ライフサイエンスコーパス: pol gene

1 ance arising from point mutations in the CMV Pol gene.

2 tivator, and a potential promoter within the pol gene.

3 riptase, and integrase portions of the HIV-1 pol gene.

4 clinically relevant escape mutations in the Pol gene.

5 ively structure-free template from the HIV-1 pol gene.

6 al frameshift event to enter the overlapping pol gene.

7 er junctions were distributed throughout the pol gene.

8 eletions were also introduced into the viral pol gene.

9 , presumably corresponding to the end of the pol gene.

10 in the human immunodeficiency type 1 (HIV-1) pol gene.

11 alignment of over 110 000 sequences of HIV-1 pol genes.

12 age RNA molecules that encode HERV-K-related pol genes.

13 of diversity and divergence in both env and pol genes.

14 promoter in antisense orientation to the gag-pol genes.

15 B env gene rather than the subtype C gag and pol genes.

16 nous retrovirus K10 in 3.5 kb of the gag and pol genes.

17 n influenza virus A, and HIV-1 env, vif, and pol genes.

18 d in the hepatitis B virus (HBV) polymerase (Pol) gene.

19 transcriptase encoded by the HBV polymerase (pol) gene.

20 ARS-CoV-2) and the relatively highly diverse pol gene (2637) of the human immunodeficiency virus-1 (H

21 5%) followed by alkyl phosphonate-associated pol-gene (7.4%), immune-associated S gene (specifically

22 highly conserved regions of the polymerase (pol) gene, allowed the identification of two novel porci

23 istic evolutionary model for analyses of the pol gene, although it is inapplicable to analyses involv

24 eotide ligation assay specific codons in the pol gene amplified by PCR.

25 ce analysis of the RT-encoding region of the pol gene amplified from resistant viruses consistently i

26 ce analysis of the RT-encoding region of the pol gene amplified from the plaque-purified mutants reve

27 The primers used for nested PCR of the HIV-1 pol gene amplified templates from a reference panel of m

28 blindly for HIV-1 subtypes by sequencing the pol gene and by gag-HMA.

29 PR-Cas9, we disrupted all copies of the PERV pol gene and demonstrated a >1000-fold reduction in PERV

30 s biotinylated proteins encoded by the HIV-1 pol gene and neighbor Gag proteins, but, surprisingly, o

31 ntral polypurine tract (cPPT) from the HIV-1 pol gene and removing the cytoplasmic tail of EnvA, the

32 e primary site of hypermutation is the viral pol gene and the dominant selective force acting on this

33 an internal deletion that removes all of the pol gene and various amounts of gag and env gene sequenc

34 ift similar to frameshifts in retroviral gag-pol genes and bacterial insertion elements was found to

35 The pol genes and deduced amino acid sequences from 23 provi

36 sted of two plasmids, one expressing the gag/pol genes and the other expressing the env gene of FeLV-

37 lated depended on the individual env and gag-pol genes and their suppressive effects on virus replica

38 dogenous mammalian DNA polymerase beta (beta-pol) gene and of the cloned promoter in transient expres

39 iral diversity and divergence in the env and pol genes, and determined coreceptor tropism and the fre

40 lass was observed in l-nucleoside-associated pol gene/antiviral-associated S gene mutations (cumulati

41 Incidence of l-nucleoside-associated pol-gene/antiviral-associated S gene mutations was signi

42 murine leukemia virus (MuLV), whose gag and pol genes are in the same reading frame but separated by

43 rtain mutations in the viral DNA polymerase (pol) gene are known to confer drug resistance when trans

44 ion between two viruses containing subtype B pol genes (B/B) and between viruses with pol genes from

45 -acting element located at the 3' end of the pol gene between position 6486 and 6975 to be critical f

46 ng the Moloney murine leukemia virus gag and pol genes but lacking virus envelope genes produce virus

47 ched the subtypes determined for the gag and pol genes but not the env gene, suggesting that a recomb

48 (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene conferring resistance to multiple dideoxynucleo

49 In northern koalas, pol gene copies were ubiquitously present at above five

50 f the Moloney murine leukemia virus (M-MuLV) pol gene encoding the connection-RNase H domains of reve

51 In this study, an individual patient's HIV-1 pol gene encoding the full length of protease and part o

52 Sequence comparison of portions of the PoEV pol gene expressed in pig cell lines productively infect

53 t is a required transcription factor in beta-pol gene expression.

54 res a programmed -1 ribosomal frameshift for Pol gene expression.

55 ification at one ambiguous site in the viral pol gene for biological activity.

56 le that SFV-1 contains a promoter within the pol gene for initiating a reverse transcriptase transcri

57 ducting a BLASTN search, the initial partial pol gene fragment was found to have 95% to 97% nucleotid

58 HTLV-1 pol gene fragments encoding reverse transcriptase were a

59 vity, we sequenced and phenotypically tested pol genes from a variety of HTLV-1 isolates derived from

60 VA-TZC (MVA-T) vaccines contain gag, env and pol genes from HIV-1 subtypes CRF01_AE, A and C, respect

61 e B pol genes (B/B) and between viruses with pol genes from subtype B or F (B/F).

62 our rate estimates for the RNA polymerase 3D(pol) gene from five viruses to four published 3D(pol) ra

63 e of infection without selection pressure on pol gene function were analyzed by single-genome sequenc

64 l repeat and the 5' half of env; the gag and pol genes have been partially deleted.

