ライフサイエンスコーパス: poison

1 nse, following the dogma "the dose makes the poison".

2 "The dose makes the poison".

3 ing hemorrhage, major polytrauma, burns, and poisoning).

4 ns gcna-1 mutants are hypersensitive to TOP2 poison.

5 gamete-killing poison and an antidote to the poison.

6 es account for many of the world's deadliest poisons.

7 could render cancer cells resistant to TOP2 poisons.

8 ultures over millennia as both medicines and poisons.

9 type mediating aversion imposed by multiple poisons.

10 me, and it is one of the longest established poisons.

11 hydrometalation which are otherwise catalyst poisons.

12 as putative biomarkers for response to TOP2 poisons.

13 mammalian cells to acquire resistance to Eg5 poisons.

14 generated new type II topoisomerase (topoII) poisons.

15 thermal stability, and tolerance to chemical poisons.

16 rain tumors in adults, is responsive to TOP2 poisons.

17 more, Ir(1)/CN displays high tolerance to CO poisoning.

18 s of extracorporeal membrane oxygenation for poisoning.

19 lation and protection to FeS enzymes from Cu poisoning.

20 was notably reduced due to prevention of CO poisoning.

21 st genetic hyperoxaluria and ethylene glycol poisoning.

22 ere complications such as infection and food poisoning.

23 ed foods such as fish is known to cause food poisoning.

24 s the dilemma between reactivity and anti-CO poisoning.

25 activity, high overpotential, and severe CO poisoning.

26 patients with severe chloroquine or quinine poisoning.

27 chronic liver disease, and drug and alcohol poisoning.

28 ant isoleucyl tRNA synthase, preventing self-poisoning.

29 eam inflammatory and oxidative effects of CO poisoning.

30 old pesticide storage reduces pesticide self-poisoning.

31 oach for adults with calcium channel blocker poisoning.

32 a reduction in blood oxygen level and acute poisoning.

33 containers for prevention of pesticide self-poisoning.

34 predictive of mortality in chloroquine self-poisoning.

35 ropriate flushing procedures to prevent lead poisoning.

36 ributing to the lack of heterocycle catalyst poisoning.

37 or storage and prevention of accidental self-poisoning.

38 episodes of opioid overdose and nerve agent poisoning.

39 se of extracorporeal membrane oxygenation in poisoning.

40 suggesting a complicated mechanism of water poisoning.

41 cytotoxic activity through topoisomerase II poisoning.

42 asive and rapid diagnostic tool for methanol poisoning.

43 rse the clinical and molecular effects of CO poisoning.

44 (CO) remains the most common cause of human poisoning.

45 detector material(9,10), a burnable reactor poison(11) and a potential medical neutron capture thera

46 ed by NMD, and (ii) RPS3 binding activates a poison 5'-splice site in its pre-mRNA that leads to a fr

47 en we may be able to induce accumulation and poison a cancer cell by targeting the downstream enzyme.

48 ent neurological and affective effects of CO poisoning, a portion of survivors still have substantial

49 d Ir) nanowires (NWs) with excellent anti-CO-poisoning ability and high activity.

50 Drug poisoning accounted for 59.4% of acts but only 13.5% of

51 Pesticide self-poisoning accounts for 14-20% of suicides worldwide.

52 tants of ULS1 are hypersensitive to the Top2 poison acriflavine (ACF), activating the DNA damage chec

53 also associated with susceptibility to TOP2 poisons across cell lines from gliomas and multiple othe

54 ar to the lowest concentration at which TOP2 poison activity was detected (above 20 muM), which sugge

55 Carbon monoxide (CO) poisoning affects 50,000 people a year in the United Sta

56 n barrier and triggers lethal phenethylamine poisoning after monoamine oxidase inhibitor administrati

57 a formal total synthesis of the famous arrow poison alkaloid tubocurarine.

58 : self-injury alone pound753 (SD 2061), self-poisoning alone pound806 (SD 1568), self-poisoning and s

59 1150 (70%) presentations were for self-poisoning alone, 367 (22%) for self-injury alone, and 13

60 Similarly, relative to self-harm by self-poisoning alone, attempted hanging or asphyxiation (adju

61 elative to hospital presentations after self-poisoning alone, presentations involving both self-injur

62 Ethylene glycol poisoning also results in hyperoxaluria promoting acute

63 transcripts to encode both a gamete-killing poison and an antidote to the poison.

