalyzed caC excision.

199 llectively referred to as soft photonics-are poised to form the platform for tunable optical devices

200 nk represents a new branch on a tree that is poised to grow rapidly and offer new kinds of insights o

201 mportant generalization of the HMM, which is poised to have a deep impact across the field of biophys

202 or the interpretation of these data, and are poised to have a substantial effect on diagnosis, manage

203 Terahertz (THz) radiation is poised to have an essential role in many imaging applica

204 ddressing these challenges, iGxE research is poised to help identify the neural mechanisms underlying

205 ake the choices they do, then we may be more poised to help them manage their medications, influence

206 Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medi

207 he-art deep learning for object detection is poised to improve the accuracy and efficiency of biologi

208 ms, artificial intelligence (AI) methods are poised to improve the precision of diagnostic and therap

209 The field of congenital heart surgery is poised to incorporate new innovations such as bioenginee

210 reasing in intensity and size and, thus, are poised to increase in importance as disturbance agents.

211 Fertilizer use is poised to increase in the tropics, where widespread food

212 this complex acts as a latent Z-type ligand poised to increase the Lewis acidity of the gold center,

213 olitogenic memory CD4+ T cell subset that is poised to initiate inflammation when there is loss of to

214 Prior to S phase, multiple origins are poised to initiate replication by recruitment of the pre

215 The insights presented herein are poised to inspire the design of other catalyst-controlle

216 ions of the brain's "scene network" are well poised to integrate retinal input and memory [1]: they a

217 mmensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infection

218 ever, the mechanisms by which T cells remain poised to kill cancer cells despite expressing high leve

219 as a valuable tool in drug discovery, and is poised to make a major impact on the design of enzyme in

220 rials developed and studied in this area are poised to make a substantial impact in real-world applic

221 ls has completed clinical development and is poised to make an impact on clinical practice.

222 Today, glycobiology is poised to make major new contributions to cell biology a

223 rative of the unique contribution SiMPull is poised to make to in planta protein interaction studies.

224 analysis reveals that B. phytofirmans PRF is poised to metabolize thiosulfate to sulfite in a sulfur

225 Acots in the mitochondrial matrix are poised to mitigate beta-oxidation overload and maintain

226 explain how a strong pOFC pathway, which is poised to moderate activity of CeM, through IM, can be u

227 site of intense immune cell activity that is poised to mount an effective response against a pathogen

228 macrophages of the islets of Langerhans are poised to mount an immune response even at steady state,

229 anges gamma-tubulins into a helical geometry poised to nucleate microtubules.

230 the plasma membrane in resting cells that is poised to orchestrate assembly of key signaling componen

231 Gastroenterologists are uniquely poised to participate in the multidisciplinary managemen

232 Thus, it is well poised to play a broad and integrative role in visual pe

233 for further improvement, HASEL actuators are poised to play an important role in a paradigm shift tha

234 g protein (GPBP), a BM protein, was uniquely poised to play diverse roles in this transition owing to

235 (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating t

236 essed in resting B cell and shifted from non-poised to poised state after B cell activation.

237 These novel strategies are not only poised to prevent progressive tissue scarring, but also

238 ditionally, CCR6-expressing resident T cells poised to produce IFN-gamma and IL-17 were enriched in e

239 TPH cells appear to be uniquely poised to promote B-cell responses and antibody producti

240 shape changes, but if they go awry, they are poised to promote disease states such as cancer cell met

241 C1 protomers are placed close to each other, poised to promote the active dimer of the intracellular

242 raphy-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules underlyi

243 Large-scale genome sequencing is poised to provide a substantial increase in the rate of

244 mediators of central tolerance, DCs are thus poised to provide homeostatic regulation of thymic expor

245 The developed constructs provide a platform poised to provide new insights into the subcellular dist

246 tead are a broadly reactive layer of T cells poised to quickly develop into regulatory or effector ce

247 t exposes its ligand-binding site, but it is poised to rapidly assemble into intracellular signal-gen