65 We found sequences homologous to retroviral pol genes in the cell-free cerebrospinal fluids (CSFs) o

66 LV with differences from EU-8 in the gag and pol genes, induces rapid-onset lymphoma at only a low in

67 HIV-1 pol gene intersubtype and RC differences are associated

68 d the finding of a cis-acting element in the pol gene is unique among retroviruses.

69 is virus (MHV) gene 1, the 22-kb polymerase (pol) gene, is first translated into a polyprotein and su

70 nd the identification of clinically relevant pol gene length polymorphisms will impact the generaliza

71 iations with treatment experience, clade, or pol gene mutations were observed.

72 0/s145, 6.4%), and d-cyclopentane-associated pol-gene mutations (2.4%).

73 found in the TK (n = 15, 83%) or in the DNA pol gene (n = 3, 17%).

74 ion to patient data from one-time samples of pol gene obtained by single-genome sequencing from repre

75 tified a conserved cis-acting element in the pol gene of gammaretroviruses, including murine leukemia

76 describes the detection of mutations in the pol gene of human immunodeficiency virus type 1 associat

77 the 3' end of the gag gene and preceding the pol gene of SFV-1.

78 tional frameshift similar to that of the gag-pol genes of many retroviruses to produce the proteins g

79 frames (ORFs) that correspond to the gag and pol genes of previously described retrotransposons and r

80 the env gene of HIV-1 HXBc2 and the gag and pol genes of simian immunodeficiency virus SIVmac239.

81 A 182-bp fragment of the pol genes of the two remaining mandrill SIV isolates was

82 ct of a gene-targeted disruption in the beta-pol gene on DNA repair capacity and on in vivo sensitivi

83 ther simian immunodeficiency virus (SIV) gag/pol genes or no SIV genes in vivo to test the additional

84 Moloney murine leukemia virus (MLV) gag and pol genes produce large amounts of noninfectious virus-l

85 the primer species can be attributed to the pol gene product, nothing is known regarding mechanisms

86 at resulted in two amino acid changes in the pol gene product; and a single nucleotide change in the

87 and SNV vectors, indicating that the gag and pol gene products from two different viruses can functio

88 ng elements are not ideal substrates for MLV pol gene products since infectious viruses were generate

89 n a multiple cycle assay, so that functional pol gene products were selected.

90 In all other retroviruses, the pol gene products, including reverse transcriptase, are

91 d as genomic RNA and as mRNA for the Gag and Pol gene products.

92 spliced RNAs as mRNAs to produce the gag and pol gene products.

93 al TATA-less human DNA polymerase beta (beta-pol) gene promoter.

94 drug pressure can direct evolution of viral pol gene quasispecies independently of direct drug-resis

95 mployed for an extensive genetic analysis of pol gene quasispecies.

96 ear evidence of A/B recombination within the pol gene segment, whereas in the other patient, GA132, n

97 To determine whether variations in the pol gene sequence correlated with virus infectivity, we

98 hree distinct strains A, B, and C defined by pol gene sequence divergences, is endemic in the large o

99 The pol gene sequence was amplified to ascertain the HIV-1 s

100 mong 159 case patients who had an HIV type 1 pol gene sequence, 157 (98.7%) had sequences that were h

101 molecular epidemiology studies analyse viral pol gene sequences due to their availability, but whole

102 Phylogenetic analysis of HIV-1 pol gene sequences from Britain showed at least six larg

103 We extracted all subtype B HIV-1 pol gene sequences from treatment-naive patients within

104 enetic analysis of 14,061 HIV type 1 (HIV-1) pol gene sequences generated in the United Kingdom from

105 FIV-Pco pol gene sequences isolated from pumas revealed extensiv

106 ylodynamic analysis was performed on partial pol gene sequences obtained for routine clinical care fr

107 A total of 209 partial pol gene sequences of HIV-1 CRF55_01B were sampled durin

108 from the conserved motifs of the polymerase pol gene sequences to detect members of the Paramyxoviri

109 Using HTLV-I/II pol primers, no HTLV-I pol gene sequences were detected.

110 ntical to viruses in resting CD4+ T cells by pol gene sequencing.

111 the Alu repeat in human genomic DNA and HIV pol gene simultaneously.

112 te the genetic relationship to SIVcpz in the pol gene, SIVrcmNG411 did not replicate in chimpanzee pe

113 opteran (moth) retroelement contains gag and pol genes that encode proteins capable of forming virusl

114 Vectors carrying pol genes that matched the consensus sequence had the hi

115 y conserved region of integrase in the HIV-1 pol gene (the integrase single-copy assay [iSCA]), and i

116 ORFs 1 and 3 correspond to gag and pol genes; the second ORF, pro, corresponding to proteas

117 nsposon Ty1 element is replaced with the HBV pol gene to produce the hybrid Ty1/HBV element.

118 fragments of envelope (env) and polymerase (pol) genes, two genetically distinct lineages of FIVpco

119 Sequencing of the CMV pol gene was performed in 30 isolates.

120 Genotyping of the HIV-1 pol gene was performed using a broadly sensitive in-hous

121 ing human immunodeficiency virus env and gag-pol genes, we detected nonexpressing mutants by immunost

122 INS elements from the HIV-1 p17 gag and pol genes were equally active in complementing Rev-depen

123 Mutations at the POLTERGEIST (POL) gene were previously described as phenotypic suppre

124 ines depends on an enhancer within the viral pol gene which can be localized to a minimal 183-bp regi

125 (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene, which confers resistance to multiple dideoxynu

126 The POL gene, which encodes a functional protein phosphatase

127 next-generation sequencing (NGS) of the HIV pol gene with MiSeq technology.