64 litate the oxidative removal of carbonaceous poison and combination with CH3CO radicals on adjacent P

65 Some of these compounds act as topoII poison and exhibit good solubility, metabolic (microsoma

66 y reduce the activity of etoposide as a TOP2 poison and thus reduce the efficacy of drug combinations

67 um perfringens enterotoxin (CPE) causes food poisoning and antibiotic-associated diarrhea.

68 rfringens enterotoxin (CPE) cause human food poisoning and antibiotic-associated diarrhea.

69 certain dietary exposures or ethylene glycol poisoning and are a well known cause of AKI.

70 h, promising for rapid screening of methanol poisoning and assessment of severity.

71 arrying enterotoxin A gene (sea) causes food poisoning and cannot be distinguished from non-pathogeni

72 idium perfringens is a leading cause of food-poisoning and causes avian necrotic enteritis, posing a

73 , low selectivity, poor durability, impurity poisoning and fuel crossover effects, and detrimental ef

74 ides new perspectives for the design of anti-poisoning and highly effective catalysts.

75 s an effective strategy to circumvent the CO poisoning and improve the performance of CO(2) reduction

76 nal pain may be a presenting symptom of lead poisoning and is often difficult to diagnose.

77 Bacillus cereus a pathogen that causes food poisoning and life-threatening wound infections, secrete

78 tinction, condors remain compromised by lead poisoning and limited genetic diversity.

79 med to evaluate the association between lead poisoning and liver fibrosis as well as the change in th

80 ponders to distinguish methanol from ethanol poisoning and monitor in real time the subsequent hospit

81 Addition of detergent in milk can cause food poisoning and other complications.

82 a subclass of PFTs widely implicated in food poisoning and other related infections.

83 favour the adsorption of O2, alleviating CO poisoning and promoting the catalysis.

84 O(2) and NO movements averts irreversible NO poisoning and reductive inactivation of the enzyme.

85 elf-poisoning alone pound806 (SD 1568), self-poisoning and self-injury pound987 (SD 1823; p<0.0001).

86 causes the symptoms of common bacterial food poisoning and several non-foodborne human gastrointestin

87 sulfate species responsible for the surface poisoning and shows how this product can be obtained fro

88 e show a clear relationship between red kite poisoning and the decline of its breeding population in

89 on and blooms in people recovering from food poisoning and Vibrio cholerae infections.

90 on steps also confers excellent tolerance to poisons and impurities introduced to the electrolyte.

91 y review the cell biology behind microtubule poisons and their clinical use in cancer patients.

92 Wtf4(antidote) can co-assemble with the Wtf4(poison) and promote its trafficking to vacuoles.

93 ne vosaroxin acts solely as an intercalating poison, and that the antibacterial ciprofloxacin can poi

94 oints were highest for deaths due to injury, poisoning, and other external causes, in both men (7.89;

95 CN exhibits greatly enhanced tolerance to CO poisoning, and Rh atoms in SA-Rh/CN resist sintering aft

96 , recent history of intentional use for mass poisoning, and the absence of a known antidote raise pub

97 ety (such as restricting access to firearms, poisons, and medications and installing barriers to prev

98 ide drug candidates, mycalamide-type contact poisons, and the eukaryotic translation-inhibiting patea

99 ver in Schizosaccharomyces pombe that uses a poison-antidote mechanism to selectively kill meiotic pr

100 Topoisomerase II (TOP2) poisons are effective cytotoxic anticancer agents that s

101 Topoisomerase II poisons are one of the most common class of chemotherape

102 TOP2 poisons are valuable and widely used anticancer drugs, b

103 re, curing is robust and not as sensitive to poisoning as other silicone elastomer formulations.

104 ratio=15.86, 95% CI=10.7-23.4; computed with poisoning as reference), and to a lesser extent after ev

105 Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleava

106 erase I and II (TOP1 and TOP2, respectively) poisons as well as topoisomerase II DNA binding and ATPa

107 ) catalyst that severely suffers from oxygen poisoning at high O(2) /C(3) H(8) ratios.