248 These memory CD8 T cells remain poised to rapidly elaborate effector functions upon re-e

249 Macrophages stand poised to rapidly produce large amounts of inflammatory

250 evelopment, physiological cardiac models are poised to realise the promise of translational research

251 ficial nor purely biological approaches seem poised to realize the potential of solar-to-chemical syn

252 unteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate a

253 Optical atomic clocks are poised to redefine the Systeme International (SI) second

254 chromatin compaction states and may be more poised to redifferentiate into contractile fibroblasts i

255 Membrane-based separation is poised to reduce the operation cost of propylene/propane

256 area required a community of arbovirologists poised to refocus their research efforts and rapidly cha

257 re of KCCs including an extracellular domain poised to regulate transport activity through an outer g

258 roplet microfluidic screening processors are poised to replace robotic automation by miniaturizing bi

259 sickness), orally dosed fexinidazole stands poised to replace the current treatment regimen for Tryp

260 mproved understanding of brain disorders are poised to reshape how DBS is viewed and delivered to pat

261 romatin architecture allowing genes that are poised to respond rapidly to developmental cues to be pr

262 erprint of their effector history and remain poised to respond rapidly upon re-exposure to the pathog

263 We demonstrate that the MHB region is poised to respond to calcium transients that occur in th

264 LC), a diverse class of lymphocytes that are poised to respond to environmental insults including vir

265 nd an inflamed microenvironment and thus are poised to respond to immune checkpoint inhibitors (ICIs)

266 ns, which specify polarity in the zygote, be poised to respond to the centrosome.

267 In summary, hepatic ILC2s are poised to respond to the release of IL-33 upon liver tis

268 e-resolved RNA structure probing with TMO is poised to reveal a wide range of dynamic RNA folding pro

269 They are poised to revolutionize optics by enabling complex low-c

270 South Africa is poised to scale up PrEP services for transgender women.

271 The VA is poised to share and extend best practices to other healt

272 ring, changes in the maternal microbiota are poised to significantly affect the newborn.

273 equatorial gap increases in an ADP football poised to split into half-footballs.

274 Use of the technology is poised to substantially advance integrated control of se

275 Single-cell microfluidic devices are poised to substantially impact the hematology field by p

276 ogical challenges that their communities are poised to tackle in the near future.

277 d maternal-child health researchers who were poised to tackle this new public health challenge; and (

278 ies in the animal kingdom, plant studies are poised to take a lead role in this area because of their

279 euroscience of brain-wide neural circuits is poised to take off.

280 our homes, hospitals, and schools, they are poised to take on increasingly social roles.

281 indicating that the genetic loci are already poised to transcribe these novel RNAs.

282 Connected vehicles are poised to transform the field of environmental sensing b

283 Synthetic biology is now poised to transform the potential of plant biotechnology

284 interface with partner disciplines that are poised to transform the practice of drug discovery and d

285 anxiety, the ventral hippocampus is uniquely poised to translate the experience of stress into altere

286 icate that not only is resting alphaIIbbeta3 poised to undergo a conformational change that exposes i

287 en bond donor catalyzed cascade reaction are poised to undergo a McMurry coupling to form previously

288 l reasons, biological mixtures are naturally poised to undergo a small number of demixing phase trans

289 unsaturated morpholine derivatives that are poised to undergo further functionalization for the prep

290 at a significant fraction of the proteome is poised to undergo phase separation under physiological c

291 hich has accumulated four [e(-)/H(+)] and is poised to undergo reductive elimination of H(2) coupled

292 f inhibitory principal neurons that are well poised to use GABAergic and NPY signaling to regulate th

293 olymeric capsules, the developed strategy is poised to usher the development of the next generation o

294 d ENaC, altering the cyst phenotype from one poised toward fluid secretion toward one more favorable

295 , acetaldehyde, and ethanol but seemed to be poised toward the production of ethanol from acetaldehyd

296 7me3 at developmental promoters represents a poised transcriptional state.

297 rized by a type 17 program associated with a poised type 2 state.

298 nctionalized anilines and aldehydes suitably poised with Micheal acceptor.

299 l implantable microphone technology has been poised with physiologic issues such as sound distortion

300 stone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.