108 NA covalent complexes, thus behaving as TOP2 poisons at low concentration and inhibitors at high conc

109 mitoxantrone act as topoisomerase II (TOP2) poisons at low concentration but attenuate TOP2 activity

110 Unlike TOP2A poisons, ATP-competitive inhibitors do not damage DNA, p

111 ciated with several diseases, including food poisoning, bacterial arthritis, and toxic shock syndrome

112 ble Absorber (IFBA) is an excellent burnable poison (BP) candidate for long life soluble-boron-free c

113 s therefore not only the dose that makes the poison but also the exposure sequence.

114 resistant to treatment with topoisomerase II poisons but not other DNA damaging agents.

115 e is no evidence that silver is a cumulative poison, but its levels can build up in the body tissues

116 at another key step in central metabolism is poisoned by molecular oxygen itself.

117 s O2 , and Ag/Pt surface proximity disfavors poisoning by CO or oxidized species.

118 eaction will be inhibited because of surface poisoning by CO.

119 ilizing these nanoscale Ni catalysts against poisoning by interactions with the BN substrate.

120 These materials are resistant to poisoning by small reactive gases (CO and H2S) that may

121 response to concerns for wide-scale mercury poisoning by these activities.

122 sm of developing resistance to topoisomerase poisons by ensuring rapid TOP2cc reversal.

123 distribution across all other methods, self-poisoning (by medication) (25%) was significantly more l

124 all causes (by race and ethnicity) and drug poisoning, by county, for the periods of 2000-03 and 201

125 risk of future opioid dependence, abuse, or poisoning can be predicted in advance of an initial opio

126 cytotoxicity of DNA topoisomerase II (TOP2) poisons can be enhanced through combination therapy with

127 s and those that result from ethylene glycol poisoning, can result in end-stage renal disease.

128 Colorado and documented the response of the Poison Canyon aquifer system several years after upward

129 cs of groundwater-methane attenuation in the Poison Canyon aquifer: (i) consumption of methane and su

130 its premessenger RNA promotes inclusion of a poison cassette exon and transcript degradation via nons

131 cts as dominant-negative isoform suppressing poison cassette exon inclusion and instead promoting the

132 reen to measure the functional relevance of 'poison' cassette exons, which disrupt their host genes'

133 the distal regions of gene bodies, and TOP2 poisons cause a proximal shift in their distribution.

134 phimurium (ST), a major source of human food poisoning, caused inflammation of murine intestinal tiss

135 hich receives exposure reports from regional poison centers serving the United States, Puerto Rico, a

136 Poison Centers, 2000-2018.

137 s/porous nanomaterials through intentionally poisoning certain MNPs using suitable modifiers.

138 d steps, leading to the abrupt desorption of poisoning CO from all crystal facets at the same tempera

139 es to prevent suicides due to pesticide self-poisoning, compared with a null comparator.

140 me of 95 454 calls per year were reported to poison control centers, with most exposures occurring un

141 SAAs also offer reduced susceptibility to CO poisoning, cost savings from reduced precious metal usag

142 especially for young people and against self-poisoning, could potentially lower future costs at a tim

143 To define potential biomarkers for TOP2 poisons, CRISPR hits were overlapped with genes whose ex

144 Poison-dart Phyllobates terribilis frogs sequester letha

145 METHOD: The National Poison Data System, which receives exposure reports from

146 74 calls for ocular exposure to the National Poison Data System.

147 has been largely driven by increases in drug poisoning deaths.

148 hat this hybrid new chemical class of topoII poisons deserves further exploration and that 3f is a fa

149 e control group; incidence of pesticide self-poisoning did not differ between groups (293.3 per 100 0

150 entific questions can help avert future lead poisoning disasters.

151 ISPR/Cas9-mediated chromosome cutting, or by poisoning DNA decatenation resulted in mistiming of MapZ

152 ollateral resistance to the topoisomerase II poison doxorubicin.

153 ined all-cause mortality (ACM), drug-related poisoning (DRP) mortality, and mortality not attributabl

154 lyst has high immunity to typical sigma-base poisons due to the antibonding interactions of the high

155 ive role of electride support where the H(2) poisoning effect is absent during ammonia synthesis over

156 ed directing group capable of overriding the poisoning effect of a wide range of heterocycle substrat

157 redispersion process removes impurities and poisoning elements, yet is able to maintain the integrit

158 practical cells using a series of carbonate-poisoned ether-based electrolytes.

159 th similar efficiency to the archetypal TOP2 poison etoposide.

160 an enhanced response to the topoisomerase-II poison etoposide.

161 s and transforms the topoisomerase II (TOP2) poisons etoposide and mitoxantrone to chemical forms tha

162 illed medication prescriptions, and nonfatal poisoning events during the 30 days and 12 months before

163 SFs contain ultraconserved poison exon (PE) sequences that exhibit greater identity

164 BRD9 and thereby induces the inclusion of a poison exon that is derived from an endogenous retrovira

165 The essentiality and cancer relevance of poison exons are likely to contribute to their unusually

166 Many poison exons were essential for the growth of both cultu

167 Based on poisoning experiments, we propose that the microbially m

168 The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup sought to determine the eff

169 ns, especially in the setting of intentional poisoning, fire-related toxic gas exposures, and inhalat

170 ectively subvert innate immune-mediated zinc poisoning for systemic spread.

171 Using a polytypic poison frog (Dendrobates tinctorius), we explored the fo

172 amino acid replacements that differed among poison frog lineages.

173 pring and relies on similar brain regions in poison frog species with convergently evolved toxicity a

174 y serves to prevent misdirected care in this poison frog.

175 we show that both male and female strawberry poison frogs (Oophaga pumilio) imprint on coloration, wh

176 Here we show experimentally that male poison frogs adjust their parental responses - care or i

177 Poison frogs have a diverse arsenal of defensive alkaloi

178 ological level, we found that nursing allows poison frogs to provide chemical defenses to their tadpo

179 ural mechanisms in dendrobatid and mantellid poison frogs.

180 ive OD were identified using ICD-9 codes for poisoning from opioids or adverse effects from opioids.

181 Whether cancers avoid poisoning from oxidized nucleotides by preventing incorp

182 lation variation in TTX levels is related to poison gland morphology.

183 y swallow their antimicrobial, highly acidic poison gland secretion.

184 TTX concentration within poison glands is related to the volume of a single cell

185 TTX levels, presumably concentrated in skin poison glands, acting as an agent of selection upon pred

186 years or older, 611 cases of pesticide self-poisoning had occurred by 3 years in the intervention gr

187 TOP2 poisons have shown significant variability in their ther

188 ssion product that was first discovered as a poison in early reactors(7,8), and (157)Gd (2.5 x 10(5)

189 This suggests that swallowing of the poison in formicine ants acts as a microbial filter and

190 lated role in preventing magnetite formation poisoning in magnetotactic bacteria via Mn(2+) incorpora

191 is the leading cause of Paralytic Shellfish Poisoning in North and South America, Europe, Africa, Au

192 mary outcome was incidence of pesticide self-poisoning in people aged 14 years or older during 3 year

193 0027), and those who used methods other than poisoning in their index presentation (fatal and non-fat

194 lter Top2 chromatin binding and prevent Top2 poisoning in yeast.

195 The consequences of CO poisoning include cardiac dysfunction, brain injury, and

196 nt layer of regulation in the repair of TOP2 poison-induced DNA damage.

197 trate a straightforward relationship between poison-induced individual mortality and population chang

198 -619 is a potent DNA topoisomerase II (TOP2) poison, inducing both DNA topoisomerase IIalpha (TOP2A)

199 Treatments with drugs used to poison/inhibit TOP2A function, such as etoposide and ICR

200 gments can be fully oxidized without CO as a poisoning intermediate.

201 Agricultural pesticide self-poisoning is a major public health problem in rural Asia

202 EB) as a bacterial toxin causing severe food poisoning is of great importance.

203 Lead poisoning is often seen as a problem of the past.

204 Nanoparticles suffer from aggregation and poisoning issues (e.g., oxidation) that severely hinder

205 ts used as therapeutics, "the dose makes the poison," it is now realized that this aptly applies to t

206 en reduction reaction, (iii) carbonate anion poisoning, (iv) unique challenges arising from the speci

207 are linked to multidimensional states (e.g., poison ivy is green in summer but red in spring).

208 object features (e.g., the three leaflets of poison ivy leaves) and outcomes (e.g., rash).

209 h at the site of contact with allergens like poison ivy or nickel.

210 hat minor amounts of O are present in the CO-poisoned layer that explain why, surprisingly, CO desorb

211 ntrol in place of the conventional method of poison, macaques could provide an important ecosystem se

212 Furthermore, this poisoning may be cancer cell selective if this pathway i

213 ases, we suggest that the very nature of CS2 poisoning may be related to interrupting or overwhelming

214 , rather than DNA damage resulting from TOP2 poisoning, may play a role in doxorubicin cardiotoxicity

215 vel of the mutant in the cell, suggesting a 'poisoning' mechanism in which R402 mutant alpha-tubulin

216 es is a key step towards addressing catalyst poisoning mechanisms in fuel cells.

217 could protect hematopoietic cells from TOP2 poison-mediated genotoxic damage and, therefore, reduce

218 3f is a favorable lead candidate as a topoII poison, meriting future studies to test its efficacy in

219 4Q-CCC-treated compared with PBS-treated, CO-poisoned mice.

220 al activity of EDP on food spoilage and food poisoning microorganisms was evaluated through the measu

221 nthracyclines and another intercalating TOP2 poison, mitoxantrone, stabilize TOP2-DNA covalent comple

222 ed US trends in premature all-cause and drug poisoning mortality between 2000 and 2015 at the county

223 Drug poisoning mortality increased in counties throughout the

224 Although drug poisoning mortality increased rapidly in counties with t

225 Increasing drug poisoning mortality was not limited to poor white people

226 een cells, allowing a SitA inhibitor cell to poison multiple targets, including cells that never made

227 se, n = 6; viral infections, n = 3; mushroom poisoning, n = 5; indeterminate, n = 20) were compared.

228 trategy that enables access to four of these poisons, namely 11-saxitoxinethanoic acid, C13-acetoxy s

229 tit-for-tat, whereby cells stab rivals with poisoned needles (the type VI secretion system) after be

230 which beta-ntx hinders production of ATP in poisoned nerve endings.

231 LA(2)s) block neuro-muscular transmission by poisoning nerve terminals.

232 dity index of 0 vs 2), diagnoses of overdose/poisoning (odds ratio, 1.35; 95% CI, 1.23-1.47) and diab

233 s of splicing activators, thereby preventing poisoning of key transcripts and disruption to gene expr

234 ersibly store hydrogen prevents the hydrogen poisoning of Ru surfaces.

235 The poisoning of rural populations in South and Southeast As

236 0.1 under light, thereby suppressing oxygen poisoning of the Pt catalyst.

237 mits formation of EPFRs due to inhibition or poisoning of the transition metal active sites necessary

238 ow that alterations conferring resistance to poisons of human and yeast topoisomerase II derive from

239 We demonstrate that the poison oligomers can act as habit modifiers both during

240 The introduction of "poison" oligonucleotides that specifically disrupt criti

241 om problematic operation stability due to CO poisoning on surface.

242 Our data reveal the effect of Top2 poisons on the global Top2 binding landscape and highlig

243 Methanol poisoning outbreaks after consumption of adulterated alc

244 roximately one-third of moderate to severely poisoned patients exhibit cardiac dysfunction, including

245 Extracorporeal membrane oxygenation use in poisoned patients in the United States has significantly

246 brane oxygenation to support critically ill, poisoned patients in the United States is increasing, dr

247 eaction tolerates heterocycles that commonly poison Pd catalysts.

248 s epitomize the serious threat that wildlife poisoning poses to biodiversity.

249 Anticancer drugs targeting TOP2 (TOP2 poisons) prevent religation of the DSB and stabilize a n

250 to mitochondria allow for the opportunity to poison proliferating cancer cell mtDNA replication as ce

251 The Wtf4(poison) protein forms dispersed, toxic aggregates.

252 veterinary drugs have caused severe wildlife poisoning, pushing the populations of several apex speci

253 suicides are attributable to pesticide self-poisoning, reaching a cost-effectiveness ratio of $75 pe

254 called SitA in their delivered cargo, which poison recipient cells that lack the cognate, allele-spe

255 By linking field data of 1,075 poisoned red kites to changes in occupancy and abundance

256 We show that neutralization of the Wtf4(poison) requires both co-assembly with the Wtf4(antidote

257 e evidence on population effects of wildlife poisoning rests on assessments conducted at an individua

258 e stabilized by a class of drugs termed Top2 poisons, resulting in massive DNA damage.

259 ety of stresses, including the mitochondrial poison rotenone, amyloid beta-peptide, hydrogen peroxide

260 which are commonly ingested in acts of self-poisoning, seem to be effective in reducing pesticide-sp

261 cidental death, particularly accidental self-poisoning, should be considered to be as important as th

262 rophylactic efficacy against organophosphate poisoning, showing its application potential.

263 This first set of hybrid topoII poisons shows promising antiproliferative activity on hu

264 n is critical for C. perfringens type A food poisoning since spores contribute to transmission and re

265 , a derivative of C. perfringens type A food-poisoning strain NCTC8798.

266 Four examined acute Three neonic poisoning studies reported two fatalities (n = 1,280 cas

267 ly reversible, but can be stabilized by TOP2 poisons, such as the chemotherapeutic agent etoposide (E

268 ignificant number of patients who survive CO poisoning suffer from long-term neurological and affecti

269 red the response of cells to the microtubule poison Taxol.

270 ibitor dexrazoxane (ICRF187) and mechanistic poison teniposide (VM26), can interfere with DNA gate dy

271 al use, these compounds do not act as topoII poisons that enhance enzyme-mediated DNA cleavage, a mec

272 as a stable surface product that is known to poison the catalytic surface.

273 cancer natural products that bind to DNA and poison the topoisomerase II-DNA complex in cancer cells.

274 genate aminoalkenes and aminoalkynes without poisoning the catalyst through competitive amine ligatio

275 thway features high chemoselectivity without poisoning the surface.

276 ransiently reducing paralysis following BoNT poisoning, the precise mechanisms by which aminopyridine

277 ns; however, ancillary ligands also commonly poison these reactions.

278 Given that poisoning threatens the global populations of more than

279 no evidence of switching from pesticide self-poisoning to other forms of self-harm, with no significa

280 increase their chances of spreading by using poisons to kill other alleles, and antidotes to save the

281 loiting the ability of several topoisomerase poisons to stabilize this intermediate we developed a Ch

282 es suppresses the action of other drugs that poison TOP2.

283 arkable given the propensity for sulfides to poison transition-metal catalysts.

284 By selectively poisoning under-coordinated sites with Pb, we have confi

285 ystericus, vocal cord dysfunction, scombroid poisoning, vasoactive amine intolerance, carcinoid syndr

286 Self-cutting combined with self-poisoning was also associated with increased suicide ris

287 For this study, lead poisoning was defined as a blood lead level (BLL) greate

288 bioterrorism agent and a major cause of food poisoning, we developed a "class T" anti-SEB neutralizin

289 ntations involving both self-injury and self-poisoning were associated with higher suicide risk (adju

290 cle crashes, and suicide by means other than poisoning-were compared with a counterfactual estimate o

291 To enact drive, all gametes are poisoned, whereas only those that inherit wtf4 are rescu

292 Methanol is a poison which is frequently discovered in alcoholic bever

293 irst set of hybrid topoisomerase II (topoII) poisons whose chemical core merges key pharmacophoric el

294 ition to standard care for patients severely poisoned with either chloroquine or quinine (strong reco

295 achieve non-toxic concentrations in patients poisoned with these two prescription drugs.

296 , poor durability, and susceptibility to gas poisoning with adverse environmental issues.

297 are often managed using similar tools, like poisoning with antibiotics or algicides.

298 ns for extracorporeal treatments in cases of poisoning with these drugs.

299 and that the antibacterial ciprofloxacin can poison yeast topoisomerase II.

300 f which is found to act as a potent catalyst poison, yielding a catalytically inactive tris-ligated [